HORMA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HORMA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1W5_LEIMA

TriTrypDb:

LmjF.36.1110 , LMJLV39_360016900 , LMJSD75_360017000

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.414
CLV_NRD_NRD_1	144	146	PF00675	0.440
CLV_NRD_NRD_1	147	149	PF00675	0.418
CLV_NRD_NRD_1	385	387	PF00675	0.605
CLV_NRD_NRD_1	524	526	PF00675	0.712
CLV_NRD_NRD_1	548	550	PF00675	0.674
CLV_PCSK_FUR_1	145	149	PF00082	0.376
CLV_PCSK_KEX2_1	146	148	PF00082	0.380
CLV_PCSK_KEX2_1	385	387	PF00082	0.605
CLV_PCSK_KEX2_1	524	526	PF00082	0.712
CLV_PCSK_KEX2_1	547	549	PF00082	0.669
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.433
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.669
CLV_PCSK_PC7_1	520	526	PF00082	0.679
CLV_PCSK_SKI1_1	179	183	PF00082	0.430
CLV_PCSK_SKI1_1	246	250	PF00082	0.573
CLV_PCSK_SKI1_1	385	389	PF00082	0.577
CLV_PCSK_SKI1_1	43	47	PF00082	0.373
CLV_PCSK_SKI1_1	436	440	PF00082	0.381
CLV_PCSK_SKI1_1	528	532	PF00082	0.708
CLV_PCSK_SKI1_1	69	73	PF00082	0.397
DEG_APCC_DBOX_1	76	84	PF00400	0.430
DOC_CKS1_1	273	278	PF01111	0.699
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.509
DOC_MAPK_MEF2A_6	43	50	PF00069	0.373
DOC_PP2B_LxvP_1	46	49	PF13499	0.425
DOC_PP4_FxxP_1	450	453	PF00568	0.503
DOC_USP7_MATH_1	123	127	PF00917	0.339
DOC_USP7_MATH_1	23	27	PF00917	0.356
DOC_USP7_MATH_1	271	275	PF00917	0.731
DOC_USP7_MATH_1	279	283	PF00917	0.647
DOC_USP7_MATH_1	293	297	PF00917	0.767
DOC_USP7_MATH_1	339	343	PF00917	0.721
DOC_WW_Pin1_4	189	194	PF00397	0.376
DOC_WW_Pin1_4	260	265	PF00397	0.746
DOC_WW_Pin1_4	272	277	PF00397	0.679
DOC_WW_Pin1_4	471	476	PF00397	0.755
LIG_14-3-3_CanoR_1	111	117	PF00244	0.376
LIG_14-3-3_CanoR_1	179	184	PF00244	0.430
LIG_14-3-3_CanoR_1	22	30	PF00244	0.335
LIG_14-3-3_CanoR_1	32	40	PF00244	0.341
LIG_14-3-3_CanoR_1	525	531	PF00244	0.679
LIG_14-3-3_CterR_2	548	552	PF00244	0.698
LIG_Actin_WH2_2	266	283	PF00022	0.558
LIG_BRCT_BRCA1_1	97	101	PF00533	0.359
LIG_Clathr_ClatBox_1	493	497	PF01394	0.527
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.430
LIG_FHA_1	126	132	PF00498	0.501
LIG_FHA_1	157	163	PF00498	0.385
LIG_FHA_1	180	186	PF00498	0.426
LIG_FHA_1	251	257	PF00498	0.654
LIG_FHA_1	304	310	PF00498	0.698
LIG_FHA_1	392	398	PF00498	0.474
LIG_FHA_1	435	441	PF00498	0.572
LIG_FHA_1	472	478	PF00498	0.630
LIG_FHA_1	498	504	PF00498	0.531
LIG_FHA_1	56	62	PF00498	0.430
LIG_FHA_1	9	15	PF00498	0.519
