Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1T0_LEIMA

TriTrypDb:

LmjF.36.1460 , LMJLV39_360020700 , LMJSD75_360020700

Length:

655

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1T0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1T0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.599
CLV_C14_Caspase3-7	345	349	PF00656	0.650
CLV_C14_Caspase3-7	436	440	PF00656	0.563
CLV_C14_Caspase3-7	71	75	PF00656	0.677
CLV_MEL_PAP_1	564	570	PF00089	0.626
CLV_NRD_NRD_1	101	103	PF00675	0.612
CLV_NRD_NRD_1	327	329	PF00675	0.803
CLV_NRD_NRD_1	425	427	PF00675	0.669
CLV_NRD_NRD_1	482	484	PF00675	0.708
CLV_NRD_NRD_1	513	515	PF00675	0.654
CLV_NRD_NRD_1	52	54	PF00675	0.718
CLV_NRD_NRD_1	558	560	PF00675	0.536
CLV_NRD_NRD_1	647	649	PF00675	0.593
CLV_PCSK_FUR_1	99	103	PF00082	0.610
CLV_PCSK_KEX2_1	101	103	PF00082	0.612
CLV_PCSK_KEX2_1	327	329	PF00082	0.793
CLV_PCSK_KEX2_1	425	427	PF00082	0.739
CLV_PCSK_KEX2_1	482	484	PF00082	0.708
CLV_PCSK_KEX2_1	513	515	PF00082	0.654
CLV_PCSK_KEX2_1	52	54	PF00082	0.711
CLV_PCSK_KEX2_1	557	559	PF00082	0.541
CLV_PCSK_KEX2_1	646	648	PF00082	0.601
CLV_PCSK_PC7_1	421	427	PF00082	0.638
CLV_PCSK_PC7_1	642	648	PF00082	0.584
CLV_PCSK_SKI1_1	13	17	PF00082	0.578
CLV_PCSK_SKI1_1	210	214	PF00082	0.722
CLV_PCSK_SKI1_1	327	331	PF00082	0.813
CLV_PCSK_SKI1_1	457	461	PF00082	0.642
CLV_PCSK_SKI1_1	513	517	PF00082	0.677
DEG_APCC_DBOX_1	392	400	PF00400	0.625
DEG_SCF_FBW7_2	458	465	PF00400	0.647
DEG_SPOP_SBC_1	198	202	PF00917	0.552
DEG_SPOP_SBC_1	252	256	PF00917	0.701
DEG_SPOP_SBC_1	409	413	PF00917	0.682
DEG_SPOP_SBC_1	518	522	PF00917	0.651
DEG_SPOP_SBC_1	78	82	PF00917	0.646
DOC_CKS1_1	459	464	PF01111	0.749
DOC_CYCLIN_RxL_1	324	334	PF00134	0.764
DOC_MAPK_DCC_7	482	492	PF00069	0.553
DOC_MAPK_HePTP_8	480	492	PF00069	0.532
DOC_MAPK_MEF2A_6	483	492	PF00069	0.553
DOC_MAPK_RevD_3	87	102	PF00069	0.593
DOC_PP1_RVXF_1	58	65	PF00149	0.690
DOC_PP2B_PxIxI_1	335	341	PF00149	0.544
DOC_PP4_FxxP_1	150	153	PF00568	0.652
DOC_PP4_FxxP_1	29	32	PF00568	0.708
DOC_PP4_FxxP_1	485	488	PF00568	0.589
DOC_PP4_FxxP_1	64	67	PF00568	0.689
DOC_USP7_MATH_1	112	116	PF00917	0.595
DOC_USP7_MATH_1	173	177	PF00917	0.675
DOC_USP7_MATH_1	197	201	PF00917	0.558
DOC_USP7_MATH_1	212	216	PF00917	0.697
DOC_USP7_MATH_1	224	228	PF00917	0.681
DOC_USP7_MATH_1	310	314	PF00917	0.579
DOC_USP7_MATH_1	33	37	PF00917	0.674
DOC_USP7_MATH_1	372	376	PF00917	0.699
DOC_USP7_MATH_1	409	413	PF00917	0.665
DOC_USP7_MATH_1	417	421	PF00917	0.647
DOC_USP7_MATH_1	563	567	PF00917	0.658
DOC_USP7_MATH_1	575	579	PF00917	0.671
DOC_USP7_MATH_1	596	600	PF00917	0.509
DOC_USP7_MATH_1	97	101	PF00917	0.557
DOC_WW_Pin1_4	162	167	PF00397	0.718
DOC_WW_Pin1_4	18	23	PF00397	0.633
DOC_WW_Pin1_4	216	221	PF00397	0.661
DOC_WW_Pin1_4	263	268	PF00397	0.664
DOC_WW_Pin1_4	338	343	PF00397	0.708
DOC_WW_Pin1_4	351	356	PF00397	0.595
DOC_WW_Pin1_4	361	366	PF00397	0.607
DOC_WW_Pin1_4	387	392	PF00397	0.722
DOC_WW_Pin1_4	458	463	PF00397	0.783
DOC_WW_Pin1_4	466	471	PF00397	0.723
DOC_WW_Pin1_4	493	498	PF00397	0.650
DOC_WW_Pin1_4	568	573	PF00397	0.601
LIG_14-3-3_CanoR_1	13	18	PF00244	0.581
LIG_14-3-3_CanoR_1	210	220	PF00244	0.704
LIG_14-3-3_CanoR_1	244	252	PF00244	0.684
LIG_14-3-3_CanoR_1	304	312	PF00244	0.607
