LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
SNF1-related protein kinases, putative
Species:
Leishmania major
UniProt:
Q4Q1Y6_LEIMA
TriTrypDb:
LmjF.36.0900 * , LMJLV39_360014700 * , LMJSD75_360014700 *
Length:
793

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1Y6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Y6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 10
GO:0006793 phosphorus metabolic process 3 10
GO:0006796 phosphate-containing compound metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0007165 signal transduction 2 2
GO:0008152 metabolic process 1 10
GO:0009987 cellular process 1 10
GO:0016310 phosphorylation 5 10
GO:0019538 protein metabolic process 3 10
GO:0035556 intracellular signal transduction 3 2
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0065007 biological regulation 1 2
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003824 catalytic activity 1 10
GO:0004672 protein kinase activity 3 10
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140096 catalytic activity, acting on a protein 2 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 14 20 PF00089 0.545
CLV_NRD_NRD_1 356 358 PF00675 0.626
CLV_NRD_NRD_1 53 55 PF00675 0.303
CLV_NRD_NRD_1 553 555 PF00675 0.693
CLV_PCSK_KEX2_1 356 358 PF00082 0.622
CLV_PCSK_KEX2_1 553 555 PF00082 0.693
CLV_PCSK_KEX2_1 561 563 PF00082 0.599
CLV_PCSK_KEX2_1 68 70 PF00082 0.406
CLV_PCSK_KEX2_1 772 774 PF00082 0.497
CLV_PCSK_PC1ET2_1 561 563 PF00082 0.600
CLV_PCSK_PC1ET2_1 68 70 PF00082 0.406
CLV_PCSK_PC1ET2_1 772 774 PF00082 0.503
CLV_PCSK_PC7_1 768 774 PF00082 0.557
CLV_PCSK_SKI1_1 123 127 PF00082 0.299
CLV_PCSK_SKI1_1 144 148 PF00082 0.308
CLV_PCSK_SKI1_1 281 285 PF00082 0.491
CLV_PCSK_SKI1_1 46 50 PF00082 0.313
CLV_PCSK_SKI1_1 529 533 PF00082 0.630
CLV_PCSK_SKI1_1 553 557 PF00082 0.678
CLV_PCSK_SKI1_1 558 562 PF00082 0.691
CLV_PCSK_SKI1_1 62 66 PF00082 0.263
CLV_PCSK_SKI1_1 69 73 PF00082 0.279
CLV_PCSK_SKI1_1 786 790 PF00082 0.615
CLV_Separin_Metazoa 311 315 PF03568 0.522
DEG_APCC_DBOX_1 45 53 PF00400 0.420
DEG_SCF_FBW7_1 788 793 PF00400 0.582
DEG_SPOP_SBC_1 688 692 PF00917 0.558
DOC_CKS1_1 376 381 PF01111 0.643
DOC_CYCLIN_RxL_1 120 130 PF00134 0.400
DOC_CYCLIN_RxL_1 276 285 PF00134 0.517
DOC_CYCLIN_yCln2_LP_2 491 497 PF00134 0.655
DOC_MAPK_DCC_7 374 382 PF00069 0.522
DOC_MAPK_gen_1 44 51 PF00069 0.338
DOC_MAPK_gen_1 66 76 PF00069 0.313
DOC_MAPK_gen_1 90 98 PF00069 0.420
DOC_MAPK_MEF2A_6 44 51 PF00069 0.338
