Putative Transitional endoplasmic reticulum ATPase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Valosin-containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1T9_LEIMA

TriTrypDb:

LmjF.36.1370 , LMJLV39_360019600 , LMJSD75_360019600

Length:

784

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	2
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098552	side of membrane	2	2
GO:0098554	cytoplasmic side of endoplasmic reticulum membrane	4	2
GO:0098562	cytoplasmic side of membrane	3	2
GO:0098796	membrane protein complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0140534	endoplasmic reticulum protein-containing complex	2	2

Expansion

Sequence features

Q4Q1T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T9

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006950	response to stress	2	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007051	spindle organization	3	2
GO:0007052	mitotic spindle organization	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	3
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0022402	cell cycle process	2	2
GO:0022411	cellular component disassembly	4	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0030970	retrograde protein transport, ER to cytosol	5	2
GO:0032527	protein exit from endoplasmic reticulum	5	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0033036	macromolecule localization	2	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0050896	response to stimulus	1	2
GO:0051179	localization	1	2
GO:0051228	mitotic spindle disassembly	5	2
GO:0051230	spindle disassembly	4	2
GO:0051234	establishment of localization	2	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051716	cellular response to stimulus	2	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0071712	ER-associated misfolded protein catabolic process	6	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097352	autophagosome maturation	6	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	2
GO:1903008	organelle disassembly	5	2
GO:1903047	mitotic cell cycle process	3	2
GO:1903513	endoplasmic reticulum to cytosol transport	4	2
GO:0051301	cell division	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0031593	polyubiquitin modification-dependent protein binding	4	2
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0042802	identical protein binding	3	2
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140030	modification-dependent protein binding	3	2
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.639
CLV_C14_Caspase3-7	294	298	PF00656	0.352
CLV_C14_Caspase3-7	320	324	PF00656	0.357
CLV_C14_Caspase3-7	425	429	PF00656	0.321
CLV_C14_Caspase3-7	567	571	PF00656	0.357
CLV_C14_Caspase3-7	594	598	PF00656	0.357
CLV_C14_Caspase3-7	733	737	PF00656	0.460
CLV_NRD_NRD_1	199	201	PF00675	0.580
CLV_NRD_NRD_1	276	278	PF00675	0.376
CLV_NRD_NRD_1	348	350	PF00675	0.357
CLV_NRD_NRD_1	649	651	PF00675	0.463
CLV_NRD_NRD_1	731	733	PF00675	0.513
CLV_NRD_NRD_1	740	742	PF00675	0.492
CLV_NRD_NRD_1	80	82	PF00675	0.357
CLV_PCSK_KEX2_1	302	304	PF00082	0.352
CLV_PCSK_KEX2_1	312	314	PF00082	0.352
CLV_PCSK_KEX2_1	348	350	PF00082	0.357
CLV_PCSK_KEX2_1	35	37	PF00082	0.357
CLV_PCSK_KEX2_1	476	478	PF00082	0.439
CLV_PCSK_KEX2_1	731	733	PF00082	0.537
CLV_PCSK_KEX2_1	740	742	PF00082	0.497
CLV_PCSK_KEX2_1	80	82	PF00082	0.357
