Flagellar C1a complex subunit C1a-32

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar C1a complex subunit C1a-32, putative

Species:

Leishmania major

UniProt:

Q4Q1X2_LEIMA

TriTrypDb:

LmjF.36.1040 , LMJLV39_360016100 , LMJSD75_360016100

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0005929	cilium	4	3
GO:0031514	motile cilium	5	3
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0120025	plasma membrane bounded cell projection	3	3

Expansion

Sequence features

Q4Q1X2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1X2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.383
CLV_C14_Caspase3-7	36	40	PF00656	0.358
CLV_NRD_NRD_1	284	286	PF00675	0.579
CLV_PCSK_KEX2_1	284	286	PF00082	0.579
CLV_PCSK_KEX2_1	32	34	PF00082	0.454
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.598
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.454
CLV_PCSK_PC7_1	28	34	PF00082	0.445
CLV_PCSK_PC7_1	280	286	PF00082	0.567
CLV_PCSK_SKI1_1	48	52	PF00082	0.384
DOC_MAPK_MEF2A_6	48	57	PF00069	0.443
DOC_USP7_MATH_1	268	272	PF00917	0.578
DOC_USP7_MATH_1	67	71	PF00917	0.306
DOC_USP7_MATH_2	153	159	PF00917	0.413
DOC_USP7_UBL2_3	190	194	PF12436	0.437
DOC_WW_Pin1_4	70	75	PF00397	0.303
LIG_14-3-3_CanoR_1	111	115	PF00244	0.296
LIG_14-3-3_CanoR_1	116	126	PF00244	0.173
LIG_14-3-3_CanoR_1	48	57	PF00244	0.348
LIG_14-3-3_CanoR_1	98	103	PF00244	0.294
LIG_Actin_WH2_2	145	162	PF00022	0.396
LIG_Actin_WH2_2	15	30	PF00022	0.424
LIG_BIR_II_1	1	5	PF00653	0.395
LIG_BRCT_BRCA1_1	77	81	PF00533	0.379
LIG_DLG_GKlike_1	98	105	PF00625	0.348
LIG_eIF4E_1	60	66	PF01652	0.396
LIG_FHA_1	159	165	PF00498	0.582
LIG_FHA_1	4	10	PF00498	0.392
LIG_FHA_1	75	81	PF00498	0.405
LIG_FHA_2	195	201	PF00498	0.513
LIG_FHA_2	257	263	PF00498	0.556
LIG_LIR_Gen_1	101	110	PF02991	0.272
LIG_LIR_Gen_1	6	11	PF02991	0.471
LIG_LIR_LC3C_4	107	110	PF02991	0.334
LIG_LIR_Nem_3	138	144	PF02991	0.264
LIG_LIR_Nem_3	58	63	PF02991	0.378
LIG_LIR_Nem_3	6	10	PF02991	0.331
LIG_LIR_Nem_3	70	75	PF02991	0.348
LIG_LIR_Nem_3	78	84	PF02991	0.362
LIG_LIR_Nem_3	97	102	PF02991	0.354
LIG_PTB_Apo_2	222	229	PF02174	0.504
LIG_SH2_CRK	102	106	PF00017	0.348
LIG_SH2_CRK	149	153	PF00017	0.288
LIG_SH2_STAP1	119	123	PF00017	0.396
LIG_SH2_STAT5	147	150	PF00017	0.296
LIG_SH3_3	111	117	PF00018	0.254
LIG_SUMO_SIM_anti_2	247	256	PF11976	0.513
LIG_SUMO_SIM_par_1	160	167	PF11976	0.513
LIG_TRAF2_1	197	200	PF00917	0.460
MOD_CDC14_SPxK_1	73	76	PF00782	0.303
MOD_CDK_SPxK_1	70	76	PF00069	0.303
MOD_CK1_1	158	164	PF00069	0.554
MOD_CK1_1	244	250	PF00069	0.495
MOD_CK1_1	279	285	PF00069	0.670
MOD_CK1_1	46	52	PF00069	0.482
MOD_CK1_1	70	76	PF00069	0.396
MOD_CK2_1	122	128	PF00069	0.234
MOD_CK2_1	194	200	PF00069	0.476
MOD_CK2_1	256	262	PF00069	0.557
MOD_GlcNHglycan	178	181	PF01048	0.567
MOD_GlcNHglycan	232	235	PF01048	0.487
MOD_GlcNHglycan	270	273	PF01048	0.613
MOD_GSK3_1	118	125	PF00069	0.444
MOD_GSK3_1	131	138	PF00069	0.381
MOD_GSK3_1	207	214	PF00069	0.546
MOD_GSK3_1	219	226	PF00069	0.558
MOD_GSK3_1	241	248	PF00069	0.553
MOD_GSK3_1	268	275	PF00069	0.556
MOD_GSK3_1	276	283	PF00069	0.599
MOD_GSK3_1	42	49	PF00069	0.519
MOD_GSK3_1	70	77	PF00069	0.300
MOD_GSK3_1	94	101	PF00069	0.285
MOD_N-GLC_1	164	169	PF02516	0.541
MOD_N-GLC_1	272	277	PF02516	0.481
MOD_NEK2_1	122	127	PF00069	0.366
MOD_NEK2_1	136	141	PF00069	0.240
MOD_NEK2_1	223	228	PF00069	0.593
MOD_NEK2_1	75	80	PF00069	0.338
MOD_PIKK_1	48	54	PF00454	0.364
MOD_PIKK_1	67	73	PF00454	0.354
MOD_PKA_2	110	116	PF00069	0.348
MOD_PKA_2	12	18	PF00069	0.527
MOD_PKA_2	279	285	PF00069	0.758
MOD_PKA_2	94	100	PF00069	0.303
MOD_PKB_1	274	282	PF00069	0.625
MOD_Plk_1	223	229	PF00069	0.502
MOD_Plk_1	88	94	PF00069	0.348
MOD_Plk_4	118	124	PF00069	0.412
MOD_Plk_4	131	137	PF00069	0.206
MOD_Plk_4	76	82	PF00069	0.269
MOD_ProDKin_1	70	76	PF00069	0.303
MOD_SUMO_rev_2	249	259	PF00179	0.444
TRG_DiLeu_BaEn_1	249	254	PF01217	0.405
TRG_ENDOCYTIC_2	102	105	PF00928	0.254
TRG_ENDOCYTIC_2	119	122	PF00928	0.385
TRG_ENDOCYTIC_2	149	152	PF00928	0.305
TRG_ENDOCYTIC_2	60	63	PF00928	0.374
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE82	Leptomonas seymouri	70%	100%
A0A0S4JAR9	Bodo saltans	34%	95%
A0A1X0P8D5	Trypanosomatidae	43%	100%
A0A3Q8IVT9	Leishmania donovani	97%	100%
A0A3R7MW02	Trypanosoma rangeli	42%	100%
A4HNW4	Leishmania braziliensis	83%	100%
A4ICN0	Leishmania infantum	97%	100%
B0BMZ6	Rattus norvegicus	23%	86%
D0A2T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ASM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BQE4	Trypanosoma cruzi	45%	100%