Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

The ARF-like 2 binding protein BART, putative

Species:

Leishmania major

UniProt:

Q4Q1T6_LEIMA

TriTrypDb:

LmjF.36.1400 , LMJLV39_360020100 , LMJSD75_360020100

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005930	axoneme	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0097546	ciliary base	2	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

Q4Q1T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.444
CLV_NRD_NRD_1	178	180	PF00675	0.587
CLV_NRD_NRD_1	197	199	PF00675	0.385
CLV_NRD_NRD_1	428	430	PF00675	0.484
CLV_NRD_NRD_1	438	440	PF00675	0.607
CLV_PCSK_KEX2_1	120	122	PF00082	0.290
CLV_PCSK_KEX2_1	178	180	PF00082	0.610
CLV_PCSK_KEX2_1	370	372	PF00082	0.642
CLV_PCSK_KEX2_1	428	430	PF00082	0.484
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.325
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.675
CLV_PCSK_SKI1_1	5	9	PF00082	0.386
CLV_PCSK_SKI1_1	99	103	PF00082	0.361
DEG_SCF_FBW7_1	353	360	PF00400	0.648
DOC_CKS1_1	20	25	PF01111	0.482
DOC_CYCLIN_RxL_1	115	126	PF00134	0.556
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.549
DOC_MAPK_gen_1	120	127	PF00069	0.488
DOC_MAPK_gen_1	158	167	PF00069	0.452
DOC_MAPK_gen_1	178	185	PF00069	0.618
DOC_MAPK_MEF2A_6	120	127	PF00069	0.496
DOC_MAPK_MEF2A_6	178	185	PF00069	0.578
DOC_MAPK_NFAT4_5	120	128	PF00069	0.496
DOC_PP2B_LxvP_1	296	299	PF13499	0.553
DOC_PP4_FxxP_1	284	287	PF00568	0.726
DOC_USP7_MATH_1	132	136	PF00917	0.573
DOC_USP7_MATH_1	300	304	PF00917	0.685
DOC_USP7_MATH_1	314	318	PF00917	0.699
DOC_USP7_MATH_1	324	328	PF00917	0.625
DOC_USP7_MATH_1	418	422	PF00917	0.557
DOC_USP7_MATH_1	438	442	PF00917	0.459
DOC_USP7_MATH_1	77	81	PF00917	0.570
DOC_USP7_UBL2_3	99	103	PF12436	0.591
DOC_WW_Pin1_4	14	19	PF00397	0.482
DOC_WW_Pin1_4	283	288	PF00397	0.745
DOC_WW_Pin1_4	353	358	PF00397	0.677
LIG_14-3-3_CanoR_1	5	14	PF00244	0.586
LIG_14-3-3_CterR_2	439	443	PF00244	0.761
LIG_Actin_WH2_2	164	180	PF00022	0.566
LIG_Actin_WH2_2	325	340	PF00022	0.539
LIG_FHA_1	114	120	PF00498	0.553
LIG_FHA_1	146	152	PF00498	0.614
LIG_FHA_1	331	337	PF00498	0.735
LIG_FHA_1	421	427	PF00498	0.488
LIG_FHA_1	59	65	PF00498	0.482
LIG_FHA_1	6	12	PF00498	0.534
LIG_FHA_2	20	26	PF00498	0.513
LIG_FHA_2	209	215	PF00498	0.570
LIG_FHA_2	362	368	PF00498	0.598
LIG_FHA_2	71	77	PF00498	0.521
LIG_GBD_Chelix_1	426	434	PF00786	0.566
LIG_Integrin_RGD_1	431	433	PF01839	0.630
LIG_LIR_Apic_2	17	23	PF02991	0.471
LIG_LIR_Gen_1	109	119	PF02991	0.502
LIG_LIR_Nem_3	109	114	PF02991	0.485
LIG_PCNA_PIPBox_1	391	400	PF02747	0.641
LIG_PCNA_yPIPBox_3	385	398	PF02747	0.623
LIG_PTAP_UEV_1	340	345	PF05743	0.704
LIG_SH2_STAT5	45	48	PF00017	0.534
