RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted RanGDP binding protein

Species:

Leishmania major

UniProt:

Q4Q1T5_LEIMA

TriTrypDb:

LmjF.36.1410 , LMJLV39_360020200 , LMJSD75_360020200

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.636
CLV_C14_Caspase3-7	427	431	PF00656	0.501
CLV_C14_Caspase3-7	547	551	PF00656	0.498
CLV_C14_Caspase3-7	887	891	PF00656	0.630
CLV_NRD_NRD_1	226	228	PF00675	0.661
CLV_NRD_NRD_1	258	260	PF00675	0.509
CLV_NRD_NRD_1	386	388	PF00675	0.544
CLV_NRD_NRD_1	536	538	PF00675	0.475
CLV_NRD_NRD_1	60	62	PF00675	0.629
CLV_NRD_NRD_1	608	610	PF00675	0.526
CLV_NRD_NRD_1	623	625	PF00675	0.352
CLV_NRD_NRD_1	653	655	PF00675	0.536
CLV_NRD_NRD_1	827	829	PF00675	0.449
CLV_PCSK_KEX2_1	226	228	PF00082	0.629
CLV_PCSK_KEX2_1	386	388	PF00082	0.596
CLV_PCSK_KEX2_1	536	538	PF00082	0.475
CLV_PCSK_KEX2_1	60	62	PF00082	0.629
CLV_PCSK_KEX2_1	623	625	PF00082	0.457
CLV_PCSK_KEX2_1	653	655	PF00082	0.433
CLV_PCSK_KEX2_1	826	828	PF00082	0.377
CLV_PCSK_SKI1_1	270	274	PF00082	0.649
CLV_PCSK_SKI1_1	345	349	PF00082	0.594
CLV_PCSK_SKI1_1	465	469	PF00082	0.530
CLV_PCSK_SKI1_1	516	520	PF00082	0.511
CLV_PCSK_SKI1_1	537	541	PF00082	0.454
CLV_PCSK_SKI1_1	609	613	PF00082	0.521
CLV_PCSK_SKI1_1	745	749	PF00082	0.482
CLV_PCSK_SKI1_1	75	79	PF00082	0.727
DEG_APCC_DBOX_1	60	68	PF00400	0.718
DEG_APCC_DBOX_1	724	732	PF00400	0.470
DEG_APCC_DBOX_1	825	833	PF00400	0.508
DEG_SCF_FBW7_1	436	442	PF00400	0.646
DEG_SCF_FBW7_1	681	688	PF00400	0.483
DEG_SCF_FBW7_1	770	777	PF00400	0.422
DEG_SPOP_SBC_1	107	111	PF00917	0.674
DEG_SPOP_SBC_1	700	704	PF00917	0.496
DOC_ANK_TNKS_1	877	884	PF00023	0.468
DOC_CKS1_1	436	441	PF01111	0.650
DOC_CKS1_1	682	687	PF01111	0.485
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.465
DOC_MAPK_DCC_7	169	178	PF00069	0.524
DOC_MAPK_gen_1	840	849	PF00069	0.498
DOC_MAPK_JIP1_4	22	28	PF00069	0.475
DOC_MAPK_MEF2A_6	169	178	PF00069	0.524
DOC_MAPK_MEF2A_6	50	59	PF00069	0.583
DOC_PP1_RVXF_1	234	241	PF00149	0.515
DOC_PP1_RVXF_1	355	362	PF00149	0.538
DOC_PP1_RVXF_1	535	542	PF00149	0.467
DOC_PP1_RVXF_1	727	734	PF00149	0.459
DOC_PP2B_LxvP_1	28	31	PF13499	0.465
DOC_PP2B_LxvP_1	67	70	PF13499	0.725
DOC_USP7_MATH_1	108	112	PF00917	0.645
DOC_USP7_MATH_1	177	181	PF00917	0.762
DOC_USP7_MATH_1	205	209	PF00917	0.603
DOC_USP7_MATH_1	265	269	PF00917	0.644
DOC_USP7_MATH_1	309	313	PF00917	0.463
DOC_USP7_MATH_1	337	341	PF00917	0.393
DOC_USP7_MATH_1	34	38	PF00917	0.480
DOC_USP7_MATH_1	417	421	PF00917	0.599
DOC_USP7_MATH_1	477	481	PF00917	0.714
