Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1V4_LEIMA

TriTrypDb:

LmjF.36.1220 , LMJLV39_360018000 , LMJSD75_360018100

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.632
CLV_C14_Caspase3-7	360	364	PF00656	0.602
CLV_NRD_NRD_1	332	334	PF00675	0.573
CLV_NRD_NRD_1	406	408	PF00675	0.461
CLV_NRD_NRD_1	435	437	PF00675	0.590
CLV_NRD_NRD_1	451	453	PF00675	0.665
CLV_PCSK_KEX2_1	331	333	PF00082	0.568
CLV_PCSK_KEX2_1	406	408	PF00082	0.482
CLV_PCSK_KEX2_1	435	437	PF00082	0.578
CLV_PCSK_PC1ET2_1	331	333	PF00082	0.568
CLV_PCSK_SKI1_1	333	337	PF00082	0.637
CLV_PCSK_SKI1_1	389	393	PF00082	0.566
CLV_PCSK_SKI1_1	406	410	PF00082	0.551
CLV_PCSK_SKI1_1	435	439	PF00082	0.497
CLV_PCSK_SKI1_1	7	11	PF00082	0.575
CLV_PCSK_SKI1_1	78	82	PF00082	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DOC_CKS1_1	233	238	PF01111	0.630
DOC_CKS1_1	382	387	PF01111	0.685
DOC_CKS1_1	9	14	PF01111	0.566
DOC_CYCLIN_RxL_1	75	85	PF00134	0.548
DOC_MAPK_gen_1	331	337	PF00069	0.568
DOC_MAPK_MEF2A_6	130	139	PF00069	0.651
DOC_PP1_RVXF_1	331	338	PF00149	0.635
DOC_PP4_FxxP_1	35	38	PF00568	0.585
DOC_USP7_MATH_1	286	290	PF00917	0.678
DOC_USP7_MATH_1	344	348	PF00917	0.624
DOC_USP7_MATH_1	54	58	PF00917	0.617
DOC_USP7_MATH_1	67	71	PF00917	0.486
DOC_WW_Pin1_4	232	237	PF00397	0.629
DOC_WW_Pin1_4	255	260	PF00397	0.633
DOC_WW_Pin1_4	294	299	PF00397	0.602
DOC_WW_Pin1_4	337	342	PF00397	0.570
DOC_WW_Pin1_4	34	39	PF00397	0.631
DOC_WW_Pin1_4	369	374	PF00397	0.768
DOC_WW_Pin1_4	381	386	PF00397	0.709
DOC_WW_Pin1_4	8	13	PF00397	0.719
LIG_14-3-3_CanoR_1	249	254	PF00244	0.620
LIG_14-3-3_CanoR_1	271	275	PF00244	0.596
LIG_14-3-3_CanoR_1	291	299	PF00244	0.531
LIG_14-3-3_CanoR_1	389	399	PF00244	0.622
LIG_14-3-3_CanoR_1	416	421	PF00244	0.477
LIG_14-3-3_CanoR_1	452	456	PF00244	0.569
LIG_14-3-3_CanoR_1	7	12	PF00244	0.681
LIG_Actin_WH2_2	257	273	PF00022	0.589
LIG_BIR_III_2	195	199	PF00653	0.627
LIG_BRCT_BRCA1_1	256	260	PF00533	0.642
LIG_BRCT_BRCA1_1	265	269	PF00533	0.536
LIG_BRCT_BRCA1_1	425	429	PF00533	0.444
LIG_FHA_1	130	136	PF00498	0.560
LIG_FHA_1	165	171	PF00498	0.629
LIG_FHA_1	23	29	PF00498	0.566
LIG_FHA_1	233	239	PF00498	0.631
LIG_FHA_1	316	322	PF00498	0.633
LIG_FHA_1	390	396	PF00498	0.564
LIG_FHA_1	46	52	PF00498	0.635
LIG_FHA_1	8	14	PF00498	0.679
LIG_FHA_1	98	104	PF00498	0.576
LIG_FHA_2	291	297	PF00498	0.588
LIG_FHA_2	338	344	PF00498	0.563
LIG_FHA_2	365	371	PF00498	0.648
LIG_FHA_2	391	397	PF00498	0.585
