Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

GPI alpha-mannosyltransferase III

Species:

Leishmania major

UniProt:

Q4Q1V6_LEIMA

TriTrypDb:

LmjF.36.1200 , LMJLV39_360017800 , LMJSD75_360017900

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q1V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V6

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.361
CLV_C14_Caspase3-7	38	42	PF00656	0.150
CLV_NRD_NRD_1	131	133	PF00675	0.281
CLV_NRD_NRD_1	154	156	PF00675	0.206
CLV_NRD_NRD_1	17	19	PF00675	0.481
CLV_NRD_NRD_1	413	415	PF00675	0.318
CLV_NRD_NRD_1	427	429	PF00675	0.306
CLV_NRD_NRD_1	449	451	PF00675	0.414
CLV_NRD_NRD_1	557	559	PF00675	0.542
CLV_NRD_NRD_1	593	595	PF00675	0.455
CLV_PCSK_FUR_1	15	19	PF00082	0.403
CLV_PCSK_KEX2_1	131	133	PF00082	0.285
CLV_PCSK_KEX2_1	153	155	PF00082	0.203
CLV_PCSK_KEX2_1	17	19	PF00082	0.481
CLV_PCSK_KEX2_1	355	357	PF00082	0.310
CLV_PCSK_KEX2_1	413	415	PF00082	0.317
CLV_PCSK_KEX2_1	427	429	PF00082	0.305
CLV_PCSK_KEX2_1	449	451	PF00082	0.449
CLV_PCSK_KEX2_1	557	559	PF00082	0.517
CLV_PCSK_KEX2_1	593	595	PF00082	0.559
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.161
CLV_PCSK_PC1ET2_1	355	357	PF00082	0.377
CLV_PCSK_PC7_1	351	357	PF00082	0.206
CLV_PCSK_SKI1_1	135	139	PF00082	0.247
CLV_PCSK_SKI1_1	17	21	PF00082	0.455
CLV_PCSK_SKI1_1	239	243	PF00082	0.210
CLV_PCSK_SKI1_1	268	272	PF00082	0.457
CLV_PCSK_SKI1_1	356	360	PF00082	0.316
CLV_PCSK_SKI1_1	427	431	PF00082	0.270
CLV_PCSK_SKI1_1	513	517	PF00082	0.510
CLV_PCSK_SKI1_1	52	56	PF00082	0.473
DEG_APCC_DBOX_1	16	24	PF00400	0.331
DEG_Nend_UBRbox_2	1	3	PF02207	0.440
DEG_SPOP_SBC_1	141	145	PF00917	0.397
DOC_AGCK_PIF_1	260	265	PF00069	0.161
DOC_ANK_TNKS_1	557	564	PF00023	0.236
DOC_CDC14_PxL_1	359	367	PF14671	0.233
DOC_CDC14_PxL_1	380	388	PF14671	0.257
DOC_CDC14_PxL_1	76	84	PF14671	0.209
DOC_CKS1_1	270	275	PF01111	0.213
DOC_CKS1_1	476	481	PF01111	0.206
DOC_CYCLIN_RxL_1	265	272	PF00134	0.160
DOC_CYCLIN_RxL_1	424	433	PF00134	0.496
DOC_CYCLIN_RxL_1	520	532	PF00134	0.207
DOC_CYCLIN_yCln2_LP_2	270	276	PF00134	0.150
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.222
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.310
DOC_MAPK_DCC_7	377	387	PF00069	0.200
DOC_MAPK_gen_1	12	22	PF00069	0.339
DOC_MAPK_gen_1	413	420	PF00069	0.521
DOC_MAPK_gen_1	526	536	PF00069	0.364
DOC_MAPK_gen_1	593	599	PF00069	0.252
DOC_MAPK_MEF2A_6	15	24	PF00069	0.358
DOC_MAPK_MEF2A_6	27	34	PF00069	0.208
DOC_MAPK_NFAT4_5	17	25	PF00069	0.399
DOC_MAPK_NFAT4_5	27	35	PF00069	0.335
DOC_PP1_RVXF_1	266	272	PF00149	0.217
DOC_PP1_RVXF_1	375	382	PF00149	0.304
DOC_PP1_RVXF_1	488	494	PF00149	0.318
