Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1U6_LEIMA

TriTrypDb:

LmjF.36.1300 , LMJLV39_360018700 , LMJSD75_360018700

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0032797	SMN complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0120114	Sm-like protein family complex	2	2

Expansion

Sequence features

Q4Q1U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1U6

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.521
CLV_C14_Caspase3-7	421	425	PF00656	0.722
CLV_C14_Caspase3-7	67	71	PF00656	0.501
CLV_C14_Caspase3-7	99	103	PF00656	0.691
CLV_NRD_NRD_1	236	238	PF00675	0.639
CLV_NRD_NRD_1	304	306	PF00675	0.701
CLV_NRD_NRD_1	357	359	PF00675	0.536
CLV_NRD_NRD_1	567	569	PF00675	0.519
CLV_PCSK_FUR_1	355	359	PF00082	0.556
CLV_PCSK_KEX2_1	147	149	PF00082	0.665
CLV_PCSK_KEX2_1	151	153	PF00082	0.677
CLV_PCSK_KEX2_1	304	306	PF00082	0.716
CLV_PCSK_KEX2_1	355	357	PF00082	0.519
CLV_PCSK_KEX2_1	567	569	PF00082	0.540
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.652
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.662
CLV_PCSK_PC7_1	351	357	PF00082	0.573
CLV_PCSK_SKI1_1	148	152	PF00082	0.735
CLV_PCSK_SKI1_1	484	488	PF00082	0.464
CLV_PCSK_SKI1_1	557	561	PF00082	0.575
DEG_APCC_DBOX_1	483	491	PF00400	0.501
DEG_SIAH_1	208	216	PF03145	0.771
DEG_SPOP_SBC_1	178	182	PF00917	0.753
DEG_SPOP_SBC_1	395	399	PF00917	0.501
DEG_SPOP_SBC_1	58	62	PF00917	0.459
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	520	526	PF00134	0.545
DOC_MAPK_gen_1	160	168	PF00069	0.566
DOC_MAPK_gen_1	256	266	PF00069	0.501
DOC_MAPK_gen_1	383	393	PF00069	0.473
DOC_MAPK_JIP1_4	162	168	PF00069	0.566
DOC_PP1_RVXF_1	191	198	PF00149	0.708
DOC_PP2B_LxvP_1	42	45	PF13499	0.479
DOC_PP2B_LxvP_1	469	472	PF13499	0.475
DOC_PP2B_LxvP_1	520	523	PF13499	0.543
DOC_PP4_FxxP_1	492	495	PF00568	0.511
DOC_USP7_MATH_1	106	110	PF00917	0.684
DOC_USP7_MATH_1	150	154	PF00917	0.744
DOC_USP7_MATH_1	167	171	PF00917	0.647
DOC_USP7_MATH_1	178	182	PF00917	0.615
DOC_USP7_MATH_1	396	400	PF00917	0.446
DOC_USP7_MATH_1	404	408	PF00917	0.400
DOC_USP7_MATH_1	96	100	PF00917	0.624
DOC_USP7_MATH_2	186	192	PF00917	0.684
DOC_USP7_UBL2_3	147	151	PF12436	0.765
DOC_USP7_UBL2_3	76	80	PF12436	0.605
DOC_WW_Pin1_4	205	210	PF00397	0.668
DOC_WW_Pin1_4	477	482	PF00397	0.616
DOC_WW_Pin1_4	54	59	PF00397	0.522
DOC_WW_Pin1_4	8	13	PF00397	0.405
LIG_14-3-3_CanoR_1	282	289	PF00244	0.689
LIG_14-3-3_CanoR_1	326	334	PF00244	0.552
LIG_14-3-3_CanoR_1	386	393	PF00244	0.569
LIG_14-3-3_CanoR_1	411	420	PF00244	0.520
LIG_14-3-3_CanoR_1	484	490	PF00244	0.531
LIG_14-3-3_CanoR_1	503	508	PF00244	0.560
LIG_14-3-3_CanoR_1	541	547	PF00244	0.453
LIG_Actin_WH2_2	253	270	PF00022	0.521
LIG_Actin_WH2_2	61	78	PF00022	0.508
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.664
LIG_BIR_III_2	570	574	PF00653	0.550
LIG_BRCT_BRCA1_1	245	249	PF00533	0.585
LIG_BRCT_BRCA1_1	398	402	PF00533	0.481
LIG_BRCT_BRCA1_1	82	86	PF00533	0.640
