Tuzin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tuzin-like protein

Gene product:

tuzin-like protein

Species:

Leishmania major

UniProt:

Q4Q1U8_LEIMA

TriTrypDb:

LmjF.36.1280 , LMJLV39_360018500 , LMJSD75_340024800

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 35
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4Q1U8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1U8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.437
CLV_NRD_NRD_1	224	226	PF00675	0.474
CLV_NRD_NRD_1	265	267	PF00675	0.657
CLV_NRD_NRD_1	286	288	PF00675	0.748
CLV_NRD_NRD_1	303	305	PF00675	0.647
CLV_NRD_NRD_1	341	343	PF00675	0.573
CLV_NRD_NRD_1	449	451	PF00675	0.576
CLV_NRD_NRD_1	461	463	PF00675	0.518
CLV_NRD_NRD_1	518	520	PF00675	0.630
CLV_NRD_NRD_1	67	69	PF00675	0.522
CLV_PCSK_KEX2_1	224	226	PF00082	0.436
CLV_PCSK_KEX2_1	265	267	PF00082	0.687
CLV_PCSK_KEX2_1	303	305	PF00082	0.647
CLV_PCSK_KEX2_1	341	343	PF00082	0.647
CLV_PCSK_KEX2_1	449	451	PF00082	0.576
CLV_PCSK_KEX2_1	461	463	PF00082	0.518
CLV_PCSK_KEX2_1	518	520	PF00082	0.652
CLV_PCSK_KEX2_1	59	61	PF00082	0.523
CLV_PCSK_KEX2_1	67	69	PF00082	0.482
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.510
CLV_PCSK_SKI1_1	142	146	PF00082	0.470
CLV_PCSK_SKI1_1	234	238	PF00082	0.390
CLV_PCSK_SKI1_1	312	316	PF00082	0.637
CLV_PCSK_SKI1_1	390	394	PF00082	0.644
CLV_PCSK_SKI1_1	439	443	PF00082	0.651
CLV_PCSK_SKI1_1	462	466	PF00082	0.669
CLV_PCSK_SKI1_1	588	592	PF00082	0.669
CLV_Separin_Metazoa	53	57	PF03568	0.694
DEG_APCC_DBOX_1	199	207	PF00400	0.546
DEG_APCC_DBOX_1	311	319	PF00400	0.444
DEG_APCC_DBOX_1	449	457	PF00400	0.270
DEG_Nend_UBRbox_1	1	4	PF02207	0.626
DOC_CYCLIN_RxL_1	139	147	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	434	440	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	568	574	PF00134	0.363
DOC_MAPK_DCC_7	395	405	PF00069	0.373
DOC_MAPK_gen_1	177	186	PF00069	0.577
DOC_MAPK_gen_1	341	351	PF00069	0.379
DOC_MAPK_MEF2A_6	123	130	PF00069	0.578
DOC_MAPK_MEF2A_6	165	174	PF00069	0.557
DOC_PP2B_LxvP_1	434	437	PF13499	0.403
DOC_PP2B_LxvP_1	524	527	PF13499	0.487
DOC_USP7_MATH_1	11	15	PF00917	0.738
DOC_USP7_MATH_1	329	333	PF00917	0.475
DOC_WW_Pin1_4	4	9	PF00397	0.717
DOC_WW_Pin1_4	439	444	PF00397	0.385
DOC_WW_Pin1_4	526	531	PF00397	0.398
LIG_14-3-3_CanoR_1	23	31	PF00244	0.787
LIG_14-3-3_CanoR_1	312	320	PF00244	0.414
LIG_14-3-3_CanoR_1	390	395	PF00244	0.423
LIG_14-3-3_CanoR_1	44	50	PF00244	0.670
LIG_14-3-3_CanoR_1	487	494	PF00244	0.470
LIG_14-3-3_CanoR_1	536	542	PF00244	0.368
LIG_14-3-3_CanoR_1	82	86	PF00244	0.633
LIG_Actin_WH2_2	349	366	PF00022	0.380
LIG_BIR_III_4	550	554	PF00653	0.428
LIG_BRCT_BRCA1_1	539	543	PF00533	0.449
