Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1V9_LEIMA

TriTrypDb:

LmjF.36.1170 , LMJLV39_360017500 , LMJSD75_360017600

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q1V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0015693	magnesium ion transport	7	2
GO:0030001	metal ion transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0046873	metal ion transmembrane transporter activity	5	3
GO:0015095	magnesium ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.588
CLV_C14_Caspase3-7	233	237	PF00656	0.563
CLV_C14_Caspase3-7	242	246	PF00656	0.532
CLV_C14_Caspase3-7	82	86	PF00656	0.715
CLV_C14_Caspase3-7	87	91	PF00656	0.729
CLV_NRD_NRD_1	418	420	PF00675	0.328
CLV_NRD_NRD_1	459	461	PF00675	0.421
CLV_NRD_NRD_1	475	477	PF00675	0.248
CLV_NRD_NRD_1	487	489	PF00675	0.273
CLV_NRD_NRD_1	5	7	PF00675	0.463
CLV_NRD_NRD_1	512	514	PF00675	0.392
CLV_NRD_NRD_1	553	555	PF00675	0.424
CLV_NRD_NRD_1	627	629	PF00675	0.393
CLV_PCSK_KEX2_1	294	296	PF00082	0.455
CLV_PCSK_KEX2_1	324	326	PF00082	0.471
CLV_PCSK_KEX2_1	418	420	PF00082	0.385
CLV_PCSK_KEX2_1	461	463	PF00082	0.365
CLV_PCSK_KEX2_1	475	477	PF00082	0.267
CLV_PCSK_KEX2_1	487	489	PF00082	0.288
CLV_PCSK_KEX2_1	5	7	PF00082	0.464
CLV_PCSK_KEX2_1	512	514	PF00082	0.363
CLV_PCSK_KEX2_1	553	555	PF00082	0.424
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.455
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.471
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.404
CLV_PCSK_SKI1_1	294	298	PF00082	0.534
CLV_PCSK_SKI1_1	390	394	PF00082	0.349
CLV_PCSK_SKI1_1	418	422	PF00082	0.387
CLV_PCSK_SKI1_1	469	473	PF00082	0.331
CLV_PCSK_SKI1_1	488	492	PF00082	0.317
CLV_PCSK_SKI1_1	560	564	PF00082	0.276
CLV_PCSK_SKI1_1	623	627	PF00082	0.371
DEG_Nend_UBRbox_1	1	4	PF02207	0.689
DEG_ODPH_VHL_1	601	613	PF01847	0.419
DEG_SCF_FBW7_2	269	276	PF00400	0.547
DOC_ANK_TNKS_1	58	65	PF00023	0.696
DOC_CKS1_1	270	275	PF01111	0.506
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.595
DOC_MAPK_DCC_7	356	365	PF00069	0.575
DOC_MAPK_gen_1	553	564	PF00069	0.541
DOC_MAPK_HePTP_8	550	565	PF00069	0.565
DOC_MAPK_MEF2A_6	557	565	PF00069	0.485
DOC_PP1_RVXF_1	486	493	PF00149	0.627
DOC_PP2B_LxvP_1	158	161	PF13499	0.567
DOC_PP4_FxxP_1	420	423	PF00568	0.569
DOC_SPAK_OSR1_1	503	507	PF12202	0.538
DOC_USP7_MATH_1	100	104	PF00917	0.751
DOC_USP7_MATH_1	328	332	PF00917	0.806
DOC_USP7_MATH_1	355	359	PF00917	0.550
DOC_USP7_MATH_1	72	76	PF00917	0.735
DOC_USP7_UBL2_3	314	318	PF12436	0.759
DOC_WW_Pin1_4	14	19	PF00397	0.702
DOC_WW_Pin1_4	214	219	PF00397	0.639
DOC_WW_Pin1_4	269	274	PF00397	0.494
DOC_WW_Pin1_4	410	415	PF00397	0.644
LIG_14-3-3_CanoR_1	220	228	PF00244	0.596
LIG_14-3-3_CanoR_1	356	360	PF00244	0.622
LIG_14-3-3_CanoR_1	418	423	PF00244	0.524
LIG_14-3-3_CanoR_1	51	56	PF00244	0.665
LIG_14-3-3_CanoR_1	628	632	PF00244	0.615
LIG_Actin_WH2_2	544	562	PF00022	0.617
LIG_AP2alpha_1	500	504	PF02296	0.547
LIG_APCC_ABBA_1	27	32	PF00400	0.623
LIG_APCC_ABBA_1	367	372	PF00400	0.475
LIG_BIR_III_4	448	452	PF00653	0.506
LIG_Clathr_ClatBox_1	116	120	PF01394	0.663