DOC_PP2B_LxvP_1	299	302	PF13499	0.199
DOC_PP2B_LxvP_1	418	421	PF13499	0.496
DOC_PP2B_LxvP_1	599	602	PF13499	0.331
DOC_PP4_FxxP_1	138	141	PF00568	0.395
DOC_PP4_FxxP_1	381	384	PF00568	0.288
DOC_PP4_FxxP_1	77	80	PF00568	0.366
DOC_USP7_MATH_1	13	17	PF00917	0.422
DOC_USP7_MATH_1	141	145	PF00917	0.460
DOC_USP7_MATH_1	419	423	PF00917	0.401
DOC_USP7_MATH_1	621	625	PF00917	0.347
DOC_USP7_MATH_1	67	71	PF00917	0.225
DOC_WW_Pin1_4	269	274	PF00397	0.191
DOC_WW_Pin1_4	36	41	PF00397	0.250
DOC_WW_Pin1_4	398	403	PF00397	0.272
DOC_WW_Pin1_4	475	480	PF00397	0.210
LIG_14-3-3_CanoR_1	213	221	PF00244	0.206
LIG_14-3-3_CanoR_1	27	31	PF00244	0.342
LIG_14-3-3_CanoR_1	427	433	PF00244	0.459
LIG_14-3-3_CanoR_1	513	522	PF00244	0.319
LIG_14-3-3_CanoR_1	57	63	PF00244	0.296
LIG_14-3-3_CanoR_1	594	600	PF00244	0.331
LIG_Actin_WH2_2	110	127	PF00022	0.459
LIG_Actin_WH2_2	390	408	PF00022	0.225
LIG_BRCT_BRCA1_1	338	342	PF00533	0.395
LIG_BRCT_BRCA1_1	436	440	PF00533	0.209
LIG_BRCT_BRCA1_1	69	73	PF00533	0.232
LIG_CSL_BTD_1	313	316	PF09270	0.345
LIG_deltaCOP1_diTrp_1	463	466	PF00928	0.170
LIG_eIF4E_1	380	386	PF01652	0.345
LIG_FHA_1	161	167	PF00498	0.299
LIG_FHA_1	27	33	PF00498	0.379
LIG_FHA_1	362	368	PF00498	0.330
LIG_FHA_1	439	445	PF00498	0.315
LIG_FHA_1	576	582	PF00498	0.327
LIG_FHA_2	131	137	PF00498	0.473
LIG_FHA_2	143	149	PF00498	0.451
LIG_FHA_2	85	91	PF00498	0.418
LIG_GBD_Chelix_1	237	245	PF00786	0.245
LIG_IRF3_LxIS_1	383	390	PF10401	0.225
LIG_LIR_Apic_2	136	141	PF02991	0.361
LIG_LIR_Apic_2	70	74	PF02991	0.309
LIG_LIR_Apic_2	8	13	PF02991	0.377
LIG_LIR_Gen_1	180	189	PF02991	0.273
LIG_LIR_Gen_1	215	226	PF02991	0.302
LIG_LIR_Gen_1	264	274	PF02991	0.273
LIG_LIR_Gen_1	375	386	PF02991	0.255
LIG_LIR_Gen_1	437	448	PF02991	0.252
LIG_LIR_Gen_1	478	488	PF02991	0.200
LIG_LIR_Gen_1	609	619	PF02991	0.278
LIG_LIR_Nem_3	180	184	PF02991	0.219
LIG_LIR_Nem_3	186	192	PF02991	0.260
LIG_LIR_Nem_3	197	202	PF02991	0.162
LIG_LIR_Nem_3	215	221	PF02991	0.229
LIG_LIR_Nem_3	262	266	PF02991	0.212
LIG_LIR_Nem_3	272	277	PF02991	0.204
LIG_LIR_Nem_3	286	291	PF02991	0.158
LIG_LIR_Nem_3	375	381	PF02991	0.275
LIG_LIR_Nem_3	437	443	PF02991	0.261
LIG_LIR_Nem_3	454	459	PF02991	0.255
LIG_LIR_Nem_3	463	469	PF02991	0.296
LIG_LIR_Nem_3	478	484	PF02991	0.263
LIG_LIR_Nem_3	48	54	PF02991	0.191
LIG_LIR_Nem_3	609	615	PF02991	0.364
LIG_LIR_Nem_3	70	76	PF02991	0.227
LIG_NRBOX	18	24	PF00104	0.338
LIG_NRBOX	187	193	PF00104	0.218
LIG_PCNA_PIPBox_1	114	123	PF02747	0.350
LIG_PCNA_PIPBox_1	234	243	PF02747	0.350
LIG_Pex14_2	310	314	PF04695	0.345
LIG_Pex14_2	430	434	PF04695	0.375
LIG_Pex14_2	73	77	PF04695	0.318
LIG_SH2_CRK	181	185	PF00017	0.223
