by homology
Contact email: dnandan@interchange.ubc.ca
Publication title: Identification of leishmania fructose-1 6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1
Publication 1st author(s): Nandan
Publication Identifier(s): 18028878
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: western blot
ID(s) interactor A: Q9ES52
ID(s) interactor B: Q9U5N6
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania mexicana
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 6 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 20 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | yes | yes: 6 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 12 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 13 |
| NetGPI | no | yes: 0, no: 13 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005777 | peroxisome | 6 | 2 |
| GO:0005829 | cytosol | 2 | 2 |
| GO:0020015 | glycosome | 7 | 2 |
| GO:0042579 | microbody | 5 | 2 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 14 |
| GO:0005737 | cytoplasm | 2 | 12 |
Related structures:
AlphaFold database: Q4Q1V0
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | 3 | 14 |
| GO:0006082 | organic acid metabolic process | 3 | 14 |
| GO:0006090 | pyruvate metabolic process | 7 | 14 |
| GO:0006091 | generation of precursor metabolites and energy | 3 | 14 |
| GO:0006096 | glycolytic process | 5 | 14 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 14 |
| GO:0006163 | purine nucleotide metabolic process | 5 | 14 |
| GO:0006165 | obsolete nucleoside diphosphate phosphorylation | 6 | 14 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 14 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 14 |
| GO:0006757 | obsolete ATP generation from ADP | 4 | 14 |
| GO:0006793 | phosphorus metabolic process | 3 | 14 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 14 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 14 |
| GO:0008152 | metabolic process | 1 | 14 |
| GO:0009056 | catabolic process | 2 | 14 |
| GO:0009117 | nucleotide metabolic process | 5 | 14 |
| GO:0009132 | nucleoside diphosphate metabolic process | 5 | 14 |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 6 | 14 |
| GO:0009141 | nucleoside triphosphate metabolic process | 5 | 14 |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 6 | 14 |
| GO:0009150 | purine ribonucleotide metabolic process | 6 | 14 |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 7 | 14 |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 6 | 14 |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 6 | 14 |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 7 | 14 |
| GO:0009259 | ribonucleotide metabolic process | 5 | 14 |
| GO:0009987 | cellular process | 1 | 14 |
| GO:0016052 | carbohydrate catabolic process | 4 | 14 |
| GO:0016310 | phosphorylation | 5 | 14 |
| GO:0019637 | organophosphate metabolic process | 3 | 14 |