DOC_MAPK_MEF2A_6 541 549 PF00069 0.575
DOC_MAPK_MEF2A_6 722 730 PF00069 0.583
DOC_MAPK_MEF2A_6 90 99 PF00069 0.344
DOC_MAPK_NFAT4_5 92 100 PF00069 0.372
DOC_MAPK_RevD_3 540 554 PF00069 0.644
DOC_PP2B_LxvP_1 491 494 PF13499 0.597
DOC_PP4_FxxP_1 569 572 PF00568 0.630
DOC_SPAK_OSR1_1 319 323 PF12202 0.535
DOC_USP7_MATH_1 239 243 PF00917 0.336
DOC_USP7_MATH_1 418 422 PF00917 0.601
DOC_USP7_MATH_1 469 473 PF00917 0.738
DOC_USP7_MATH_1 511 515 PF00917 0.718
DOC_USP7_MATH_1 643 647 PF00917 0.723
DOC_USP7_MATH_2 324 330 PF00917 0.513
DOC_USP7_UBL2_3 406 410 PF12436 0.656
DOC_USP7_UBL2_3 68 72 PF12436 0.439
DOC_USP7_UBL2_3 727 731 PF12436 0.481
DOC_WW_Pin1_4 180 185 PF00397 0.294
DOC_WW_Pin1_4 320 325 PF00397 0.600
DOC_WW_Pin1_4 375 380 PF00397 0.602
DOC_WW_Pin1_4 409 414 PF00397 0.616
DOC_WW_Pin1_4 471 476 PF00397 0.758
DOC_WW_Pin1_4 489 494 PF00397 0.537
DOC_WW_Pin1_4 568 573 PF00397 0.663
DOC_WW_Pin1_4 575 580 PF00397 0.695
DOC_WW_Pin1_4 605 610 PF00397 0.701
DOC_WW_Pin1_4 633 638 PF00397 0.748
DOC_WW_Pin1_4 786 791 PF00397 0.715
LIG_14-3-3_CanoR_1 138 148 PF00244 0.430
LIG_14-3-3_CanoR_1 155 161 PF00244 0.448
LIG_14-3-3_CanoR_1 263 267 PF00244 0.323
LIG_14-3-3_CanoR_1 281 287 PF00244 0.391
LIG_14-3-3_CanoR_1 296 302 PF00244 0.595
LIG_14-3-3_CanoR_1 342 351 PF00244 0.657
LIG_14-3-3_CanoR_1 553 558 PF00244 0.623
LIG_14-3-3_CanoR_1 612 621 PF00244 0.777
LIG_14-3-3_CanoR_1 780 788 PF00244 0.444
LIG_AP2alpha_2 510 512 PF02296 0.699
LIG_BIR_II_1 1 5 PF00653 0.649
LIG_BRCT_BRCA1_1 565 569 PF00533 0.661
LIG_FHA_1 128 134 PF00498 0.355
LIG_FHA_1 298 304 PF00498 0.639
LIG_FHA_1 391 397 PF00498 0.452
LIG_FHA_1 40 46 PF00498 0.406
LIG_FHA_1 500 506 PF00498 0.603
LIG_FHA_1 530 536 PF00498 0.601
LIG_FHA_1 565 571 PF00498 0.635
LIG_FHA_1 765 771 PF00498 0.559
LIG_FHA_2 140 146 PF00498 0.428
LIG_FHA_2 376 382 PF00498 0.644
LIG_FHA_2 410 416 PF00498 0.555
LIG_FHA_2 660 666 PF00498 0.680
LIG_FHA_2 689 695 PF00498 0.578
LIG_FHA_2 733 739 PF00498 0.607
LIG_FHA_2 89 95 PF00498 0.294
LIG_GBD_Chelix_1 757 765 PF00786 0.480
LIG_LIR_Apic_2 183 189 PF02991 0.294
LIG_LIR_Apic_2 235 241 PF02991 0.295
LIG_LIR_Apic_2 373 379 PF02991 0.658
LIG_LIR_Apic_2 566 572 PF02991 0.631
LIG_LIR_Gen_1 106 113 PF02991 0.329
LIG_LIR_Gen_1 285 292 PF02991 0.475
LIG_LIR_Gen_1 31 39 PF02991 0.372
LIG_LIR_Gen_1 365 375 PF02991 0.594
LIG_LIR_Gen_1 514 524 PF02991 0.583
LIG_LIR_Gen_1 578 589 PF02991 0.696
LIG_LIR_Gen_1 698 708 PF02991 0.601
