Protein MEMO1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein MEMO1

Gene product:

AmmeMemoRadiSam system protein B, putative

Species:

Leishmania major

UniProt:

Q4Q1W0_LEIMA

TriTrypDb:

LmjF.36.1160 , LMJLV39_360017400 , LMJSD75_360017500

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1W0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.427
CLV_NRD_NRD_1	188	190	PF00675	0.316
CLV_PCSK_KEX2_1	188	190	PF00082	0.369
CLV_PCSK_KEX2_1	279	281	PF00082	0.413
CLV_PCSK_KEX2_1	303	305	PF00082	0.318
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.403
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.313
CLV_PCSK_SKI1_1	171	175	PF00082	0.342
CLV_PCSK_SKI1_1	20	24	PF00082	0.593
CLV_PCSK_SKI1_1	256	260	PF00082	0.343
CLV_PCSK_SKI1_1	47	51	PF00082	0.507
DEG_SCF_FBW7_1	199	205	PF00400	0.422
DEG_SPOP_SBC_1	211	215	PF00917	0.318
DOC_CKS1_1	155	160	PF01111	0.371
DOC_CKS1_1	199	204	PF01111	0.422
DOC_MAPK_DCC_7	225	233	PF00069	0.334
DOC_MAPK_gen_1	336	344	PF00069	0.255
DOC_MAPK_MEF2A_6	225	233	PF00069	0.334
DOC_MAPK_MEF2A_6	323	330	PF00069	0.309
DOC_PP1_RVXF_1	339	345	PF00149	0.294
DOC_PP2B_LxvP_1	95	98	PF13499	0.449
DOC_PP4_FxxP_1	45	48	PF00568	0.513
DOC_USP7_MATH_1	100	104	PF00917	0.463
DOC_USP7_MATH_1	122	126	PF00917	0.378
DOC_USP7_MATH_1	184	188	PF00917	0.390
DOC_USP7_MATH_1	193	197	PF00917	0.337
DOC_USP7_MATH_1	356	360	PF00917	0.312
DOC_USP7_UBL2_3	339	343	PF12436	0.367
DOC_WW_Pin1_4	154	159	PF00397	0.330
DOC_WW_Pin1_4	198	203	PF00397	0.407
DOC_WW_Pin1_4	24	29	PF00397	0.620
LIG_14-3-3_CanoR_1	271	277	PF00244	0.369
LIG_14-3-3_CanoR_1	47	54	PF00244	0.385
LIG_Actin_WH2_2	161	179	PF00022	0.239
LIG_APCC_ABBA_1	113	118	PF00400	0.422
LIG_APCC_ABBA_1	248	253	PF00400	0.367
LIG_BRCT_BRCA1_1	261	265	PF00533	0.291
LIG_FHA_1	164	170	PF00498	0.369
LIG_FHA_1	199	205	PF00498	0.407
LIG_FHA_1	91	97	PF00498	0.407
LIG_FHA_2	106	112	PF00498	0.422
LIG_FHA_2	68	74	PF00498	0.342
LIG_LIR_Apic_2	153	158	PF02991	0.371
LIG_LIR_Gen_1	111	121	PF02991	0.391
LIG_LIR_Gen_1	307	315	PF02991	0.409
LIG_LIR_Nem_3	111	116	PF02991	0.372
LIG_LIR_Nem_3	156	162	PF02991	0.310
LIG_LIR_Nem_3	281	286	PF02991	0.312
LIG_LIR_Nem_3	307	313	PF02991	0.399
LIG_LYPXL_yS_3	283	286	PF13949	0.309
LIG_PCNA_TLS_4	68	75	PF02747	0.422
LIG_Pex14_1	268	272	PF04695	0.291
LIG_SH2_CRK	310	314	PF00017	0.335
LIG_SH2_NCK_1	155	159	PF00017	0.334
LIG_SH2_NCK_1	60	64	PF00017	0.449
LIG_SH2_SRC	119	122	PF00017	0.309
LIG_SH2_STAP1	274	278	PF00017	0.369
LIG_SH2_STAP1	363	367	PF00017	0.334
LIG_SH2_STAT5	119	122	PF00017	0.316
LIG_SH2_STAT5	203	206	PF00017	0.376
LIG_SH2_STAT5	274	277	PF00017	0.369
LIG_SH2_STAT5	312	315	PF00017	0.318
LIG_SH2_STAT5	74	77	PF00017	0.422
LIG_SH3_1	155	161	PF00018	0.280
LIG_SH3_2	158	163	PF14604	0.374
LIG_SH3_3	11	17	PF00018	0.538
LIG_SH3_3	155	161	PF00018	0.280
LIG_SH3_3	215	221	PF00018	0.318
LIG_SH3_3	244	250	PF00018	0.422
LIG_SH3_4	2	9	PF00018	0.599
LIG_TRAF2_1	83	86	PF00917	0.222
LIG_TRFH_1	134	138	PF08558	0.309
MOD_CK1_1	105	111	PF00069	0.300
MOD_CK1_1	125	131	PF00069	0.365
MOD_CK1_1	150	156	PF00069	0.398
MOD_CK1_1	187	193	PF00069	0.369
MOD_CK1_1	359	365	PF00069	0.296
MOD_CK1_1	76	82	PF00069	0.381
MOD_CK2_1	105	111	PF00069	0.422
MOD_CK2_1	125	131	PF00069	0.361
MOD_CK2_1	150	156	PF00069	0.422
MOD_CK2_1	80	86	PF00069	0.222
MOD_GlcNHglycan	104	107	PF01048	0.309
MOD_GlcNHglycan	148	152	PF01048	0.312
MOD_GlcNHglycan	38	41	PF01048	0.537
MOD_GSK3_1	150	157	PF00069	0.381
MOD_GSK3_1	16	23	PF00069	0.681
MOD_GSK3_1	198	205	PF00069	0.401
MOD_GSK3_1	32	39	PF00069	0.605
MOD_GSK3_1	76	83	PF00069	0.369
MOD_LATS_1	18	24	PF00433	0.543
MOD_N-GLC_2	351	353	PF02516	0.291
MOD_NEK2_1	102	107	PF00069	0.369
MOD_NEK2_1	272	277	PF00069	0.369
MOD_NEK2_1	31	36	PF00069	0.675
MOD_NEK2_1	313	318	PF00069	0.291
MOD_PIKK_1	345	351	PF00454	0.325
MOD_PKA_2	187	193	PF00069	0.313
MOD_PKA_2	270	276	PF00069	0.422
MOD_PKA_2	36	42	PF00069	0.568
MOD_PKA_2	90	96	PF00069	0.425
MOD_Plk_1	193	199	PF00069	0.291
MOD_Plk_1	356	362	PF00069	0.294
MOD_Plk_4	286	292	PF00069	0.422
MOD_ProDKin_1	154	160	PF00069	0.330
MOD_ProDKin_1	198	204	PF00069	0.407
MOD_ProDKin_1	24	30	PF00069	0.621
TRG_ENDOCYTIC_2	283	286	PF00928	0.309
TRG_ENDOCYTIC_2	310	313	PF00928	0.321
TRG_ENDOCYTIC_2	60	63	PF00928	0.449
TRG_ER_diArg_1	42	45	PF00400	0.491
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.246

