| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 25 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 16 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005730 | nucleolus | 5 | 12 |
| GO:0005829 | cytosol | 2 | 2 |
| GO:0030684 | preribosome | 3 | 2 |
| GO:0030687 | preribosome, large subunit precursor | 4 | 2 |
| GO:0032991 | protein-containing complex | 1 | 2 |
| GO:0043226 | organelle | 2 | 12 |
| GO:0043228 | non-membrane-bounded organelle | 3 | 12 |
| GO:0043229 | intracellular organelle | 3 | 12 |
| GO:0043232 | intracellular non-membrane-bounded organelle | 4 | 12 |
| GO:0110165 | cellular anatomical entity | 1 | 12 |
| GO:1990904 | ribonucleoprotein complex | 2 | 2 |
| GO:0005737 | cytoplasm | 2 | 10 |
| GO:0016020 | membrane | 2 | 1 |
Related structures:
AlphaFold database: Q4Q1Y7
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000054 | ribosomal subunit export from nucleus | 3 | 2 |
| GO:0000460 | maturation of 5.8S rRNA | 9 | 2 |
| GO:0000470 | maturation of LSU-rRNA | 9 | 2 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 2 |
| GO:0006364 | rRNA processing | 8 | 2 |
| GO:0006396 | RNA processing | 6 | 2 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 2 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 2 |
| GO:0006810 | transport | 3 | 2 |
| GO:0006913 | nucleocytoplasmic transport | 5 | 2 |
| GO:0006996 | organelle organization | 4 | 12 |
| GO:0008152 | metabolic process | 1 | 2 |
| GO:0009987 | cellular process | 1 | 12 |
| GO:0016043 | cellular component organization | 3 | 12 |
| GO:0016070 | RNA metabolic process | 5 | 2 |
| GO:0016072 | rRNA metabolic process | 7 | 2 |
| GO:0022607 | cellular component assembly | 4 | 12 |
| GO:0022618 | ribonucleoprotein complex assembly | 6 | 2 |
| GO:0031503 | protein-containing complex localization | 2 | 2 |
| GO:0033750 | ribosome localization | 3 | 2 |
| GO:0034470 | ncRNA processing | 7 | 2 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 2 |
| GO:0034660 | ncRNA metabolic process | 6 | 2 |
| GO:0042255 | ribosome assembly | 7 | 12 |
| GO:0042256 | cytosolic ribosome assembly | 8 | 12 |
| GO:0043170 | macromolecule metabolic process | 3 | 2 |
| GO:0043933 | protein-containing complex organization | 4 | 2 |
| GO:0044237 | cellular metabolic process | 2 | 2 |
| GO:0044238 | primary metabolic process | 2 | 2 |
| GO:0046483 | heterocycle metabolic process | 3 | 2 |
| GO:0046907 | intracellular transport | 3 | 2 |
| GO:0051168 | nuclear export | 6 | 2 |
| GO:0051169 | nuclear transport | 4 | 2 |
| GO:0051179 | localization | 1 | 2 |
| GO:0051234 | establishment of localization | 2 | 2 |
| GO:0051640 | organelle localization | 2 | 2 |
| GO:0051641 | cellular localization | 2 | 2 |
| GO:0051649 | establishment of localization in cell | 3 | 2 |
| GO:0051656 | establishment of organelle localization | 3 | 2 |
| GO:0065003 | protein-containing complex assembly | 5 | 2 |
| GO:0070925 | organelle assembly | 5 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 2 |
| GO:0071826 | ribonucleoprotein complex subunit organization | 5 | 2 |
| GO:0071840 | cellular component organization or biogenesis | 2 | 12 |
| GO:0090304 | nucleic acid metabolic process | 4 | 2 |
| GO:0140694 | non-membrane-bounded organelle assembly | 6 | 12 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 2 |
| GO:1902626 | assembly of large subunit precursor of preribosome | 7 | 2 |
| GO:0022613 | ribonucleoprotein complex biogenesis | 4 | 10 |
| GO:0042273 | ribosomal large subunit biogenesis | 5 | 10 |
| GO:0044085 | cellular component biogenesis | 3 | 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | 3 | 12 |
