Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q1Y0_LEIMA

TriTrypDb:

LmjF.36.0960 , LMJLV39_360015400 , LMJSD75_360015300

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Y0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.698
CLV_C14_Caspase3-7	248	252	PF00656	0.608
CLV_C14_Caspase3-7	323	327	PF00656	0.437
CLV_C14_Caspase3-7	643	647	PF00656	0.693
CLV_C14_Caspase3-7	692	696	PF00656	0.734
CLV_C14_Caspase3-7	747	751	PF00656	0.771
CLV_NRD_NRD_1	163	165	PF00675	0.653
CLV_NRD_NRD_1	31	33	PF00675	0.521
CLV_NRD_NRD_1	387	389	PF00675	0.521
CLV_NRD_NRD_1	407	409	PF00675	0.606
CLV_NRD_NRD_1	446	448	PF00675	0.599
CLV_NRD_NRD_1	458	460	PF00675	0.574
CLV_NRD_NRD_1	484	486	PF00675	0.477
CLV_NRD_NRD_1	589	591	PF00675	0.482
CLV_NRD_NRD_1	617	619	PF00675	0.642
CLV_NRD_NRD_1	665	667	PF00675	0.560
CLV_PCSK_FUR_1	587	591	PF00082	0.478
CLV_PCSK_KEX2_1	162	164	PF00082	0.714
CLV_PCSK_KEX2_1	387	389	PF00082	0.521
CLV_PCSK_KEX2_1	407	409	PF00082	0.606
CLV_PCSK_KEX2_1	445	447	PF00082	0.602
CLV_PCSK_KEX2_1	458	460	PF00082	0.574
CLV_PCSK_KEX2_1	484	486	PF00082	0.455
CLV_PCSK_KEX2_1	589	591	PF00082	0.482
CLV_PCSK_KEX2_1	616	618	PF00082	0.650
CLV_PCSK_KEX2_1	665	667	PF00082	0.560
CLV_PCSK_PC7_1	383	389	PF00082	0.506
CLV_PCSK_PC7_1	403	409	PF00082	0.525
CLV_PCSK_SKI1_1	387	391	PF00082	0.480
CLV_PCSK_SKI1_1	41	45	PF00082	0.492
CLV_PCSK_SKI1_1	471	475	PF00082	0.443
CLV_PCSK_SKI1_1	485	489	PF00082	0.454
DEG_APCC_DBOX_1	142	150	PF00400	0.499
DEG_APCC_DBOX_1	382	390	PF00400	0.699
DEG_Nend_Nbox_1	1	3	PF02207	0.656
DEG_SCF_FBW7_1	16	23	PF00400	0.748
DEG_SPOP_SBC_1	673	677	PF00917	0.798
DOC_CKS1_1	17	22	PF01111	0.746
DOC_CKS1_1	270	275	PF01111	0.643
DOC_CKS1_1	332	337	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.739
DOC_MAPK_gen_1	266	276	PF00069	0.643
DOC_MAPK_gen_1	684	691	PF00069	0.747
DOC_MAPK_MEF2A_6	415	422	PF00069	0.640
DOC_PP2B_LxvP_1	15	18	PF13499	0.726
DOC_PP2B_LxvP_1	253	256	PF13499	0.661
DOC_PP4_FxxP_1	449	452	PF00568	0.724
DOC_PP4_FxxP_1	522	525	PF00568	0.676
DOC_PP4_FxxP_1	679	682	PF00568	0.760
DOC_USP7_MATH_1	102	106	PF00917	0.567
DOC_USP7_MATH_1	342	346	PF00917	0.438
DOC_USP7_MATH_1	411	415	PF00917	0.741
DOC_USP7_MATH_1	43	47	PF00917	0.723
DOC_USP7_MATH_1	596	600	PF00917	0.735
DOC_USP7_MATH_1	673	677	PF00917	0.853
DOC_USP7_MATH_1	801	805	PF00917	0.799
DOC_USP7_MATH_1	809	813	PF00917	0.726
