Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1X4_LEIMA

TriTrypDb:

LmjF.36.1020 , LMJLV39_360015900 , LMJSD75_360015900

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q1X4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1X4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.684
CLV_NRD_NRD_1	253	255	PF00675	0.666
CLV_NRD_NRD_1	338	340	PF00675	0.599
CLV_NRD_NRD_1	443	445	PF00675	0.456
CLV_NRD_NRD_1	540	542	PF00675	0.401
CLV_PCSK_FUR_1	441	445	PF00082	0.485
CLV_PCSK_KEX2_1	141	143	PF00082	0.665
CLV_PCSK_KEX2_1	253	255	PF00082	0.666
CLV_PCSK_KEX2_1	324	326	PF00082	0.626
CLV_PCSK_KEX2_1	443	445	PF00082	0.427
CLV_PCSK_KEX2_1	539	541	PF00082	0.400
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.633
CLV_PCSK_PC7_1	137	143	PF00082	0.742
CLV_PCSK_PC7_1	439	445	PF00082	0.500
CLV_PCSK_SKI1_1	329	333	PF00082	0.621
CLV_PCSK_SKI1_1	342	346	PF00082	0.475
CLV_PCSK_SKI1_1	435	439	PF00082	0.419
CLV_PCSK_SKI1_1	460	464	PF00082	0.406
CLV_PCSK_SKI1_1	541	545	PF00082	0.453
DEG_APCC_DBOX_1	324	332	PF00400	0.426
DEG_APCC_DBOX_1	459	467	PF00400	0.419
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DEG_SPOP_SBC_1	215	219	PF00917	0.410
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.674
DOC_MAPK_gen_1	441	449	PF00069	0.689
DOC_MAPK_MEF2A_6	443	451	PF00069	0.737
DOC_MAPK_MEF2A_6	460	468	PF00069	0.510
DOC_MAPK_NFAT4_5	444	452	PF00069	0.672
DOC_MAPK_RevD_3	530	546	PF00069	0.638
DOC_PP2B_LxvP_1	225	228	PF13499	0.483
DOC_PP2B_LxvP_1	445	448	PF13499	0.667
DOC_PP2B_LxvP_1	449	452	PF13499	0.572
DOC_PP2B_LxvP_1	471	474	PF13499	0.369
DOC_PP4_FxxP_1	71	74	PF00568	0.484
DOC_USP7_MATH_1	182	186	PF00917	0.456
DOC_USP7_MATH_1	206	210	PF00917	0.532
DOC_USP7_MATH_1	215	219	PF00917	0.519
DOC_USP7_MATH_1	260	264	PF00917	0.483
DOC_USP7_MATH_1	266	270	PF00917	0.470
DOC_USP7_MATH_1	28	32	PF00917	0.549
DOC_USP7_MATH_1	323	327	PF00917	0.458
DOC_USP7_MATH_1	453	457	PF00917	0.691
DOC_USP7_MATH_1	510	514	PF00917	0.381
DOC_USP7_UBL2_3	329	333	PF12436	0.403
DOC_WW_Pin1_4	110	115	PF00397	0.554
DOC_WW_Pin1_4	16	21	PF00397	0.658
DOC_WW_Pin1_4	256	261	PF00397	0.493
LIG_14-3-3_CanoR_1	116	125	PF00244	0.456
LIG_14-3-3_CanoR_1	32	37	PF00244	0.593
LIG_Actin_WH2_2	324	341	PF00022	0.412
LIG_APCC_ABBA_1	235	240	PF00400	0.467
LIG_BIR_III_4	157	161	PF00653	0.465
LIG_BRCT_BRCA1_1	216	220	PF00533	0.478
LIG_BRCT_BRCA1_1	510	514	PF00533	0.494
LIG_Clathr_ClatBox_1	165	169	PF01394	0.311
LIG_deltaCOP1_diTrp_1	58	63	PF00928	0.528
LIG_EH1_1	414	422	PF00400	0.363
LIG_EH1_1	519	527	PF00400	0.363
LIG_eIF4E_1	415	421	PF01652	0.427
LIG_FHA_1	142	148	PF00498	0.400
LIG_FHA_1	257	263	PF00498	0.386
LIG_FHA_1	33	39	PF00498	0.548
LIG_FHA_1	394	400	PF00498	0.402
LIG_FHA_1	457	463	PF00498	0.611
LIG_FHA_2	307	313	PF00498	0.430
LIG_FHA_2	40	46	PF00498	0.568
LIG_LIR_Apic_2	68	74	PF02991	0.482
LIG_LIR_Gen_1	219	230	PF02991	0.474
LIG_LIR_Gen_1	349	356	PF02991	0.358
LIG_LIR_Gen_1	422	432	PF02991	0.363
LIG_LIR_Gen_1	511	522	PF02991	0.391
LIG_LIR_LC3C_4	470	473	PF02991	0.480
LIG_LIR_Nem_3	190	196	PF02991	0.375
LIG_LIR_Nem_3	219	225	PF02991	0.458
LIG_LIR_Nem_3	349	355	PF02991	0.406
LIG_LIR_Nem_3	422	428	PF02991	0.377
LIG_LIR_Nem_3	511	517	PF02991	0.386
LIG_MYND_1	474	478	PF01753	0.378
LIG_NRBOX	327	333	PF00104	0.474
LIG_NRBOX	464	470	PF00104	0.424
LIG_PAM2_1	360	372	PF00658	0.416