LIG_FHA_1	111	117	PF00498	0.765
LIG_FHA_1	122	128	PF00498	0.637
LIG_FHA_1	190	196	PF00498	0.741
LIG_FHA_1	208	214	PF00498	0.515
LIG_FHA_1	21	27	PF00498	0.598
LIG_FHA_1	326	332	PF00498	0.436
LIG_FHA_1	502	508	PF00498	0.542
LIG_FHA_1	526	532	PF00498	0.514
LIG_FHA_1	554	560	PF00498	0.552
LIG_FHA_1	590	596	PF00498	0.344
LIG_FHA_1	60	66	PF00498	0.449
LIG_FHA_2	432	438	PF00498	0.740
LIG_FHA_2	452	458	PF00498	0.692
LIG_LIR_Gen_1	262	271	PF02991	0.504
LIG_LIR_Gen_1	3	12	PF02991	0.402
LIG_LIR_Gen_1	31	42	PF02991	0.370
LIG_LIR_Gen_1	388	396	PF02991	0.452
LIG_LIR_Gen_1	488	495	PF02991	0.433
LIG_LIR_LC3C_4	124	129	PF02991	0.765
LIG_LIR_Nem_3	262	266	PF02991	0.520
LIG_LIR_Nem_3	306	310	PF02991	0.499
LIG_LIR_Nem_3	31	37	PF02991	0.369
LIG_LIR_Nem_3	388	393	PF02991	0.447
LIG_LIR_Nem_3	488	492	PF02991	0.425
LIG_LIR_Nem_3	606	611	PF02991	0.556
LIG_LIR_Nem_3	9	13	PF02991	0.406
LIG_MYND_1	54	58	PF01753	0.459
LIG_NRBOX	32	38	PF00104	0.369
LIG_PCNA_PIPBox_1	483	492	PF02747	0.532
LIG_PCNA_yPIPBox_3	483	491	PF02747	0.533
LIG_Pex14_2	339	343	PF04695	0.508
LIG_Pex14_2	39	43	PF04695	0.426
LIG_PTAP_UEV_1	208	213	PF05743	0.777
LIG_REV1ctd_RIR_1	598	606	PF16727	0.518
LIG_SH2_CRK	350	354	PF00017	0.554
LIG_SH2_CRK	591	595	PF00017	0.429
LIG_SH2_GRB2like	373	376	PF00017	0.582
LIG_SH2_NCK_1	104	108	PF00017	0.555
LIG_SH2_PTP2	263	266	PF00017	0.566
LIG_SH2_STAP1	104	108	PF00017	0.759
LIG_SH2_STAP1	591	595	PF00017	0.420
LIG_SH2_STAT5	263	266	PF00017	0.495
LIG_SH2_STAT5	373	376	PF00017	0.459
LIG_SH2_STAT5	4	7	PF00017	0.460
LIG_SH2_STAT5	591	594	PF00017	0.390
LIG_SH2_STAT5	74	77	PF00017	0.543
LIG_SH3_1	563	569	PF00018	0.559
LIG_SH3_3	203	209	PF00018	0.693
LIG_SH3_3	319	325	PF00018	0.574
LIG_SH3_3	356	362	PF00018	0.544
LIG_SH3_3	470	476	PF00018	0.629
LIG_SH3_3	520	526	PF00018	0.462
LIG_SH3_3	563	569	PF00018	0.559
LIG_SUMO_SIM_anti_2	122	131	PF11976	0.754
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.558
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.347
LIG_SUMO_SIM_par_1	585	592	PF11976	0.372
LIG_TRAF2_1	233	236	PF00917	0.649
LIG_TRAF2_1	455	458	PF00917	0.767
LIG_TRAF2_1	92	95	PF00917	0.704
LIG_WRC_WIRS_1	486	491	PF05994	0.421
LIG_WRC_WIRS_1	7	12	PF05994	0.403
LIG_WW_1	573	576	PF00397	0.534
MOD_CDK_SPxxK_3	477	484	PF00069	0.469
MOD_CDK_SPxxK_3	8	15	PF00069	0.408
MOD_CK1_1	120	126	PF00069	0.719
MOD_CK1_1	172	178	PF00069	0.788
MOD_CK1_1	341	347	PF00069	0.463
MOD_CK1_1	394	400	PF00069	0.422
MOD_CK1_1	423	429	PF00069	0.716
MOD_CK1_1	497	503	PF00069	0.597
MOD_CK1_1	553	559	PF00069	0.574
MOD_CK1_1	57	63	PF00069	0.549
MOD_CK2_1	230	236	PF00069	0.617
MOD_CK2_1	308	314	PF00069	0.516
MOD_CK2_1	412	418	PF00069	0.412
MOD_CK2_1	431	437	PF00069	0.749
MOD_CK2_1	451	457	PF00069	0.693
MOD_CK2_1	496	502	PF00069	0.643
MOD_Cter_Amidation	289	292	PF01082	0.514
MOD_Cter_Amidation	77	80	PF01082	0.656
MOD_GlcNHglycan	124	127	PF01048	0.709
MOD_GlcNHglycan	154	157	PF01048	0.785
MOD_GlcNHglycan	18	21	PF01048	0.464