DOC_USP7_UBL2_3	762	766	PF12436	0.767
DOC_WW_Pin1_4	114	119	PF00397	0.494
DOC_WW_Pin1_4	16	21	PF00397	0.750
DOC_WW_Pin1_4	189	194	PF00397	0.527
DOC_WW_Pin1_4	269	274	PF00397	0.655
DOC_WW_Pin1_4	331	336	PF00397	0.441
DOC_WW_Pin1_4	618	623	PF00397	0.787
DOC_WW_Pin1_4	678	683	PF00397	0.748
DOC_WW_Pin1_4	775	780	PF00397	0.697
DOC_WW_Pin1_4	793	798	PF00397	0.713
LIG_14-3-3_CanoR_1	126	130	PF00244	0.429
LIG_14-3-3_CanoR_1	387	395	PF00244	0.690
LIG_14-3-3_CanoR_1	458	464	PF00244	0.796
LIG_14-3-3_CanoR_1	560	566	PF00244	0.688
LIG_14-3-3_CanoR_1	626	635	PF00244	0.738
LIG_14-3-3_CanoR_1	788	794	PF00244	0.737
LIG_14-3-3_CanoR_1	808	814	PF00244	0.611
LIG_14-3-3_CanoR_1	831	836	PF00244	0.700
LIG_BRCT_BRCA1_1	363	367	PF00533	0.397
LIG_BRCT_BRCA1_1	491	495	PF00533	0.689
LIG_BRCT_BRCA1_1	598	602	PF00533	0.732
LIG_BRCT_BRCA1_1	675	679	PF00533	0.790
LIG_BRCT_BRCA1_1	779	783	PF00533	0.651
LIG_EVH1_1	17	21	PF00568	0.749
LIG_FHA_1	131	137	PF00498	0.456
LIG_FHA_1	200	206	PF00498	0.411
LIG_FHA_1	21	27	PF00498	0.705
LIG_FHA_1	230	236	PF00498	0.641
LIG_FHA_1	270	276	PF00498	0.563
LIG_FHA_1	290	296	PF00498	0.286
LIG_FHA_1	342	348	PF00498	0.369
LIG_FHA_1	502	508	PF00498	0.613
LIG_FHA_1	547	553	PF00498	0.769
LIG_FHA_1	782	788	PF00498	0.746
LIG_FHA_1	9	15	PF00498	0.679
LIG_FHA_2	237	243	PF00498	0.684
LIG_FHA_2	246	252	PF00498	0.612
LIG_FHA_2	646	652	PF00498	0.699
LIG_HCF-1_HBM_1	319	322	PF13415	0.338
LIG_Integrin_isoDGR_2	667	669	PF01839	0.508
LIG_LIR_Apic_2	676	682	PF02991	0.777
LIG_LIR_Gen_1	175	186	PF02991	0.457
LIG_LIR_Gen_1	344	353	PF02991	0.419
LIG_LIR_Gen_1	426	437	PF02991	0.712
LIG_LIR_Gen_1	492	501	PF02991	0.652
LIG_LIR_Gen_1	637	647	PF02991	0.641
LIG_LIR_Gen_1	772	781	PF02991	0.732
LIG_LIR_Gen_1	847	851	PF02991	0.776
LIG_LIR_Nem_3	119	125	PF02991	0.499
LIG_LIR_Nem_3	175	181	PF02991	0.443
LIG_LIR_Nem_3	282	286	PF02991	0.401
LIG_LIR_Nem_3	319	324	PF02991	0.412
LIG_LIR_Nem_3	344	349	PF02991	0.419
LIG_LIR_Nem_3	364	370	PF02991	0.183
LIG_LIR_Nem_3	468	473	PF02991	0.766
LIG_LIR_Nem_3	492	498	PF02991	0.661
LIG_LIR_Nem_3	637	642	PF02991	0.645
LIG_LIR_Nem_3	772	776	PF02991	0.739
LIG_LIR_Nem_3	847	851	PF02991	0.776
LIG_NRBOX	214	220	PF00104	0.313
LIG_OCRL_FandH_1	367	379	PF00620	0.519
LIG_PALB2_WD40_1	634	642	PF16756	0.614
LIG_PCNA_PIPBox_1	261	270	PF02747	0.639
LIG_Pex14_1	40	44	PF04695	0.735