| GO:0003743 | translation initiation factor activity | 4 | 12 |
| GO:0005488 | binding | 1 | 12 |
| GO:0008135 | translation factor activity, RNA binding | 3 | 12 |
| GO:0043021 | ribonucleoprotein complex binding | 3 | 12 |
| GO:0043022 | ribosome binding | 4 | 12 |
| GO:0043023 | ribosomal large subunit binding | 4 | 12 |
| GO:0044877 | protein-containing complex binding | 2 | 12 |
| GO:0045182 | translation regulator activity | 1 | 12 |
| GO:0090079 | translation regulator activity, nucleic acid binding | 2 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 52 | 56 | PF00656 | 0.591 |
| CLV_C14_Caspase3-7 | 87 | 91 | PF00656 | 0.486 |
| CLV_NRD_NRD_1 | 225 | 227 | PF00675 | 0.560 |
| CLV_PCSK_KEX2_1 | 225 | 227 | PF00082 | 0.557 |
| DOC_CKS1_1 | 163 | 168 | PF01111 | 0.486 |
| DOC_CYCLIN_yCln2_LP_2 | 177 | 183 | PF00134 | 0.486 |
| DOC_PP2B_LxvP_1 | 177 | 180 | PF13499 | 0.486 |
| DOC_PP2B_LxvP_1 | 70 | 73 | PF13499 | 0.480 |
| DOC_USP7_MATH_1 | 192 | 196 | PF00917 | 0.486 |
| DOC_USP7_MATH_1 | 28 | 32 | PF00917 | 0.497 |
| DOC_WW_Pin1_4 | 162 | 167 | PF00397 | 0.486 |
| LIG_14-3-3_CanoR_1 | 100 | 108 | PF00244 | 0.486 |
| LIG_14-3-3_CanoR_1 | 85 | 89 | PF00244 | 0.486 |
| LIG_BRCT_BRCA1_1 | 30 | 34 | PF00533 | 0.486 |
| LIG_deltaCOP1_diTrp_1 | 201 | 205 | PF00928 | 0.486 |
| LIG_FHA_1 | 123 | 129 | PF00498 | 0.490 |
| LIG_FHA_1 | 130 | 136 | PF00498 | 0.480 |
| LIG_FHA_2 | 209 | 215 | PF00498 | 0.407 |
| LIG_FHA_2 | 241 | 247 | PF00498 | 0.518 |
| LIG_FHA_2 | 3 | 9 | PF00498 | 0.327 |
| LIG_FHA_2 | 75 | 81 | PF00498 | 0.479 |
| LIG_LIR_Gen_1 | 20 | 30 | PF02991 | 0.482 |
| LIG_LIR_Gen_1 | 201 | 208 | PF02991 | 0.512 |
| LIG_LIR_LC3C_4 | 195 | 199 | PF02991 | 0.486 |
| LIG_LIR_Nem_3 | 20 | 26 | PF02991 | 0.482 |
| LIG_LIR_Nem_3 | 201 | 205 | PF02991 | 0.479 |
| LIG_LIR_Nem_3 | 31 | 37 | PF02991 | 0.486 |
| LIG_PDZ_Class_3 | 244 | 249 | PF00595 | 0.539 |
| LIG_Pex14_2 | 34 | 38 | PF04695 | 0.485 |
| LIG_SH2_CRK | 23 | 27 | PF00017 | 0.486 |
| LIG_SH2_CRK | 50 | 54 | PF00017 | 0.486 |
| LIG_SH2_NCK_1 | 151 | 155 | PF00017 | 0.497 |
| LIG_SH2_NCK_1 | 50 | 54 | PF00017 | 0.486 |
| LIG_SH2_STAT5 | 23 | 26 | PF00017 | 0.476 |
| LIG_SH2_STAT5 | 50 | 53 | PF00017 | 0.486 |
| LIG_SH3_3 | 160 | 166 | PF00018 | 0.486 |
| LIG_SUMO_SIM_anti_2 | 112 | 120 | PF11976 | 0.486 |
| LIG_SUMO_SIM_anti_2 | 213 | 219 | PF11976 | 0.412 |
| LIG_TRAF2_1 | 77 | 80 | PF00917 | 0.486 |
| LIG_TRAF2_2 | 166 | 171 | PF00917 | 0.486 |
| LIG_TYR_ITIM | 48 | 53 | PF00017 | 0.486 |
| LIG_WRC_WIRS_1 | 135 | 140 | PF05994 | 0.486 |
| MOD_CK1_1 | 122 | 128 | PF00069 | 0.486 |
| MOD_CK1_1 | 17 | 23 | PF00069 | 0.547 |
| MOD_CK1_1 | 74 | 80 | PF00069 | 0.486 |
| MOD_CK2_1 | 138 | 144 | PF00069 | 0.486 |
| MOD_CK2_1 | 2 | 8 | PF00069 | 0.338 |
| MOD_CK2_1 | 208 | 214 | PF00069 | 0.414 |
| MOD_CK2_1 | 33 | 39 | PF00069 | 0.486 |
| MOD_CK2_1 | 74 | 80 | PF00069 | 0.479 |
| MOD_GlcNHglycan | 101 | 104 | PF01048 | 0.297 |
| MOD_GlcNHglycan | 194 | 197 | PF01048 | 0.288 |
| MOD_GSK3_1 | 134 | 141 | PF00069 | 0.486 |
| MOD_GSK3_1 | 2 | 9 | PF00069 | 0.335 |
| MOD_GSK3_1 | 84 | 91 | PF00069 | 0.497 |
| MOD_N-GLC_1 | 208 | 213 | PF02516 | 0.436 |
| MOD_NEK2_1 | 138 | 143 | PF00069 | 0.496 |
| MOD_NEK2_1 | 147 | 152 | PF00069 | 0.505 |
| MOD_NEK2_1 | 208 | 213 | PF00069 | 0.420 |
| MOD_NEK2_1 | 84 | 89 | PF00069 | 0.486 |
| MOD_PIKK_1 | 28 | 34 | PF00454 | 0.486 |
| MOD_PKA_1 | 225 | 231 | PF00069 | 0.678 |
| MOD_PKA_2 | 122 | 128 | PF00069 | 0.495 |
| MOD_PKA_2 | 129 | 135 | PF00069 | 0.482 |