MOD_GlcNHglycan	28	31	PF01048	0.379
MOD_GlcNHglycan	343	346	PF01048	0.488
MOD_GlcNHglycan	380	383	PF01048	0.446
MOD_GlcNHglycan	393	396	PF01048	0.431
MOD_GlcNHglycan	398	401	PF01048	0.349
MOD_GlcNHglycan	469	472	PF01048	0.611
MOD_GlcNHglycan	517	520	PF01048	0.424
MOD_GlcNHglycan	552	555	PF01048	0.595
MOD_GSK3_1	106	113	PF00069	0.698
MOD_GSK3_1	11	18	PF00069	0.445
MOD_GSK3_1	116	123	PF00069	0.687
MOD_GSK3_1	150	157	PF00069	0.733
MOD_GSK3_1	184	191	PF00069	0.712
MOD_GSK3_1	201	208	PF00069	0.732
MOD_GSK3_1	337	344	PF00069	0.440
MOD_GSK3_1	391	398	PF00069	0.427
MOD_GSK3_1	400	407	PF00069	0.381
MOD_GSK3_1	429	436	PF00069	0.763
MOD_GSK3_1	493	500	PF00069	0.560
MOD_GSK3_1	54	61	PF00069	0.459
MOD_N-GLC_1	120	125	PF02516	0.697
MOD_N-GLC_1	201	206	PF02516	0.704
MOD_N-GLC_1	296	301	PF02516	0.690
MOD_NEK2_1	201	206	PF00069	0.704
MOD_NEK2_1	278	283	PF00069	0.588
MOD_NEK2_1	318	323	PF00069	0.550
MOD_NEK2_1	391	396	PF00069	0.485
MOD_NEK2_1	402	407	PF00069	0.425
MOD_NEK2_1	535	540	PF00069	0.470
MOD_NEK2_1	559	564	PF00069	0.544
MOD_PIKK_1	281	287	PF00454	0.566
MOD_PIKK_1	325	331	PF00454	0.473
MOD_PIKK_1	96	102	PF00454	0.604
MOD_PK_1	503	509	PF00069	0.516
MOD_PKA_2	161	167	PF00069	0.762
MOD_PKA_2	281	287	PF00069	0.574
MOD_PKA_2	325	331	PF00069	0.549
MOD_PKA_2	385	391	PF00069	0.578
MOD_PKA_2	429	435	PF00069	0.768
MOD_PKA_2	502	508	PF00069	0.574
MOD_PKB_1	152	160	PF00069	0.774
MOD_PKB_1	501	509	PF00069	0.546
MOD_Plk_1	250	256	PF00069	0.479
MOD_Plk_1	423	429	PF00069	0.686
MOD_Plk_1	94	100	PF00069	0.761
MOD_Plk_2-3	418	424	PF00069	0.650
MOD_Plk_4	243	249	PF00069	0.544
MOD_Plk_4	485	491	PF00069	0.405
MOD_Plk_4	589	595	PF00069	0.348
MOD_ProDKin_1	205	211	PF00069	0.666
MOD_ProDKin_1	477	483	PF00069	0.608
MOD_ProDKin_1	54	60	PF00069	0.522
MOD_ProDKin_1	8	14	PF00069	0.406
MOD_SUMO_rev_2	233	239	PF00179	0.601
TRG_DiLeu_BaEn_1	314	319	PF01217	0.574
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.483
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.508
TRG_ENDOCYTIC_2	263	266	PF00928	0.535
TRG_ENDOCYTIC_2	307	310	PF00928	0.575
TRG_ENDOCYTIC_2	350	353	PF00928	0.555
TRG_ENDOCYTIC_2	4	7	PF00928	0.460
TRG_ENDOCYTIC_2	576	579	PF00928	0.395
TRG_ENDOCYTIC_2	591	594	PF00928	0.345
TRG_ENDOCYTIC_2	74	77	PF00928	0.631
TRG_ER_diArg_1	303	305	PF00400	0.726
TRG_ER_diArg_1	355	358	PF00400	0.558
TRG_ER_diArg_1	445	448	PF00400	0.767
TRG_ER_diArg_1	566	568	PF00400	0.510
TRG_NLS_MonoCore_2	144	149	PF00514	0.688
TRG_NLS_MonoExtN_4	143	150	PF00514	0.643

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC77	Leptomonas seymouri	48%	100%
A0A0S4IYS2	Bodo saltans	28%	100%
A0A1X0P8B5	Trypanosomatidae	31%	100%
A0A3Q8IJZ4	Leishmania donovani	92%	100%
A0A3R7RAQ0	Trypanosoma rangeli	31%	100%
A4HNY7	Leishmania braziliensis	78%	100%
A4ICK6	Leishmania infantum	91%	100%
D0A2V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ASP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%