Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1T1_LEIMA

TriTrypDb:

LmjF.36.1450 , LMJLV39_360020600 , LMJSD75_360020600

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1T1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.316
CLV_NRD_NRD_1	56	58	PF00675	0.546
CLV_PCSK_SKI1_1	141	145	PF00082	0.378
CLV_PCSK_SKI1_1	49	53	PF00082	0.413
CLV_PCSK_SKI1_1	87	91	PF00082	0.413
DOC_MAPK_gen_1	57	66	PF00069	0.350
DOC_MAPK_MEF2A_6	60	68	PF00069	0.603
DOC_USP7_MATH_1	102	106	PF00917	0.646
DOC_USP7_MATH_1	3	7	PF00917	0.669
LIG_14-3-3_CanoR_1	134	138	PF00244	0.504
LIG_14-3-3_CanoR_1	87	92	PF00244	0.423
LIG_14-3-3_CanoR_1	95	101	PF00244	0.415
LIG_APCC_ABBA_1	66	71	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BIR_III_4	130	134	PF00653	0.517
LIG_FHA_2	68	74	PF00498	0.448
LIG_LIR_Gen_1	75	85	PF02991	0.410
LIG_LIR_Nem_3	138	143	PF02991	0.382
LIG_LIR_Nem_3	31	36	PF02991	0.403
LIG_LIR_Nem_3	75	81	PF02991	0.385
LIG_NRBOX	143	149	PF00104	0.533
LIG_SH2_STAT5	23	26	PF00017	0.439
LIG_SH3_1	42	48	PF00018	0.406
LIG_SH3_3	10	16	PF00018	0.673
LIG_SH3_3	42	48	PF00018	0.406
LIG_TRAF2_1	119	122	PF00917	0.511
MOD_CK1_1	6	12	PF00069	0.726
MOD_CK1_1	67	73	PF00069	0.559
MOD_CK2_1	73	79	PF00069	0.517
MOD_GlcNHglycan	1	4	PF01048	0.715
MOD_GlcNHglycan	105	108	PF01048	0.656
MOD_GlcNHglycan	7	11	PF01048	0.651
MOD_GSK3_1	143	150	PF00069	0.544
MOD_N-GLC_1	108	113	PF02516	0.676
MOD_N-GLC_2	96	98	PF02516	0.382
MOD_NEK2_1	147	152	PF00069	0.539
MOD_NEK2_1	94	99	PF00069	0.398
MOD_PKA_2	133	139	PF00069	0.507
MOD_PKA_2	94	100	PF00069	0.419
MOD_Plk_2-3	73	79	PF00069	0.397
MOD_Plk_4	143	149	PF00069	0.491
MOD_Plk_4	64	70	PF00069	0.486
MOD_Plk_4	73	79	PF00069	0.354
MOD_SUMO_rev_2	55	65	PF00179	0.525
TRG_DiLeu_BaEn_4	61	67	PF01217	0.373
TRG_ER_diLys_1	151	155	PF00400	0.547
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.535
TRG_PTS2	1	36	PF00400	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX85	Leptomonas seymouri	65%	93%
A0A0S4JG18	Bodo saltans	52%	100%
A0A1X0P8S8	Trypanosomatidae	53%	97%
A0A3Q8IKE9	Leishmania donovani	92%	100%
A0A422NI72	Trypanosoma rangeli	53%	100%
A4HP05	Leishmania braziliensis	82%	100%
A4IDB4	Leishmania infantum	93%	100%
D0A2Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BJX8	Trypanosoma cruzi	53%	100%