LIG_LIR_Gen_1 715 726 PF02991 0.406
LIG_LIR_Nem_3 106 111 PF02991 0.294
LIG_LIR_Nem_3 278 282 PF02991 0.486
LIG_LIR_Nem_3 285 291 PF02991 0.449
LIG_LIR_Nem_3 31 35 PF02991 0.350
LIG_LIR_Nem_3 365 370 PF02991 0.536
LIG_LIR_Nem_3 395 400 PF02991 0.537
LIG_LIR_Nem_3 453 458 PF02991 0.773
LIG_LIR_Nem_3 514 519 PF02991 0.577
LIG_LIR_Nem_3 520 526 PF02991 0.535
LIG_LIR_Nem_3 578 584 PF02991 0.693
LIG_LIR_Nem_3 715 721 PF02991 0.557
LIG_LIR_Nem_3 83 89 PF02991 0.420
LIG_LYPXL_SIV_4 754 762 PF13949 0.520
LIG_LYPXL_yS_3 723 726 PF13949 0.556
LIG_MYND_1 273 277 PF01753 0.372
LIG_PCNA_yPIPBox_3 249 263 PF02747 0.381
LIG_Pex14_1 512 516 PF04695 0.687
LIG_Pex14_1 710 714 PF04695 0.623
LIG_Pex14_2 676 680 PF04695 0.554
LIG_PTB_Apo_2 416 423 PF02174 0.622
LIG_Rb_pABgroove_1 80 88 PF01858 0.313
LIG_SH2_CRK 212 216 PF00017 0.294
LIG_SH2_CRK 238 242 PF00017 0.328
LIG_SH2_CRK 288 292 PF00017 0.451
LIG_SH2_CRK 367 371 PF00017 0.579
LIG_SH2_CRK 438 442 PF00017 0.585
LIG_SH2_CRK 516 520 PF00017 0.585
LIG_SH2_CRK 86 90 PF00017 0.294
LIG_SH2_GRB2like 367 370 PF00017 0.544
LIG_SH2_GRB2like 5 8 PF00017 0.604
LIG_SH2_NCK_1 186 190 PF00017 0.294
LIG_SH2_NCK_1 238 242 PF00017 0.346
LIG_SH2_NCK_1 516 520 PF00017 0.667
LIG_SH2_PTP2 110 113 PF00017 0.231
LIG_SH2_PTP2 400 403 PF00017 0.609
LIG_SH2_SRC 238 241 PF00017 0.420
LIG_SH2_STAP1 288 292 PF00017 0.374
LIG_SH2_STAP1 367 371 PF00017 0.550
LIG_SH2_STAP1 714 718 PF00017 0.616
LIG_SH2_STAP1 755 759 PF00017 0.534
LIG_SH2_STAT5 101 104 PF00017 0.294
LIG_SH2_STAT5 110 113 PF00017 0.294
LIG_SH2_STAT5 135 138 PF00017 0.294
LIG_SH2_STAT5 282 285 PF00017 0.437
LIG_SH2_STAT5 302 305 PF00017 0.646
LIG_SH2_STAT5 363 366 PF00017 0.617
LIG_SH2_STAT5 397 400 PF00017 0.550
LIG_SH2_STAT5 717 720 PF00017 0.529
LIG_SH3_3 254 260 PF00018 0.294
LIG_SH3_3 274 280 PF00018 0.224
LIG_SH3_3 501 507 PF00018 0.715
LIG_SH3_3 516 522 PF00018 0.587
LIG_SH3_3 6 12 PF00018 0.595
LIG_SH3_3 718 724 PF00018 0.472
LIG_SUMO_SIM_anti_2 222 230 PF11976 0.406
LIG_SUMO_SIM_anti_2 94 100 PF11976 0.301
LIG_SUMO_SIM_par_1 94 100 PF11976 0.301
LIG_SxIP_EBH_1 631 645 PF03271 0.530
LIG_TRAF2_1 323 326 PF00917 0.539
LIG_TRAF2_1 333 336 PF00917 0.522
LIG_TRAF2_1 412 415 PF00917 0.707
LIG_TRAF2_1 695 698 PF00917 0.493
LIG_TRAF2_2 20 25 PF00917 0.400
LIG_TYR_ITIM 210 215 PF00017 0.294
LIG_TYR_ITIM 286 291 PF00017 0.367
LIG_TYR_ITIM 398 403 PF00017 0.496
LIG_TYR_ITIM 721 726 PF00017 0.558
LIG_UBA3_1 620 626 PF00899 0.615
MOD_CDK_SPxxK_3 471 478 PF00069 0.669
