Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1W8_LEIMA

TriTrypDb:

LmjF.36.1080 , LMJLV39_360016500 , LMJSD75_360016500 , LMJSD75_360016600

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	14	16	PF00675	0.465
CLV_NRD_NRD_1	168	170	PF00675	0.613
CLV_NRD_NRD_1	308	310	PF00675	0.636
CLV_NRD_NRD_1	318	320	PF00675	0.566
CLV_NRD_NRD_1	53	55	PF00675	0.690
CLV_NRD_NRD_1	574	576	PF00675	0.440
CLV_PCSK_KEX2_1	14	16	PF00082	0.465
CLV_PCSK_KEX2_1	168	170	PF00082	0.615
CLV_PCSK_KEX2_1	310	312	PF00082	0.648
CLV_PCSK_KEX2_1	318	320	PF00082	0.575
CLV_PCSK_KEX2_1	52	54	PF00082	0.695
CLV_PCSK_KEX2_1	573	575	PF00082	0.441
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.648
CLV_PCSK_PC7_1	569	575	PF00082	0.437
CLV_PCSK_SKI1_1	242	246	PF00082	0.589
CLV_PCSK_SKI1_1	310	314	PF00082	0.650
CLV_PCSK_SKI1_1	388	392	PF00082	0.559
CLV_PCSK_SKI1_1	430	434	PF00082	0.598
CLV_PCSK_SKI1_1	449	453	PF00082	0.596
DEG_APCC_DBOX_1	228	236	PF00400	0.293
DEG_APCC_DBOX_1	349	357	PF00400	0.278
DEG_APCC_DBOX_1	387	395	PF00400	0.359
DEG_APCC_DBOX_1	436	444	PF00400	0.356
DEG_MDM2_SWIB_1	395	403	PF02201	0.365
DEG_SCF_FBW7_2	521	527	PF00400	0.468
DEG_SPOP_SBC_1	2	6	PF00917	0.748
DOC_CKS1_1	521	526	PF01111	0.467
DOC_CYCLIN_RxL_1	385	393	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.422
DOC_MAPK_gen_1	168	175	PF00069	0.328
DOC_MAPK_gen_1	386	394	PF00069	0.324
DOC_MAPK_gen_1	463	471	PF00069	0.385
DOC_MAPK_gen_1	52	60	PF00069	0.523
DOC_MAPK_JIP1_4	169	175	PF00069	0.324
DOC_MAPK_JIP1_4	386	392	PF00069	0.326
DOC_MAPK_MEF2A_6	386	394	PF00069	0.324
DOC_MAPK_MEF2A_6	52	60	PF00069	0.487
DOC_MAPK_RevD_3	38	53	PF00069	0.552
DOC_PP2B_LxvP_1	82	85	PF13499	0.396
DOC_PP4_FxxP_1	557	560	PF00568	0.310
DOC_USP7_MATH_1	164	168	PF00917	0.483
DOC_USP7_MATH_1	228	232	PF00917	0.345
DOC_USP7_MATH_1	273	277	PF00917	0.380
DOC_USP7_MATH_1	305	309	PF00917	0.378
DOC_USP7_MATH_1	374	378	PF00917	0.334
DOC_USP7_MATH_1	42	46	PF00917	0.401
DOC_USP7_MATH_1	493	497	PF00917	0.450
DOC_USP7_MATH_1	538	542	PF00917	0.472
DOC_USP7_MATH_1	98	102	PF00917	0.364
DOC_USP7_UBL2_3	310	314	PF12436	0.397
DOC_WW_Pin1_4	160	165	PF00397	0.571
DOC_WW_Pin1_4	180	185	PF00397	0.299
DOC_WW_Pin1_4	430	435	PF00397	0.397
DOC_WW_Pin1_4	455	460	PF00397	0.397
DOC_WW_Pin1_4	499	504	PF00397	0.400
DOC_WW_Pin1_4	512	517	PF00397	0.410
DOC_WW_Pin1_4	52	57	PF00397	0.476
DOC_WW_Pin1_4	520	525	PF00397	0.464
DOC_WW_Pin1_4	67	72	PF00397	0.415
LIG_14-3-3_CanoR_1	125	133	PF00244	0.405
LIG_14-3-3_CanoR_1	242	250	PF00244	0.408
LIG_14-3-3_CanoR_1	318	327	PF00244	0.498
LIG_14-3-3_CanoR_1	415	421	PF00244	0.296
LIG_14-3-3_CanoR_1	437	447	PF00244	0.362
LIG_14-3-3_CanoR_1	478	484	PF00244	0.320
LIG_14-3-3_CanoR_1	539	547	PF00244	0.375
LIG_14-3-3_CanoR_1	7	11	PF00244	0.649
LIG_Actin_WH2_2	129	145	PF00022	0.317
LIG_APCC_ABBAyCdc20_2	309	315	PF00400	0.395
LIG_Clathr_ClatBox_1	355	359	PF01394	0.357
LIG_Clathr_ClatBox_1	407	411	PF01394	0.319
LIG_CtBP_PxDLS_1	352	356	PF00389	0.336
