BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1U5_LEIMA

TriTrypDb:

LmjF.36.1310 , LMJLV39_360018800 , LMJSD75_360018800

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1U5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1U5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.550
CLV_NRD_NRD_1	176	178	PF00675	0.484
CLV_NRD_NRD_1	190	192	PF00675	0.431
CLV_NRD_NRD_1	210	212	PF00675	0.434
CLV_PCSK_FUR_1	208	212	PF00082	0.585
CLV_PCSK_KEX2_1	176	178	PF00082	0.480
CLV_PCSK_KEX2_1	190	192	PF00082	0.439
CLV_PCSK_KEX2_1	208	210	PF00082	0.439
CLV_PCSK_SKI1_1	217	221	PF00082	0.542
CLV_PCSK_SKI1_1	230	234	PF00082	0.381
CLV_PCSK_SKI1_1	241	245	PF00082	0.596
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DOC_CYCLIN_yClb5_NLxxxL_5	14	21	PF00134	0.447
DOC_MAPK_MEF2A_6	14	21	PF00069	0.337
DOC_MIT_MIM_1	179	191	PF04212	0.503
DOC_PP2B_LxvP_1	106	109	PF13499	0.335
DOC_USP7_MATH_1	112	116	PF00917	0.579
DOC_USP7_MATH_1	161	165	PF00917	0.679
DOC_WW_Pin1_4	135	140	PF00397	0.628
DOC_WW_Pin1_4	157	162	PF00397	0.663
DOC_WW_Pin1_4	163	168	PF00397	0.503
DOC_WW_Pin1_4	251	256	PF00397	0.695
LIG_14-3-3_CanoR_1	148	155	PF00244	0.685
LIG_14-3-3_CanoR_1	185	190	PF00244	0.559
LIG_14-3-3_CanoR_1	208	214	PF00244	0.610
LIG_Actin_WH2_2	57	75	PF00022	0.344
LIG_APCC_ABBA_1	64	69	PF00400	0.355
LIG_FHA_1	213	219	PF00498	0.532
LIG_FHA_2	73	79	PF00498	0.246
LIG_LIR_Gen_1	57	67	PF02991	0.473
LIG_LIR_Gen_1	85	94	PF02991	0.335
LIG_LIR_Nem_3	214	219	PF02991	0.523
LIG_LIR_Nem_3	237	243	PF02991	0.481
LIG_LIR_Nem_3	85	89	PF02991	0.335
LIG_Rb_LxCxE_1	214	231	PF01857	0.516
LIG_SH2_CRK	216	220	PF00017	0.519
LIG_SH2_CRK	86	90	PF00017	0.335
LIG_SH2_SRC	67	70	PF00017	0.335
LIG_SH2_STAP1	67	71	PF00017	0.335
LIG_SH2_STAP1	86	90	PF00017	0.335
LIG_SH2_STAT3	90	93	PF00017	0.335
LIG_SH2_STAT5	90	93	PF00017	0.355
LIG_SH3_2	109	114	PF14604	0.617
LIG_SH3_3	105	111	PF00018	0.354
LIG_SH3_3	52	58	PF00018	0.432
LIG_SH3_3	88	94	PF00018	0.338
LIG_TRAF2_1	236	239	PF00917	0.472
LIG_WW_3	107	111	PF00397	0.356
MOD_CDC14_SPxK_1	166	169	PF00782	0.568
MOD_CDK_SPxK_1	163	169	PF00069	0.591
MOD_CDK_SPxxK_3	135	142	PF00069	0.666
MOD_CK1_1	115	121	PF00069	0.726
MOD_CK1_1	143	149	PF00069	0.714
MOD_CK1_1	212	218	PF00069	0.591
MOD_CK2_1	72	78	PF00069	0.246
MOD_GlcNHglycan	123	126	PF01048	0.666
MOD_GlcNHglycan	142	145	PF01048	0.735
MOD_GlcNHglycan	149	152	PF01048	0.694
MOD_GlcNHglycan	44	48	PF01048	0.423
MOD_GSK3_1	112	119	PF00069	0.616
MOD_GSK3_1	140	147	PF00069	0.653
MOD_GSK3_1	157	164	PF00069	0.624
MOD_GSK3_1	20	27	PF00069	0.414
MOD_GSK3_1	72	79	PF00069	0.447
MOD_N-GLC_2	133	135	PF02516	0.529
MOD_NEK2_1	72	77	PF00069	0.487
MOD_PIKK_1	225	231	PF00454	0.599
MOD_PIKK_1	78	84	PF00454	0.264
MOD_PIKK_1	93	99	PF00454	0.447
MOD_PK_1	116	122	PF00069	0.668
MOD_PKA_1	209	215	PF00069	0.611
MOD_PKA_2	115	121	PF00069	0.781
MOD_PKA_2	147	153	PF00069	0.682
MOD_PKA_2	184	190	PF00069	0.529
MOD_PKA_2	209	215	PF00069	0.611
MOD_PKA_2	72	78	PF00069	0.480
MOD_PKB_1	114	122	PF00069	0.770
MOD_Plk_4	60	66	PF00069	0.438
MOD_ProDKin_1	135	141	PF00069	0.626
MOD_ProDKin_1	157	163	PF00069	0.663
MOD_ProDKin_1	251	257	PF00069	0.734
TRG_DiLeu_BaEn_1	214	219	PF01217	0.561
TRG_DiLeu_BaEn_1	246	251	PF01217	0.610
TRG_DiLeu_BaEn_3	238	244	PF01217	0.561
TRG_DiLeu_LyEn_5	214	219	PF01217	0.561
TRG_ENDOCYTIC_2	216	219	PF00928	0.523
TRG_ENDOCYTIC_2	67	70	PF00928	0.398
TRG_ENDOCYTIC_2	86	89	PF00928	0.335
TRG_ER_diArg_1	189	191	PF00400	0.541
TRG_ER_diArg_1	208	211	PF00400	0.408
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R9	Leptomonas seymouri	49%	93%
A0A0S4J2G2	Bodo saltans	41%	100%
A0A1X0P9F2	Trypanosomatidae	43%	100%
A0A3Q8IH20	Leishmania donovani	90%	100%
A0A422N0I0	Trypanosoma rangeli	44%	100%
A4HNY8	Leishmania braziliensis	74%	100%
A4ICK5	Leishmania infantum	90%	100%
E9ASQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BQB2	Trypanosoma cruzi	41%	100%