| MOD_PKA_2 | 138 | 144 | PF00069 | 0.435 |
| MOD_PKA_2 | 17 | 23 | PF00069 | 0.497 |
| MOD_PKA_2 | 225 | 231 | PF00069 | 0.633 |
| MOD_PKA_2 | 240 | 246 | PF00069 | 0.473 |
| MOD_PKA_2 | 60 | 66 | PF00069 | 0.507 |
| MOD_PKA_2 | 84 | 90 | PF00069 | 0.484 |
| MOD_PKA_2 | 99 | 105 | PF00069 | 0.486 |
| MOD_PKB_1 | 4 | 12 | PF00069 | 0.486 |
| MOD_Plk_1 | 171 | 177 | PF00069 | 0.529 |
| MOD_Plk_1 | 213 | 219 | PF00069 | 0.406 |
| MOD_Plk_4 | 172 | 178 | PF00069 | 0.486 |
| MOD_Plk_4 | 240 | 246 | PF00069 | 0.518 |
| MOD_Plk_4 | 33 | 39 | PF00069 | 0.482 |
| MOD_ProDKin_1 | 162 | 168 | PF00069 | 0.486 |
| TRG_DiLeu_BaEn_1 | 172 | 177 | PF01217 | 0.486 |
| TRG_ENDOCYTIC_2 | 23 | 26 | PF00928 | 0.486 |
| TRG_ENDOCYTIC_2 | 35 | 38 | PF00928 | 0.486 |
| TRG_ENDOCYTIC_2 | 50 | 53 | PF00928 | 0.486 |
| TRG_ER_diArg_1 | 224 | 226 | PF00400 | 0.501 |
| TRG_ER_diArg_1 | 3 | 6 | PF00400 | 0.338 |
| TRG_NES_CRM1_1 | 214 | 227 | PF08389 | 0.449 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1PDV4 | Leptomonas seymouri | 96% | 100% |
| A0A0S4IVB2 | Bodo saltans | 87% | 100% |
| A0A1X0P9I9 | Trypanosomatidae | 91% | 100% |
| A0A3Q8IVS9 | Leishmania donovani | 99% | 100% |
| A0A422NK30 | Trypanosoma rangeli | 91% | 100% |
| A0RYC3 | Cenarchaeum symbiosum (strain A) | 28% | 100% |
| A1RXF3 | Thermofilum pendens (strain DSM 2475 / Hrk 5) | 30% | 100% |
| A2BN57 | Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) | 30% | 100% |
| A2STI7 | Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) | 27% | 100% |
| A3CWZ4 | Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) | 30% | 100% |
| A3DNH5 | Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) | 30% | 100% |
| A4G0C9 | Methanococcus maripaludis (strain C5 / ATCC BAA-1333) | 32% | 100% |
| A4HNU9 | Leishmania braziliensis | 99% | 100% |
| A4ICP5 | Leishmania infantum | 99% | 100% |
| A4RSQ6 | Ostreococcus lucimarinus (strain CCE9901) | 59% | 100% |
| A4WL95 | Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) | 24% | 100% |
| A5UL31 | Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) | 27% | 100% |
| A6UR54 | Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) | 32% | 100% |
| A6UT95 | Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) | 29% | 100% |
| A6VI48 | Methanococcus maripaludis (strain C7 / ATCC BAA-1331) | 32% | 100% |
| A7ANL7 | Babesia bovis | 55% | 100% |
| A7I9I6 | Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) | 33% | 100% |
| A9A305 | Nitrosopumilus maritimus (strain SCM1) | 32% | 100% |
| A9A8N1 | Methanococcus maripaludis (strain C6 / ATCC BAA-1332) | 32% | 100% |
| B0EMY3 | Entamoeba dispar (strain ATCC PRA-260 / SAW760) | 57% | 100% |
| B0R7X7 | Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) | 34% | 100% |
| B6YWY2 | Thermococcus onnurineus (strain NA1) | 30% | 100% |
| B8GEU6 | Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) | 28% | 100% |
| B8MDN4 | Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) | 61% | 100% |
| B9LUU8 | Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) | 32% | 100% |
| B9PVB9 | Toxoplasma gondii (strain ATCC 50861 / VEG) | 60% | 94% |
| C3MR78 | Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) | 32% | 100% |
| C3MXG7 | Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) | 32% | 100% |
| C3MZB3 | Sulfolobus islandicus (strain M.16.27) | 32% | 100% |
| C3N7D3 | Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) | 32% | 100% |
| C3NGA1 | Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) | 32% | 100% |
| C4KIJ1 | Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) | 32% | 100% |