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.352
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.352
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.357
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.439
CLV_PCSK_SKI1_1	135	139	PF00082	0.417
CLV_PCSK_SKI1_1	229	233	PF00082	0.352
CLV_PCSK_SKI1_1	277	281	PF00082	0.352
CLV_PCSK_SKI1_1	376	380	PF00082	0.458
CLV_PCSK_SKI1_1	388	392	PF00082	0.357
CLV_PCSK_SKI1_1	502	506	PF00082	0.357
CLV_PCSK_SKI1_1	514	518	PF00082	0.357
CLV_PCSK_SKI1_1	550	554	PF00082	0.357
CLV_PCSK_SKI1_1	603	607	PF00082	0.357
DEG_APCC_DBOX_1	103	111	PF00400	0.438
DEG_APCC_DBOX_1	199	207	PF00400	0.461
DEG_APCC_DBOX_1	413	421	PF00400	0.473
DEG_COP1_1	707	718	PF00400	0.563
DOC_CKS1_1	459	464	PF01111	0.504
DOC_MAPK_gen_1	11	19	PF00069	0.581
DOC_MAPK_gen_1	326	333	PF00069	0.357
DOC_MAPK_gen_1	348	359	PF00069	0.357
DOC_MAPK_gen_1	35	42	PF00069	0.357
DOC_MAPK_gen_1	376	386	PF00069	0.496
DOC_MAPK_gen_1	51	61	PF00069	0.357
DOC_MAPK_gen_1	623	633	PF00069	0.357
DOC_MAPK_gen_1	77	87	PF00069	0.381
DOC_MAPK_MEF2A_6	207	214	PF00069	0.447
DOC_MAPK_MEF2A_6	285	292	PF00069	0.352
DOC_MAPK_MEF2A_6	352	361	PF00069	0.357
DOC_MAPK_MEF2A_6	54	63	PF00069	0.357
DOC_MAPK_MEF2A_6	557	565	PF00069	0.357
DOC_MAPK_MEF2A_6	626	635	PF00069	0.357
DOC_MAPK_MEF2A_6	80	87	PF00069	0.381
DOC_MAPK_RevD_3	288	303	PF00069	0.352
DOC_PP1_RVXF_1	148	155	PF00149	0.357
DOC_PP1_RVXF_1	500	507	PF00149	0.427
DOC_PP4_FxxP_1	125	128	PF00568	0.357
DOC_PP4_FxxP_1	506	509	PF00568	0.357
DOC_PP4_MxPP_1	498	501	PF00568	0.533
DOC_USP7_MATH_1	148	152	PF00917	0.357
DOC_USP7_MATH_1	269	273	PF00917	0.360
DOC_USP7_MATH_1	390	394	PF00917	0.397
DOC_USP7_MATH_1	653	657	PF00917	0.556
DOC_USP7_MATH_1	730	734	PF00917	0.492
DOC_USP7_MATH_1	768	772	PF00917	0.885
DOC_WW_Pin1_4	165	170	PF00397	0.381
DOC_WW_Pin1_4	458	463	PF00397	0.530
DOC_WW_Pin1_4	496	501	PF00397	0.501
DOC_WW_Pin1_4	649	654	PF00397	0.470
LIG_14-3-3_CanoR_1	313	322	PF00244	0.352
LIG_14-3-3_CanoR_1	56	60	PF00244	0.473
LIG_14-3-3_CanoR_1	731	739	PF00244	0.487
LIG_Actin_WH2_2	261	279	PF00022	0.352
LIG_Actin_WH2_2	439	457	PF00022	0.495
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_3	1	5	PF00653	0.736
LIG_BIR_III_4	3	7	PF00653	0.662
LIG_BRCT_BRCA1_1	150	154	PF00533	0.357
LIG_BRCT_BRCA1_1	288	292	PF00533	0.318
LIG_BRCT_BRCA1_1	392	396	PF00533	0.433
LIG_BRCT_BRCA1_1	751	755	PF00533	0.590
LIG_CaM_IQ_9	435	450	PF13499	0.576
LIG_Clathr_ClatBox_1	107	111	PF01394	0.431
LIG_deltaCOP1_diTrp_1	488	493	PF00928	0.466
LIG_FHA_1	116	122	PF00498	0.408
LIG_FHA_1	363	369	PF00498	0.551
LIG_FHA_1	45	51	PF00498	0.357
LIG_FHA_1	459	465	PF00498	0.499
LIG_FHA_1	56	62	PF00498	0.357
LIG_FHA_1	88	94	PF00498	0.381
LIG_FHA_2	318	324	PF00498	0.357
LIG_FHA_2	455	461	PF00498	0.568
LIG_FHA_2	592	598	PF00498	0.357
LIG_GBD_Chelix_1	314	322	PF00786	0.352
LIG_Integrin_RGD_1	44	46	PF01839	0.357
LIG_LIR_Apic_2	123	128	PF02991	0.390
LIG_LIR_Gen_1	120	130	PF02991	0.357
LIG_LIR_Gen_1	163	172	PF02991	0.391
LIG_LIR_Nem_3	120	125	PF02991	0.357
LIG_LIR_Nem_3	132	137	PF02991	0.357
LIG_LIR_Nem_3	151	157	PF02991	0.357
LIG_LIR_Nem_3	163	167	PF02991	0.380
LIG_LIR_Nem_3	218	223	PF02991	0.490
LIG_LIR_Nem_3	252	258	PF02991	0.352
LIG_SH2_CRK	134	138	PF00017	0.357
LIG_SH2_CRK	164	168	PF00017	0.427
LIG_SH2_CRK	234	238	PF00017	0.352
LIG_SH2_CRK	507	511	PF00017	0.357
LIG_SH2_NCK_1	193	197	PF00017	0.437