LIG_REV1ctd_RIR_1	365	375	PF16727	0.502
LIG_SH2_CRK	178	182	PF00017	0.429
LIG_SH2_CRK	470	474	PF00017	0.690
LIG_SH2_GRB2like	96	99	PF00017	0.483
LIG_SH2_NCK_1	173	177	PF00017	0.490
LIG_SH2_NCK_1	322	326	PF00017	0.483
LIG_SH2_PTP2	346	349	PF00017	0.436
LIG_SH2_PTP2	486	489	PF00017	0.599
LIG_SH2_PTP2	76	79	PF00017	0.474
LIG_SH2_SRC	173	176	PF00017	0.493
LIG_SH2_SRC	178	181	PF00017	0.448
LIG_SH2_STAT3	338	341	PF00017	0.373
LIG_SH2_STAT3	725	728	PF00017	0.771
LIG_SH2_STAT3	86	89	PF00017	0.452
LIG_SH2_STAT5	180	183	PF00017	0.516
LIG_SH2_STAT5	346	349	PF00017	0.513
LIG_SH2_STAT5	448	451	PF00017	0.659
LIG_SH2_STAT5	486	489	PF00017	0.627
LIG_SH2_STAT5	57	60	PF00017	0.566
LIG_SH2_STAT5	76	79	PF00017	0.273
LIG_SH3_1	616	622	PF00018	0.758
LIG_SH3_3	15	21	PF00018	0.746
LIG_SH3_3	329	335	PF00018	0.446
LIG_SH3_3	563	569	PF00018	0.721
LIG_SH3_3	616	622	PF00018	0.758
LIG_SH3_3	699	705	PF00018	0.768
LIG_SH3_3	717	723	PF00018	0.637
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.645
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.507
LIG_SUMO_SIM_anti_2	816	824	PF11976	0.663
LIG_SUMO_SIM_par_1	13	19	PF11976	0.645
LIG_SUMO_SIM_par_1	217	222	PF11976	0.319
LIG_SUMO_SIM_par_1	272	277	PF11976	0.563
LIG_SUMO_SIM_par_1	416	424	PF11976	0.744
LIG_TRAF2_1	172	175	PF00917	0.495
LIG_TRAF2_1	478	481	PF00917	0.731
LIG_TYR_ITSM	342	349	PF00017	0.319
LIG_WRC_WIRS_1	200	205	PF05994	0.395
LIG_WRC_WIRS_1	280	285	PF05994	0.280
LIG_WRC_WIRS_1	350	355	PF05994	0.436
LIG_WW_3	662	666	PF00397	0.757
MOD_CDC14_SPxK_1	681	684	PF00782	0.748
MOD_CDK_SPK_2	189	194	PF00069	0.399
MOD_CDK_SPK_2	331	336	PF00069	0.441
MOD_CDK_SPxK_1	678	684	PF00069	0.749
MOD_CDK_SPxxK_3	189	196	PF00069	0.484
MOD_CK1_1	144	150	PF00069	0.526
MOD_CK1_1	199	205	PF00069	0.461
MOD_CK1_1	208	214	PF00069	0.417
MOD_CK1_1	237	243	PF00069	0.712
MOD_CK1_1	289	295	PF00069	0.457
MOD_CK1_1	414	420	PF00069	0.707
MOD_CK1_1	421	427	PF00069	0.698
MOD_CK1_1	678	684	PF00069	0.793
MOD_CK1_1	69	75	PF00069	0.513
MOD_CK1_1	743	749	PF00069	0.718
MOD_CK1_1	814	820	PF00069	0.691
MOD_CK1_1	836	842	PF00069	0.757
MOD_CK1_1	97	103	PF00069	0.527
MOD_CK2_1	551	557	PF00069	0.689
MOD_CK2_1	646	652	PF00069	0.720
MOD_CK2_1	655	661	PF00069	0.726
MOD_DYRK1A_RPxSP_1	618	622	PF00069	0.754
MOD_GlcNHglycan	104	107	PF01048	0.663
MOD_GlcNHglycan	146	149	PF01048	0.723
