Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1V2_LEIMA

TriTrypDb:

LmjF.36.1240 , LMJLV39_360018200 , LMJSD75_360018300

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1V2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.285
CLV_C14_Caspase3-7	722	726	PF00656	0.395
CLV_NRD_NRD_1	317	319	PF00675	0.311
CLV_PCSK_KEX2_1	317	319	PF00082	0.311
CLV_PCSK_SKI1_1	144	148	PF00082	0.411
CLV_PCSK_SKI1_1	23	27	PF00082	0.552
CLV_PCSK_SKI1_1	267	271	PF00082	0.411
CLV_PCSK_SKI1_1	377	381	PF00082	0.321
CLV_PCSK_SKI1_1	402	406	PF00082	0.411
CLV_PCSK_SKI1_1	450	454	PF00082	0.321
CLV_PCSK_SKI1_1	480	484	PF00082	0.452
CLV_PCSK_SKI1_1	710	714	PF00082	0.411
CLV_PCSK_SKI1_1	741	745	PF00082	0.411
DEG_APCC_DBOX_1	22	30	PF00400	0.638
DEG_APCC_DBOX_1	316	324	PF00400	0.321
DEG_APCC_KENBOX_2	665	669	PF00400	0.331
DEG_Nend_UBRbox_1	1	4	PF02207	0.689
DEG_SCF_FBW7_1	163	170	PF00400	0.296
DEG_SCF_FBW7_2	759	764	PF00400	0.250
DEG_SPOP_SBC_1	122	126	PF00917	0.321
DEG_SPOP_SBC_1	575	579	PF00917	0.250
DOC_CKS1_1	164	169	PF01111	0.287
DOC_CKS1_1	262	267	PF01111	0.358
DOC_CYCLIN_RxL_1	20	30	PF00134	0.532
DOC_CYCLIN_RxL_1	374	382	PF00134	0.321
DOC_CYCLIN_yCln2_LP_2	616	622	PF00134	0.411
DOC_MAPK_gen_1	20	28	PF00069	0.591
DOC_MAPK_gen_1	317	325	PF00069	0.311
DOC_MAPK_gen_1	697	705	PF00069	0.321
DOC_MAPK_MEF2A_6	317	324	PF00069	0.411
DOC_MAPK_MEF2A_6	628	636	PF00069	0.266
DOC_MAPK_RevD_3	303	318	PF00069	0.314
DOC_PP2B_LxvP_1	437	440	PF13499	0.411
DOC_PP2B_LxvP_1	98	101	PF13499	0.396
DOC_PP4_FxxP_1	687	690	PF00568	0.411
DOC_USP7_MATH_1	122	126	PF00917	0.321
DOC_USP7_MATH_1	14	18	PF00917	0.604
DOC_USP7_MATH_1	173	177	PF00917	0.323
DOC_USP7_MATH_1	239	243	PF00917	0.420
DOC_USP7_MATH_1	286	290	PF00917	0.335
DOC_USP7_MATH_1	298	302	PF00917	0.395
DOC_USP7_MATH_1	575	579	PF00917	0.346
DOC_USP7_MATH_1	658	662	PF00917	0.327
DOC_USP7_MATH_1	673	677	PF00917	0.279
DOC_USP7_MATH_2	440	446	PF00917	0.358
DOC_WW_Pin1_4	163	168	PF00397	0.287
DOC_WW_Pin1_4	197	202	PF00397	0.352
DOC_WW_Pin1_4	203	208	PF00397	0.225
DOC_WW_Pin1_4	213	218	PF00397	0.339
DOC_WW_Pin1_4	235	240	PF00397	0.250
DOC_WW_Pin1_4	261	266	PF00397	0.411
DOC_WW_Pin1_4	3	8	PF00397	0.710
DOC_WW_Pin1_4	410	415	PF00397	0.334
DOC_WW_Pin1_4	431	436	PF00397	0.446
DOC_WW_Pin1_4	564	569	PF00397	0.321
