Ch36-1990 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ch36-1990 protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q1W3_LEIMA

TriTrypDb:

LmjF.36.1130 , LMJLV39_360017100 , LMJSD75_360017200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1W3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.501
CLV_C14_Caspase3-7	325	329	PF00656	0.441
CLV_NRD_NRD_1	269	271	PF00675	0.462
CLV_PCSK_KEX2_1	269	271	PF00082	0.467
CLV_PCSK_SKI1_1	233	237	PF00082	0.464
CLV_PCSK_SKI1_1	391	395	PF00082	0.458
CLV_PCSK_SKI1_1	6	10	PF00082	0.648
CLV_PCSK_SKI1_1	89	93	PF00082	0.588
DEG_APCC_DBOX_1	232	240	PF00400	0.465
DEG_Nend_UBRbox_3	1	3	PF02207	0.570
DEG_SPOP_SBC_1	52	56	PF00917	0.434
DOC_CDC14_PxL_1	135	143	PF14671	0.465
DOC_CYCLIN_RxL_1	332	343	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.501
DOC_MAPK_DCC_7	194	202	PF00069	0.462
DOC_MAPK_HePTP_8	191	203	PF00069	0.411
DOC_MAPK_HePTP_8	349	361	PF00069	0.419
DOC_MAPK_MEF2A_6	194	203	PF00069	0.460
DOC_MAPK_MEF2A_6	337	346	PF00069	0.384
DOC_MAPK_MEF2A_6	352	361	PF00069	0.296
DOC_PP2B_LxvP_1	91	94	PF13499	0.533
DOC_PP4_FxxP_1	177	180	PF00568	0.476
DOC_PP4_FxxP_1	30	33	PF00568	0.441
DOC_USP7_MATH_1	148	152	PF00917	0.499
DOC_USP7_MATH_1	214	218	PF00917	0.599
DOC_USP7_MATH_1	226	230	PF00917	0.433
DOC_USP7_MATH_1	326	330	PF00917	0.441
DOC_USP7_MATH_1	53	57	PF00917	0.579
DOC_WW_Pin1_4	150	155	PF00397	0.475
DOC_WW_Pin1_4	80	85	PF00397	0.546
LIG_14-3-3_CanoR_1	188	198	PF00244	0.584
LIG_14-3-3_CanoR_1	424	430	PF00244	0.544
LIG_14-3-3_CanoR_1	6	16	PF00244	0.515
LIG_BIR_III_4	209	213	PF00653	0.478
LIG_BIR_III_4	43	47	PF00653	0.403
LIG_BRCT_BRCA1_1	160	164	PF00533	0.347
LIG_Clathr_ClatBox_1	359	363	PF01394	0.416
LIG_EH1_1	271	279	PF00400	0.496
LIG_eIF4E_1	272	278	PF01652	0.455
LIG_FHA_1	117	123	PF00498	0.463
LIG_FHA_1	242	248	PF00498	0.551
LIG_FHA_1	406	412	PF00498	0.419
LIG_FHA_2	190	196	PF00498	0.553
LIG_FHA_2	417	423	PF00498	0.560
LIG_FHA_2	52	58	PF00498	0.453
LIG_FHA_2	81	87	PF00498	0.585
LIG_LIR_Apic_2	28	33	PF02991	0.455
LIG_LIR_Gen_1	383	393	PF02991	0.458
LIG_LIR_LC3C_4	358	361	PF02991	0.443
LIG_LIR_Nem_3	167	173	PF02991	0.433
LIG_LIR_Nem_3	28	34	PF02991	0.593
LIG_LIR_Nem_3	372	376	PF02991	0.489
LIG_LIR_Nem_3	383	389	PF02991	0.310
LIG_LYPXL_yS_3	138	141	PF13949	0.439
LIG_MYND_3	434	438	PF01753	0.456
LIG_PDZ_Class_3	449	454	PF00595	0.642
LIG_Pex14_2	398	402	PF04695	0.499
LIG_SH2_CRK	396	400	PF00017	0.451
LIG_SH2_GRB2like	395	398	PF00017	0.414
LIG_SH2_STAT5	146	149	PF00017	0.369
LIG_SH2_STAT5	152	155	PF00017	0.383
