PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C, putative

Species:

Leishmania major

UniProt:

Q4Q1V3_LEIMA

TriTrypDb:

LmjF.36.1230 , LMJLV39_360018100 , LMJSD75_360018200

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016311	dephosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0017018	myosin phosphatase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.581
CLV_C14_Caspase3-7	336	340	PF00656	0.334
CLV_NRD_NRD_1	123	125	PF00675	0.504
CLV_NRD_NRD_1	143	145	PF00675	0.558
CLV_NRD_NRD_1	178	180	PF00675	0.464
CLV_NRD_NRD_1	230	232	PF00675	0.454
CLV_NRD_NRD_1	321	323	PF00675	0.334
CLV_NRD_NRD_1	360	362	PF00675	0.417
CLV_NRD_NRD_1	492	494	PF00675	0.532
CLV_NRD_NRD_1	511	513	PF00675	0.455
CLV_PCSK_KEX2_1	142	144	PF00082	0.550
CLV_PCSK_KEX2_1	178	180	PF00082	0.485
CLV_PCSK_KEX2_1	230	232	PF00082	0.430
CLV_PCSK_KEX2_1	321	323	PF00082	0.334
CLV_PCSK_KEX2_1	360	362	PF00082	0.340
CLV_PCSK_KEX2_1	491	493	PF00082	0.534
CLV_PCSK_KEX2_1	510	512	PF00082	0.460
CLV_PCSK_KEX2_1	575	577	PF00082	0.523
CLV_PCSK_PC1ET2_1	575	577	PF00082	0.523
CLV_PCSK_SKI1_1	230	234	PF00082	0.595
CLV_PCSK_SKI1_1	260	264	PF00082	0.605
CLV_PCSK_SKI1_1	287	291	PF00082	0.424
CLV_PCSK_SKI1_1	517	521	PF00082	0.455
CLV_PCSK_SKI1_1	556	560	PF00082	0.580
CLV_PCSK_SKI1_1	572	576	PF00082	0.442
CLV_Separin_Metazoa	553	557	PF03568	0.472
DEG_APCC_DBOX_1	12	20	PF00400	0.384
DEG_APCC_DBOX_1	522	530	PF00400	0.473
DEG_COP1_1	461	470	PF00400	0.459
DEG_Nend_UBRbox_1	1	4	PF02207	0.535
DOC_CYCLIN_RxL_1	511	522	PF00134	0.285
DOC_MAPK_DCC_7	13	21	PF00069	0.465
DOC_MAPK_gen_1	13	21	PF00069	0.400
DOC_MAPK_gen_1	302	310	PF00069	0.399
DOC_MAPK_MEF2A_6	13	21	PF00069	0.433
DOC_MAPK_MEF2A_6	302	310	PF00069	0.401
DOC_MAPK_RevD_3	131	144	PF00069	0.448
DOC_PIKK_1	399	406	PF02985	0.417
DOC_PP1_RVXF_1	210	217	PF00149	0.363
DOC_PP2B_LxvP_1	14	17	PF13499	0.364
DOC_PP2B_LxvP_1	416	419	PF13499	0.302
DOC_PP2B_PxIxI_1	16	22	PF00149	0.456
DOC_USP7_MATH_1	206	210	PF00917	0.501
DOC_USP7_MATH_1	436	440	PF00917	0.289
DOC_USP7_MATH_1	455	459	PF00917	0.553
DOC_WW_Pin1_4	199	204	PF00397	0.733
DOC_WW_Pin1_4	218	223	PF00397	0.250
DOC_WW_Pin1_4	240	245	PF00397	0.633
DOC_WW_Pin1_4	263	268	PF00397	0.514
DOC_WW_Pin1_4	359	364	PF00397	0.380
DOC_WW_Pin1_4	451	456	PF00397	0.431
DOC_WW_Pin1_4	60	65	PF00397	0.566
LIG_14-3-3_CanoR_1	144	154	PF00244	0.532
LIG_14-3-3_CanoR_1	230	240	PF00244	0.540
LIG_14-3-3_CanoR_1	316	324	PF00244	0.383
LIG_14-3-3_CanoR_1	412	417	PF00244	0.424