DOC_WW_Pin1_4	735	740	PF00397	0.363
DOC_WW_Pin1_4	74	79	PF00397	0.678
DOC_WW_Pin1_4	757	762	PF00397	0.239
DOC_WW_Pin1_4	85	90	PF00397	0.540
LIG_14-3-3_CanoR_1	131	136	PF00244	0.358
LIG_14-3-3_CanoR_1	2	7	PF00244	0.679
LIG_14-3-3_CanoR_1	221	227	PF00244	0.384
LIG_14-3-3_CanoR_1	317	321	PF00244	0.321
LIG_14-3-3_CanoR_1	393	399	PF00244	0.358
LIG_14-3-3_CanoR_1	443	447	PF00244	0.358
LIG_14-3-3_CanoR_1	491	497	PF00244	0.411
LIG_14-3-3_CanoR_1	635	639	PF00244	0.411
LIG_14-3-3_CanoR_1	689	698	PF00244	0.411
LIG_14-3-3_CanoR_1	741	750	PF00244	0.299
LIG_Actin_WH2_2	320	335	PF00022	0.384
LIG_ActinCP_TwfCPI_2	687	697	PF01115	0.411
LIG_APCC_ABBA_1	151	156	PF00400	0.411
LIG_APCC_ABBA_1	419	424	PF00400	0.358
LIG_BIR_III_2	591	595	PF00653	0.411
LIG_BIR_III_4	429	433	PF00653	0.358
LIG_BIR_III_4	451	455	PF00653	0.363
LIG_BRCT_BRCA1_1	101	105	PF00533	0.411
LIG_deltaCOP1_diTrp_1	442	446	PF00928	0.321
LIG_EVH1_1	411	415	PF00568	0.358
LIG_EVH1_2	415	419	PF00568	0.358
LIG_FHA_1	204	210	PF00498	0.403
LIG_FHA_1	346	352	PF00498	0.244
LIG_FHA_1	373	379	PF00498	0.299
LIG_FHA_1	432	438	PF00498	0.336
LIG_FHA_1	548	554	PF00498	0.384
LIG_FHA_1	611	617	PF00498	0.387
LIG_FHA_1	758	764	PF00498	0.250
LIG_FHA_1	8	14	PF00498	0.711
LIG_FHA_2	164	170	PF00498	0.474
LIG_FHA_2	274	280	PF00498	0.474
LIG_FHA_2	67	73	PF00498	0.601
LIG_FHA_2	720	726	PF00498	0.358
LIG_FHA_2	75	81	PF00498	0.675
LIG_LIR_Gen_1	145	155	PF02991	0.321
LIG_LIR_Gen_1	434	441	PF02991	0.405
LIG_LIR_Nem_3	115	120	PF02991	0.321
LIG_LIR_Nem_3	145	150	PF02991	0.321
LIG_LIR_Nem_3	334	340	PF02991	0.321
LIG_LIR_Nem_3	434	439	PF02991	0.405
LIG_LIR_Nem_3	494	499	PF02991	0.411
LIG_NRBOX	148	154	PF00104	0.321
LIG_NRBOX	309	315	PF00104	0.411
LIG_NRBOX	460	466	PF00104	0.321
LIG_NRBOX	536	542	PF00104	0.411
LIG_Pex14_1	390	394	PF04695	0.358
LIG_Pex14_2	154	158	PF04695	0.411
LIG_Pex14_2	597	601	PF04695	0.299
LIG_Pex14_2	687	691	PF04695	0.411
LIG_RPA_C_Fungi	313	325	PF08784	0.311
LIG_SH2_CRK	22	26	PF00017	0.550
LIG_SH2_CRK	457	461	PF00017	0.299
LIG_SH2_STAP1	457	461	PF00017	0.299
LIG_SH2_STAT3	31	34	PF00017	0.642
LIG_SH2_STAT5	478	481	PF00017	0.411
LIG_SH2_STAT5	698	701	PF00017	0.321
LIG_SH3_3	161	167	PF00018	0.287
LIG_SH3_3	187	193	PF00018	0.436
LIG_SH3_3	196	202	PF00018	0.287
LIG_SH3_3	205	211	PF00018	0.206
LIG_SH3_3	259	265	PF00018	0.358