LIG_deltaCOP1_diTrp_1	124	128	PF00928	0.516
LIG_deltaCOP1_diTrp_1	372	375	PF00928	0.552
LIG_EH1_1	423	431	PF00400	0.508
LIG_FHA_1	194	200	PF00498	0.717
LIG_FHA_1	201	207	PF00498	0.612
LIG_FHA_1	220	226	PF00498	0.517
LIG_FHA_1	252	258	PF00498	0.670
LIG_FHA_1	270	276	PF00498	0.452
LIG_FHA_1	32	38	PF00498	0.673
LIG_FHA_1	337	343	PF00498	0.581
LIG_FHA_1	401	407	PF00498	0.618
LIG_FHA_1	533	539	PF00498	0.506
LIG_FHA_1	631	637	PF00498	0.588
LIG_FHA_2	287	293	PF00498	0.771
LIG_FHA_2	374	380	PF00498	0.481
LIG_FHA_2	64	70	PF00498	0.660
LIG_IRF3_LxIS_1	224	231	PF10401	0.616
LIG_LIR_Gen_1	136	146	PF02991	0.564
LIG_LIR_Gen_1	20	29	PF02991	0.634
LIG_LIR_Gen_1	203	210	PF02991	0.570
LIG_LIR_Gen_1	262	270	PF02991	0.551
LIG_LIR_Gen_1	344	355	PF02991	0.610
LIG_LIR_Gen_1	379	389	PF02991	0.489
LIG_LIR_Gen_1	489	500	PF02991	0.533
LIG_LIR_Gen_1	75	81	PF02991	0.625
LIG_LIR_Nem_3	136	142	PF02991	0.574
LIG_LIR_Nem_3	20	24	PF02991	0.644
LIG_LIR_Nem_3	203	208	PF02991	0.568
LIG_LIR_Nem_3	262	267	PF02991	0.533
LIG_LIR_Nem_3	344	350	PF02991	0.593
LIG_LIR_Nem_3	38	42	PF02991	0.615
LIG_LIR_Nem_3	489	495	PF02991	0.524
LIG_LIR_Nem_3	75	79	PF02991	0.611
LIG_PCNA_PIPBox_1	431	440	PF02747	0.584
LIG_PDZ_Class_2	632	637	PF00595	0.695
LIG_Pex14_2	420	424	PF04695	0.517
LIG_Pex14_2	500	504	PF04695	0.547
LIG_PTB_Apo_2	55	62	PF02174	0.661
LIG_SH2_CRK	139	143	PF00017	0.559
LIG_SH2_CRK	21	25	PF00017	0.704
LIG_SH2_CRK	614	618	PF00017	0.394
LIG_SH2_PTP2	264	267	PF00017	0.517
LIG_SH2_SRC	28	31	PF00017	0.681
LIG_SH2_STAP1	139	143	PF00017	0.642
LIG_SH2_STAP1	408	412	PF00017	0.640
LIG_SH2_STAP1	582	586	PF00017	0.352
LIG_SH2_STAT3	152	155	PF00017	0.617
LIG_SH2_STAT5	152	155	PF00017	0.600
LIG_SH2_STAT5	21	24	PF00017	0.671
LIG_SH2_STAT5	240	243	PF00017	0.545
LIG_SH2_STAT5	264	267	PF00017	0.465
LIG_SH2_STAT5	28	31	PF00017	0.648
LIG_SH2_STAT5	614	617	PF00017	0.332
LIG_SH2_STAT5	76	79	PF00017	0.605
LIG_SH3_1	212	218	PF00018	0.484
LIG_SH3_2	215	220	PF14604	0.484
LIG_SH3_3	10	16	PF00018	0.698
LIG_SH3_3	195	201	PF00018	0.582
LIG_SH3_3	212	218	PF00018	0.455
LIG_SH3_3	356	362	PF00018	0.602
LIG_SH3_3	503	509	PF00018	0.601
LIG_SH3_3	583	589	PF00018	0.351
LIG_Sin3_3	364	371	PF02671	0.507
LIG_SUMO_SIM_anti_2	248	256	PF11976	0.555
LIG_SUMO_SIM_par_1	534	539	PF11976	0.504
LIG_SUMO_SIM_par_1	574	580	PF11976	0.363
LIG_TRAF2_1	290	293	PF00917	0.586
LIG_TRAF2_1	9	12	PF00917	0.672
LIG_TYR_ITIM	612	617	PF00017	0.305
LIG_UBA3_1	199	204	PF00899	0.516
LIG_UBA3_1	374	380	PF00899	0.537
LIG_UBA3_1	388	393	PF00899	0.572
LIG_WRC_WIRS_1	52	57	PF05994	0.696
LIG_WW_3	104	108	PF00397	0.701
MOD_CDC14_SPxK_1	217	220	PF00782	0.475
MOD_CDK_SPxK_1	214	220	PF00069	0.482
MOD_CK1_1	165	171	PF00069	0.718
MOD_CK1_1	188	194	PF00069	0.736
MOD_CK1_1	231	237	PF00069	0.509
MOD_CK1_1	255	261	PF00069	0.665
MOD_CK1_1	31	37	PF00069	0.675
MOD_CK1_1	319	325	PF00069	0.799
MOD_CK1_1	399	405	PF00069	0.598
MOD_CK1_1	630	636	PF00069	0.710
MOD_CK2_1	148	154	PF00069	0.521
MOD_CK2_1	286	292	PF00069	0.767
MOD_CK2_1	338	344	PF00069	0.627
MOD_CK2_1	355	361	PF00069	0.563