LIG_14-3-3_CanoR_1	523	529	PF00244	0.564
LIG_14-3-3_CanoR_1	59	64	PF00244	0.515
LIG_Actin_WH2_2	303	318	PF00022	0.410
LIG_APCC_ABBAyCdc20_2	143	149	PF00400	0.506
LIG_BRCT_BRCA1_1	279	283	PF00533	0.352
LIG_FHA_1	21	27	PF00498	0.444
LIG_FHA_1	303	309	PF00498	0.417
LIG_FHA_2	153	159	PF00498	0.426
LIG_FHA_2	331	337	PF00498	0.302
LIG_FHA_2	464	470	PF00498	0.481
LIG_FHA_2	61	67	PF00498	0.572
LIG_FHA_2	92	98	PF00498	0.417
LIG_IBAR_NPY_1	341	343	PF08397	0.338
LIG_LIR_Apic_2	472	476	PF02991	0.401
LIG_LIR_Gen_1	567	577	PF02991	0.438
LIG_LIR_Nem_3	317	323	PF02991	0.329
LIG_LIR_Nem_3	36	41	PF02991	0.446
LIG_LIR_Nem_3	376	380	PF02991	0.338
LIG_LIR_Nem_3	567	573	PF02991	0.435
LIG_Pex14_2	430	434	PF04695	0.417
LIG_PTAP_UEV_1	578	583	PF05743	0.495
LIG_PTB_Apo_2	338	345	PF02174	0.334
LIG_PTB_Phospho_1	338	344	PF10480	0.334
LIG_Rb_LxCxE_1	243	261	PF01857	0.479
LIG_REV1ctd_RIR_1	168	176	PF16727	0.449
LIG_SH2_CRK	320	324	PF00017	0.417
LIG_SH2_GRB2like	343	346	PF00017	0.338
LIG_SH2_PTP2	18	21	PF00017	0.387
LIG_SH2_SRC	162	165	PF00017	0.385
LIG_SH2_STAP1	162	166	PF00017	0.306
LIG_SH2_STAT5	105	108	PF00017	0.320
LIG_SH2_STAT5	18	21	PF00017	0.387
LIG_SH2_STAT5	182	185	PF00017	0.492
LIG_SH2_STAT5	480	483	PF00017	0.395
LIG_SH2_STAT5	93	96	PF00017	0.438
LIG_SH3_1	125	131	PF00018	0.478
LIG_SH3_1	200	206	PF00018	0.540
LIG_SH3_1	576	582	PF00018	0.453
LIG_SH3_3	125	131	PF00018	0.545
LIG_SH3_3	200	206	PF00018	0.689
LIG_SH3_3	558	564	PF00018	0.463
LIG_SH3_3	576	582	PF00018	0.453
LIG_SUMO_SIM_anti_2	525	530	PF11976	0.461
LIG_SUMO_SIM_par_1	305	311	PF11976	0.395
LIG_SUMO_SIM_par_1	367	373	PF11976	0.337
LIG_TRAF2_1	205	208	PF00917	0.581
LIG_TYR_ITIM	16	21	PF00017	0.459
LIG_UBA3_1	10	15	PF00899	0.451
LIG_UBA3_1	368	375	PF00899	0.400
LIG_WRC_WIRS_1	35	40	PF05994	0.357
MOD_CDC14_SPxK_1	243	246	PF00782	0.544
MOD_CDK_SPxK_1	240	246	PF00069	0.531
MOD_CK1_1	111	117	PF00069	0.355
MOD_CK1_1	152	158	PF00069	0.466
MOD_CK1_1	181	187	PF00069	0.444
MOD_CK1_1	463	469	PF00069	0.634
MOD_CK2_1	152	158	PF00069	0.435
MOD_CK2_1	359	365	PF00069	0.393
MOD_CK2_1	399	405	PF00069	0.284
MOD_CK2_1	463	469	PF00069	0.556
MOD_CK2_1	91	97	PF00069	0.417
MOD_Cter_Amidation	176	179	PF01082	0.554
MOD_Cter_Amidation	358	361	PF01082	0.350
MOD_GlcNHglycan	149	152	PF01048	0.597
MOD_GlcNHglycan	164	167	PF01048	0.467
MOD_GlcNHglycan	184	187	PF01048	0.728
MOD_GlcNHglycan	207	211	PF01048	0.418
MOD_GlcNHglycan	216	219	PF01048	0.361
MOD_GlcNHglycan	448	451	PF01048	0.461
