PUL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1T8_LEIMA

TriTrypDb:

LmjF.36.1380 , LMJLV39_360019700 , LMJSD75_360019700

Length:

618

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.587
CLV_NRD_NRD_1	18	20	PF00675	0.528
CLV_NRD_NRD_1	25	27	PF00675	0.520
CLV_NRD_NRD_1	54	56	PF00675	0.451
CLV_PCSK_FUR_1	16	20	PF00082	0.466
CLV_PCSK_KEX2_1	18	20	PF00082	0.528
CLV_PCSK_KEX2_1	238	240	PF00082	0.387
CLV_PCSK_KEX2_1	25	27	PF00082	0.520
CLV_PCSK_KEX2_1	53	55	PF00082	0.454
CLV_PCSK_KEX2_1	65	67	PF00082	0.598
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.387
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.456
CLV_PCSK_SKI1_1	299	303	PF00082	0.344
CLV_PCSK_SKI1_1	459	463	PF00082	0.444
CLV_PCSK_SKI1_1	479	483	PF00082	0.250
CLV_PCSK_SKI1_1	517	521	PF00082	0.488
CLV_Separin_Metazoa	242	246	PF03568	0.343
DEG_APCC_DBOX_1	44	52	PF00400	0.441
DEG_APCC_DBOX_1	605	613	PF00400	0.371
DEG_SPOP_SBC_1	68	72	PF00917	0.566
DOC_ANK_TNKS_1	280	287	PF00023	0.493
DOC_CYCLIN_RxL_1	14	23	PF00134	0.467
DOC_CYCLIN_RxL_1	287	296	PF00134	0.445
DOC_MAPK_gen_1	132	140	PF00069	0.389
DOC_MAPK_gen_1	245	252	PF00069	0.432
DOC_MAPK_gen_1	515	524	PF00069	0.396
DOC_MAPK_MEF2A_6	132	140	PF00069	0.389
DOC_MAPK_MEF2A_6	517	526	PF00069	0.522
DOC_MAPK_MEF2A_6	600	609	PF00069	0.409
DOC_PP1_RVXF_1	16	23	PF00149	0.506
DOC_USP7_MATH_1	115	119	PF00917	0.502
DOC_USP7_MATH_1	550	554	PF00917	0.472
DOC_USP7_MATH_1	61	65	PF00917	0.669
DOC_USP7_MATH_1	68	72	PF00917	0.643
DOC_WW_Pin1_4	168	173	PF00397	0.400
DOC_WW_Pin1_4	20	25	PF00397	0.495
DOC_WW_Pin1_4	543	548	PF00397	0.584
LIG_14-3-3_CanoR_1	119	127	PF00244	0.417
LIG_14-3-3_CanoR_1	18	23	PF00244	0.540
LIG_14-3-3_CanoR_1	231	240	PF00244	0.371
LIG_14-3-3_CanoR_1	247	253	PF00244	0.328
LIG_14-3-3_CanoR_1	29	38	PF00244	0.537
LIG_14-3-3_CanoR_1	290	295	PF00244	0.397
LIG_14-3-3_CanoR_1	45	49	PF00244	0.507
LIG_14-3-3_CanoR_1	606	610	PF00244	0.391
LIG_deltaCOP1_diTrp_1	318	324	PF00928	0.378
LIG_EH1_1	555	563	PF00400	0.456
LIG_eIF4E_1	556	562	PF01652	0.422
LIG_FHA_1	119	125	PF00498	0.445
LIG_FHA_1	202	208	PF00498	0.663
LIG_FHA_1	26	32	PF00498	0.611
LIG_FHA_1	321	327	PF00498	0.349
LIG_FHA_1	329	335	PF00498	0.333
LIG_FHA_1	348	354	PF00498	0.255
LIG_FHA_1	507	513	PF00498	0.369
LIG_FHA_1	536	542	PF00498	0.503
LIG_FHA_1	68	74	PF00498	0.633
LIG_FHA_2	124	130	PF00498	0.515
LIG_FHA_2	314	320	PF00498	0.453
LIG_FHA_2	416	422	PF00498	0.399
LIG_FHA_2	429	435	PF00498	0.407
LIG_IRF3_LxIS_1	602	608	PF10401	0.455
LIG_LIR_Gen_1	154	165	PF02991	0.342
LIG_LIR_Gen_1	224	234	PF02991	0.529
LIG_LIR_Gen_1	314	325	PF02991	0.369
LIG_LIR_Gen_1	483	491	PF02991	0.343
LIG_LIR_Nem_3	154	160	PF02991	0.338
LIG_LIR_Nem_3	224	230	PF02991	0.545
LIG_LIR_Nem_3	314	320	PF02991	0.407