MOD_CDK_SPxxK_3 605 612 PF00069 0.705
MOD_CK1_1 168 174 PF00069 0.343
MOD_CK1_1 180 186 PF00069 0.243
MOD_CK1_1 242 248 PF00069 0.420
MOD_CK1_1 425 431 PF00069 0.651
MOD_CK1_1 453 459 PF00069 0.596
MOD_CK1_1 464 470 PF00069 0.592
MOD_CK1_1 474 480 PF00069 0.503
MOD_CK1_1 484 490 PF00069 0.736
MOD_CK1_1 577 583 PF00069 0.663
MOD_CK1_1 593 599 PF00069 0.700
MOD_CK1_1 608 614 PF00069 0.536
MOD_CK1_1 633 639 PF00069 0.574
MOD_CK1_1 692 698 PF00069 0.586
MOD_CK1_1 747 753 PF00069 0.490
MOD_CK2_1 100 106 PF00069 0.294
MOD_CK2_1 320 326 PF00069 0.467
MOD_CK2_1 330 336 PF00069 0.490
MOD_CK2_1 375 381 PF00069 0.635
MOD_CK2_1 409 415 PF00069 0.703
MOD_CK2_1 418 424 PF00069 0.717
MOD_CK2_1 456 462 PF00069 0.765
MOD_CK2_1 622 628 PF00069 0.666
MOD_CK2_1 688 694 PF00069 0.581
MOD_CK2_1 757 763 PF00069 0.515
MOD_GlcNHglycan 102 105 PF01048 0.294
MOD_GlcNHglycan 192 195 PF01048 0.322
MOD_GlcNHglycan 244 247 PF01048 0.353
MOD_GlcNHglycan 424 427 PF01048 0.743
MOD_GlcNHglycan 483 486 PF01048 0.756
MOD_GlcNHglycan 513 516 PF01048 0.668
MOD_GlcNHglycan 614 617 PF01048 0.670
MOD_GlcNHglycan 62 65 PF01048 0.420
MOD_GlcNHglycan 746 749 PF01048 0.502
MOD_GlcNHglycan 782 785 PF01048 0.539
MOD_GSK3_1 156 163 PF00069 0.426
MOD_GSK3_1 176 183 PF00069 0.164
MOD_GSK3_1 292 299 PF00069 0.554
MOD_GSK3_1 326 333 PF00069 0.545
MOD_GSK3_1 418 425 PF00069 0.605
MOD_GSK3_1 447 454 PF00069 0.575
MOD_GSK3_1 456 463 PF00069 0.587
MOD_GSK3_1 470 477 PF00069 0.710
MOD_GSK3_1 549 556 PF00069 0.595
MOD_GSK3_1 564 571 PF00069 0.595
MOD_GSK3_1 589 596 PF00069 0.661
MOD_GSK3_1 608 615 PF00069 0.582
MOD_GSK3_1 629 636 PF00069 0.634
MOD_GSK3_1 659 666 PF00069 0.603
MOD_GSK3_1 688 695 PF00069 0.475
MOD_GSK3_1 780 787 PF00069 0.637
MOD_LATS_1 527 533 PF00433 0.645
MOD_N-GLC_1 451 456 PF02516 0.670
MOD_N-GLC_1 688 693 PF02516 0.567
MOD_N-GLC_1 780 785 PF02516 0.559
MOD_NEK2_1 165 170 PF00069 0.307
MOD_NEK2_1 176 181 PF00069 0.276
MOD_NEK2_1 215 220 PF00069 0.344
MOD_NEK2_1 221 226 PF00069 0.283
MOD_NEK2_1 297 302 PF00069 0.610
MOD_NEK2_1 422 427 PF00069 0.632
MOD_NEK2_1 429 434 PF00069 0.542
MOD_NEK2_1 460 465 PF00069 0.666
MOD_NEK2_1 499 504 PF00069 0.640
MOD_NEK2_1 549 554 PF00069 0.638
MOD_NEK2_1 574 579 PF00069 0.648
MOD_NEK2_1 631 636 PF00069 0.708
MOD_NEK2_1 687 692 PF00069 0.566
MOD_NEK2_2 156 161 PF00069 0.338
MOD_NEK2_2 282 287 PF00069 0.451
MOD_NEK2_2 564 569 PF00069 0.632
MOD_NEK2_2 663 668 PF00069 0.664
MOD_PIKK_1 401 407 PF00454 0.619