LIG_Pex14_1	59	63	PF04695	0.524
LIG_Pex14_2	5	9	PF04695	0.433
LIG_SH2_CRK	352	356	PF00017	0.440
LIG_SH2_STAP1	143	147	PF00017	0.481
LIG_SH2_STAT5	133	136	PF00017	0.518
LIG_SH2_STAT5	143	146	PF00017	0.396
LIG_SH3_3	111	117	PF00018	0.589
LIG_SH3_3	408	414	PF00018	0.355
LIG_SH3_3	469	475	PF00018	0.449
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.318
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.480
LIG_SUMO_SIM_par_1	163	169	PF11976	0.318
LIG_SUMO_SIM_par_1	227	232	PF11976	0.412
LIG_SUMO_SIM_par_1	33	40	PF11976	0.530
LIG_SUMO_SIM_par_1	461	467	PF11976	0.490
LIG_TRAF2_1	65	68	PF00917	0.508
LIG_TRAF2_1	94	97	PF00917	0.504
LIG_UBA3_1	368	376	PF00899	0.370
MOD_CDK_SPxK_1	110	116	PF00069	0.585
MOD_CK1_1	184	190	PF00069	0.456
MOD_CK1_1	19	25	PF00069	0.675
MOD_CK1_1	456	462	PF00069	0.645
MOD_CK2_1	273	279	PF00069	0.449
MOD_CK2_1	306	312	PF00069	0.436
MOD_CK2_1	39	45	PF00069	0.524
MOD_CK2_1	464	470	PF00069	0.480
MOD_CMANNOS	82	85	PF00535	0.699
MOD_GlcNHglycan	208	211	PF01048	0.765
MOD_GlcNHglycan	21	24	PF01048	0.698
MOD_GlcNHglycan	275	278	PF01048	0.603
MOD_GlcNHglycan	382	386	PF01048	0.675
MOD_GlcNHglycan	39	42	PF01048	0.701
MOD_GlcNHglycan	455	458	PF01048	0.443
MOD_GlcNHglycan	517	520	PF01048	0.450
MOD_GSK3_1	256	263	PF00069	0.491
MOD_GSK3_1	28	35	PF00069	0.559
MOD_GSK3_1	298	305	PF00069	0.438
MOD_GSK3_1	393	400	PF00069	0.380
MOD_LATS_1	30	36	PF00433	0.523
MOD_N-GLC_1	153	158	PF02516	0.676
MOD_N-GLC_1	206	211	PF02516	0.662
MOD_NEK2_1	201	206	PF00069	0.414
MOD_NEK2_1	249	254	PF00069	0.426
MOD_NEK2_1	273	278	PF00069	0.427
MOD_NEK2_1	392	397	PF00069	0.413
MOD_NEK2_1	464	469	PF00069	0.449
MOD_NEK2_1	515	520	PF00069	0.374
MOD_NEK2_1	521	526	PF00069	0.342
MOD_NEK2_2	364	369	PF00069	0.435
MOD_PIKK_1	266	272	PF00454	0.405
MOD_PIKK_1	500	506	PF00454	0.399
MOD_PIKK_1	92	98	PF00454	0.349
MOD_PKA_1	141	147	PF00069	0.418
MOD_PKA_2	141	147	PF00069	0.437
MOD_PKA_2	500	506	PF00069	0.431
MOD_Plk_1	148	154	PF00069	0.471
MOD_Plk_1	364	370	PF00069	0.401
MOD_Plk_2-3	39	45	PF00069	0.542
MOD_Plk_4	351	357	PF00069	0.363
MOD_Plk_4	364	370	PF00069	0.373
MOD_Plk_4	464	470	PF00069	0.451
MOD_Plk_4	510	516	PF00069	0.327
MOD_Plk_4	521	527	PF00069	0.299
MOD_Plk_4	533	539	PF00069	0.682
MOD_ProDKin_1	110	116	PF00069	0.556
MOD_ProDKin_1	16	22	PF00069	0.663
MOD_ProDKin_1	256	262	PF00069	0.496
MOD_SUMO_rev_2	318	326	PF00179	0.465
MOD_SUMO_rev_2	39	49	PF00179	0.514
TRG_DiLeu_BaEn_1	327	332	PF01217	0.474
TRG_DiLeu_BaEn_2	233	239	PF01217	0.388
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.413
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.484
TRG_DiLeu_LyEn_5	388	393	PF01217	0.402
TRG_ENDOCYTIC_2	352	355	PF00928	0.423
TRG_ER_diArg_1	141	143	PF00400	0.477
TRG_ER_diArg_1	440	443	PF00400	0.647
TRG_ER_diArg_1	538	541	PF00400	0.623
TRG_NLS_Bipartite_1	324	343	PF00514	0.412
TRG_NLS_MonoExtC_3	338	343	PF00514	0.401
TRG_NLS_MonoExtN_4	337	343	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R2	Leptomonas seymouri	43%	98%
A0A1X0P8Z7	Trypanosomatidae	25%	97%
A0A3Q8INF1	Leishmania donovani	90%	100%
A0A3R7NN64	Trypanosoma rangeli	26%	97%
A4HNW2	Leishmania braziliensis	67%	100%
A4ICN2	Leishmania infantum	90%	100%
D0A2T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	95%
E9ASM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BV13	Trypanosoma cruzi	24%	85%