DOC_USP7_MATH_1	565	569	PF00917	0.578
DOC_USP7_MATH_1	577	581	PF00917	0.689
DOC_USP7_MATH_1	701	705	PF00917	0.568
DOC_WW_Pin1_4	143	148	PF00397	0.687
DOC_WW_Pin1_4	195	200	PF00397	0.733
DOC_WW_Pin1_4	435	440	PF00397	0.615
DOC_WW_Pin1_4	497	502	PF00397	0.720
DOC_WW_Pin1_4	503	508	PF00397	0.716
DOC_WW_Pin1_4	566	571	PF00397	0.643
DOC_WW_Pin1_4	573	578	PF00397	0.733
DOC_WW_Pin1_4	681	686	PF00397	0.582
DOC_WW_Pin1_4	770	775	PF00397	0.540
DOC_WW_Pin1_4	842	847	PF00397	0.446
DOC_WW_Pin1_4	86	91	PF00397	0.689
LIG_14-3-3_CanoR_1	33	39	PF00244	0.742
LIG_14-3-3_CanoR_1	345	354	PF00244	0.577
LIG_14-3-3_CanoR_1	396	403	PF00244	0.565
LIG_14-3-3_CanoR_1	536	542	PF00244	0.522
LIG_14-3-3_CanoR_1	564	570	PF00244	0.482
LIG_14-3-3_CanoR_1	63	68	PF00244	0.618
LIG_14-3-3_CanoR_1	691	696	PF00244	0.649
LIG_14-3-3_CanoR_1	852	856	PF00244	0.388
LIG_BIR_III_2	890	894	PF00653	0.528
LIG_deltaCOP1_diTrp_1	523	529	PF00928	0.425
LIG_eIF4E_1	39	45	PF01652	0.567
LIG_EVH1_1	436	440	PF00568	0.587
LIG_FHA_1	108	114	PF00498	0.660
LIG_FHA_1	204	210	PF00498	0.709
LIG_FHA_1	282	288	PF00498	0.598
LIG_FHA_1	436	442	PF00498	0.695
LIG_FHA_1	447	453	PF00498	0.645
LIG_FHA_1	469	475	PF00498	0.564
LIG_FHA_1	528	534	PF00498	0.472
LIG_FHA_1	770	776	PF00498	0.550
LIG_FHA_1	816	822	PF00498	0.311
LIG_FHA_1	875	881	PF00498	0.581
LIG_FHA_2	114	120	PF00498	0.516
LIG_FHA_2	425	431	PF00498	0.639
LIG_FHA_2	538	544	PF00498	0.569
LIG_FHA_2	659	665	PF00498	0.512
LIG_FHA_2	685	691	PF00498	0.570
LIG_FHA_2	692	698	PF00498	0.535
LIG_FHA_2	843	849	PF00498	0.395
LIG_LIR_Apic_2	333	337	PF02991	0.514
LIG_LIR_Apic_2	600	606	PF02991	0.405
LIG_LIR_Gen_1	247	256	PF02991	0.518
LIG_LIR_Gen_1	540	546	PF02991	0.522
LIG_LIR_Nem_3	220	225	PF02991	0.586
LIG_LIR_Nem_3	247	251	PF02991	0.453
LIG_LIR_Nem_3	271	276	PF02991	0.565
LIG_LIR_Nem_3	523	529	PF02991	0.595
LIG_LIR_Nem_3	540	544	PF02991	0.374
LIG_PDZ_Class_2	898	903	PF00595	0.652
LIG_Pex14_1	603	607	PF04695	0.443
LIG_Pex14_1	73	77	PF04695	0.612
LIG_PTB_Apo_2	369	376	PF02174	0.548
LIG_Rb_LxCxE_1	643	666	PF01857	0.476
LIG_SH2_CRK	248	252	PF00017	0.486
LIG_SH2_GRB2like	390	393	PF00017	0.591
LIG_SH2_SRC	39	42	PF00017	0.601
LIG_SH2_STAP1	390	394	PF00017	0.590
LIG_SH2_STAT5	607	610	PF00017	0.461
LIG_SH2_STAT5	855	858	PF00017	0.563
LIG_SH3_1	50	56	PF00018	0.579
LIG_SH3_3	167	173	PF00018	0.621
LIG_SH3_3	277	283	PF00018	0.443
LIG_SH3_3	434	440	PF00018	0.616
LIG_SH3_3	498	504	PF00018	0.777
LIG_SH3_3	50	56	PF00018	0.667
LIG_SH3_3	571	577	PF00018	0.570
LIG_SH3_3	590	596	PF00018	0.459