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKG9	Leptomonas seymouri	74%	100%
A0A1X0P836	Trypanosomatidae	49%	100%
A0A3Q8IIU9	Leishmania donovani	92%	100%
A0A422NTW6	Trypanosoma rangeli	50%	100%
A1RTJ4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	25%	100%
A3MS51	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	25%	100%
A4FWD2	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	24%	100%
A4HNX6	Leishmania braziliensis	83%	100%
A4ICL8	Leishmania infantum	92%	100%
A4WH12	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	24%	100%
A5UN65	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	27%	100%
A6VGX3	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	24%	100%
A8AB69	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	24%	100%
A8M9U2	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	24%	100%
A9A2Y3	Nitrosopumilus maritimus (strain SCM1)	23%	100%
A9A9S6	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	24%	100%
B1LA64	Thermotoga sp. (strain RQ2)	21%	100%
B6YST0	Thermococcus onnurineus (strain NA1)	24%	100%
B8D6F2	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	26%	100%
B9K748	Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)	22%	100%
C3MJQ3	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	24%	100%
C3MZ11	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	24%	100%
C3N060	Sulfolobus islandicus (strain M.16.27)	24%	100%
C3N8S4	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	24%	100%
C3NMP4	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	24%	100%
C4KJ99	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	24%	100%
C5A7L6	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	25%	100%
D0A2U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9ASN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O26151	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O27974	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O59292	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	25%	100%
O67039	Aquifex aeolicus (strain VF5)	23%	100%
P47085	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P61652	Methanococcus maripaludis (strain S2 / LL)	27%	100%
P95994	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	24%	100%
Q10212	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q12TI1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	24%	100%
Q22915	Caenorhabditis elegans	33%	100%
Q2HJH7	Bos taurus	32%	100%
Q46CL1	Methanosarcina barkeri (strain Fusaro / DSM 804)	24%	100%
Q4JCG3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	23%	100%
Q4QQR9	Rattus norvegicus	34%	100%
Q4R6D9	Macaca fascicularis	34%	100%
Q54NZ1	Dictyostelium discoideum	35%	100%
Q5JJC3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	24%	100%
Q6DJ03	Xenopus tropicalis	35%	100%
Q6GNT9	Xenopus laevis	36%	100%
Q803S3	Danio rerio	36%	100%
Q8PW40	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	24%	100%
Q8TT38	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	25%	100%
Q8TWR9	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	100%
Q8U0F2	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	25%	100%
Q8ZYE1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q91VH6	Mus musculus	34%	100%
Q96YW6	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	100%
Q978N2	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	23%	100%
Q9HLJ1	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	23%	100%
Q9V189	Pyrococcus abyssi (strain GE5 / Orsay)	23%	100%
Q9WXU2	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	22%	100%
Q9Y316	Homo sapiens	34%	100%
V5DRI1	Trypanosoma cruzi	52%	100%