Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1V5_LEIMA

TriTrypDb:

LmjF.36.1210 , LMJLV39_360017900 , LMJSD75_360018000

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.467
CLV_C14_Caspase3-7	206	210	PF00656	0.710
CLV_PCSK_SKI1_1	114	118	PF00082	0.445
CLV_PCSK_SKI1_1	126	130	PF00082	0.423
CLV_PCSK_SKI1_1	167	171	PF00082	0.554
CLV_PCSK_SKI1_1	211	215	PF00082	0.581
CLV_PCSK_SKI1_1	61	65	PF00082	0.414
DEG_APCC_DBOX_1	166	174	PF00400	0.488
DEG_SPOP_SBC_1	192	196	PF00917	0.646
DOC_PP1_RVXF_1	66	73	PF00149	0.433
DOC_USP7_MATH_1	108	112	PF00917	0.487
DOC_USP7_MATH_1	188	192	PF00917	0.675
DOC_USP7_MATH_1	2	6	PF00917	0.503
DOC_USP7_MATH_1	9	13	PF00917	0.542
DOC_USP7_UBL2_3	242	246	PF12436	0.458
DOC_WW_Pin1_4	182	187	PF00397	0.720
LIG_14-3-3_CanoR_1	7	17	PF00244	0.501
LIG_14-3-3_CanoR_1	92	98	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	209	213	PF00533	0.467
LIG_FHA_1	100	106	PF00498	0.479
LIG_FHA_1	128	134	PF00498	0.356
LIG_FHA_1	192	198	PF00498	0.577
LIG_FHA_1	57	63	PF00498	0.441
LIG_FHA_1	85	91	PF00498	0.609
LIG_FHA_2	142	148	PF00498	0.567
LIG_FHA_2	170	176	PF00498	0.679
LIG_FHA_2	219	225	PF00498	0.526
LIG_LIR_Gen_1	132	141	PF02991	0.411
LIG_LIR_Gen_1	86	94	PF02991	0.524
LIG_LIR_Nem_3	132	138	PF02991	0.412
LIG_LIR_Nem_3	221	226	PF02991	0.409
LIG_LIR_Nem_3	54	60	PF02991	0.448
LIG_LIR_Nem_3	86	91	PF02991	0.496
LIG_PCNA_PIPBox_1	113	122	PF02747	0.444
LIG_PCNA_PIPBox_1	241	250	PF02747	0.617
LIG_PCNA_yPIPBox_3	241	251	PF02747	0.554
LIG_PTB_Apo_2	79	86	PF02174	0.404
LIG_SH2_CRK	223	227	PF00017	0.442
LIG_SH2_GRB2like	247	250	PF00017	0.467
LIG_SH2_STAP1	58	62	PF00017	0.417
LIG_SH2_STAT3	20	23	PF00017	0.577
LIG_SH2_STAT3	238	241	PF00017	0.574
LIG_SH2_STAT5	119	122	PF00017	0.485
LIG_SH2_STAT5	20	23	PF00017	0.511
LIG_SH2_STAT5	238	241	PF00017	0.507
LIG_SH2_STAT5	37	40	PF00017	0.321
LIG_SH2_STAT5	58	61	PF00017	0.489
LIG_SH3_3	237	243	PF00018	0.463
LIG_SH3_4	242	249	PF00018	0.460
LIG_TYR_ITSM	219	226	PF00017	0.446
MOD_CK1_1	139	145	PF00069	0.572
MOD_CK1_1	191	197	PF00069	0.620
MOD_CK1_1	49	55	PF00069	0.495
MOD_CK1_1	5	11	PF00069	0.536
MOD_CK1_1	86	92	PF00069	0.573
MOD_CK2_1	169	175	PF00069	0.650
MOD_GlcNHglycan	110	113	PF01048	0.484
MOD_GlcNHglycan	13	16	PF01048	0.638
MOD_GlcNHglycan	190	193	PF01048	0.693
MOD_GlcNHglycan	51	54	PF01048	0.414
MOD_GSK3_1	1	8	PF00069	0.619
MOD_GSK3_1	182	189	PF00069	0.645
MOD_GSK3_1	203	210	PF00069	0.658
MOD_N-GLC_2	160	162	PF02516	0.428
MOD_NEK2_1	1	6	PF00069	0.662
MOD_NEK2_1	107	112	PF00069	0.359
MOD_NEK2_1	151	156	PF00069	0.525
MOD_NEK2_1	200	205	PF00069	0.574
MOD_NEK2_1	213	218	PF00069	0.556
MOD_NEK2_1	230	235	PF00069	0.388
MOD_NEK2_1	51	56	PF00069	0.444
MOD_NEK2_1	99	104	PF00069	0.442
MOD_NEK2_2	169	174	PF00069	0.582
MOD_NEK2_2	46	51	PF00069	0.417
MOD_NEK2_2	56	61	PF00069	0.414
MOD_PIKK_1	93	99	PF00454	0.520
MOD_Plk_1	211	217	PF00069	0.577
MOD_Plk_2-3	127	133	PF00069	0.355
MOD_Plk_2-3	175	181	PF00069	0.536
MOD_Plk_4	151	157	PF00069	0.594
MOD_Plk_4	218	224	PF00069	0.437
MOD_Plk_4	230	236	PF00069	0.469
MOD_Plk_4	46	52	PF00069	0.494
MOD_ProDKin_1	182	188	PF00069	0.720
MOD_SUMO_rev_2	205	213	PF00179	0.490
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.411
TRG_ENDOCYTIC_2	223	226	PF00928	0.440
TRG_ENDOCYTIC_2	247	250	PF00928	0.552
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB2	Leptomonas seymouri	50%	92%
A0A0S4JAI8	Bodo saltans	31%	100%
A0A1X0P886	Trypanosomatidae	37%	100%
A0A3S7XAI3	Leishmania donovani	85%	100%
A4ICL3	Leishmania infantum	85%	100%
D0A2U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5B9R5	Trypanosoma cruzi	36%	100%