LIG_LIR_Nem_3	434	438	PF02991	0.357
LIG_LIR_Nem_3	483	488	PF02991	0.330
LIG_LIR_Nem_3	567	571	PF02991	0.462
LIG_LYPXL_S_1	464	468	PF13949	0.449
LIG_NRBOX	556	562	PF00104	0.364
LIG_NRBOX	570	576	PF00104	0.343
LIG_Pex14_1	321	325	PF04695	0.338
LIG_Pex14_2	317	321	PF04695	0.333
LIG_Pex14_2	480	484	PF04695	0.294
LIG_Rb_LxCxE_1	156	171	PF01857	0.431
LIG_SH2_CRK	157	161	PF00017	0.314
LIG_SH2_NCK_1	549	553	PF00017	0.401
LIG_SH2_STAT3	234	237	PF00017	0.558
LIG_SH2_STAT5	146	149	PF00017	0.375
LIG_SH2_STAT5	157	160	PF00017	0.273
LIG_SH2_STAT5	234	237	PF00017	0.543
LIG_SH2_STAT5	325	328	PF00017	0.363
LIG_SH2_STAT5	556	559	PF00017	0.420
LIG_SH3_3	191	197	PF00018	0.340
LIG_SH3_3	227	233	PF00018	0.603
LIG_SH3_3	302	308	PF00018	0.464
LIG_SH3_5	153	157	PF00018	0.360
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.349
LIG_SUMO_SIM_anti_2	293	299	PF11976	0.456
LIG_SUMO_SIM_anti_2	418	425	PF11976	0.426
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.522
LIG_SUMO_SIM_par_1	189	195	PF11976	0.491
LIG_SUMO_SIM_par_1	290	296	PF11976	0.285
LIG_SUMO_SIM_par_1	418	425	PF11976	0.380
LIG_SxIP_EBH_1	107	119	PF03271	0.370
LIG_TRAF2_1	161	164	PF00917	0.437
LIG_TRAF2_1	184	187	PF00917	0.581
LIG_TYR_ITIM	566	571	PF00017	0.455
LIG_UBA3_1	291	299	PF00899	0.442
LIG_UBA3_1	333	341	PF00899	0.449
LIG_UBA3_1	560	569	PF00899	0.396
LIG_WRC_WIRS_1	124	129	PF05994	0.501
MOD_CDC14_SPxK_1	23	26	PF00782	0.491
MOD_CDK_SPK_2	20	25	PF00069	0.487
MOD_CDK_SPxK_1	20	26	PF00069	0.488
MOD_CK1_1	118	124	PF00069	0.445
MOD_CK1_1	217	223	PF00069	0.678
MOD_CK1_1	255	261	PF00069	0.460
MOD_CK1_1	293	299	PF00069	0.385
MOD_CK1_1	365	371	PF00069	0.479
MOD_CK1_1	380	386	PF00069	0.497
MOD_CK1_1	71	77	PF00069	0.536
MOD_CK2_1	123	129	PF00069	0.469
MOD_CK2_1	158	164	PF00069	0.508
MOD_CK2_1	380	386	PF00069	0.353
MOD_CK2_1	397	403	PF00069	0.343
MOD_CK2_1	428	434	PF00069	0.398
MOD_CMANNOS	321	324	PF00535	0.377
MOD_GlcNHglycan	109	112	PF01048	0.365
MOD_GlcNHglycan	133	136	PF01048	0.580
MOD_GlcNHglycan	219	222	PF01048	0.675
MOD_GlcNHglycan	390	393	PF01048	0.358
MOD_GlcNHglycan	576	579	PF01048	0.451
MOD_GlcNHglycan	97	100	PF01048	0.488
MOD_GSK3_1	109	116	PF00069	0.561
MOD_GSK3_1	14	21	PF00069	0.505
MOD_GSK3_1	211	218	PF00069	0.696
MOD_GSK3_1	248	255	PF00069	0.403
MOD_GSK3_1	25	32	PF00069	0.501
MOD_GSK3_1	320	327	PF00069	0.448
MOD_GSK3_1	377	384	PF00069	0.508
MOD_GSK3_1	480	487	PF00069	0.324
MOD_GSK3_1	570	577	PF00069	0.364
MOD_GSK3_1	67	74	PF00069	0.622
MOD_N-GLC_1	168	173	PF02516	0.400
MOD_N-GLC_1	248	253	PF02516	0.371
MOD_N-GLC_1	255	260	PF02516	0.399
MOD_N-GLC_1	377	382	PF02516	0.487
MOD_N-GLC_1	397	402	PF02516	0.202
MOD_N-GLC_1	428	433	PF02516	0.476
MOD_N-GLC_1	450	455	PF02516	0.433
MOD_N-GLC_1	92	97	PF02516	0.502