MOD_GlcNHglycan	207	210	PF01048	0.464
MOD_GlcNHglycan	276	279	PF01048	0.472
MOD_GlcNHglycan	288	291	PF01048	0.333
MOD_GlcNHglycan	355	358	PF01048	0.513
MOD_GlcNHglycan	363	366	PF01048	0.381
MOD_GlcNHglycan	491	494	PF01048	0.380
MOD_GlcNHglycan	691	694	PF01048	0.564
MOD_GlcNHglycan	71	74	PF01048	0.513
MOD_GlcNHglycan	712	715	PF01048	0.632
MOD_GlcNHglycan	754	758	PF01048	0.601
MOD_GlcNHglycan	779	782	PF01048	0.572
MOD_GlcNHglycan	842	845	PF01048	0.544
MOD_GSK3_1	16	23	PF00069	0.741
MOD_GSK3_1	192	199	PF00069	0.513
MOD_GSK3_1	285	292	PF00069	0.455
MOD_GSK3_1	330	337	PF00069	0.486
MOD_GSK3_1	349	356	PF00069	0.289
MOD_GSK3_1	403	410	PF00069	0.758
MOD_GSK3_1	414	421	PF00069	0.707
MOD_GSK3_1	423	430	PF00069	0.593
MOD_GSK3_1	49	56	PF00069	0.655
MOD_GSK3_1	501	508	PF00069	0.580
MOD_GSK3_1	598	605	PF00069	0.793
MOD_GSK3_1	673	680	PF00069	0.799
MOD_GSK3_1	689	696	PF00069	0.735
MOD_GSK3_1	706	713	PF00069	0.638
MOD_GSK3_1	775	782	PF00069	0.749
MOD_GSK3_1	783	790	PF00069	0.693
MOD_GSK3_1	795	802	PF00069	0.650
MOD_GSK3_1	809	816	PF00069	0.642
MOD_GSK3_1	836	843	PF00069	0.771
MOD_GSK3_1	84	91	PF00069	0.530
MOD_LATS_1	624	630	PF00433	0.782
MOD_N-GLC_1	299	304	PF02516	0.686
MOD_N-GLC_1	330	335	PF02516	0.717
MOD_N-GLC_1	769	774	PF02516	0.496
MOD_N-GLC_1	814	819	PF02516	0.466
MOD_N-GLC_1	840	845	PF02516	0.582
MOD_N-GLC_1	97	102	PF02516	0.742
MOD_N-GLC_2	706	708	PF02516	0.572
MOD_NEK2_1	108	113	PF00069	0.587
MOD_NEK2_1	125	130	PF00069	0.374
MOD_NEK2_1	141	146	PF00069	0.485
MOD_NEK2_1	219	224	PF00069	0.394
MOD_NEK2_1	245	250	PF00069	0.645
MOD_NEK2_1	274	279	PF00069	0.408
MOD_NEK2_1	286	291	PF00069	0.402
MOD_NEK2_1	293	298	PF00069	0.485
MOD_NEK2_1	299	304	PF00069	0.437
MOD_NEK2_1	324	329	PF00069	0.458
MOD_NEK2_1	353	358	PF00069	0.507
MOD_NEK2_1	360	365	PF00069	0.431
MOD_NEK2_1	418	423	PF00069	0.782
MOD_NEK2_1	501	506	PF00069	0.627
MOD_NEK2_1	598	603	PF00069	0.779
MOD_NEK2_1	645	650	PF00069	0.689
MOD_NEK2_1	655	660	PF00069	0.734
MOD_NEK2_1	689	694	PF00069	0.807
MOD_NEK2_1	753	758	PF00069	0.768
MOD_NEK2_1	783	788	PF00069	0.740
MOD_NEK2_1	813	818	PF00069	0.666
MOD_NEK2_2	279	284	PF00069	0.358
MOD_OFUCOSY	5	12	PF10250	0.425
MOD_PIKK_1	423	429	PF00454	0.745
MOD_PIKK_1	531	537	PF00454	0.723
MOD_PIKK_1	561	567	PF00454	0.755
MOD_PIKK_1	801	807	PF00454	0.802
MOD_PIKK_1	88	94	PF00454	0.501
MOD_PK_1	459	465	PF00069	0.734