LIG_SH2_CRK	266	270	PF00017	0.296
LIG_SH2_CRK	274	278	PF00017	0.296
LIG_SH2_CRK	368	372	PF00017	0.210
LIG_SH2_CRK	476	480	PF00017	0.189
LIG_SH2_CRK	481	485	PF00017	0.180
LIG_SH2_CRK	51	55	PF00017	0.213
LIG_SH2_CRK	592	596	PF00017	0.273
LIG_SH2_GRB2like	181	184	PF00017	0.230
LIG_SH2_NCK_1	181	185	PF00017	0.296
LIG_SH2_PTP2	71	74	PF00017	0.345
LIG_SH2_STAT5	297	300	PF00017	0.190
LIG_SH2_STAT5	321	324	PF00017	0.433
LIG_SH2_STAT5	380	383	PF00017	0.345
LIG_SH2_STAT5	527	530	PF00017	0.250
LIG_SH2_STAT5	612	615	PF00017	0.302
LIG_SH2_STAT5	71	74	PF00017	0.286
LIG_SH3_3	288	294	PF00018	0.255
LIG_SH3_3	357	363	PF00018	0.405
LIG_SH3_3	563	569	PF00018	0.357
LIG_SUMO_SIM_anti_2	161	168	PF11976	0.177
LIG_SUMO_SIM_anti_2	390	397	PF11976	0.366
LIG_SUMO_SIM_anti_2	441	446	PF11976	0.292
LIG_SUMO_SIM_par_1	363	370	PF11976	0.225
LIG_SUMO_SIM_par_1	384	391	PF11976	0.311
LIG_SUMO_SIM_par_1	393	399	PF11976	0.313
LIG_TRAF2_1	604	607	PF00917	0.286
LIG_TRFH_1	380	384	PF08558	0.339
LIG_TYR_ITIM	49	54	PF00017	0.219
LIG_UBA3_1	81	85	PF00899	0.420
MOD_CK1_1	130	136	PF00069	0.395
MOD_CK1_1	144	150	PF00069	0.250
MOD_CK1_1	343	349	PF00069	0.361
MOD_CK1_1	617	623	PF00069	0.556
MOD_CK2_1	123	129	PF00069	0.232
MOD_CK2_1	142	148	PF00069	0.430
MOD_CK2_1	601	607	PF00069	0.493
MOD_GlcNHglycan	125	128	PF01048	0.223
MOD_GlcNHglycan	138	141	PF01048	0.202
MOD_GlcNHglycan	254	257	PF01048	0.364
MOD_GlcNHglycan	330	333	PF01048	0.370
MOD_GlcNHglycan	342	345	PF01048	0.394
MOD_GlcNHglycan	402	405	PF01048	0.377
MOD_GlcNHglycan	407	410	PF01048	0.352
MOD_GlcNHglycan	421	424	PF01048	0.193
MOD_GlcNHglycan	436	439	PF01048	0.250
MOD_GlcNHglycan	503	506	PF01048	0.355
MOD_GSK3_1	123	130	PF00069	0.410
MOD_GSK3_1	136	143	PF00069	0.309
MOD_GSK3_1	155	162	PF00069	0.270
MOD_GSK3_1	173	180	PF00069	0.182
MOD_GSK3_1	190	197	PF00069	0.181
MOD_GSK3_1	26	33	PF00069	0.225
MOD_GSK3_1	336	343	PF00069	0.401
MOD_GSK3_1	396	403	PF00069	0.361
MOD_GSK3_1	430	437	PF00069	0.358
MOD_GSK3_1	617	624	PF00069	0.418
MOD_GSK3_1	84	91	PF00069	0.345
MOD_NEK2_1	142	147	PF00069	0.341
MOD_NEK2_1	173	178	PF00069	0.316
MOD_NEK2_1	194	199	PF00069	0.255
MOD_NEK2_1	212	217	PF00069	0.206
MOD_NEK2_1	283	288	PF00069	0.370
MOD_NEK2_1	30	35	PF00069	0.245
MOD_NEK2_1	330	335	PF00069	0.306
MOD_NEK2_1	342	347	PF00069	0.399
MOD_NEK2_1	366	371	PF00069	0.279
MOD_NEK2_1	387	392	PF00069	0.288
MOD_NEK2_1	396	401	PF00069	0.302
MOD_NEK2_1	405	410	PF00069	0.274
MOD_NEK2_1	430	435	PF00069	0.240
MOD_NEK2_1	575	580	PF00069	0.341
MOD_NEK2_1	595	600	PF00069	0.248
MOD_NEK2_1	84	89	PF00069	0.287
MOD_NEK2_2	337	342	PF00069	0.391
MOD_PIKK_1	344	350	PF00454	0.169
