Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q1W7_LEIMA

TriTrypDb:

LmjF.36.1090 , LMJLV39_360016700 , LMJSD75_360016800

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 2
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.662
CLV_PCSK_KEX2_1	143	145	PF00082	0.672
CLV_PCSK_SKI1_1	135	139	PF00082	0.460
CLV_PCSK_SKI1_1	46	50	PF00082	0.594
DOC_CYCLIN_RxL_1	132	141	PF00134	0.405
DOC_PP4_FxxP_1	93	96	PF00568	0.314
DOC_USP7_MATH_1	126	130	PF00917	0.471
DOC_USP7_UBL2_3	99	103	PF12436	0.529
DOC_WW_Pin1_4	128	133	PF00397	0.481
DOC_WW_Pin1_4	138	143	PF00397	0.619
LIG_14-3-3_CanoR_1	117	125	PF00244	0.589
LIG_14-3-3_CanoR_1	83	89	PF00244	0.503
LIG_EH1_1	7	15	PF00400	0.609
LIG_eIF4E_1	89	95	PF01652	0.473
LIG_FHA_1	106	112	PF00498	0.413
LIG_FHA_1	5	11	PF00498	0.664
LIG_FHA_1	59	65	PF00498	0.482
LIG_FHA_1	89	95	PF00498	0.450
LIG_LIR_Apic_2	91	96	PF02991	0.480
LIG_LIR_Gen_1	35	44	PF02991	0.591
LIG_LIR_Gen_1	7	15	PF02991	0.655
LIG_LIR_Nem_3	131	137	PF02991	0.448
LIG_LIR_Nem_3	35	41	PF02991	0.532
LIG_LIR_Nem_3	7	11	PF02991	0.600
LIG_Pex14_2	34	38	PF04695	0.551
LIG_Pex14_2	4	8	PF04695	0.674
LIG_SH2_CRK	134	138	PF00017	0.399
LIG_SH2_CRK	89	93	PF00017	0.557
LIG_SH2_NCK_1	89	93	PF00017	0.480
LIG_SH2_STAP1	89	93	PF00017	0.480
LIG_WRC_WIRS_1	1	6	PF05994	0.668
LIG_WW_3	26	30	PF00397	0.640
MOD_CDC14_SPxK_1	141	144	PF00782	0.488
MOD_CDK_SPK_2	138	143	PF00069	0.458
MOD_CDK_SPxK_1	138	144	PF00069	0.462
MOD_CDK_SPxxK_3	128	135	PF00069	0.487
MOD_CMANNOS	79	82	PF00535	0.459
MOD_GlcNHglycan	128	131	PF01048	0.521
MOD_GSK3_1	33	40	PF00069	0.503
MOD_GSK3_1	48	55	PF00069	0.466
MOD_GSK3_1	78	85	PF00069	0.423
MOD_NEK2_1	4	9	PF00069	0.669
MOD_NEK2_1	78	83	PF00069	0.505
MOD_NEK2_2	82	87	PF00069	0.496
MOD_NEK2_2	88	93	PF00069	0.496
MOD_PIKK_1	106	112	PF00454	0.468
MOD_PIKK_1	39	45	PF00454	0.415
MOD_PK_1	37	43	PF00069	0.506
MOD_PKA_2	116	122	PF00069	0.590
MOD_PKA_2	82	88	PF00069	0.420
MOD_Plk_4	88	94	PF00069	0.564
MOD_ProDKin_1	128	134	PF00069	0.480
MOD_ProDKin_1	138	144	PF00069	0.624
MOD_SUMO_rev_2	70	78	PF00179	0.571
TRG_ENDOCYTIC_2	134	137	PF00928	0.381
TRG_ENDOCYTIC_2	89	92	PF00928	0.452
TRG_ER_diArg_1	142	144	PF00400	0.736

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R1	Leptomonas seymouri	46%	100%
A0A1X0P821	Trypanosomatidae	33%	100%
A0A3Q8IJY0	Leishmania donovani	94%	100%
A4HNW9	Leishmania braziliensis	68%	100%
A4ICM5	Leishmania infantum	94%	100%
E9ASM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%