MOD_PIKK_1 429 435 PF00454 0.636
MOD_PIKK_1 772 778 PF00454 0.549
MOD_PKA_1 553 559 PF00069 0.697
MOD_PKA_1 772 778 PF00069 0.601
MOD_PKA_2 139 145 PF00069 0.420
MOD_PKA_2 262 268 PF00069 0.294
MOD_PKA_2 28 34 PF00069 0.294
MOD_PKA_2 553 559 PF00069 0.719
MOD_PKA_2 772 778 PF00069 0.510
MOD_PKB_1 778 786 PF00069 0.436
MOD_Plk_1 292 298 PF00069 0.596
MOD_Plk_1 451 457 PF00069 0.671
MOD_Plk_1 780 786 PF00069 0.513
MOD_Plk_2-3 262 268 PF00069 0.294
MOD_Plk_4 297 303 PF00069 0.682
MOD_Plk_4 326 332 PF00069 0.606
MOD_Plk_4 396 402 PF00069 0.558
MOD_Plk_4 425 431 PF00069 0.628
MOD_Plk_4 531 537 PF00069 0.508
MOD_Plk_4 564 570 PF00069 0.635
MOD_Plk_4 616 622 PF00069 0.692
MOD_Plk_4 663 669 PF00069 0.666
MOD_Plk_4 757 763 PF00069 0.529
MOD_ProDKin_1 180 186 PF00069 0.294
MOD_ProDKin_1 320 326 PF00069 0.602
MOD_ProDKin_1 375 381 PF00069 0.598
MOD_ProDKin_1 409 415 PF00069 0.616
MOD_ProDKin_1 471 477 PF00069 0.756
MOD_ProDKin_1 489 495 PF00069 0.537
MOD_ProDKin_1 568 574 PF00069 0.661
MOD_ProDKin_1 575 581 PF00069 0.699
MOD_ProDKin_1 605 611 PF00069 0.701
MOD_ProDKin_1 633 639 PF00069 0.747
MOD_ProDKin_1 786 792 PF00069 0.717
MOD_SUMO_for_1 146 149 PF00179 0.294
MOD_SUMO_for_1 560 563 PF00179 0.705
MOD_SUMO_for_1 67 70 PF00179 0.406
MOD_SUMO_for_1 703 706 PF00179 0.456
MOD_SUMO_rev_2 368 375 PF00179 0.659
MOD_SUMO_rev_2 737 747 PF00179 0.467
TRG_ENDOCYTIC_2 110 113 PF00928 0.231
TRG_ENDOCYTIC_2 212 215 PF00928 0.294
TRG_ENDOCYTIC_2 288 291 PF00928 0.370
TRG_ENDOCYTIC_2 363 366 PF00928 0.569
TRG_ENDOCYTIC_2 367 370 PF00928 0.540
TRG_ENDOCYTIC_2 400 403 PF00928 0.502
TRG_ENDOCYTIC_2 438 441 PF00928 0.588
TRG_ENDOCYTIC_2 516 519 PF00928 0.553
TRG_ENDOCYTIC_2 700 703 PF00928 0.418
TRG_ENDOCYTIC_2 717 720 PF00928 0.454
TRG_ENDOCYTIC_2 723 726 PF00928 0.526
TRG_ENDOCYTIC_2 86 89 PF00928 0.294
TRG_ER_diArg_1 356 358 PF00400 0.659
TRG_ER_diArg_1 553 555 PF00400 0.693
TRG_ER_diArg_1 765 768 PF00400 0.467
TRG_Pf-PMV_PEXEL_1 123 127 PF00026 0.294
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.420

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7V2 Leptomonas seymouri 70% 98%
A0A1X0P956 Trypanosomatidae 50% 100%
A0A3R7KDE9 Trypanosoma rangeli 47% 100%
A0A3S7XAF4 Leishmania donovani 95% 100%
A4HNV0 Leishmania braziliensis 81% 100%
A4ICP4 Leishmania infantum 95% 100%
D0A2R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
V5BQE9 Trypanosoma cruzi 48% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS