Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1U4_LEIMA

TriTrypDb:

LmjF.36.1320 , LMJLV39_360018900 , LMJSD75_360018900

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	133	139	PF00089	0.549
CLV_NRD_NRD_1	146	148	PF00675	0.471
CLV_NRD_NRD_1	151	153	PF00675	0.478
CLV_NRD_NRD_1	17	19	PF00675	0.730
CLV_NRD_NRD_1	206	208	PF00675	0.640
CLV_NRD_NRD_1	233	235	PF00675	0.634
CLV_NRD_NRD_1	342	344	PF00675	0.650
CLV_NRD_NRD_1	38	40	PF00675	0.596
CLV_NRD_NRD_1	80	82	PF00675	0.642
CLV_PCSK_KEX2_1	145	147	PF00082	0.479
CLV_PCSK_KEX2_1	17	19	PF00082	0.730
CLV_PCSK_KEX2_1	206	208	PF00082	0.640
CLV_PCSK_KEX2_1	233	235	PF00082	0.652
CLV_PCSK_KEX2_1	342	344	PF00082	0.650
CLV_PCSK_KEX2_1	80	82	PF00082	0.671
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.650
CLV_PCSK_SKI1_1	185	189	PF00082	0.512
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DEG_SPOP_SBC_1	295	299	PF00917	0.657
DOC_MAPK_gen_1	17	27	PF00069	0.715
DOC_MAPK_gen_1	80	88	PF00069	0.543
DOC_MAPK_RevD_3	133	146	PF00069	0.455
DOC_PP2B_LxvP_1	86	89	PF13499	0.566
DOC_USP7_MATH_1	205	209	PF00917	0.626
DOC_USP7_MATH_1	277	281	PF00917	0.502
DOC_USP7_MATH_1	295	299	PF00917	0.712
DOC_USP7_MATH_1	38	42	PF00917	0.646
DOC_USP7_MATH_1	397	401	PF00917	0.632
DOC_USP7_MATH_1	8	12	PF00917	0.606
DOC_USP7_UBL2_3	36	40	PF12436	0.675
DOC_WW_Pin1_4	248	253	PF00397	0.459
DOC_WW_Pin1_4	332	337	PF00397	0.639
DOC_WW_Pin1_4	356	361	PF00397	0.720
DOC_WW_Pin1_4	56	61	PF00397	0.686
DOC_WW_Pin1_4	79	84	PF00397	0.691
DOC_WW_Pin1_4	93	98	PF00397	0.658
LIG_14-3-3_CanoR_1	136	142	PF00244	0.570
LIG_14-3-3_CanoR_1	17	27	PF00244	0.723
LIG_14-3-3_CanoR_1	185	191	PF00244	0.495
LIG_14-3-3_CanoR_1	259	268	PF00244	0.557
LIG_14-3-3_CanoR_1	305	314	PF00244	0.698
LIG_14-3-3_CanoR_1	343	349	PF00244	0.704
LIG_14-3-3_CanoR_1	93	97	PF00244	0.596
LIG_Actin_WH2_2	254	271	PF00022	0.471
LIG_BIR_III_2	285	289	PF00653	0.672
LIG_BRCT_BRCA1_1	240	244	PF00533	0.537
LIG_FHA_1	261	267	PF00498	0.441
LIG_FHA_1	307	313	PF00498	0.692
LIG_FHA_1	66	72	PF00498	0.679
LIG_FHA_1	73	79	PF00498	0.640
LIG_FHA_2	172	178	PF00498	0.402
LIG_FHA_2	235	241	PF00498	0.583
LIG_FHA_2	365	371	PF00498	0.821
LIG_LIR_Gen_1	245	255	PF02991	0.600
LIG_LIR_Nem_3	231	235	PF02991	0.478
LIG_LIR_Nem_3	241	247	PF02991	0.490
LIG_LIR_Nem_3	5	9	PF02991	0.698
LIG_LIR_Nem_3	59	65	PF02991	0.647
LIG_PDZ_Class_2	417	422	PF00595	0.484
LIG_SH3_3	287	293	PF00018	0.678
LIG_SH3_3	68	74	PF00018	0.695
LIG_SH3_5	19	23	PF00018	0.605
MOD_CDK_SPK_2	56	61	PF00069	0.608
MOD_CDK_SPxxK_3	56	63	PF00069	0.598
MOD_CK1_1	11	17	PF00069	0.644
MOD_CK1_1	260	266	PF00069	0.443
MOD_CK1_1	280	286	PF00069	0.473