LIG_EVH1_2	56	60	PF00568	0.519
LIG_FHA_1	160	166	PF00498	0.500
LIG_FHA_1	181	187	PF00498	0.375
LIG_FHA_1	243	249	PF00498	0.406
LIG_FHA_1	30	36	PF00498	0.310
LIG_FHA_1	404	410	PF00498	0.319
LIG_FHA_1	471	477	PF00498	0.386
LIG_FHA_1	53	59	PF00498	0.459
LIG_FHA_1	566	572	PF00498	0.551
LIG_FHA_1	68	74	PF00498	0.442
LIG_FHA_1	78	84	PF00498	0.394
LIG_FHA_1	90	96	PF00498	0.328
LIG_FHA_2	130	136	PF00498	0.321
LIG_FHA_2	480	486	PF00498	0.332
LIG_GBD_Chelix_1	27	35	PF00786	0.370
LIG_LIR_Apic_2	453	459	PF02991	0.426
LIG_LIR_Gen_1	134	142	PF02991	0.450
LIG_LIR_Gen_1	338	343	PF02991	0.314
LIG_LIR_LC3C_4	80	84	PF02991	0.398
LIG_LIR_Nem_3	100	105	PF02991	0.345
LIG_LIR_Nem_3	134	140	PF02991	0.443
LIG_LIR_Nem_3	282	286	PF02991	0.289
LIG_LIR_Nem_3	338	342	PF02991	0.372
LIG_LIR_Nem_3	505	510	PF02991	0.480
LIG_NRBOX	291	297	PF00104	0.384
LIG_NRBOX	482	488	PF00104	0.375
LIG_PCNA_yPIPBox_3	401	415	PF02747	0.332
LIG_PCNA_yPIPBox_3	463	475	PF02747	0.396
LIG_Pex14_2	221	225	PF04695	0.308
LIG_Pex14_2	395	399	PF04695	0.367
LIG_SH2_CRK	137	141	PF00017	0.375
LIG_SH2_CRK	283	287	PF00017	0.355
LIG_SH2_CRK	416	420	PF00017	0.300
LIG_SH2_NCK_1	416	420	PF00017	0.284
LIG_SH2_SRC	371	374	PF00017	0.320
LIG_SH2_STAP1	137	141	PF00017	0.375
LIG_SH2_STAT3	185	188	PF00017	0.380
LIG_SH2_STAT5	185	188	PF00017	0.380
LIG_SH2_STAT5	371	374	PF00017	0.355
LIG_SH2_STAT5	456	459	PF00017	0.412
LIG_SH2_STAT5	554	557	PF00017	0.317
LIG_SH2_STAT5	94	97	PF00017	0.420
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.361
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.235
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.321
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.401
LIG_SUMO_SIM_par_1	31	36	PF11976	0.310
LIG_SUMO_SIM_par_1	390	398	PF11976	0.270
LIG_SUMO_SIM_par_1	405	411	PF11976	0.294
LIG_SUMO_SIM_par_1	472	477	PF11976	0.297
LIG_SxIP_EBH_1	412	422	PF03271	0.265
LIG_TRFH_1	556	560	PF08558	0.310
LIG_UBA3_1	486	492	PF00899	0.375
LIG_Vh1_VBS_1	537	555	PF01044	0.272
LIG_WRC_WIRS_1	339	344	PF05994	0.348
LIG_WRC_WIRS_1	99	104	PF05994	0.462
MOD_CDK_SPK_2	512	517	PF00069	0.420
MOD_CDK_SPxxK_3	430	437	PF00069	0.394
MOD_CDK_SPxxK_3	499	506	PF00069	0.392
MOD_CK1_1	101	107	PF00069	0.389
MOD_CK1_1	111	117	PF00069	0.409
MOD_CK1_1	163	169	PF00069	0.580
MOD_CK1_1	177	183	PF00069	0.309
MOD_CK1_1	274	280	PF00069	0.392
MOD_CK1_1	282	288	PF00069	0.355
MOD_CK1_1	338	344	PF00069	0.302
MOD_CK1_1	362	368	PF00069	0.359
MOD_CK1_1	393	399	PF00069	0.256
MOD_CK1_1	5	11	PF00069	0.649
MOD_CK2_1	479	485	PF00069	0.335
MOD_CK2_1	499	505	PF00069	0.368
MOD_Cter_Amidation	12	15	PF01082	0.521
MOD_GlcNHglycan	108	111	PF01048	0.729
MOD_GlcNHglycan	114	117	PF01048	0.683
MOD_GlcNHglycan	137	140	PF01048	0.573
MOD_GlcNHglycan	176	179	PF01048	0.573
MOD_GlcNHglycan	257	260	PF01048	0.573
MOD_GlcNHglycan	267	270	PF01048	0.578
MOD_GlcNHglycan	323	326	PF01048	0.620
MOD_GlcNHglycan	361	364	PF01048	0.529
MOD_GlcNHglycan	416	419	PF01048	0.514
MOD_GlcNHglycan	49	52	PF01048	0.723