LIG_Clathr_ClatBox_1	351	355	PF01394	0.443
LIG_deltaCOP1_diTrp_1	575	578	PF00928	0.347
LIG_FHA_1	114	120	PF00498	0.603
LIG_FHA_1	256	262	PF00498	0.525
LIG_FHA_2	273	279	PF00498	0.429
LIG_FHA_2	85	91	PF00498	0.754
LIG_Integrin_RGD_1	68	70	PF01839	0.507
LIG_LIR_Apic_2	452	457	PF02991	0.383
LIG_LIR_Gen_1	116	121	PF02991	0.560
LIG_LIR_Gen_1	507	516	PF02991	0.437
LIG_LIR_Nem_3	116	120	PF02991	0.561
LIG_LIR_Nem_3	507	511	PF02991	0.431
LIG_PDZ_Class_2	587	592	PF00595	0.426
LIG_Pex14_2	175	179	PF04695	0.576
LIG_SH2_CRK	454	458	PF00017	0.404
LIG_SH2_CRK	508	512	PF00017	0.461
LIG_SH2_CRK	569	573	PF00017	0.414
LIG_SH2_NCK_1	569	573	PF00017	0.409
LIG_SH2_PTP2	117	120	PF00017	0.566
LIG_SH2_SRC	467	470	PF00017	0.504
LIG_SH2_SRC	569	572	PF00017	0.423
LIG_SH2_STAP1	508	512	PF00017	0.344
LIG_SH2_STAT3	264	267	PF00017	0.377
LIG_SH2_STAT5	117	120	PF00017	0.622
LIG_SH2_STAT5	185	188	PF00017	0.572
LIG_SH2_STAT5	255	258	PF00017	0.440
LIG_SH2_STAT5	454	457	PF00017	0.393
LIG_SH2_STAT5	508	511	PF00017	0.370
LIG_SH3_2	527	532	PF14604	0.392
LIG_SH3_3	158	164	PF00018	0.649
LIG_SH3_3	317	323	PF00018	0.424
LIG_SH3_3	5	11	PF00018	0.700
LIG_SH3_3	524	530	PF00018	0.395
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.697
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.554
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.456
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.473
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.404
LIG_SUMO_SIM_anti_2	473	479	PF11976	0.418
LIG_SUMO_SIM_par_1	419	426	PF11976	0.432
LIG_TYR_ITIM	506	511	PF00017	0.540
LIG_TYR_ITIM	567	572	PF00017	0.468
LIG_UBA3_1	118	123	PF00899	0.582
MOD_CAAXbox	589	592	PF01239	0.533
MOD_CDC14_SPxK_1	529	532	PF00782	0.452
MOD_CDC14_SPxK_1	7	10	PF00782	0.636
MOD_CDK_SPK_2	4	9	PF00069	0.647
MOD_CDK_SPxK_1	4	10	PF00069	0.645
MOD_CDK_SPxK_1	526	532	PF00069	0.482
MOD_CK1_1	129	135	PF00069	0.615
MOD_CK1_1	313	319	PF00069	0.538
MOD_CK1_1	422	428	PF00069	0.494
MOD_CK1_1	43	49	PF00069	0.685
MOD_CK2_1	196	202	PF00069	0.480
MOD_CK2_1	26	32	PF00069	0.679
MOD_CK2_1	272	278	PF00069	0.533
MOD_CK2_1	370	376	PF00069	0.577
MOD_Cter_Amidation	57	60	PF01082	0.643
MOD_GlcNHglycan	146	149	PF01048	0.579
MOD_GlcNHglycan	331	334	PF01048	0.498
MOD_GlcNHglycan	92	95	PF01048	0.613
MOD_GlcNHglycan	99	102	PF01048	0.651
MOD_GSK3_1	22	29	PF00069	0.666
MOD_GSK3_1	272	279	PF00069	0.530
MOD_GSK3_1	390	397	PF00069	0.587
MOD_GSK3_1	549	556	PF00069	0.639
MOD_N-GLC_1	113	118	PF02516	0.490
MOD_N-GLC_1	444	449	PF02516	0.532
MOD_NEK2_1	104	109	PF00069	0.599
MOD_NEK2_1	144	149	PF00069	0.633
MOD_NEK2_1	310	315	PF00069	0.522
MOD_NEK2_1	370	375	PF00069	0.402