LIG_SH3_3	679	685	PF00018	0.452
LIG_SUMO_SIM_anti_2	591	596	PF11976	0.616
LIG_SUMO_SIM_anti_2	868	877	PF11976	0.515
LIG_SUMO_SIM_par_1	580	588	PF11976	0.473
LIG_SUMO_SIM_par_1	844	851	PF11976	0.435
LIG_TRAF2_1	661	664	PF00917	0.452
LIG_TRAF2_1	90	93	PF00917	0.636
LIG_UBA3_1	1	6	PF00899	0.452
MOD_CDC14_SPxK_1	198	201	PF00782	0.596
MOD_CDK_SPxK_1	195	201	PF00069	0.750
MOD_CK1_1	109	115	PF00069	0.669
MOD_CK1_1	127	133	PF00069	0.514
MOD_CK1_1	180	186	PF00069	0.659
MOD_CK1_1	212	218	PF00069	0.547
MOD_CK1_1	250	256	PF00069	0.594
MOD_CK1_1	264	270	PF00069	0.506
MOD_CK1_1	502	508	PF00069	0.683
MOD_CK1_1	566	572	PF00069	0.608
MOD_CK1_1	696	702	PF00069	0.579
MOD_CK1_1	79	85	PF00069	0.727
MOD_CK1_1	815	821	PF00069	0.462
MOD_CK1_1	831	837	PF00069	0.388
MOD_CK1_1	869	875	PF00069	0.561
MOD_CK2_1	658	664	PF00069	0.522
MOD_CK2_1	774	780	PF00069	0.417
MOD_CK2_1	862	868	PF00069	0.537
MOD_GlcNHglycan	181	185	PF01048	0.660
MOD_GlcNHglycan	194	198	PF01048	0.582
MOD_GlcNHglycan	242	245	PF01048	0.501
MOD_GlcNHglycan	254	257	PF01048	0.571
MOD_GlcNHglycan	262	266	PF01048	0.534
MOD_GlcNHglycan	270	273	PF01048	0.618
MOD_GlcNHglycan	300	303	PF01048	0.690
MOD_GlcNHglycan	367	370	PF01048	0.490
MOD_GlcNHglycan	443	446	PF01048	0.707
MOD_GlcNHglycan	457	460	PF01048	0.734
MOD_GlcNHglycan	479	482	PF01048	0.650
MOD_GlcNHglycan	565	568	PF01048	0.643
MOD_GlcNHglycan	697	701	PF01048	0.594
MOD_GlcNHglycan	710	713	PF01048	0.576
MOD_GlcNHglycan	776	779	PF01048	0.368
MOD_GlcNHglycan	83	87	PF01048	0.693
MOD_GlcNHglycan	856	859	PF01048	0.520
MOD_GSK3_1	109	116	PF00069	0.601
MOD_GSK3_1	127	134	PF00069	0.516
MOD_GSK3_1	135	142	PF00069	0.734
MOD_GSK3_1	203	210	PF00069	0.633
MOD_GSK3_1	240	247	PF00069	0.485
MOD_GSK3_1	261	268	PF00069	0.434
MOD_GSK3_1	291	298	PF00069	0.567
MOD_GSK3_1	345	352	PF00069	0.539
MOD_GSK3_1	435	442	PF00069	0.640
MOD_GSK3_1	477	484	PF00069	0.587
MOD_GSK3_1	495	502	PF00069	0.645
MOD_GSK3_1	565	572	PF00069	0.619
MOD_GSK3_1	573	580	PF00069	0.590
MOD_GSK3_1	681	688	PF00069	0.574
MOD_GSK3_1	696	703	PF00069	0.550
MOD_GSK3_1	75	82	PF00069	0.673
MOD_GSK3_1	770	777	PF00069	0.417
MOD_GSK3_1	796	803	PF00069	0.488
MOD_GSK3_1	828	835	PF00069	0.492
MOD_GSK3_1	862	869	PF00069	0.434
MOD_LATS_1	535	541	PF00433	0.443
MOD_N-GLC_1	289	294	PF02516	0.597
MOD_N-GLC_1	537	542	PF02516	0.529
MOD_N-GLC_1	812	817	PF02516	0.413
MOD_N-GLC_1	884	889	PF02516	0.521
MOD_N-GLC_2	322	324	PF02516	0.384
MOD_NEK2_1	251	256	PF00069	0.622
MOD_NEK2_1	359	364	PF00069	0.581
MOD_NEK2_1	370	375	PF00069	0.538