LIG_SH2_PTP2	632	635	PF00017	0.357
LIG_SH2_SRC	193	196	PF00017	0.445
LIG_SH2_STAT5	129	132	PF00017	0.357
LIG_SH2_STAT5	164	167	PF00017	0.433
LIG_SH2_STAT5	632	635	PF00017	0.357
LIG_SH3_3	16	22	PF00018	0.436
LIG_SH3_3	207	213	PF00018	0.449
LIG_SH3_3	456	462	PF00018	0.542
LIG_SH3_3	480	486	PF00018	0.436
LIG_SH3_3	613	619	PF00018	0.414
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.381
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.473
LIG_SUMO_SIM_anti_2	640	646	PF11976	0.421
LIG_SUMO_SIM_par_1	155	160	PF11976	0.357
LIG_SUMO_SIM_par_1	316	323	PF11976	0.357
LIG_TRAF2_1	279	282	PF00917	0.376
LIG_TYR_ITIM	191	196	PF00017	0.453
LIG_TYR_ITIM	630	635	PF00017	0.357
LIG_UBA3_1	219	226	PF00899	0.491
LIG_UBA3_1	318	326	PF00899	0.381
LIG_UBA3_1	370	376	PF00899	0.444
LIG_UBA3_1	630	638	PF00899	0.373
LIG_WW_3	226	230	PF00397	0.451
MOD_CDC14_SPxK_1	499	502	PF00782	0.492
MOD_CDK_SPxK_1	496	502	PF00069	0.499
MOD_CK1_1	168	174	PF00069	0.422
MOD_CK1_1	239	245	PF00069	0.352
MOD_CK1_1	28	34	PF00069	0.473
MOD_CK2_1	454	460	PF00069	0.568
MOD_Cter_Amidation	51	54	PF01082	0.357
MOD_GlcNHglycan	238	241	PF01048	0.352
MOD_GlcNHglycan	451	454	PF01048	0.520
MOD_GlcNHglycan	670	673	PF01048	0.382
MOD_GlcNHglycan	674	678	PF01048	0.377
MOD_GlcNHglycan	702	705	PF01048	0.565
MOD_GlcNHglycan	770	773	PF01048	0.764
MOD_GSK3_1	168	175	PF00069	0.473
MOD_GSK3_1	313	320	PF00069	0.357
MOD_GSK3_1	454	461	PF00069	0.554
MOD_GSK3_1	568	575	PF00069	0.417
MOD_GSK3_1	645	652	PF00069	0.522
MOD_GSK3_1	664	671	PF00069	0.282
MOD_GSK3_1	745	752	PF00069	0.562
MOD_N-GLC_1	115	120	PF02516	0.357
MOD_N-GLC_1	249	254	PF02516	0.352
MOD_NEK2_1	130	135	PF00069	0.395
MOD_NEK2_1	334	339	PF00069	0.357
MOD_NEK2_1	446	451	PF00069	0.528
MOD_NEK2_1	454	459	PF00069	0.595
MOD_NEK2_1	700	705	PF00069	0.552
MOD_NEK2_1	744	749	PF00069	0.491
MOD_NEK2_1	755	760	PF00069	0.698
MOD_NEK2_1	87	92	PF00069	0.381
MOD_PIKK_1	313	319	PF00454	0.354
MOD_PIKK_1	326	332	PF00454	0.366
MOD_PIKK_1	435	441	PF00454	0.470
MOD_PIKK_1	454	460	PF00454	0.577
MOD_PKA_2	454	460	PF00069	0.555
MOD_PKA_2	55	61	PF00069	0.357
MOD_PKA_2	687	693	PF00069	0.357
MOD_PKA_2	730	736	PF00069	0.516
MOD_Plk_1	110	116	PF00069	0.474
MOD_Plk_1	25	31	PF00069	0.357
MOD_Plk_1	423	429	PF00069	0.373
MOD_Plk_2-3	415	421	PF00069	0.366
MOD_Plk_2-3	423	429	PF00069	0.345
MOD_Plk_4	139	145	PF00069	0.538
MOD_Plk_4	168	174	PF00069	0.375
MOD_Plk_4	239	245	PF00069	0.352
MOD_Plk_4	25	31	PF00069	0.357
MOD_Plk_4	286	292	PF00069	0.369
MOD_Plk_4	317	323	PF00069	0.357
MOD_Plk_4	415	421	PF00069	0.381
MOD_Plk_4	44	50	PF00069	0.357
MOD_Plk_4	512	518	PF00069	0.357
MOD_Plk_4	536	542	PF00069	0.357
MOD_ProDKin_1	165	171	PF00069	0.381
MOD_ProDKin_1	458	464	PF00069	0.517
MOD_ProDKin_1	496	502	PF00069	0.499
MOD_ProDKin_1	649	655	PF00069	0.465
MOD_SUMO_for_1	301	304	PF00179	0.352
MOD_SUMO_for_1	475	478	PF00179	0.431
MOD_SUMO_rev_2	151	157	PF00179	0.357
MOD_SUMO_rev_2	694	703	PF00179	0.473
TRG_DiLeu_BaEn_1	478	483	PF01217	0.429
TRG_ENDOCYTIC_2	134	137	PF00928	0.357
TRG_ENDOCYTIC_2	164	167	PF00928	0.427
TRG_ENDOCYTIC_2	193	196	PF00928	0.451
TRG_ENDOCYTIC_2	632	635	PF00928	0.357
TRG_ENDOCYTIC_2	742	745	PF00928	0.480
TRG_ER_diArg_1	347	349	PF00400	0.357
TRG_ER_diArg_1	739	741	PF00400	0.614
TRG_NES_CRM1_1	205	218	PF08389	0.466
TRG_NES_CRM1_1	425	440	PF08389	0.381
TRG_NLS_Bipartite_1	35	57	PF00514	0.357