| GO:0019693 | ribose phosphate metabolic process | 4 | 14 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 14 |
| GO:0030388 | fructose 1,6-bisphosphate metabolic process | 4 | 2 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 14 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 14 |
| GO:0043436 | oxoacid metabolic process | 4 | 14 |
| GO:0044237 | cellular metabolic process | 2 | 14 |
| GO:0044238 | primary metabolic process | 2 | 14 |
| GO:0044281 | small molecule metabolic process | 2 | 14 |
| GO:0046031 | ADP metabolic process | 7 | 14 |
| GO:0046034 | ATP metabolic process | 7 | 14 |
| GO:0046483 | heterocycle metabolic process | 3 | 14 |
| GO:0046939 | obsolete nucleotide phosphorylation | 6 | 14 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 14 |
| GO:0071704 | organic substance metabolic process | 2 | 14 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 14 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 14 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 14 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 14 |
| GO:1901575 | organic substance catabolic process | 3 | 14 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 14 |
| GO:0004332 | fructose-bisphosphate aldolase activity | 5 | 14 |
| GO:0016829 | lyase activity | 2 | 14 |
| GO:0016830 | carbon-carbon lyase activity | 3 | 14 |
| GO:0016832 | aldehyde-lyase activity | 4 | 14 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 135 | 139 | PF00656 | 0.535 |
| CLV_NRD_NRD_1 | 334 | 336 | PF00675 | 0.307 |
| CLV_NRD_NRD_1 | 65 | 67 | PF00675 | 0.307 |
| CLV_PCSK_KEX2_1 | 142 | 144 | PF00082 | 0.335 |
| CLV_PCSK_KEX2_1 | 334 | 336 | PF00082 | 0.309 |
| CLV_PCSK_KEX2_1 | 353 | 355 | PF00082 | 0.238 |
| CLV_PCSK_KEX2_1 | 51 | 53 | PF00082 | 0.325 |
| CLV_PCSK_KEX2_1 | 65 | 67 | PF00082 | 0.307 |
| CLV_PCSK_PC1ET2_1 | 142 | 144 | PF00082 | 0.335 |
| CLV_PCSK_PC1ET2_1 | 353 | 355 | PF00082 | 0.402 |
| CLV_PCSK_PC1ET2_1 | 51 | 53 | PF00082 | 0.325 |
| CLV_PCSK_SKI1_1 | 30 | 34 | PF00082 | 0.317 |
| CLV_PCSK_SKI1_1 | 334 | 338 | PF00082 | 0.316 |
| CLV_PCSK_SKI1_1 | 37 | 41 | PF00082 | 0.287 |
| DEG_SCF_FBW7_1 | 17 | 23 | PF00400 | 0.522 |
| DEG_SPOP_SBC_1 | 359 | 363 | PF00917 | 0.614 |
| DOC_AGCK_PIF_1 | 306 | 311 | PF00069 | 0.614 |
| DOC_ANK_TNKS_1 | 108 | 115 | PF00023 | 0.580 |
| DOC_ANK_TNKS_1 | 51 | 58 | PF00023 | 0.548 |
| DOC_CKS1_1 | 17 | 22 | PF01111 | 0.432 |
| DOC_CKS1_1 | 32 | 37 | PF01111 | 0.378 |
| DOC_CYCLIN_RxL_1 | 31 | 44 | PF00134 | 0.528 |
| DOC_CYCLIN_RxL_1 | 64 | 76 | PF00134 | 0.535 |
| DOC_CYCLIN_yCln2_LP_2 | 301 | 307 | PF00134 | 0.525 |
| DOC_MAPK_gen_1 | 51 | 58 | PF00069 | 0.535 |
| DOC_MAPK_gen_1 | 65 | 73 | PF00069 | 0.507 |
| DOC_MAPK_JIP1_4 | 303 | 309 | PF00069 | 0.515 |
| DOC_USP7_MATH_1 | 20 | 24 | PF00917 | 0.530 |
| DOC_USP7_MATH_1 | 314 | 318 | PF00917 | 0.525 |
| DOC_USP7_MATH_1 | 359 | 363 | PF00917 | 0.597 |
| DOC_USP7_MATH_1 | 42 | 46 | PF00917 | 0.525 |
| DOC_WW_Pin1_4 | 16 | 21 | PF00397 | 0.436 |