MOD_GlcNHglycan	458	461	PF01048	0.558
MOD_GlcNHglycan	462	465	PF01048	0.502
MOD_GlcNHglycan	579	582	PF01048	0.650
MOD_GSK3_1	111	118	PF00069	0.353
MOD_GSK3_1	145	152	PF00069	0.559
MOD_GSK3_1	178	185	PF00069	0.618
MOD_GSK3_1	214	221	PF00069	0.459
MOD_GSK3_1	298	305	PF00069	0.463
MOD_GSK3_1	446	453	PF00069	0.484
MOD_GSK3_1	456	463	PF00069	0.662
MOD_GSK3_1	58	65	PF00069	0.501
MOD_GSK3_1	96	103	PF00069	0.381
MOD_NEK2_1	101	106	PF00069	0.358
MOD_NEK2_1	216	221	PF00069	0.315
MOD_NEK2_1	29	34	PF00069	0.541
MOD_NEK2_1	48	53	PF00069	0.306
MOD_NEK2_1	89	94	PF00069	0.424
MOD_NEK2_2	351	356	PF00069	0.308
MOD_PIKK_1	71	77	PF00454	0.510
MOD_PKA_1	178	184	PF00069	0.636
MOD_PKA_2	178	184	PF00069	0.625
MOD_PKA_2	315	321	PF00069	0.326
MOD_PKA_2	522	528	PF00069	0.547
MOD_PKA_2	58	64	PF00069	0.459
MOD_Plk_1	302	308	PF00069	0.417
MOD_Plk_1	330	336	PF00069	0.302
MOD_Plk_1	398	404	PF00069	0.290
MOD_Plk_1	436	442	PF00069	0.474
MOD_Plk_1	501	507	PF00069	0.400
MOD_Plk_1	96	102	PF00069	0.472
MOD_Plk_2-3	399	405	PF00069	0.334
MOD_Plk_4	111	117	PF00069	0.319
MOD_Plk_4	149	155	PF00069	0.488
MOD_Plk_4	178	184	PF00069	0.414
MOD_Plk_4	220	226	PF00069	0.427
MOD_Plk_4	504	510	PF00069	0.485
MOD_Plk_4	524	530	PF00069	0.519
MOD_Plk_4	97	103	PF00069	0.438
MOD_ProDKin_1	199	205	PF00069	0.722
MOD_ProDKin_1	218	224	PF00069	0.261
MOD_ProDKin_1	240	246	PF00069	0.639
MOD_ProDKin_1	263	269	PF00069	0.502
MOD_ProDKin_1	359	365	PF00069	0.380
MOD_ProDKin_1	451	457	PF00069	0.439
MOD_ProDKin_1	60	66	PF00069	0.572
MOD_SUMO_rev_2	362	369	PF00179	0.337
TRG_DiLeu_BaEn_1	149	154	PF01217	0.463
TRG_DiLeu_BaEn_1	258	263	PF01217	0.541
TRG_DiLeu_BaEn_2	96	102	PF01217	0.472
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.516
TRG_ENDOCYTIC_2	18	21	PF00928	0.454
TRG_ENDOCYTIC_2	320	323	PF00928	0.442
TRG_ENDOCYTIC_2	343	346	PF00928	0.407
TRG_ER_diArg_1	142	144	PF00400	0.553
TRG_ER_diArg_1	178	180	PF00400	0.568
TRG_ER_diArg_1	320	322	PF00400	0.331
TRG_ER_diArg_1	490	493	PF00400	0.472
TRG_ER_diArg_1	509	512	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q6	Leptomonas seymouri	61%	100%
A0A0S4IM91	Bodo saltans	29%	100%
A0A0S4IRQ5	Bodo saltans	29%	100%
A0A1X0P810	Trypanosomatidae	45%	98%
A0A3S7XAR2	Leishmania donovani	96%	100%
A4HNY3	Leishmania braziliensis	81%	100%
A4ICL1	Leishmania infantum	96%	100%
D0A2U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	98%
E9ASP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BZP6	Trypanosoma cruzi	47%	100%