TRG_NLS_MonoExtN_4	51	57	PF00514	0.357
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G0	Leptomonas seymouri	92%	99%
A0A0N0P6J4	Leptomonas seymouri	45%	100%
A0A0S4IKL1	Bodo saltans	30%	100%
A0A0S4IMC7	Bodo saltans	53%	100%
A0A0S4JAU3	Bodo saltans	44%	100%
A0A0S4JI00	Bodo saltans	73%	100%
A0A1X0P433	Trypanosomatidae	45%	100%
A0A1X0P870	Trypanosomatidae	85%	100%
A0A1X0PA10	Trypanosomatidae	29%	86%
A0A3Q8IQP5	Leishmania donovani	99%	100%
A0A3R7M308	Trypanosoma rangeli	33%	100%
A0A3R7M9L0	Trypanosoma rangeli	85%	100%
A0A3R7MK02	Trypanosoma rangeli	30%	100%
A0A3S7X0L3	Leishmania donovani	45%	100%
A0A422MWE3	Trypanosoma rangeli	44%	100%
A4HFM9	Leishmania braziliensis	45%	100%
A4HNZ5	Leishmania braziliensis	96%	100%
A4I2Q7	Leishmania infantum	45%	100%
A4ICJ9	Leishmania infantum	96%	100%
A7YSY2	Bos taurus	39%	100%
C9ZR48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
D0A2X0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
D0A5V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D4A2B7	Rattus norvegicus	37%	100%
E9AD83	Leishmania major	46%	100%
E9ASQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AZ07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
G1X4S3	Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)	36%	66%
O05209	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	51%	100%
O13764	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	83%
O14325	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O15381	Homo sapiens	42%	92%
O28972	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	48%	100%
O60058	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	97%
P03974	Sus scrofa	74%	97%
P23787	Xenopus laevis	74%	97%
P25694	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	64%	94%
P32794	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P46462	Rattus norvegicus	74%	97%
P46463	Komagataella pastoris	31%	68%
P54609	Arabidopsis thaliana	71%	97%
P54774	Glycine max	71%	97%
P54777	Rattus norvegicus	35%	80%
P54811	Caenorhabditis elegans	69%	97%
P54812	Caenorhabditis elegans	71%	97%
P55072	Homo sapiens	74%	97%
Q01853	Mus musculus	74%	97%
Q07590	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	44%	100%
Q07844	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	94%
Q13608	Homo sapiens	35%	80%
Q3UMC0	Mus musculus	48%	88%
Q3ZBT1	Bos taurus	74%	97%
Q54SY2	Dictyostelium discoideum	42%	90%
Q58556	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	49%	87%
Q5AWS6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	67%	95%
Q6CPV1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	34%	78%
Q6GL04	Xenopus tropicalis	74%	97%
Q74Z13	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	33%	77%
Q7KN62	Drosophila melanogaster	71%	98%
Q7ZU99	Danio rerio	74%	97%
Q8NB90	Homo sapiens	49%	88%
Q8RY16	Arabidopsis thaliana	33%	83%
Q8SSJ5	Encephalitozoon cuniculi (strain GB-M1)	59%	100%
Q96372	Capsicum annuum	72%	97%
Q99LC9	Mus musculus	35%	80%
Q9DBY8	Mus musculus	41%	92%
Q9HPF0	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	42%	100%
Q9LZF6	Arabidopsis thaliana	73%	97%
Q9M0Y8	Arabidopsis thaliana	27%	100%
Q9NAG4	Caenorhabditis elegans	36%	96%
Q9P3A7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	65%	96%
Q9SCN8	Arabidopsis thaliana	70%	96%
Q9SS94	Arabidopsis thaliana	43%	96%
V5BD45	Trypanosoma cruzi	44%	100%
V5BKY8	Trypanosoma cruzi	27%	100%