| DOC_WW_Pin1_4 | 296 | 301 | PF00397 | 0.571 |
| DOC_WW_Pin1_4 | 31 | 36 | PF00397 | 0.434 |
| LIG_14-3-3_CanoR_1 | 143 | 147 | PF00244 | 0.496 |
| LIG_14-3-3_CanoR_1 | 213 | 219 | PF00244 | 0.515 |
| LIG_14-3-3_CanoR_1 | 313 | 323 | PF00244 | 0.530 |
| LIG_14-3-3_CanoR_1 | 342 | 347 | PF00244 | 0.577 |
| LIG_APCC_ABBA_1 | 85 | 90 | PF00400 | 0.525 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.520 |
| LIG_DLG_GKlike_1 | 342 | 349 | PF00625 | 0.614 |
| LIG_FHA_1 | 132 | 138 | PF00498 | 0.515 |
| LIG_FHA_2 | 165 | 171 | PF00498 | 0.525 |
| LIG_FHA_2 | 17 | 23 | PF00498 | 0.438 |
| LIG_FHA_2 | 99 | 105 | PF00498 | 0.553 |
| LIG_LIR_Nem_3 | 101 | 105 | PF02991 | 0.533 |
| LIG_LIR_Nem_3 | 216 | 222 | PF02991 | 0.563 |
| LIG_LIR_Nem_3 | 50 | 56 | PF02991 | 0.542 |
| LIG_Pex14_1 | 157 | 161 | PF04695 | 0.507 |
| LIG_SH2_CRK | 183 | 187 | PF00017 | 0.507 |
| LIG_SH2_CRK | 68 | 72 | PF00017 | 0.507 |
| LIG_SH2_GRB2like | 292 | 295 | PF00017 | 0.507 |
| LIG_SH2_SRC | 292 | 295 | PF00017 | 0.507 |
| LIG_SH2_STAP1 | 21 | 25 | PF00017 | 0.466 |
| LIG_SH2_STAP1 | 311 | 315 | PF00017 | 0.525 |
| LIG_SH2_STAT3 | 161 | 164 | PF00017 | 0.515 |
| LIG_SH2_STAT5 | 105 | 108 | PF00017 | 0.580 |
| LIG_SH2_STAT5 | 140 | 143 | PF00017 | 0.509 |
| LIG_SH2_STAT5 | 261 | 264 | PF00017 | 0.525 |
| LIG_SH2_STAT5 | 292 | 295 | PF00017 | 0.507 |
| LIG_SH2_STAT5 | 305 | 308 | PF00017 | 0.507 |
| LIG_SH2_STAT5 | 365 | 368 | PF00017 | 0.525 |
| LIG_SH2_STAT5 | 81 | 84 | PF00017 | 0.503 |
| LIG_SH3_3 | 165 | 171 | PF00018 | 0.557 |
| LIG_WRC_WIRS_1 | 306 | 311 | PF05994 | 0.602 |
| MOD_CDK_SPxK_1 | 31 | 37 | PF00069 | 0.602 |
| MOD_CDK_SPxxK_3 | 296 | 303 | PF00069 | 0.595 |
| MOD_CK1_1 | 187 | 193 | PF00069 | 0.520 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.556 |
| MOD_CK1_1 | 249 | 255 | PF00069 | 0.580 |
| MOD_CK1_1 | 360 | 366 | PF00069 | 0.596 |
| MOD_CK1_1 | 45 | 51 | PF00069 | 0.525 |
| MOD_CK2_1 | 16 | 22 | PF00069 | 0.457 |
| MOD_CK2_1 | 164 | 170 | PF00069 | 0.525 |
| MOD_CK2_1 | 56 | 62 | PF00069 | 0.548 |
| MOD_CK2_1 | 98 | 104 | PF00069 | 0.530 |
| MOD_Cter_Amidation | 332 | 335 | PF01082 | 0.325 |
| MOD_GlcNHglycan | 189 | 192 | PF01048 | 0.299 |
| MOD_GlcNHglycan | 248 | 251 | PF01048 | 0.307 |
| MOD_GlcNHglycan | 280 | 283 | PF01048 | 0.307 |
| MOD_GlcNHglycan | 317 | 320 | PF01048 | 0.307 |
| MOD_GlcNHglycan | 327 | 330 | PF01048 | 0.307 |
| MOD_GlcNHglycan | 82 | 85 | PF01048 | 0.315 |
| MOD_GSK3_1 | 16 | 23 | PF00069 | 0.518 |
| MOD_GSK3_1 | 2 | 9 | PF00069 | 0.576 |
| MOD_GSK3_1 | 262 | 269 | PF00069 | 0.560 |
| MOD_GSK3_1 | 278 | 285 | PF00069 | 0.430 |
| MOD_GSK3_1 | 90 | 97 | PF00069 | 0.533 |
| MOD_N-GLC_1 | 164 | 169 | PF02516 | 0.308 |
| MOD_N-GLC_1 | 296 | 301 | PF02516 | 0.369 |
| MOD_NEK2_1 | 25 | 30 | PF00069 | 0.507 |
| MOD_NEK2_1 | 266 | 271 | PF00069 | 0.580 |
| MOD_NEK2_1 | 278 | 283 | PF00069 | 0.580 |
| MOD_NEK2_1 | 307 | 312 | PF00069 | 0.506 |