LIG_GBD_Chelix_1	237	245	PF00786	0.602
LIG_LIR_Apic_2	32	38	PF02991	0.569
LIG_LIR_Gen_1	174	183	PF02991	0.574
LIG_LIR_Gen_1	224	233	PF02991	0.575
LIG_LIR_Nem_3	224	229	PF02991	0.580
LIG_MLH1_MIPbox_1	425	429	PF16413	0.444
LIG_Pex14_2	177	181	PF04695	0.649
LIG_SH2_NCK_1	247	251	PF00017	0.621
LIG_SH2_STAT5	226	229	PF00017	0.604
LIG_SH2_STAT5	247	250	PF00017	0.623
LIG_SH2_STAT5	428	431	PF00017	0.579
LIG_SH3_1	230	236	PF00018	0.632
LIG_SH3_3	136	142	PF00018	0.695
LIG_SH3_3	217	223	PF00018	0.643
LIG_SH3_3	230	236	PF00018	0.544
LIG_SH3_3	370	376	PF00018	0.700
LIG_SH3_3	379	385	PF00018	0.618
LIG_SUMO_SIM_anti_2	204	214	PF11976	0.637
LIG_TRAF2_1	367	370	PF00917	0.661
LIG_TRAF2_1	454	457	PF00917	0.559
MOD_CK1_1	119	125	PF00069	0.698
MOD_CK1_1	224	230	PF00069	0.633
MOD_CK1_1	231	237	PF00069	0.591
MOD_CK1_1	252	258	PF00069	0.646
MOD_CK1_1	263	269	PF00069	0.522
MOD_CK1_1	281	287	PF00069	0.499
MOD_CK1_1	320	326	PF00069	0.579
MOD_CK1_1	357	363	PF00069	0.668
MOD_CK1_1	57	63	PF00069	0.758
MOD_CK2_1	170	176	PF00069	0.543
MOD_CK2_1	290	296	PF00069	0.608
MOD_CK2_1	311	317	PF00069	0.632
MOD_CK2_1	322	328	PF00069	0.569
MOD_CK2_1	337	343	PF00069	0.548
MOD_CK2_1	364	370	PF00069	0.648
MOD_CK2_1	390	396	PF00069	0.596
MOD_CK2_1	451	457	PF00069	0.576
MOD_CK2_1	50	56	PF00069	0.677
MOD_GlcNHglycan	176	180	PF01048	0.656
MOD_GlcNHglycan	223	226	PF01048	0.627
MOD_GlcNHglycan	260	263	PF01048	0.624
MOD_GlcNHglycan	288	291	PF01048	0.608
MOD_GlcNHglycan	324	327	PF01048	0.657
MOD_GlcNHglycan	355	359	PF01048	0.639
MOD_GlcNHglycan	424	428	PF01048	0.490
MOD_GlcNHglycan	493	496	PF01048	0.576
MOD_GlcNHglycan	52	55	PF01048	0.612
MOD_GlcNHglycan	59	62	PF01048	0.580
MOD_GlcNHglycan	92	95	PF01048	0.725
MOD_GSK3_1	129	136	PF00069	0.568
MOD_GSK3_1	155	162	PF00069	0.675
MOD_GSK3_1	171	178	PF00069	0.659
MOD_GSK3_1	224	231	PF00069	0.638
MOD_GSK3_1	245	252	PF00069	0.610
MOD_GSK3_1	254	261	PF00069	0.569
MOD_GSK3_1	265	272	PF00069	0.447
MOD_GSK3_1	281	288	PF00069	0.521
MOD_GSK3_1	290	297	PF00069	0.561
MOD_GSK3_1	311	318	PF00069	0.632
MOD_GSK3_1	333	340	PF00069	0.661
MOD_GSK3_1	377	384	PF00069	0.697
MOD_GSK3_1	387	394	PF00069	0.552
MOD_GSK3_1	41	48	PF00069	0.786
MOD_GSK3_1	412	419	PF00069	0.701
MOD_GSK3_1	50	57	PF00069	0.652
MOD_GSK3_1	59	66	PF00069	0.530
MOD_GSK3_1	84	91	PF00069	0.780
MOD_N-GLC_1	119	124	PF02516	0.604
MOD_N-GLC_1	133	138	PF02516	0.531
MOD_N-GLC_1	159	164	PF02516	0.554
MOD_N-GLC_1	165	170	PF02516	0.525