LIG_SH2_STAT5	157	160	PF00017	0.324
LIG_SH2_STAT5	373	376	PF00017	0.445
LIG_SH3_3	133	139	PF00018	0.447
LIG_SH3_3	218	224	PF00018	0.471
LIG_SH3_3	307	313	PF00018	0.450
LIG_SH3_3	438	444	PF00018	0.633
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.424
LIG_SUMO_SIM_par_1	295	301	PF11976	0.440
LIG_SUMO_SIM_par_1	337	343	PF11976	0.396
LIG_SUMO_SIM_par_1	358	363	PF11976	0.380
LIG_SxIP_EBH_1	423	436	PF03271	0.478
LIG_UBA3_1	385	394	PF00899	0.464
LIG_WRC_WIRS_1	399	404	PF05994	0.438
MOD_CK1_1	112	118	PF00069	0.464
MOD_CK1_1	25	31	PF00069	0.411
MOD_CK1_1	340	346	PF00069	0.350
MOD_CK2_1	190	196	PF00069	0.574
MOD_CK2_1	228	234	PF00069	0.504
MOD_CK2_1	443	449	PF00069	0.611
MOD_CK2_1	51	57	PF00069	0.446
MOD_CK2_1	80	86	PF00069	0.569
MOD_GlcNHglycan	24	27	PF01048	0.468
MOD_GlcNHglycan	324	327	PF01048	0.471
MOD_GlcNHglycan	328	331	PF01048	0.434
MOD_GlcNHglycan	402	405	PF01048	0.466
MOD_GlcNHglycan	445	448	PF01048	0.607
MOD_GlcNHglycan	69	72	PF01048	0.609
MOD_GSK3_1	105	112	PF00069	0.475
MOD_GSK3_1	146	153	PF00069	0.389
MOD_GSK3_1	237	244	PF00069	0.526
MOD_GSK3_1	322	329	PF00069	0.467
MOD_N-GLC_1	180	185	PF02516	0.455
MOD_N-GLC_1	189	194	PF02516	0.420
MOD_NEK2_1	158	163	PF00069	0.399
MOD_NEK2_1	203	208	PF00069	0.403
MOD_NEK2_1	238	243	PF00069	0.432
MOD_NEK2_1	322	327	PF00069	0.408
MOD_NEK2_1	34	39	PF00069	0.405
MOD_NEK2_1	398	403	PF00069	0.439
MOD_NEK2_1	8	13	PF00069	0.480
MOD_PIKK_1	158	164	PF00454	0.385
MOD_PIKK_1	238	244	PF00454	0.476
MOD_PIKK_1	254	260	PF00454	0.410
MOD_PIKK_1	405	411	PF00454	0.452
MOD_PIKK_1	416	422	PF00454	0.447
MOD_PKA_2	204	210	PF00069	0.429
MOD_Plk_1	180	186	PF00069	0.453
MOD_Plk_4	337	343	PF00069	0.361
MOD_Plk_4	355	361	PF00069	0.540
MOD_Plk_4	425	431	PF00069	0.472
MOD_ProDKin_1	150	156	PF00069	0.468
MOD_ProDKin_1	80	86	PF00069	0.562
MOD_SUMO_for_1	252	255	PF00179	0.428
MOD_SUMO_for_1	435	438	PF00179	0.577
TRG_DiLeu_BaEn_1	196	201	PF01217	0.394
TRG_DiLeu_BaEn_2	233	239	PF01217	0.466
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.389
TRG_ENDOCYTIC_2	138	141	PF00928	0.411
TRG_ENDOCYTIC_2	157	160	PF00928	0.229
TRG_ENDOCYTIC_2	373	376	PF00928	0.419
TRG_ENDOCYTIC_2	395	398	PF00928	0.418
TRG_ER_diArg_1	269	271	PF00400	0.452
TRG_NLS_MonoExtN_4	313	318	PF00514	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q9	Leptomonas seymouri	53%	88%
A0A0S4JAW3	Bodo saltans	27%	100%
A4HNX3	Leishmania braziliensis	76%	100%
A4ICM1	Leishmania infantum	93%	100%
E9ASN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
H2ALR9	Leishmania donovani	93%	100%