| MOD_NEK2_1 | 315 | 320 | PF00069 | 0.506 |
| MOD_PIKK_1 | 184 | 190 | PF00454 | 0.510 |
| MOD_PIKK_1 | 6 | 12 | PF00454 | 0.481 |
| MOD_PIKK_1 | 90 | 96 | PF00454 | 0.447 |
| MOD_PK_1 | 142 | 148 | PF00069 | 0.447 |
| MOD_PKA_1 | 142 | 148 | PF00069 | 0.602 |
| MOD_PKA_1 | 30 | 36 | PF00069 | 0.535 |
| MOD_PKA_2 | 142 | 148 | PF00069 | 0.602 |
| MOD_PKA_2 | 2 | 8 | PF00069 | 0.556 |
| MOD_PKA_2 | 212 | 218 | PF00069 | 0.515 |
| MOD_PKB_1 | 340 | 348 | PF00069 | 0.602 |
| MOD_Plk_1 | 42 | 48 | PF00069 | 0.548 |
| MOD_Plk_1 | 88 | 94 | PF00069 | 0.515 |
| MOD_Plk_4 | 142 | 148 | PF00069 | 0.559 |
| MOD_Plk_4 | 2 | 8 | PF00069 | 0.606 |
| MOD_Plk_4 | 259 | 265 | PF00069 | 0.577 |
| MOD_Plk_4 | 360 | 366 | PF00069 | 0.535 |
| MOD_ProDKin_1 | 16 | 22 | PF00069 | 0.434 |
| MOD_ProDKin_1 | 296 | 302 | PF00069 | 0.571 |
| MOD_ProDKin_1 | 31 | 37 | PF00069 | 0.434 |
| TRG_DiLeu_BaLyEn_6 | 120 | 125 | PF01217 | 0.580 |
| TRG_ENDOCYTIC_2 | 183 | 186 | PF00928 | 0.507 |
| TRG_ENDOCYTIC_2 | 261 | 264 | PF00928 | 0.602 |
| TRG_ENDOCYTIC_2 | 68 | 71 | PF00928 | 0.507 |
| TRG_ER_diArg_1 | 340 | 343 | PF00400 | 0.593 |
| TRG_NES_CRM1_1 | 76 | 90 | PF08389 | 0.523 |
| TRG_Pf-PMV_PEXEL_1 | 69 | 74 | PF00026 | 0.335 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P299 | Leptomonas seymouri | 92% | 100% |
| A0A0N1I6D1 | Leptomonas seymouri | 62% | 100% |
| A0A0S4IZJ5 | Bodo saltans | 73% | 100% |
| A0A1X0NPL7 | Trypanosomatidae | 63% | 100% |
| A0A1X0P8X7 | Trypanosomatidae | 82% | 100% |
| A0A3Q8IFX2 | Leishmania donovani | 97% | 100% |
| A0A3R7JSV8 | Trypanosoma rangeli | 79% | 100% |
| A4HNY6 | Leishmania braziliensis | 91% | 100% |
| A4ICK8 | Leishmania infantum | 97% | 100% |
| A5A6I5 | Pan troglodytes | 48% | 100% |
| A5IW31 | Staphylococcus aureus (strain JH9) | 27% | 100% |
| A6LXU8 | Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) | 30% | 100% |
| A6QK93 | Staphylococcus aureus (strain Newman) | 26% | 100% |
| A6U4Y6 | Staphylococcus aureus (strain JH1) | 27% | 100% |
| A7X6Y6 | Staphylococcus aureus (strain Mu3 / ATCC 700698) | 27% | 100% |
| A8Z3K5 | Staphylococcus aureus (strain USA300 / TCH1516) | 26% | 100% |
| B5DGM7 | Salmo salar | 49% | 100% |
| D0A2V3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 79% | 100% |
| E9ASP6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| F4KGQ0 | Arabidopsis thaliana | 50% | 94% |
| O65581 | Arabidopsis thaliana | 50% | 100% |
| O65735 | Cicer arietinum | 48% | 100% |
| P00883 | Oryctolagus cuniculus | 48% | 100% |
| P00884 | Rattus norvegicus | 48% | 100% |
| P04075 | Homo sapiens | 49% | 100% |
| P05062 | Homo sapiens | 48% | 100% |
| P05063 | Mus musculus | 48% | 100% |
| P05064 | Mus musculus | 49% | 100% |
| P05065 | Rattus norvegicus | 49% | 100% |
| P07341 | Gallus gallus | 46% | 100% |
| P07752 | Trypanosoma brucei brucei | 79% | 100% |
| P07764 | Drosophila melanogaster | 49% | 100% |
| P08440 | Zea mays | 50% | 100% |
