Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1W4_LEIMA

TriTrypDb:

LmjF.36.1120 , LMJLV39_360017000 , LMJSD75_360017100

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.415
CLV_NRD_NRD_1	142	144	PF00675	0.666
CLV_NRD_NRD_1	37	39	PF00675	0.705
CLV_NRD_NRD_1	97	99	PF00675	0.639
CLV_PCSK_KEX2_1	37	39	PF00082	0.678
CLV_PCSK_KEX2_1	97	99	PF00082	0.680
CLV_PCSK_SKI1_1	179	183	PF00082	0.626
CLV_PCSK_SKI1_1	71	75	PF00082	0.681
DEG_APCC_DBOX_1	8	16	PF00400	0.672
DEG_Nend_Nbox_1	1	3	PF02207	0.693
DOC_CKS1_1	121	126	PF01111	0.447
DOC_CYCLIN_RxL_1	175	186	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.626
DOC_MAPK_FxFP_2	160	163	PF00069	0.424
DOC_PP1_RVXF_1	255	261	PF00149	0.479
DOC_PP4_FxxP_1	160	163	PF00568	0.424
DOC_PP4_FxxP_1	304	307	PF00568	0.591
DOC_USP7_MATH_1	22	26	PF00917	0.389
DOC_USP7_MATH_1	27	31	PF00917	0.378
DOC_USP7_MATH_1	288	292	PF00917	0.627
DOC_USP7_MATH_1	296	300	PF00917	0.653
DOC_USP7_UBL2_3	222	226	PF12436	0.465
DOC_USP7_UBL2_3	308	312	PF12436	0.623
DOC_WW_Pin1_4	120	125	PF00397	0.436
LIG_14-3-3_CanoR_1	184	188	PF00244	0.444
LIG_14-3-3_CanoR_1	205	210	PF00244	0.452
LIG_14-3-3_CanoR_1	244	248	PF00244	0.422
LIG_14-3-3_CanoR_1	249	258	PF00244	0.388
LIG_14-3-3_CanoR_1	278	284	PF00244	0.651
LIG_14-3-3_CanoR_1	287	296	PF00244	0.662
LIG_14-3-3_CanoR_1	3	12	PF00244	0.735
LIG_deltaCOP1_diTrp_1	153	160	PF00928	0.419
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.430
LIG_deltaCOP1_diTrp_1	309	317	PF00928	0.607
LIG_deltaCOP1_diTrp_1	328	338	PF00928	0.698
LIG_eIF4E_1	295	301	PF01652	0.638
LIG_FHA_1	270	276	PF00498	0.388
LIG_FHA_1	9	15	PF00498	0.685
LIG_FHA_2	193	199	PF00498	0.469
LIG_FHA_2	61	67	PF00498	0.448
LIG_LIR_Apic_2	134	139	PF02991	0.409
LIG_LIR_Apic_2	158	163	PF02991	0.429
LIG_LIR_Apic_2	212	216	PF02991	0.451
LIG_LIR_Gen_1	195	204	PF02991	0.483
LIG_LIR_Gen_1	82	90	PF02991	0.458
LIG_LIR_Nem_3	131	136	PF02991	0.411
LIG_LIR_Nem_3	195	200	PF02991	0.476
LIG_LIR_Nem_3	243	248	PF02991	0.378
LIG_LIR_Nem_3	82	86	PF02991	0.462
LIG_PCNA_PIPBox_1	267	276	PF02747	0.293
LIG_Pex14_1	51	55	PF04695	0.426
LIG_SH2_CRK	136	140	PF00017	0.411
LIG_SH2_GRB2like	340	343	PF00017	0.625
LIG_SH2_NCK_1	136	140	PF00017	0.411
LIG_SH2_STAT3	332	335	PF00017	0.692
LIG_SH2_STAT3	343	346	PF00017	0.669
LIG_SH2_STAT5	132	135	PF00017	0.419
LIG_SH2_STAT5	136	139	PF00017	0.402
LIG_SH2_STAT5	230	233	PF00017	0.512
LIG_SH2_STAT5	274	277	PF00017	0.384
LIG_SH2_STAT5	33	36	PF00017	0.521
LIG_SH2_STAT5	343	346	PF00017	0.559
LIG_SH3_3	208	214	PF00018	0.452
LIG_SUMO_SIM_anti_2	11	16	PF11976	0.631
LIG_SUMO_SIM_par_1	266	272	PF11976	0.357
LIG_TRAF2_1	320	323	PF00917	0.594
LIG_TRAF2_1	63	66	PF00917	0.462
LIG_WRC_WIRS_1	45	50	PF05994	0.513
LIG_WW_1	215	218	PF00397	0.454
MOD_CDK_SPxK_1	120	126	PF00069	0.467
MOD_CK1_1	114	120	PF00069	0.572
MOD_CK1_1	8	14	PF00069	0.789
MOD_CK2_1	237	243	PF00069	0.406
MOD_CK2_1	60	66	PF00069	0.462
MOD_CK2_1	89	95	PF00069	0.458
MOD_CMANNOS	187	190	PF00535	0.628
MOD_GlcNHglycan	17	20	PF01048	0.587
MOD_GlcNHglycan	24	27	PF01048	0.393
MOD_GlcNHglycan	29	32	PF01048	0.368
MOD_GSK3_1	188	195	PF00069	0.486
MOD_GSK3_1	22	29	PF00069	0.337
MOD_GSK3_1	243	250	PF00069	0.464
MOD_GSK3_1	4	11	PF00069	0.744
MOD_GSK3_1	56	63	PF00069	0.493
MOD_N-GLC_1	112	117	PF02516	0.678
MOD_NEK2_1	269	274	PF00069	0.365
MOD_NEK2_1	281	286	PF00069	0.603
MOD_PIKK_1	331	337	PF00454	0.620
MOD_PIKK_1	89	95	PF00454	0.548
MOD_PKA_2	183	189	PF00069	0.426
MOD_PKA_2	243	249	PF00069	0.435
MOD_PKA_2	60	66	PF00069	0.480
MOD_PKA_2	8	14	PF00069	0.704
MOD_Plk_1	111	117	PF00069	0.554
MOD_Plk_4	183	189	PF00069	0.426
MOD_Plk_4	243	249	PF00069	0.435
MOD_Plk_4	269	275	PF00069	0.374
MOD_ProDKin_1	120	126	PF00069	0.435
TRG_DiLeu_BaEn_1	234	239	PF01217	0.446
TRG_DiLeu_BaEn_2	261	267	PF01217	0.427
TRG_ENDOCYTIC_2	130	133	PF00928	0.435
TRG_ENDOCYTIC_2	230	233	PF00928	0.536
TRG_ENDOCYTIC_2	245	248	PF00928	0.344
TRG_ENDOCYTIC_2	40	43	PF00928	0.448
TRG_ENDOCYTIC_2	83	86	PF00928	0.460
TRG_ER_diArg_1	169	172	PF00400	0.481
TRG_ER_diArg_1	204	207	PF00400	0.463
TRG_ER_diArg_1	96	98	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P652	Leptomonas seymouri	84%	100%
A0A0S4JBL9	Bodo saltans	62%	100%
A0A1X0P846	Trypanosomatidae	73%	100%
A0A3S7XAH0	Leishmania donovani	93%	100%
A4HNX2	Leishmania braziliensis	88%	98%
A4ICM2	Leishmania infantum	93%	100%
D0A2T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BZU2	Trypanosoma cruzi	70%	97%