MOD_GlcNHglycan	529	532	PF01048	0.667
MOD_GSK3_1	1	8	PF00069	0.745
MOD_GSK3_1	106	113	PF00069	0.474
MOD_GSK3_1	131	138	PF00069	0.339
MOD_GSK3_1	156	163	PF00069	0.593
MOD_GSK3_1	164	171	PF00069	0.461
MOD_GSK3_1	29	36	PF00069	0.310
MOD_GSK3_1	338	345	PF00069	0.354
MOD_GSK3_1	374	381	PF00069	0.399
MOD_GSK3_1	390	397	PF00069	0.313
MOD_GSK3_1	43	50	PF00069	0.453
MOD_GSK3_1	457	464	PF00069	0.460
MOD_GSK3_1	470	477	PF00069	0.276
MOD_GSK3_1	508	515	PF00069	0.362
MOD_GSK3_1	89	96	PF00069	0.392
MOD_N-GLC_1	201	206	PF02516	0.624
MOD_N-GLC_1	319	324	PF02516	0.607
MOD_N-GLC_1	430	435	PF02516	0.552
MOD_N-GLC_2	570	572	PF02516	0.460
MOD_NEK2_1	271	276	PF00069	0.344
MOD_NEK2_1	29	34	PF00069	0.310
MOD_NEK2_1	342	347	PF00069	0.414
MOD_NEK2_1	390	395	PF00069	0.441
MOD_NEK2_1	421	426	PF00069	0.412
MOD_NEK2_1	452	457	PF00069	0.433
MOD_NEK2_1	461	466	PF00069	0.492
MOD_NEK2_1	508	513	PF00069	0.362
MOD_NEK2_1	565	570	PF00069	0.506
MOD_NEK2_2	207	212	PF00069	0.410
MOD_NEK2_2	98	103	PF00069	0.311
MOD_OFUCOSY	176	181	PF10250	0.522
MOD_PIKK_1	124	130	PF00454	0.445
MOD_PIKK_1	147	153	PF00454	0.529
MOD_PK_1	168	174	PF00069	0.482
MOD_PKA_1	168	174	PF00069	0.375
MOD_PKA_2	124	130	PF00069	0.424
MOD_PKA_2	168	174	PF00069	0.375
MOD_PKA_2	228	234	PF00069	0.288
MOD_PKA_2	414	420	PF00069	0.294
MOD_PKA_2	421	427	PF00069	0.348
MOD_PKA_2	43	49	PF00069	0.469
MOD_PKA_2	436	442	PF00069	0.373
MOD_PKA_2	538	544	PF00069	0.379
MOD_PKA_2	6	12	PF00069	0.701
MOD_Plk_4	168	174	PF00069	0.357
MOD_Plk_4	22	28	PF00069	0.327
MOD_Plk_4	291	297	PF00069	0.419
MOD_Plk_4	33	39	PF00069	0.294
MOD_Plk_4	390	396	PF00069	0.355
MOD_Plk_4	403	409	PF00069	0.262
MOD_Plk_4	452	458	PF00069	0.430
MOD_Plk_4	470	476	PF00069	0.271
MOD_Plk_4	77	83	PF00069	0.390
MOD_Plk_4	98	104	PF00069	0.371
MOD_ProDKin_1	160	166	PF00069	0.566
MOD_ProDKin_1	180	186	PF00069	0.299
MOD_ProDKin_1	430	436	PF00069	0.394
MOD_ProDKin_1	455	461	PF00069	0.392
MOD_ProDKin_1	499	505	PF00069	0.395
MOD_ProDKin_1	512	518	PF00069	0.411
MOD_ProDKin_1	52	58	PF00069	0.474
MOD_ProDKin_1	520	526	PF00069	0.466
MOD_ProDKin_1	67	73	PF00069	0.412
MOD_SUMO_for_1	516	519	PF00179	0.400
MOD_SUMO_rev_2	114	123	PF00179	0.428
TRG_DiLeu_BaEn_1	405	410	PF01217	0.321
TRG_ENDOCYTIC_2	137	140	PF00928	0.373
TRG_ENDOCYTIC_2	283	286	PF00928	0.287
TRG_ENDOCYTIC_2	416	419	PF00928	0.297
TRG_ENDOCYTIC_2	509	512	PF00928	0.461
TRG_ENDOCYTIC_2	554	557	PF00928	0.308
TRG_ER_diArg_1	14	16	PF00400	0.665
TRG_ER_diArg_1	168	170	PF00400	0.415
TRG_ER_diArg_1	211	214	PF00400	0.453
TRG_ER_diArg_1	309	312	PF00400	0.443
TRG_ER_diArg_1	317	319	PF00400	0.472
TRG_ER_diArg_1	52	54	PF00400	0.479
TRG_ER_diArg_1	573	575	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	242	247	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I575	Leptomonas seymouri	36%	99%
A0A3Q8IKB7	Leishmania donovani	91%	100%
A4HNW8	Leishmania braziliensis	65%	100%
A4ICM6	Leishmania infantum	91%	100%
E9ASM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%