LIG_SH3_1	338	344	PF00018	0.707
LIG_SH3_3	284	290	PF00018	0.696
LIG_SH3_3	303	309	PF00018	0.677
LIG_SH3_3	310	316	PF00018	0.715
LIG_SH3_3	323	329	PF00018	0.612
LIG_SH3_3	338	344	PF00018	0.542
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.599
LIG_SxIP_EBH_1	355	365	PF03271	0.522
LIG_TRAF2_1	147	150	PF00917	0.584
LIG_TRAF2_1	364	367	PF00917	0.586
LIG_TRAF2_1	389	392	PF00917	0.583
LIG_WRC_WIRS_1	394	399	PF05994	0.639
MOD_CK1_1	286	292	PF00069	0.729
MOD_CK1_1	327	333	PF00069	0.689
MOD_CK1_1	339	345	PF00069	0.715
MOD_CK1_1	36	42	PF00069	0.559
MOD_CK1_1	402	408	PF00069	0.637
MOD_CK1_1	58	64	PF00069	0.583
MOD_CK1_1	70	76	PF00069	0.523
MOD_CK1_1	85	91	PF00069	0.520
MOD_CK2_1	144	150	PF00069	0.607
MOD_CK2_1	208	214	PF00069	0.544
MOD_CK2_1	361	367	PF00069	0.607
MOD_CK2_1	386	392	PF00069	0.586
MOD_CK2_1	70	76	PF00069	0.530
MOD_GlcNHglycan	14	17	PF01048	0.386
MOD_GlcNHglycan	231	234	PF01048	0.643
MOD_GlcNHglycan	266	269	PF01048	0.523
MOD_GlcNHglycan	302	305	PF01048	0.690
MOD_GlcNHglycan	338	341	PF01048	0.767
MOD_GlcNHglycan	353	356	PF01048	0.770
MOD_GlcNHglycan	409	412	PF01048	0.747
MOD_GSK3_1	1	8	PF00069	0.459
MOD_GSK3_1	109	116	PF00069	0.546
MOD_GSK3_1	324	331	PF00069	0.666
MOD_GSK3_1	332	339	PF00069	0.726
MOD_GSK3_1	353	360	PF00069	0.765
MOD_GSK3_1	399	406	PF00069	0.640
MOD_GSK3_1	78	85	PF00069	0.565
MOD_GSK3_1	86	93	PF00069	0.531
MOD_N-GLC_1	109	114	PF02516	0.350
MOD_N-GLC_1	36	41	PF02516	0.389
MOD_N-GLC_1	399	404	PF02516	0.648
MOD_N-GLC_2	31	33	PF02516	0.362
MOD_NEK2_1	1	6	PF00069	0.447
MOD_NEK2_1	208	213	PF00069	0.389
MOD_NEK2_1	413	418	PF00069	0.722
MOD_NEK2_1	43	48	PF00069	0.525
MOD_NEK2_1	55	60	PF00069	0.471
MOD_NEK2_1	78	83	PF00069	0.595
MOD_PIKK_1	227	233	PF00454	0.619
MOD_PIKK_1	253	259	PF00454	0.580
MOD_PKA_2	386	392	PF00069	0.586
MOD_Plk_1	109	115	PF00069	0.549
MOD_Plk_1	181	187	PF00069	0.525
MOD_Plk_1	43	49	PF00069	0.518
MOD_Plk_4	113	119	PF00069	0.528
MOD_Plk_4	332	338	PF00069	0.605
MOD_Plk_4	393	399	PF00069	0.639
MOD_Plk_4	55	61	PF00069	0.498
MOD_ProDKin_1	14	20	PF00069	0.482
MOD_ProDKin_1	283	289	PF00069	0.742
MOD_ProDKin_1	353	359	PF00069	0.674
TRG_ER_diArg_1	158	161	PF00400	0.467
TRG_ER_diArg_1	177	179	PF00400	0.598
TRG_ER_diArg_1	428	431	PF00400	0.488
TRG_NES_CRM1_1	57	72	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F6	Leptomonas seymouri	50%	100%
A0A0S4JFM0	Bodo saltans	29%	99%
A0A1X0P8V3	Trypanosomatidae	32%	100%
A0A3R7MMF8	Trypanosoma rangeli	30%	100%
A0A3S7XAM0	Leishmania donovani	87%	98%
A4HP00	Leishmania braziliensis	68%	98%
A4ICJ6	Leishmania infantum	87%	98%
E9ASR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5DL00	Trypanosoma cruzi	33%	100%