MOD_PKA_1	387	393	PF00069	0.685
MOD_PKA_1	407	413	PF00069	0.808
MOD_PKA_1	617	623	PF00069	0.782
MOD_PKA_2	125	131	PF00069	0.424
MOD_PKA_2	144	150	PF00069	0.325
MOD_PKA_2	36	42	PF00069	0.738
MOD_PKA_2	370	376	PF00069	0.621
MOD_PKA_2	387	393	PF00069	0.555
MOD_PKA_2	407	413	PF00069	0.808
MOD_PKA_2	457	463	PF00069	0.655
MOD_PKA_2	501	507	PF00069	0.579
MOD_PKA_2	531	537	PF00069	0.612
MOD_PKA_2	617	623	PF00069	0.773
MOD_PKA_2	743	749	PF00069	0.700
MOD_PKA_2	787	793	PF00069	0.738
MOD_Plk_1	174	180	PF00069	0.444
MOD_Plk_1	645	651	PF00069	0.726
MOD_Plk_1	769	775	PF00069	0.696
MOD_Plk_1	97	103	PF00069	0.546
MOD_Plk_2-3	646	652	PF00069	0.700
MOD_Plk_4	10	16	PF00069	0.749
MOD_Plk_4	116	122	PF00069	0.519
MOD_Plk_4	208	214	PF00069	0.411
MOD_Plk_4	279	285	PF00069	0.401
MOD_Plk_4	342	348	PF00069	0.419
MOD_Plk_4	414	420	PF00069	0.723
MOD_Plk_4	501	507	PF00069	0.672
MOD_Plk_4	53	59	PF00069	0.613
MOD_ProDKin_1	114	120	PF00069	0.490
MOD_ProDKin_1	16	22	PF00069	0.748
MOD_ProDKin_1	189	195	PF00069	0.528
MOD_ProDKin_1	269	275	PF00069	0.649
MOD_ProDKin_1	331	337	PF00069	0.445
MOD_ProDKin_1	618	624	PF00069	0.789
MOD_ProDKin_1	678	684	PF00069	0.749
MOD_ProDKin_1	775	781	PF00069	0.697
MOD_ProDKin_1	793	799	PF00069	0.715
TRG_DiLeu_BaEn_1	116	121	PF01217	0.496
TRG_DiLeu_BaEn_1	468	473	PF01217	0.710
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.630
TRG_DiLeu_LyEn_5	468	473	PF01217	0.710
TRG_ENDOCYTIC_2	138	141	PF00928	0.425
TRG_ENDOCYTIC_2	178	181	PF00928	0.451
TRG_ENDOCYTIC_2	346	349	PF00928	0.513
TRG_ENDOCYTIC_2	429	432	PF00928	0.745
TRG_ENDOCYTIC_2	470	473	PF00928	0.692
TRG_ENDOCYTIC_2	486	489	PF00928	0.693
TRG_ENDOCYTIC_2	76	79	PF00928	0.402
TRG_ER_diArg_1	142	145	PF00400	0.510
TRG_ER_diArg_1	162	164	PF00400	0.327
TRG_ER_diArg_1	386	388	PF00400	0.727
TRG_ER_diArg_1	445	447	PF00400	0.719
TRG_ER_diArg_1	458	461	PF00400	0.776
TRG_ER_diArg_1	484	486	PF00400	0.652
TRG_ER_diArg_1	587	590	PF00400	0.676
TRG_ER_diArg_1	615	618	PF00400	0.822
TRG_ER_diArg_1	664	666	PF00400	0.756
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.655
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X5	Leptomonas seymouri	32%	100%
A0A3S7XAF2	Leishmania donovani	84%	93%
A4HNV5	Leishmania braziliensis	50%	100%
A4ICN8	Leishmania infantum	84%	93%
E9ASL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%