Non-structural maintenance of chromosomes element 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1X9_LEIMA

TriTrypDb:

LmjF.36.0970 , LMJLV39_360015500 , LMJSD75_360015400

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.491
CLV_NRD_NRD_1	125	127	PF00675	0.552
CLV_PCSK_SKI1_1	107	111	PF00082	0.606
CLV_PCSK_SKI1_1	126	130	PF00082	0.702
CLV_PCSK_SKI1_1	193	197	PF00082	0.530
CLV_PCSK_SKI1_1	92	96	PF00082	0.513
DEG_APCC_DBOX_1	64	72	PF00400	0.640
DEG_APCC_DBOX_1	91	99	PF00400	0.511
DEG_Nend_UBRbox_4	1	3	PF02207	0.613
DEG_SCF_FBW7_1	4	9	PF00400	0.527
DOC_CYCLIN_RxL_1	88	99	PF00134	0.516
DOC_MAPK_gen_1	101	112	PF00069	0.524
DOC_MAPK_MEF2A_6	105	114	PF00069	0.538
DOC_MAPK_NFAT4_5	107	115	PF00069	0.542
DOC_PP1_RVXF_1	109	115	PF00149	0.527
DOC_PP4_FxxP_1	23	26	PF00568	0.637
DOC_SPAK_OSR1_1	174	178	PF12202	0.550
DOC_USP7_MATH_1	29	33	PF00917	0.532
DOC_USP7_UBL2_3	219	223	PF12436	0.591
DOC_USP7_UBL2_3	30	34	PF12436	0.535
DOC_WW_Pin1_4	2	7	PF00397	0.534
LIG_14-3-3_CanoR_1	47	52	PF00244	0.761
LIG_Actin_WH2_2	115	132	PF00022	0.671
LIG_Actin_WH2_2	34	49	PF00022	0.607
LIG_eIF4E_1	17	23	PF01652	0.556
LIG_FHA_1	135	141	PF00498	0.609
LIG_FHA_1	144	150	PF00498	0.593
LIG_FHA_1	152	158	PF00498	0.562
LIG_FHA_1	16	22	PF00498	0.483
LIG_FHA_1	3	9	PF00498	0.590
LIG_FHA_2	114	120	PF00498	0.621
LIG_FHA_2	84	90	PF00498	0.515
LIG_Integrin_isoDGR_2	124	126	PF01839	0.554
LIG_LIR_Nem_3	166	172	PF02991	0.546
LIG_LYPXL_SIV_4	16	24	PF13949	0.496
LIG_NRBOX	93	99	PF00104	0.542
LIG_Pex14_2	114	118	PF04695	0.533
LIG_Pex14_2	212	216	PF04695	0.569
LIG_PTB_Apo_2	210	217	PF02174	0.568
LIG_SH2_STAT5	17	20	PF00017	0.563
LIG_SUMO_SIM_par_1	152	161	PF11976	0.688
LIG_SUMO_SIM_par_1	93	99	PF11976	0.620
LIG_TRAF2_1	158	161	PF00917	0.558
LIG_UBA3_1	21	28	PF00899	0.479
LIG_UBA3_1	211	219	PF00899	0.607
LIG_UBA3_1	94	102	PF00899	0.504
LIG_WRC_WIRS_1	115	120	PF05994	0.537
MOD_CK1_1	135	141	PF00069	0.632
MOD_CK1_1	221	227	PF00069	0.542
MOD_CK1_1	32	38	PF00069	0.511
MOD_CK2_1	113	119	PF00069	0.629
MOD_CK2_1	130	136	PF00069	0.753
MOD_CK2_1	155	161	PF00069	0.685
MOD_CK2_1	83	89	PF00069	0.527
MOD_Cter_Amidation	124	127	PF01082	0.558
MOD_GlcNHglycan	132	135	PF01048	0.703
MOD_GlcNHglycan	178	181	PF01048	0.586
MOD_GSK3_1	130	137	PF00069	0.696
MOD_GSK3_1	151	158	PF00069	0.595
MOD_GSK3_1	2	9	PF00069	0.593
MOD_N-GLC_1	212	217	PF02516	0.451
MOD_N-GLC_1	39	44	PF02516	0.587
MOD_NEK2_1	129	134	PF00069	0.639
MOD_NEK2_1	212	217	PF00069	0.562
MOD_NEK2_1	218	223	PF00069	0.573
MOD_NEK2_1	39	44	PF00069	0.598
MOD_PIKK_1	39	45	PF00454	0.601
MOD_PIKK_1	6	12	PF00454	0.580
MOD_PK_1	145	151	PF00069	0.596
MOD_PKB_1	45	53	PF00069	0.614
MOD_Plk_1	135	141	PF00069	0.544
MOD_Plk_1	151	157	PF00069	0.574
MOD_Plk_1	212	218	PF00069	0.453
MOD_Plk_2-3	83	89	PF00069	0.571
MOD_Plk_4	212	218	PF00069	0.453
MOD_ProDKin_1	2	8	PF00069	0.534
MOD_SUMO_for_1	84	87	PF00179	0.545
MOD_SUMO_rev_2	81	86	PF00179	0.567
TRG_DiLeu_BaEn_2	170	176	PF01217	0.549
TRG_DiLeu_BaEn_2	182	188	PF01217	0.554
TRG_DiLeu_BaEn_4	160	166	PF01217	0.550
TRG_NES_CRM1_1	167	178	PF08389	0.546
TRG_Pf-PMV_PEXEL_1	92	96	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHX7	Leptomonas seymouri	86%	100%
A0A0S4JAX8	Bodo saltans	26%	100%
A0A1X0P947	Trypanosomatidae	64%	100%
A0A3S5H817	Leishmania donovani	96%	100%
A0A422NTY7	Trypanosoma rangeli	68%	100%
A4HNV6	Leishmania braziliensis	91%	100%
A4ICN7	Leishmania infantum	96%	100%
E9ASL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5B9W8	Trypanosoma cruzi	63%	100%