| P09117 | Rattus norvegicus | 48% | 100% |
| P09972 | Homo sapiens | 48% | 100% |
| P14223 | Plasmodium falciparum | 47% | 100% |
| P16096 | Spinacia oleracea | 47% | 94% |
| P17784 | Oryza sativa subsp. japonica | 50% | 100% |
| P22197 | Arabidopsis thaliana | 48% | 100% |
| P29356 | Spinacia oleracea | 51% | 100% |
| P46256 | Pisum sativum | 48% | 100% |
| P46257 | Pisum sativum | 50% | 100% |
| P46563 | Caenorhabditis elegans | 49% | 100% |
| P49577 | Plasmodium berghei (strain Anka) | 45% | 100% |
| P52210 | Ovis aries | 48% | 100% |
| P53442 | Schistosoma mansoni | 46% | 100% |
| P53445 | Lethenteron camtschaticum | 46% | 100% |
| P53446 | Lethenteron camtschaticum | 48% | 100% |
| P53447 | Sparus aurata | 48% | 100% |
| P53448 | Carassius auratus | 48% | 100% |
| P54216 | Caenorhabditis elegans | 48% | 100% |
| P67472 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 27% | 100% |
| P79226 | Oryctolagus cuniculus | 48% | 100% |
| P99117 | Staphylococcus aureus (strain N315) | 27% | 100% |
| Q01516 | Pisum sativum | 49% | 100% |
| Q01517 | Pisum sativum | 50% | 100% |
| Q10A30 | Oryza sativa subsp. japonica | 49% | 100% |
| Q27744 | Plasmodium falciparum (isolate K1 / Thailand) | 47% | 100% |
| Q2FDQ4 | Staphylococcus aureus (strain USA300) | 26% | 100% |
| Q2FV17 | Staphylococcus aureus (strain NCTC 8325 / PS 47) | 26% | 100% |
| Q3T0S5 | Bos taurus | 48% | 100% |
| Q40677 | Oryza sativa subsp. japonica | 50% | 96% |
| Q42690 | Chlamydomonas reinhardtii | 49% | 98% |
| Q4KMC8 | Danio rerio | 45% | 100% |
| Q4L9B6 | Staphylococcus haemolyticus (strain JCSC1435) | 27% | 100% |
| Q5HCU6 | Staphylococcus aureus (strain COL) | 26% | 100% |
| Q5N725 | Oryza sativa subsp. japonica | 48% | 100% |
| Q5NVR5 | Pongo abelii | 48% | 100% |
| Q5R1X4 | Pan troglodytes | 48% | 100% |
| Q5RFA6 | Pongo abelii | 47% | 100% |
| Q6G670 | Staphylococcus aureus (strain MSSA476) | 27% | 100% |
| Q7KQL9 | Plasmodium falciparum (isolate 3D7) | 47% | 100% |
| Q86A67 | Dictyostelium discoideum | 47% | 100% |
| Q87AI0 | Xylella fastidiosa (strain Temecula1 / ATCC 700964) | 46% | 100% |
| Q8JH70 | Danio rerio | 48% | 100% |
| Q8JH71 | Danio rerio | 46% | 100% |
| Q8NUM5 | Staphylococcus aureus (strain MW2) | 27% | 100% |
| Q8P5Z7 | Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) | 46% | 100% |
| Q8PHB5 | Xanthomonas axonopodis pv. citri (strain 306) | 47% | 100% |
| Q8SSM8 | Encephalitozoon cuniculi (strain GB-M1) | 38% | 100% |
| Q91Y97 | Mus musculus | 48% | 100% |
| Q944G9 | Arabidopsis thaliana | 50% | 93% |
| Q9GKW3 | Macaca fascicularis | 48% | 100% |
| Q9GP32 | Echinococcus multilocularis | 50% | 100% |
| Q9LF98 | Arabidopsis thaliana | 48% | 100% |
| Q9PF52 | Xylella fastidiosa (strain 9a5c) | 46% | 100% |
| Q9SJQ9 | Arabidopsis thaliana | 48% | 100% |
| Q9SJU4 | Arabidopsis thaliana | 50% | 93% |
| Q9ZU52 | Arabidopsis thaliana | 49% | 95% |
| V5DRF2 | Trypanosoma cruzi | 80% | 99% |