MOD_NEK2_1	410	415	PF00069	0.451
MOD_NEK2_1	441	446	PF00069	0.771
MOD_NEK2_1	461	466	PF00069	0.679
MOD_NEK2_1	5	10	PF00069	0.474
MOD_NEK2_1	563	568	PF00069	0.580
MOD_NEK2_1	716	721	PF00069	0.450
MOD_NEK2_1	812	817	PF00069	0.381
MOD_NEK2_1	832	837	PF00069	0.307
MOD_NEK2_2	221	226	PF00069	0.647
MOD_NEK2_2	34	39	PF00069	0.480
MOD_PIKK_1	139	145	PF00454	0.795
MOD_PIKK_1	345	351	PF00454	0.542
MOD_PK_1	653	659	PF00069	0.503
MOD_PKA_1	653	659	PF00069	0.503
MOD_PKA_2	17	23	PF00069	0.469
MOD_PKA_2	212	218	PF00069	0.571
MOD_PKA_2	295	301	PF00069	0.605
MOD_PKA_2	395	401	PF00069	0.581
MOD_PKA_2	424	430	PF00069	0.496
MOD_PKA_2	477	483	PF00069	0.590
MOD_PKA_2	563	569	PF00069	0.495
MOD_PKA_2	653	659	PF00069	0.524
MOD_PKA_2	690	696	PF00069	0.656
MOD_PKA_2	79	85	PF00069	0.731
MOD_PKA_2	815	821	PF00069	0.435
MOD_PKA_2	851	857	PF00069	0.369
MOD_PKB_1	514	522	PF00069	0.468
MOD_PKB_1	61	69	PF00069	0.587
MOD_PKB_1	826	834	PF00069	0.515
MOD_Plk_1	261	267	PF00069	0.390
MOD_Plk_1	537	543	PF00069	0.522
MOD_Plk_1	642	648	PF00069	0.460
MOD_Plk_1	812	818	PF00069	0.545
MOD_Plk_1	867	873	PF00069	0.543
MOD_Plk_2-3	582	588	PF00069	0.468
MOD_Plk_4	34	40	PF00069	0.553
MOD_Plk_4	370	376	PF00069	0.533
MOD_Plk_4	390	396	PF00069	0.345
MOD_Plk_4	417	423	PF00069	0.531
MOD_Plk_4	463	469	PF00069	0.726
MOD_Plk_4	869	875	PF00069	0.449
MOD_ProDKin_1	143	149	PF00069	0.685
MOD_ProDKin_1	195	201	PF00069	0.733
MOD_ProDKin_1	435	441	PF00069	0.614
MOD_ProDKin_1	497	503	PF00069	0.719
MOD_ProDKin_1	566	572	PF00069	0.647
MOD_ProDKin_1	573	579	PF00069	0.734
MOD_ProDKin_1	681	687	PF00069	0.593
MOD_ProDKin_1	770	776	PF00069	0.540
MOD_ProDKin_1	842	848	PF00069	0.446
MOD_ProDKin_1	86	92	PF00069	0.683
TRG_DiLeu_BaEn_4	494	500	PF01217	0.566
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.572
TRG_ENDOCYTIC_2	248	251	PF00928	0.448
TRG_ER_diArg_1	225	227	PF00400	0.636
TRG_ER_diArg_1	514	517	PF00400	0.659
TRG_ER_diArg_1	59	61	PF00400	0.625
TRG_ER_diArg_1	722	725	PF00400	0.437
TRG_ER_diArg_1	814	817	PF00400	0.487
TRG_ER_diArg_1	826	828	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	878	882	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS2	Leptomonas seymouri	42%	100%
A0A0S4JGK3	Bodo saltans	27%	100%
A0A1X0P808	Trypanosomatidae	31%	85%
A0A3Q8IJ60	Leishmania donovani	88%	100%
A4HP01	Leishmania braziliensis	68%	100%
A4ICJ5	Leishmania infantum	88%	100%
D0A2X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	90%
E9ASR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5B4G3	Trypanosoma cruzi	31%	89%