MOD_CK1_1	308	314	PF00069	0.613
MOD_CK1_1	319	325	PF00069	0.616
MOD_CK1_1	395	401	PF00069	0.560
MOD_CK1_1	411	417	PF00069	0.513
MOD_CK1_1	43	49	PF00069	0.696
MOD_CK2_1	234	240	PF00069	0.550
MOD_CK2_1	356	362	PF00069	0.761
MOD_CK2_1	364	370	PF00069	0.728
MOD_CK2_1	401	407	PF00069	0.632
MOD_CK2_1	45	51	PF00069	0.695
MOD_GlcNHglycan	11	14	PF01048	0.627
MOD_GlcNHglycan	123	126	PF01048	0.560
MOD_GlcNHglycan	214	217	PF01048	0.574
MOD_GlcNHglycan	219	222	PF01048	0.474
MOD_GlcNHglycan	244	247	PF01048	0.603
MOD_GlcNHglycan	302	305	PF01048	0.715
MOD_GlcNHglycan	318	321	PF01048	0.700
MOD_GlcNHglycan	396	400	PF01048	0.511
MOD_GlcNHglycan	42	45	PF01048	0.641
MOD_GlcNHglycan	47	50	PF01048	0.622
MOD_GSK3_1	108	115	PF00069	0.571
MOD_GSK3_1	121	128	PF00069	0.496
MOD_GSK3_1	234	241	PF00069	0.597
MOD_GSK3_1	296	303	PF00069	0.695
MOD_GSK3_1	304	311	PF00069	0.797
MOD_GSK3_1	356	363	PF00069	0.595
MOD_GSK3_1	38	45	PF00069	0.653
MOD_GSK3_1	397	404	PF00069	0.700
MOD_GSK3_1	65	72	PF00069	0.581
MOD_N-GLC_1	316	321	PF02516	0.786
MOD_N-GLC_1	356	361	PF02516	0.685
MOD_NEK2_1	186	191	PF00069	0.425
MOD_NEK2_1	300	305	PF00069	0.680
MOD_NEK2_1	316	321	PF00069	0.678
MOD_NEK2_1	9	14	PF00069	0.631
MOD_PIKK_1	171	177	PF00454	0.445
MOD_PIKK_1	260	266	PF00454	0.443
MOD_PIKK_1	69	75	PF00454	0.558
MOD_PKA_1	233	239	PF00069	0.548
MOD_PKA_1	344	350	PF00069	0.658
MOD_PKA_1	39	45	PF00069	0.621
MOD_PKA_2	135	141	PF00069	0.556
MOD_PKA_2	205	211	PF00069	0.580
MOD_PKA_2	233	239	PF00069	0.552
MOD_PKA_2	300	306	PF00069	0.744
MOD_PKA_2	38	44	PF00069	0.617
MOD_PKA_2	65	71	PF00069	0.643
MOD_PKA_2	9	15	PF00069	0.606
MOD_PKA_2	92	98	PF00069	0.604
MOD_Plk_1	181	187	PF00069	0.486
MOD_Plk_4	234	240	PF00069	0.454
MOD_Plk_4	308	314	PF00069	0.726
MOD_Plk_4	344	350	PF00069	0.660
MOD_Plk_4	408	414	PF00069	0.464
MOD_ProDKin_1	248	254	PF00069	0.475
MOD_ProDKin_1	332	338	PF00069	0.638
MOD_ProDKin_1	356	362	PF00069	0.723
MOD_ProDKin_1	56	62	PF00069	0.689
MOD_ProDKin_1	79	85	PF00069	0.692
MOD_ProDKin_1	93	99	PF00069	0.682
TRG_DiLeu_BaEn_1	182	187	PF01217	0.487
TRG_DiLeu_LyEn_5	182	187	PF01217	0.458
TRG_ENDOCYTIC_2	6	9	PF00928	0.704
TRG_ER_diArg_1	145	147	PF00400	0.551
TRG_ER_diArg_1	16	18	PF00400	0.726
TRG_ER_diArg_1	206	209	PF00400	0.553
TRG_ER_diArg_1	232	234	PF00400	0.583
TRG_ER_diArg_1	416	419	PF00400	0.466
TRG_NLS_MonoExtN_4	342	347	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ64	Leptomonas seymouri	33%	100%
A0A3S7XAJ3	Leishmania donovani	84%	100%
A4HNY9	Leishmania braziliensis	61%	99%
A4ICK4	Leishmania infantum	83%	100%
E9ASQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%