MOD_NEK2_1	444	449	PF00069	0.516
MOD_NEK2_1	54	59	PF00069	0.649
MOD_PIKK_1	313	319	PF00454	0.564
MOD_PKA_2	22	28	PF00069	0.647
MOD_PKA_2	43	49	PF00069	0.712
MOD_PKA_2	486	492	PF00069	0.598
MOD_PKA_2	81	87	PF00069	0.612
MOD_PKB_1	406	414	PF00069	0.444
MOD_Plk_1	113	119	PF00069	0.541
MOD_Plk_1	126	132	PF00069	0.520
MOD_Plk_1	359	365	PF00069	0.543
MOD_Plk_1	468	474	PF00069	0.522
MOD_Plk_2-3	202	208	PF00069	0.437
MOD_Plk_4	113	119	PF00069	0.552
MOD_Plk_4	26	32	PF00069	0.627
MOD_Plk_4	419	425	PF00069	0.411
MOD_Plk_4	507	513	PF00069	0.602
MOD_Plk_4	553	559	PF00069	0.597
MOD_ProDKin_1	4	10	PF00069	0.650
MOD_ProDKin_1	439	445	PF00069	0.460
MOD_ProDKin_1	526	532	PF00069	0.482
TRG_DiLeu_BaEn_1	168	173	PF01217	0.559
TRG_DiLeu_BaEn_1	182	187	PF01217	0.456
TRG_DiLeu_BaEn_1	188	193	PF01217	0.417
TRG_DiLeu_BaEn_1	347	352	PF01217	0.580
TRG_DiLeu_BaEn_1	419	424	PF01217	0.454
TRG_ENDOCYTIC_2	117	120	PF00928	0.505
TRG_ENDOCYTIC_2	417	420	PF00928	0.420
TRG_ENDOCYTIC_2	508	511	PF00928	0.576
TRG_ENDOCYTIC_2	569	572	PF00928	0.507
TRG_ER_diArg_1	1	4	PF00400	0.688
TRG_ER_diArg_1	223	225	PF00400	0.596
TRG_ER_diArg_1	264	266	PF00400	0.597
TRG_ER_diArg_1	302	304	PF00400	0.588
TRG_ER_diArg_1	405	408	PF00400	0.568
TRG_ER_diArg_1	449	451	PF00400	0.453
TRG_ER_diArg_1	498	501	PF00400	0.591
TRG_ER_diArg_1	517	519	PF00400	0.579
TRG_NES_CRM1_1	191	204	PF08389	0.538
TRG_NES_CRM1_1	361	376	PF08389	0.439
TRG_NLS_MonoExtN_4	140	145	PF00514	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	63%	90%
A0A0N1PB02	Leptomonas seymouri	40%	90%
A0A0S4J6C6	Bodo saltans	33%	91%
A0A1X0P9A6	Trypanosomatidae	36%	87%
A0A3Q8IHH1	Leishmania donovani	87%	81%
A0A3R7K2Y9	Trypanosoma rangeli	39%	86%
A0A3S5H668	Leishmania donovani	39%	100%
A0A3S5H669	Leishmania donovani	38%	93%
A0A3S7X835	Leishmania donovani	39%	100%
A4H5C9	Leishmania braziliensis	38%	100%
A4H5D0	Leishmania braziliensis	40%	99%
A4HAZ7	Leishmania braziliensis	41%	100%
A4HAZ9	Leishmania braziliensis	42%	95%
A4HB01	Leishmania braziliensis	42%	100%
A4HTM0	Leishmania infantum	38%	100%
A4HTM1	Leishmania infantum	38%	93%
A4IA57	Leishmania infantum	39%	100%
C6K3V8	Leptomonas seymouri	38%	98%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	88%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	94%
E8NHF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
E8NHR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	93%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4Q2R4	Leishmania major	40%	100%
Q4Q310	Leishmania major	99%	89%
Q4Q312	Leishmania major	99%	89%
Q4Q340	Leishmania major	99%	89%
Q4Q342	Leishmania major	100%	89%
Q4QI90	Leishmania major	38%	93%
Q4QI91	Leishmania major	38%	100%