LIG_FHA_2	119	125	PF00498	0.424
LIG_FHA_2	148	154	PF00498	0.397
LIG_FHA_2	184	190	PF00498	0.376
LIG_FHA_2	273	279	PF00498	0.772
LIG_FHA_2	378	384	PF00498	0.466
LIG_FHA_2	60	66	PF00498	0.380
LIG_LIR_Apic_2	195	199	PF02991	0.430
LIG_LIR_Apic_2	448	453	PF02991	0.450
LIG_LIR_Gen_1	186	196	PF02991	0.376
LIG_LIR_Gen_1	392	403	PF02991	0.454
LIG_LIR_Nem_3	186	191	PF02991	0.376
LIG_LIR_Nem_3	392	398	PF02991	0.378
LIG_LIR_Nem_3	422	427	PF02991	0.510
LIG_NRBOX	392	398	PF00104	0.456
LIG_NRP_CendR_1	549	552	PF00754	0.701
LIG_Pex14_1	284	288	PF04695	0.665
LIG_SH2_CRK	188	192	PF00017	0.385
LIG_SH2_CRK	424	428	PF00017	0.520
LIG_SH2_NCK_1	188	192	PF00017	0.376
LIG_SH2_SRC	196	199	PF00017	0.405
LIG_SH2_STAT5	105	108	PF00017	0.416
LIG_SH2_STAT5	395	398	PF00017	0.466
LIG_SH2_STAT5	517	520	PF00017	0.592
LIG_SH2_STAT5	79	82	PF00017	0.376
LIG_SH2_STAT5	99	102	PF00017	0.171
LIG_SH3_2	276	281	PF14604	0.779
LIG_SH3_3	136	142	PF00018	0.462
LIG_SH3_3	270	276	PF00018	0.728
LIG_SH3_3	459	465	PF00018	0.712
LIG_SH3_3	479	485	PF00018	0.474
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.479
LIG_TRAF2_1	150	153	PF00917	0.376
LIG_TRAF2_1	334	337	PF00917	0.801
LIG_TRAF2_1	519	522	PF00917	0.638
LIG_TYR_ITSM	184	191	PF00017	0.376
MOD_CDK_SPxxK_3	471	478	PF00069	0.712
MOD_CK1_1	126	132	PF00069	0.441
MOD_CK1_1	224	230	PF00069	0.341
MOD_CK1_1	26	32	PF00069	0.345
MOD_CK1_1	263	269	PF00069	0.699
MOD_CK1_1	274	280	PF00069	0.694
MOD_CK1_1	286	292	PF00069	0.605
MOD_CK1_1	3	9	PF00069	0.571
MOD_CK1_1	312	318	PF00069	0.718
MOD_CK1_1	434	440	PF00069	0.434
MOD_CK1_1	471	477	PF00069	0.719
MOD_CK2_1	147	153	PF00069	0.376
MOD_CK2_1	157	163	PF00069	0.376
MOD_CK2_1	279	285	PF00069	0.678
MOD_CK2_1	340	346	PF00069	0.702
MOD_CK2_1	378	384	PF00069	0.700
MOD_CK2_1	53	59	PF00069	0.347
MOD_Cter_Amidation	545	548	PF01082	0.689
MOD_GlcNHglycan	134	137	PF01048	0.501
MOD_GlcNHglycan	253	256	PF01048	0.685
MOD_GlcNHglycan	265	268	PF01048	0.737
MOD_GlcNHglycan	281	284	PF01048	0.621
MOD_GlcNHglycan	295	298	PF01048	0.574
MOD_GlcNHglycan	380	383	PF01048	0.641
MOD_GlcNHglycan	407	410	PF01048	0.629
MOD_GlcNHglycan	432	436	PF01048	0.581
MOD_GlcNHglycan	535	538	PF01048	0.652
MOD_GlcNHglycan	544	547	PF01048	0.625
MOD_GSK3_1	112	119	PF00069	0.326
MOD_GSK3_1	125	132	PF00069	0.386
MOD_GSK3_1	179	186	PF00069	0.430
MOD_GSK3_1	221	228	PF00069	0.353
MOD_GSK3_1	246	253	PF00069	0.634
MOD_GSK3_1	279	286	PF00069	0.638