MOD_NEK2_1	106	111	PF00069	0.348
MOD_NEK2_1	128	133	PF00069	0.464
MOD_NEK2_1	175	180	PF00069	0.309
MOD_NEK2_1	215	220	PF00069	0.618
MOD_NEK2_1	252	257	PF00069	0.498
MOD_NEK2_1	362	367	PF00069	0.397
MOD_NEK2_1	388	393	PF00069	0.348
MOD_NEK2_1	471	476	PF00069	0.387
MOD_NEK2_1	480	485	PF00069	0.322
MOD_NEK2_1	541	546	PF00069	0.319
MOD_NEK2_1	574	579	PF00069	0.422
MOD_NEK2_1	605	610	PF00069	0.349
MOD_NEK2_1	612	617	PF00069	0.365
MOD_NEK2_1	69	74	PF00069	0.574
MOD_PIKK_1	113	119	PF00454	0.386
MOD_PIKK_1	275	281	PF00454	0.376
MOD_PKA_1	18	24	PF00069	0.502
MOD_PKA_1	25	31	PF00069	0.501
MOD_PKA_2	118	124	PF00069	0.442
MOD_PKA_2	18	24	PF00069	0.514
MOD_PKA_2	25	31	PF00069	0.489
MOD_PKA_2	44	50	PF00069	0.472
MOD_PKA_2	471	477	PF00069	0.465
MOD_PKA_2	605	611	PF00069	0.395
MOD_PKA_2	61	67	PF00069	0.475
MOD_PKA_2	89	95	PF00069	0.421
MOD_PKB_1	16	24	PF00069	0.475
MOD_PKB_1	53	61	PF00069	0.482
MOD_Plk_1	248	254	PF00069	0.377
MOD_Plk_1	313	319	PF00069	0.418
MOD_Plk_1	328	334	PF00069	0.273
MOD_Plk_1	377	383	PF00069	0.487
MOD_Plk_1	397	403	PF00069	0.206
MOD_Plk_1	428	434	PF00069	0.446
MOD_Plk_1	92	98	PF00069	0.525
MOD_Plk_2-3	313	319	PF00069	0.513
MOD_Plk_4	123	129	PF00069	0.497
MOD_Plk_4	248	254	PF00069	0.575
MOD_Plk_4	290	296	PF00069	0.361
MOD_Plk_4	320	326	PF00069	0.351
MOD_Plk_4	377	383	PF00069	0.449
MOD_Plk_4	406	412	PF00069	0.447
MOD_Plk_4	415	421	PF00069	0.364
MOD_Plk_4	428	434	PF00069	0.407
MOD_Plk_4	471	477	PF00069	0.352
MOD_Plk_4	480	486	PF00069	0.314
MOD_Plk_4	552	558	PF00069	0.274
MOD_Plk_4	570	576	PF00069	0.344
MOD_ProDKin_1	168	174	PF00069	0.405
MOD_ProDKin_1	20	26	PF00069	0.496
MOD_ProDKin_1	543	549	PF00069	0.587
MOD_SUMO_for_1	411	414	PF00179	0.556
MOD_SUMO_rev_2	380	389	PF00179	0.360
TRG_DiLeu_BaEn_1	269	274	PF01217	0.476
TRG_DiLeu_BaEn_4	163	169	PF01217	0.482
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.418
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.264
TRG_DiLeu_LyEn_5	163	168	PF01217	0.363
TRG_ENDOCYTIC_2	157	160	PF00928	0.309
TRG_ENDOCYTIC_2	465	468	PF00928	0.452
TRG_ENDOCYTIC_2	568	571	PF00928	0.345
TRG_ER_diArg_1	15	18	PF00400	0.517
TRG_ER_diArg_1	24	26	PF00400	0.521
TRG_ER_diArg_1	244	247	PF00400	0.354
TRG_ER_diArg_1	53	55	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E7	Leptomonas seymouri	68%	100%
A0A0S4JC36	Bodo saltans	40%	100%
A0A1X0P7Z1	Trypanosomatidae	44%	100%
A0A3Q8IIW2	Leishmania donovani	95%	100%
A0A422MZU5	Trypanosoma rangeli	46%	100%
A4HNZ3	Leishmania braziliensis	79%	100%
A4HNZ7	Leishmania braziliensis	79%	100%
A4ICJ8	Leishmania infantum	92%	100%
D0A2X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ASQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
V5BU60	Trypanosoma cruzi	46%	100%