LIG_SH3_3	409	415	PF00018	0.406
LIG_SH3_3	48	54	PF00018	0.490
LIG_SH3_3	522	528	PF00018	0.335
LIG_Sin3_3	744	751	PF02671	0.411
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.321
LIG_SUMO_SIM_anti_2	306	311	PF11976	0.411
LIG_SUMO_SIM_anti_2	319	324	PF11976	0.263
LIG_SUMO_SIM_par_1	303	308	PF11976	0.328
LIG_SUMO_SIM_par_1	321	326	PF11976	0.200
LIG_TRAF2_1	89	92	PF00917	0.683
LIG_TYR_ITIM	335	340	PF00017	0.321
LIG_UBA3_1	743	749	PF00899	0.411
LIG_UBA3_1	95	104	PF00899	0.496
LIG_WRC_WIRS_1	117	122	PF05994	0.358
LIG_WW_2	415	418	PF00397	0.250
MOD_CDC14_SPxK_1	738	741	PF00782	0.358
MOD_CDK_SPK_2	85	90	PF00069	0.541
MOD_CDK_SPxK_1	261	267	PF00069	0.411
MOD_CDK_SPxK_1	735	741	PF00069	0.358
MOD_CK1_1	130	136	PF00069	0.411
MOD_CK1_1	194	200	PF00069	0.403
MOD_CK1_1	284	290	PF00069	0.395
MOD_CK1_1	316	322	PF00069	0.335
MOD_CK1_1	343	349	PF00069	0.317
MOD_CK1_1	382	388	PF00069	0.411
MOD_CK1_1	492	498	PF00069	0.347
MOD_CK1_1	5	11	PF00069	0.632
MOD_CK1_1	514	520	PF00069	0.384
MOD_CK1_1	579	585	PF00069	0.436
MOD_CK1_1	648	654	PF00069	0.348
MOD_CK1_1	656	662	PF00069	0.330
MOD_CK1_1	735	741	PF00069	0.358
MOD_CK2_1	163	169	PF00069	0.474
MOD_CK2_1	173	179	PF00069	0.270
MOD_CK2_1	222	228	PF00069	0.312
MOD_CK2_1	273	279	PF00069	0.486
MOD_CK2_1	602	608	PF00069	0.321
MOD_CK2_1	85	91	PF00069	0.616
MOD_GlcNHglycan	217	220	PF01048	0.358
MOD_GlcNHglycan	241	244	PF01048	0.266
MOD_GlcNHglycan	284	287	PF01048	0.298
MOD_GlcNHglycan	300	303	PF01048	0.311
MOD_GlcNHglycan	368	371	PF01048	0.411
MOD_GlcNHglycan	384	387	PF01048	0.262
MOD_GlcNHglycan	521	524	PF01048	0.358
MOD_GlcNHglycan	578	581	PF01048	0.436
MOD_GlcNHglycan	588	591	PF01048	0.321
MOD_GlcNHglycan	622	625	PF01048	0.277
MOD_GlcNHglycan	649	653	PF01048	0.304
MOD_GlcNHglycan	691	694	PF01048	0.411
MOD_GlcNHglycan	744	747	PF01048	0.358
MOD_GlcNHglycan	83	86	PF01048	0.717
MOD_GSK3_1	1	8	PF00069	0.694
MOD_GSK3_1	123	130	PF00069	0.411
MOD_GSK3_1	159	166	PF00069	0.420
MOD_GSK3_1	173	180	PF00069	0.264
MOD_GSK3_1	197	204	PF00069	0.411
MOD_GSK3_1	215	222	PF00069	0.250
MOD_GSK3_1	235	242	PF00069	0.427
MOD_GSK3_1	282	289	PF00069	0.411
MOD_GSK3_1	340	347	PF00069	0.341
MOD_GSK3_1	431	438	PF00069	0.454
MOD_GSK3_1	478	485	PF00069	0.340
MOD_GSK3_1	562	569	PF00069	0.381
MOD_GSK3_1	575	582	PF00069	0.257
