PARP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1U1_LEIMA

TriTrypDb:

LmjF.36.1350 , LMJLV39_360019200 , LMJSD75_360019200

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

Q4Q1U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1U1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.755
CLV_C14_Caspase3-7	213	217	PF00656	0.696
CLV_C14_Caspase3-7	261	265	PF00656	0.752
CLV_NRD_NRD_1	201	203	PF00675	0.760
CLV_NRD_NRD_1	282	284	PF00675	0.700
CLV_NRD_NRD_1	44	46	PF00675	0.551
CLV_PCSK_FUR_1	42	46	PF00082	0.431
CLV_PCSK_KEX2_1	195	197	PF00082	0.711
CLV_PCSK_KEX2_1	281	283	PF00082	0.649
CLV_PCSK_KEX2_1	42	44	PF00082	0.515
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.711
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.649
CLV_PCSK_PC7_1	39	45	PF00082	0.439
CLV_PCSK_SKI1_1	170	174	PF00082	0.724
DOC_MAPK_gen_1	138	148	PF00069	0.392
DOC_MAPK_gen_1	70	79	PF00069	0.561
DOC_MAPK_MEF2A_6	44	53	PF00069	0.482
DOC_USP7_MATH_1	111	115	PF00917	0.551
DOC_USP7_MATH_1	176	180	PF00917	0.807
DOC_USP7_MATH_1	188	192	PF00917	0.750
DOC_USP7_MATH_1	266	270	PF00917	0.775
DOC_USP7_MATH_1	61	65	PF00917	0.508
DOC_USP7_UBL2_3	173	177	PF12436	0.768
DOC_USP7_UBL2_3	70	74	PF12436	0.512
LIG_14-3-3_CanoR_1	13	23	PF00244	0.522
LIG_14-3-3_CanoR_1	42	51	PF00244	0.657
LIG_Actin_WH2_2	17	32	PF00022	0.488
LIG_APCC_ABBA_1	84	89	PF00400	0.543
LIG_BIR_II_1	1	5	PF00653	0.531
LIG_BRCT_BRCA1_1	18	22	PF00533	0.497
LIG_deltaCOP1_diTrp_1	93	97	PF00928	0.561
LIG_FHA_1	159	165	PF00498	0.704
LIG_FHA_1	79	85	PF00498	0.522
LIG_FHA_2	243	249	PF00498	0.531
LIG_FHA_2	252	258	PF00498	0.531
LIG_FHA_2	259	265	PF00498	0.692
LIG_LIR_Nem_3	19	24	PF02991	0.429
LIG_LIR_Nem_3	247	253	PF02991	0.563
LIG_LIR_Nem_3	94	100	PF02991	0.490
LIG_MLH1_MIPbox_1	18	22	PF16413	0.497
LIG_SH2_STAP1	223	227	PF00017	0.615
LIG_SH2_STAT5	253	256	PF00017	0.561
LIG_SH3_1	198	204	PF00018	0.660
LIG_SH3_2	197	202	PF14604	0.792
LIG_SH3_3	194	200	PF00018	0.766
LIG_SH3_3	201	207	PF00018	0.749
LIG_SH3_3	231	237	PF00018	0.304
LIG_SH3_3	80	86	PF00018	0.506
LIG_SH3_4	173	180	PF00018	0.720
LIG_SH3_CIN85_PxpxPR_1	197	202	PF14604	0.715
LIG_TRAF2_1	160	163	PF00917	0.481
LIG_TRAF2_1	219	222	PF00917	0.624
LIG_TRAF2_1	245	248	PF00917	0.591
LIG_UBA3_1	276	284	PF00899	0.497
LIG_WW_3	199	203	PF00397	0.713
MOD_CK1_1	158	164	PF00069	0.631
MOD_CK1_1	217	223	PF00069	0.606
MOD_CK1_1	64	70	PF00069	0.514
MOD_CK2_1	188	194	PF00069	0.726
MOD_CK2_1	216	222	PF00069	0.630
MOD_CK2_1	242	248	PF00069	0.531
MOD_Cter_Amidation	68	71	PF01082	0.361
MOD_GlcNHglycan	113	116	PF01048	0.402
MOD_GlcNHglycan	157	160	PF01048	0.623
MOD_GlcNHglycan	16	19	PF01048	0.491
MOD_GlcNHglycan	178	181	PF01048	0.807
MOD_GlcNHglycan	272	275	PF01048	0.690
MOD_GlcNHglycan	45	48	PF01048	0.587
MOD_GlcNHglycan	57	60	PF01048	0.276
MOD_GSK3_1	106	113	PF00069	0.536
MOD_GSK3_1	12	19	PF00069	0.489
MOD_GSK3_1	266	273	PF00069	0.735
MOD_LATS_1	249	255	PF00433	0.591
MOD_N-GLC_1	258	263	PF02516	0.769
MOD_N-GLC_1	64	69	PF02516	0.391
MOD_NEK2_1	16	21	PF00069	0.494
MOD_NEK2_1	22	27	PF00069	0.448
MOD_OFUCOSY	63	68	PF10250	0.331
MOD_PKA_1	43	49	PF00069	0.533
MOD_PKA_2	111	117	PF00069	0.551
MOD_PKA_2	12	18	PF00069	0.488
MOD_PKA_2	43	49	PF00069	0.692
MOD_Plk_1	144	150	PF00069	0.550
MOD_Plk_4	144	150	PF00069	0.526
TRG_ER_diArg_1	3	6	PF00400	0.448
TRG_ER_diArg_1	42	45	PF00400	0.514
TRG_NLS_MonoCore_2	201	206	PF00514	0.681
TRG_NLS_MonoCore_2	280	285	PF00514	0.696
TRG_NLS_MonoExtN_4	200	206	PF00514	0.702
TRG_NLS_MonoExtN_4	278	285	PF00514	0.691

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA52	Leptomonas seymouri	71%	100%
A0A0S4J2P2	Bodo saltans	38%	100%
A0A1X0P7R0	Trypanosomatidae	45%	100%
A0A3S5H819	Leishmania donovani	90%	100%
A4HNZ2	Leishmania braziliensis	76%	100%
A4ICK1	Leishmania infantum	90%	100%
D0A369	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%