MOD_PIKK_1	507	513	PF00454	0.457
MOD_PKA_2	130	136	PF00069	0.372
MOD_PKA_2	212	218	PF00069	0.206
MOD_PKA_2	26	32	PF00069	0.225
MOD_PKA_2	459	465	PF00069	0.450
MOD_PKA_2	617	623	PF00069	0.388
MOD_Plk_1	110	116	PF00069	0.366
MOD_Plk_1	261	267	PF00069	0.294
MOD_Plk_1	89	95	PF00069	0.210
MOD_Plk_4	110	116	PF00069	0.149
MOD_Plk_4	184	190	PF00069	0.295
MOD_Plk_4	261	267	PF00069	0.201
MOD_Plk_4	337	343	PF00069	0.257
MOD_Plk_4	361	367	PF00069	0.255
MOD_Plk_4	388	394	PF00069	0.299
MOD_Plk_4	430	436	PF00069	0.230
MOD_Plk_4	451	457	PF00069	0.328
MOD_Plk_4	468	474	PF00069	0.203
MOD_Plk_4	91	97	PF00069	0.318
MOD_ProDKin_1	269	275	PF00069	0.219
MOD_ProDKin_1	36	42	PF00069	0.250
MOD_ProDKin_1	398	404	PF00069	0.272
MOD_ProDKin_1	475	481	PF00069	0.246
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.292
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.161
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.225
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.340
TRG_ENDOCYTIC_2	181	184	PF00928	0.297
TRG_ENDOCYTIC_2	199	202	PF00928	0.232
TRG_ENDOCYTIC_2	232	235	PF00928	0.226
TRG_ENDOCYTIC_2	266	269	PF00928	0.274
TRG_ENDOCYTIC_2	274	277	PF00928	0.274
TRG_ENDOCYTIC_2	288	291	PF00928	0.188
TRG_ENDOCYTIC_2	368	371	PF00928	0.226
TRG_ENDOCYTIC_2	380	383	PF00928	0.224
TRG_ENDOCYTIC_2	481	484	PF00928	0.265
TRG_ENDOCYTIC_2	51	54	PF00928	0.219
TRG_ENDOCYTIC_2	527	530	PF00928	0.292
TRG_ENDOCYTIC_2	592	595	PF00928	0.344
TRG_ENDOCYTIC_2	612	615	PF00928	0.187
TRG_ER_diArg_1	14	17	PF00400	0.338
TRG_ER_diArg_1	426	428	PF00400	0.380
TRG_ER_diArg_1	448	450	PF00400	0.295
TRG_ER_diArg_1	556	558	PF00400	0.246
TRG_ER_diArg_1	592	594	PF00400	0.286
TRG_NES_CRM1_1	489	501	PF08389	0.489
TRG_NLS_MonoExtC_3	152	157	PF00514	0.177
TRG_NLS_MonoExtN_4	151	157	PF00514	0.177

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q8	Leptomonas seymouri	54%	100%
A0A0S4J7A7	Bodo saltans	29%	100%
A0A1X0P926	Trypanosomatidae	33%	100%
A0A3Q8IJ48	Leishmania donovani	88%	100%
A0A422NTW3	Trypanosoma rangeli	31%	100%
A4HNY0	Leishmania braziliensis	67%	100%
A4ICL4	Leishmania infantum	88%	100%
D0A2U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
P86935	Trypanosoma brucei brucei	34%	100%
P86936	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	34%	100%
Q4IB63	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	25%	100%
Q4V7R2	Xenopus laevis	24%	100%
Q6CN76	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
Q6FTY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	24%	100%
Q94A15	Arabidopsis thaliana	24%	100%
Q9VZM5	Drosophila melanogaster	26%	100%
V5DRF7	Trypanosoma cruzi	32%	100%