MOD_GSK3_1	644	651	PF00069	0.382
MOD_GSK3_1	654	661	PF00069	0.375
MOD_GSK3_1	81	88	PF00069	0.571
MOD_GSK3_1	9	16	PF00069	0.585
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	105	110	PF00069	0.411
MOD_NEK2_1	256	261	PF00069	0.311
MOD_NEK2_1	281	286	PF00069	0.321
MOD_NEK2_1	313	318	PF00069	0.390
MOD_NEK2_1	340	345	PF00069	0.451
MOD_NEK2_1	379	384	PF00069	0.358
MOD_NEK2_1	521	526	PF00069	0.365
MOD_NEK2_1	55	60	PF00069	0.569
MOD_NEK2_1	562	567	PF00069	0.389
MOD_NEK2_1	654	659	PF00069	0.331
MOD_PIKK_1	177	183	PF00454	0.323
MOD_PIKK_1	219	225	PF00454	0.325
MOD_PIKK_1	656	662	PF00454	0.331
MOD_PKA_2	1	7	PF00069	0.680
MOD_PKA_2	130	136	PF00069	0.358
MOD_PKA_2	14	20	PF00069	0.585
MOD_PKA_2	316	322	PF00069	0.321
MOD_PKA_2	392	398	PF00069	0.411
MOD_PKA_2	442	448	PF00069	0.358
MOD_PKA_2	502	508	PF00069	0.312
MOD_PKA_2	519	525	PF00069	0.365
MOD_PKA_2	634	640	PF00069	0.321
MOD_Plk_1	511	517	PF00069	0.319
MOD_Plk_1	648	654	PF00069	0.411
MOD_Plk_4	108	114	PF00069	0.306
MOD_Plk_4	323	329	PF00069	0.340
MOD_Plk_4	379	385	PF00069	0.411
MOD_Plk_4	634	640	PF00069	0.329
MOD_ProDKin_1	163	169	PF00069	0.287
MOD_ProDKin_1	197	203	PF00069	0.352
MOD_ProDKin_1	213	219	PF00069	0.370
MOD_ProDKin_1	235	241	PF00069	0.250
MOD_ProDKin_1	261	267	PF00069	0.411
MOD_ProDKin_1	3	9	PF00069	0.710
MOD_ProDKin_1	410	416	PF00069	0.334
MOD_ProDKin_1	431	437	PF00069	0.446
MOD_ProDKin_1	564	570	PF00069	0.321
MOD_ProDKin_1	735	741	PF00069	0.363
MOD_ProDKin_1	74	80	PF00069	0.680
MOD_ProDKin_1	757	763	PF00069	0.239
MOD_ProDKin_1	85	91	PF00069	0.537
MOD_SUMO_rev_2	544	550	PF00179	0.304
MOD_SUMO_rev_2	661	671	PF00179	0.250
TRG_DiLeu_BaEn_1	536	541	PF01217	0.321
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.340
TRG_ENDOCYTIC_2	22	25	PF00928	0.549
TRG_ENDOCYTIC_2	337	340	PF00928	0.321
TRG_ENDOCYTIC_2	457	460	PF00928	0.299
TRG_ER_diArg_1	211	214	PF00400	0.331
TRG_ER_diArg_1	390	393	PF00400	0.321
TRG_ER_diArg_1	597	600	PF00400	0.330
TRG_ER_diArg_1	641	644	PF00400	0.358
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	706	711	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL2	Leptomonas seymouri	41%	100%
A0A3S7XAL8	Leishmania donovani	92%	100%
A4HNY4	Leishmania braziliensis	75%	100%
A4ICL0	Leishmania infantum	93%	100%
E9ASP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%