| C5A7H2 | Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) | 32% | 100% |
| C9SV08 | Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136) | 57% | 100% |
| D0A2R7 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 92% | 100% |
| D1ZG64 | Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) | 59% | 100% |
| E9ASK9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 100% | 100% |
| O22290 | Arabidopsis thaliana | 54% | 100% |
| O27648 | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) | 29% | 100% |
| O28214 | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) | 25% | 100% |
| O55135 | Mus musculus | 58% | 100% |
| O58264 | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) | 32% | 100% |
| O62106 | Caenorhabditis elegans | 56% | 100% |
| O81920 | Beta vulgaris | 63% | 100% |
| O94476 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 66% | 100% |
| P38619 | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) | 30% | 100% |
| P56537 | Homo sapiens | 58% | 100% |
| P56538 | Drosophila melanogaster | 65% | 100% |
| Q0W5H2 | Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) | 29% | 100% |
| Q12522 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 60% | 100% |
| Q12ZJ5 | Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) | 31% | 100% |
| Q18EU8 | Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) | 35% | 100% |
| Q245F2 | Tetrahymena thermophila (strain SB210) | 63% | 100% |
| Q2FS97 | Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) | 30% | 100% |
| Q2NGQ7 | Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) | 29% | 100% |
| Q2UTN7 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 63% | 100% |
| Q3ITD5 | Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) | 35% | 100% |
| Q3KRD8 | Rattus norvegicus | 58% | 100% |
| Q46FA1 | Methanosarcina barkeri (strain Fusaro / DSM 804) | 36% | 100% |
| Q4E097 | Trypanosoma cruzi (strain CL Brener) | 91% | 100% |
| Q551M2 | Dictyostelium discoideum | 56% | 100% |
| Q59L13 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 59% | 100% |
| Q5ASA6 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 63% | 100% |
| Q5JGT4 | Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) | 33% | 100% |
| Q60357 | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 31% | 100% |
| Q6GR45 | Xenopus laevis | 58% | 100% |
| Q6L2L0 | Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) | 28% | 100% |
| Q6M156 | Methanococcus maripaludis (strain S2 / LL) | 32% | 100% |
| Q6ZM19 | Danio rerio | 57% | 100% |
| Q7S2W6 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 59% | 100% |
| Q8PYQ3 | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) | 35% | 100% |
| Q8SS47 | Encephalitozoon cuniculi (strain GB-M1) | 47% | 100% |
| Q8TIN4 | Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) | 34% | 100% |
| Q8TUY5 | Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 30% | 100% |
| Q8U3S8 | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) | 34% | 100% |
| Q8ZTU1 | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) | 25% | 100% |
| Q971I4 | Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) | 31% | 100% |
| Q97CU0 | Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) | 28% | 100% |
| Q980G0 | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) | 32% | 100% |
| Q98RM8 | Guillardia theta | 34% | 100% |
| Q9HM16 | Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) | 29% | 100% |
| Q9M060 | Arabidopsis thaliana | 59% | 100% |
| Q9TU47 | Bos taurus | 58% | 100% |
| Q9UYI6 | Pyrococcus abyssi (strain GE5 / Orsay) | 32% | 100% |
| V5B9X2 | Trypanosoma cruzi | 91% | 82% |