MOD_CK2_1	373	379	PF00069	0.419
MOD_CK2_1	63	69	PF00069	0.664
MOD_Cter_Amidation	322	325	PF01082	0.403
MOD_GlcNHglycan	102	105	PF01048	0.603
MOD_GlcNHglycan	109	112	PF01048	0.568
MOD_GlcNHglycan	120	124	PF01048	0.344
MOD_GlcNHglycan	167	170	PF01048	0.483
MOD_GlcNHglycan	256	260	PF01048	0.442
MOD_GlcNHglycan	318	321	PF01048	0.562
MOD_GlcNHglycan	38	42	PF01048	0.483
MOD_GSK3_1	107	114	PF00069	0.708
MOD_GSK3_1	165	172	PF00069	0.666
MOD_GSK3_1	186	193	PF00069	0.761
MOD_GSK3_1	210	217	PF00069	0.558
MOD_GSK3_1	239	246	PF00069	0.622
MOD_GSK3_1	247	254	PF00069	0.644
MOD_GSK3_1	255	262	PF00069	0.660
MOD_GSK3_1	282	289	PF00069	0.758
MOD_GSK3_1	334	341	PF00069	0.655
MOD_GSK3_1	396	403	PF00069	0.588
MOD_GSK3_1	532	539	PF00069	0.495
MOD_GSK3_1	85	92	PF00069	0.777
MOD_N-GLC_1	57	62	PF02516	0.470
MOD_NEK2_1	167	172	PF00069	0.692
MOD_NEK2_1	19	24	PF00069	0.652
MOD_NEK2_1	239	244	PF00069	0.577
MOD_NEK2_1	305	310	PF00069	0.657
MOD_NEK2_1	336	341	PF00069	0.700
MOD_NEK2_1	424	429	PF00069	0.480
MOD_NEK2_1	491	496	PF00069	0.507
MOD_NEK2_2	373	378	PF00069	0.447
MOD_PIKK_1	219	225	PF00454	0.608
MOD_PIKK_1	228	234	PF00454	0.599
MOD_PIKK_1	329	335	PF00454	0.643
MOD_PKA_1	313	319	PF00069	0.768
MOD_PKA_1	418	424	PF00069	0.568
MOD_PKA_2	219	225	PF00069	0.657
MOD_PKA_2	355	361	PF00069	0.628
MOD_PKA_2	418	424	PF00069	0.563
MOD_PKA_2	532	538	PF00069	0.523
MOD_PKA_2	627	633	PF00069	0.582
MOD_PKB_1	49	57	PF00069	0.625
MOD_Plk_1	19	25	PF00069	0.696
MOD_Plk_1	247	253	PF00069	0.592
MOD_Plk_1	57	63	PF00069	0.668
MOD_Plk_2-3	148	154	PF00069	0.521
MOD_Plk_2-3	85	91	PF00069	0.654
MOD_Plk_4	148	154	PF00069	0.597
MOD_Plk_4	19	25	PF00069	0.667
MOD_Plk_4	424	430	PF00069	0.459
MOD_Plk_4	491	497	PF00069	0.484
MOD_Plk_4	51	57	PF00069	0.712
MOD_Plk_4	577	583	PF00069	0.512
MOD_Plk_4	72	78	PF00069	0.666
MOD_ProDKin_1	14	20	PF00069	0.702
MOD_ProDKin_1	214	220	PF00069	0.639
MOD_ProDKin_1	269	275	PF00069	0.503
MOD_ProDKin_1	410	416	PF00069	0.635
MOD_SUMO_rev_2	231	237	PF00179	0.554
MOD_SUMO_rev_2	291	296	PF00179	0.653
TRG_DiLeu_BaEn_2	123	129	PF01217	0.526
TRG_DiLeu_BaEn_2	291	297	PF01217	0.583
TRG_DiLeu_BaEn_4	292	298	PF01217	0.583
TRG_DiLeu_BaLyEn_6	631	636	PF01217	0.621
TRG_ENDOCYTIC_2	139	142	PF00928	0.584
TRG_ENDOCYTIC_2	21	24	PF00928	0.644
TRG_ENDOCYTIC_2	264	267	PF00928	0.474
TRG_ENDOCYTIC_2	614	617	PF00928	0.323
TRG_ENDOCYTIC_2	76	79	PF00928	0.600
TRG_ER_diArg_1	418	420	PF00400	0.567
TRG_ER_diArg_1	474	476	PF00400	0.501
TRG_ER_diArg_1	49	52	PF00400	0.727
TRG_ER_diArg_1	511	513	PF00400	0.588
TRG_ER_diArg_1	552	554	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ8	Leptomonas seymouri	57%	96%
A0A0S4J7H4	Bodo saltans	20%	87%
A0A1X0NDD2	Trypanosomatidae	34%	100%
A0A3R7L723	Trypanosoma rangeli	31%	100%
A0A3S7XAL7	Leishmania donovani	94%	100%
A4HNX7	Leishmania braziliensis	72%	99%
A4ICL7	Leishmania infantum	94%	100%
B6DT97	Bodo saltans	22%	76%
D0A2U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ASN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B9T6	Trypanosoma cruzi	34%	100%