MOD_N-GLC_1	294	299	PF02516	0.568
MOD_N-GLC_1	363	368	PF02516	0.698
MOD_N-GLC_1	72	77	PF02516	0.615
MOD_N-GLC_1	97	102	PF02516	0.549
MOD_NEK2_1	116	121	PF00069	0.669
MOD_NEK2_1	164	169	PF00069	0.618
MOD_NEK2_1	237	242	PF00069	0.622
MOD_NEK2_1	245	250	PF00069	0.591
MOD_NEK2_1	254	259	PF00069	0.534
MOD_NEK2_1	260	265	PF00069	0.504
MOD_NEK2_1	269	274	PF00069	0.482
MOD_NEK2_1	278	283	PF00069	0.475
MOD_NEK2_1	311	316	PF00069	0.633
MOD_NEK2_1	41	46	PF00069	0.737
MOD_NEK2_1	429	434	PF00069	0.582
MOD_NEK2_1	462	467	PF00069	0.565
MOD_PIKK_1	165	171	PF00454	0.538
MOD_PIKK_1	278	284	PF00454	0.641
MOD_PIKK_1	320	326	PF00454	0.579
MOD_PIKK_1	457	463	PF00454	0.524
MOD_PIKK_1	67	73	PF00454	0.564
MOD_PK_1	249	255	PF00069	0.531
MOD_PKA_2	129	135	PF00069	0.590
MOD_PKA_2	22	28	PF00069	0.645
MOD_PKA_2	248	254	PF00069	0.620
MOD_PKA_2	270	276	PF00069	0.585
MOD_PKA_2	290	296	PF00069	0.508
MOD_PKA_2	451	457	PF00069	0.627
MOD_Plk_1	114	120	PF00069	0.571
MOD_Plk_1	133	139	PF00069	0.510
MOD_Plk_1	159	165	PF00069	0.618
MOD_Plk_1	175	181	PF00069	0.558
MOD_Plk_1	201	207	PF00069	0.630
MOD_Plk_1	333	339	PF00069	0.661
MOD_Plk_1	412	418	PF00069	0.611
MOD_Plk_1	423	429	PF00069	0.640
MOD_Plk_1	457	463	PF00069	0.603
MOD_Plk_1	72	78	PF00069	0.632
MOD_Plk_2-3	27	33	PF00069	0.631
MOD_Plk_4	202	208	PF00069	0.631
MOD_Plk_4	249	255	PF00069	0.628
MOD_Plk_4	311	317	PF00069	0.587
MOD_Plk_4	416	422	PF00069	0.572
MOD_Plk_4	99	105	PF00069	0.601
MOD_ProDKin_1	232	238	PF00069	0.629
MOD_ProDKin_1	255	261	PF00069	0.630
MOD_ProDKin_1	294	300	PF00069	0.604
MOD_ProDKin_1	337	343	PF00069	0.568
MOD_ProDKin_1	34	40	PF00069	0.632
MOD_ProDKin_1	369	375	PF00069	0.770
MOD_ProDKin_1	381	387	PF00069	0.707
MOD_ProDKin_1	8	14	PF00069	0.720
MOD_SUMO_for_1	400	403	PF00179	0.460
TRG_DiLeu_BaEn_1	405	410	PF01217	0.527
TRG_DiLeu_BaEn_2	475	481	PF01217	0.549
TRG_DiLeu_BaEn_4	457	463	PF01217	0.524
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.572
TRG_DiLeu_LyEn_5	349	354	PF01217	0.647
TRG_ENDOCYTIC_2	226	229	PF00928	0.582
TRG_ENDOCYTIC_2	428	431	PF00928	0.601
TRG_ENDOCYTIC_2	484	487	PF00928	0.681
TRG_ER_diArg_1	435	437	PF00400	0.583
TRG_ER_diArg_1	466	469	PF00400	0.550
TRG_NES_CRM1_1	461	476	PF08389	0.504
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAI1	Leishmania donovani	81%	100%
A4HNY2	Leishmania braziliensis	51%	100%
A4ICL2	Leishmania infantum	82%	100%
E9ASP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%