MOD_GSK3_1	401	408	PF00069	0.562
MOD_GSK3_1	497	504	PF00069	0.536
MOD_GSK3_1	528	535	PF00069	0.694
MOD_GSK3_1	53	60	PF00069	0.372
MOD_GSK3_1	538	545	PF00069	0.816
MOD_N-GLC_1	103	108	PF02516	0.408
MOD_N-GLC_1	116	121	PF02516	0.430
MOD_N-GLC_1	8	13	PF02516	0.507
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	116	121	PF00069	0.359
MOD_NEK2_1	157	162	PF00069	0.497
MOD_NEK2_1	183	188	PF00069	0.376
MOD_NEK2_1	225	230	PF00069	0.355
MOD_NEK2_1	376	381	PF00069	0.569
MOD_NEK2_1	401	406	PF00069	0.433
MOD_NEK2_1	431	436	PF00069	0.486
MOD_NEK2_1	95	100	PF00069	0.359
MOD_PIKK_1	116	122	PF00454	0.351
MOD_PIKK_1	129	135	PF00454	0.470
MOD_PIKK_1	8	14	PF00454	0.466
MOD_PKA_1	147	153	PF00069	0.376
MOD_PKA_2	147	153	PF00069	0.376
MOD_PKA_2	183	189	PF00069	0.430
MOD_PKA_2	21	27	PF00069	0.425
MOD_PKA_2	250	256	PF00069	0.683
MOD_PKA_2	443	449	PF00069	0.594
MOD_PKA_2	537	543	PF00069	0.708
MOD_PKB_1	145	153	PF00069	0.430
MOD_Plk_1	284	290	PF00069	0.655
MOD_Plk_1	391	397	PF00069	0.533
MOD_Plk_1	512	518	PF00069	0.530
MOD_Plk_1	81	87	PF00069	0.430
MOD_Plk_2-3	59	65	PF00069	0.430
MOD_Plk_4	157	163	PF00069	0.501
MOD_Plk_4	183	189	PF00069	0.376
MOD_Plk_4	391	397	PF00069	0.483
MOD_Plk_4	434	440	PF00069	0.382
MOD_Plk_4	485	491	PF00069	0.513
MOD_Plk_4	512	518	PF00069	0.530
MOD_ProDKin_1	189	195	PF00069	0.376
MOD_ProDKin_1	260	266	PF00069	0.746
MOD_ProDKin_1	272	278	PF00069	0.676
MOD_ProDKin_1	471	477	PF00069	0.742
MOD_SUMO_for_1	465	468	PF00179	0.593
MOD_SUMO_rev_2	330	340	PF00179	0.569
TRG_DiLeu_BaEn_1	153	158	PF01217	0.501
TRG_DiLeu_BaEn_1	392	397	PF01217	0.457
TRG_DiLeu_BaEn_2	40	46	PF01217	0.425
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.363
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.469
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.639
TRG_ENDOCYTIC_2	188	191	PF00928	0.376
TRG_ENDOCYTIC_2	373	376	PF00928	0.407
TRG_ENDOCYTIC_2	395	398	PF00928	0.459
TRG_ENDOCYTIC_2	424	427	PF00928	0.501
TRG_ER_diArg_1	144	147	PF00400	0.430
TRG_ER_diArg_1	385	387	PF00400	0.685
TRG_ER_diArg_1	523	525	PF00400	0.631
TRG_NLS_MonoCore_2	144	149	PF00514	0.501
TRG_NLS_MonoExtN_4	142	149	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U4	Leptomonas seymouri	56%	100%
A0A3R7MNU5	Trypanosoma rangeli	36%	100%
A0A3S7XAH4	Leishmania donovani	90%	100%
A4HNX1	Leishmania braziliensis	73%	100%
A4ICM3	Leishmania infantum	90%	100%
E9ASN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%