LIG_14-3-3_CanoR_1	373	378	PF00244	0.664
LIG_14-3-3_CanoR_1	386	391	PF00244	0.569
LIG_14-3-3_CanoR_1	434	442	PF00244	0.761
LIG_14-3-3_CanoR_1	457	462	PF00244	0.646
LIG_14-3-3_CanoR_1	567	572	PF00244	0.689
LIG_14-3-3_CanoR_1	576	584	PF00244	0.613
LIG_APCC_ABBA_1	490	495	PF00400	0.540
LIG_BIR_III_2	439	443	PF00653	0.559
LIG_BRCT_BRCA1_1	542	546	PF00533	0.637
LIG_deltaCOP1_diTrp_1	475	485	PF00928	0.594
LIG_EVH1_1	150	154	PF00568	0.693
LIG_FHA_1	147	153	PF00498	0.564
LIG_FHA_1	178	184	PF00498	0.587
LIG_FHA_1	253	259	PF00498	0.637
LIG_FHA_1	563	569	PF00498	0.660
LIG_FHA_1	588	594	PF00498	0.598
LIG_FHA_2	200	206	PF00498	0.602
LIG_FHA_2	343	349	PF00498	0.673
LIG_FHA_2	351	357	PF00498	0.649
LIG_FHA_2	434	440	PF00498	0.585
LIG_FHA_2	503	509	PF00498	0.676
LIG_FHA_2	514	520	PF00498	0.639
LIG_FHA_2	618	624	PF00498	0.539
LIG_GBD_Chelix_1	621	629	PF00786	0.413
LIG_LIR_Apic_2	149	153	PF02991	0.644
LIG_LIR_Apic_2	337	342	PF02991	0.697
LIG_LIR_Apic_2	484	488	PF02991	0.589
LIG_LIR_Apic_2	63	67	PF02991	0.552
LIG_LIR_Nem_3	205	211	PF02991	0.558
LIG_LIR_Nem_3	314	320	PF02991	0.810
LIG_LIR_Nem_3	599	604	PF02991	0.684
LIG_PDZ_Class_1	650	655	PF00595	0.679
LIG_RPA_C_Fungi	96	108	PF08784	0.565
LIG_SH2_CRK	25	29	PF00017	0.578
LIG_SH2_CRK	317	321	PF00017	0.709
LIG_SH2_PTP2	339	342	PF00017	0.684
LIG_SH2_STAP1	532	536	PF00017	0.561
LIG_SH2_STAT5	339	342	PF00017	0.780
LIG_SH3_3	135	141	PF00018	0.728
LIG_SH3_3	145	151	PF00018	0.762
LIG_SH3_3	153	159	PF00018	0.627
LIG_SH3_3	366	372	PF00018	0.584
LIG_SH3_3	445	451	PF00018	0.701
LIG_SUMO_SIM_par_1	126	132	PF11976	0.655
LIG_SUMO_SIM_par_1	398	404	PF11976	0.546
LIG_SUMO_SIM_par_1	87	92	PF11976	0.637
LIG_TRAF2_2	45	50	PF00917	0.690
LIG_TRFH_1	150	154	PF08558	0.580
LIG_TRFH_1	181	185	PF08558	0.576
LIG_TYR_ITIM	315	320	PF00017	0.626
LIG_WRC_WIRS_1	553	558	PF05994	0.611
LIG_WW_3	370	374	PF00397	0.583
LIG_WW_3	461	465	PF00397	0.649
MOD_CDK_SPxK_1	18	24	PF00069	0.598
MOD_CDK_SPxK_1	387	393	PF00069	0.667
MOD_CDK_SPxK_1	458	464	PF00069	0.643
MOD_CK1_1	115	121	PF00069	0.653
MOD_CK1_1	226	232	PF00069	0.788
MOD_CK1_1	253	259	PF00069	0.767
MOD_CK1_1	266	272	PF00069	0.630
MOD_CK1_1	281	287	PF00069	0.644
MOD_CK1_1	385	391	PF00069	0.726
MOD_CK1_1	411	417	PF00069	0.687
MOD_CK1_1	443	449	PF00069	0.630
MOD_CK1_1	478	484	PF00069	0.589
MOD_CK1_1	496	502	PF00069	0.524
MOD_CK1_1	517	523	PF00069	0.737
MOD_CK1_1	541	547	PF00069	0.784
MOD_CK1_1	55	61	PF00069	0.651
MOD_CK1_1	566	572	PF00069	0.658
MOD_CK1_1	582	588	PF00069	0.520
MOD_CK1_1	636	642	PF00069	0.504
MOD_CK2_1	212	218	PF00069	0.690
MOD_CK2_1	305	311	PF00069	0.671
MOD_CK2_1	350	356	PF00069	0.735
MOD_CK2_1	372	378	PF00069	0.684
MOD_CK2_1	386	392	PF00069	0.628
MOD_CK2_1	395	401	PF00069	0.620
MOD_CK2_1	502	508	PF00069	0.678
MOD_CK2_1	513	519	PF00069	0.642
MOD_CK2_1	531	537	PF00069	0.582
MOD_CK2_1	608	614	PF00069	0.664
MOD_CK2_1	617	623	PF00069	0.533
MOD_GlcNHglycan	112	115	PF01048	0.623
MOD_GlcNHglycan	117	120	PF01048	0.668
MOD_GlcNHglycan	175	178	PF01048	0.657
MOD_GlcNHglycan	226	229	PF01048	0.823
MOD_GlcNHglycan	307	310	PF01048	0.691
MOD_GlcNHglycan	35	38	PF01048	0.692
MOD_GlcNHglycan	445	448	PF01048	0.577
MOD_GlcNHglycan	516	519	PF01048	0.754
MOD_GlcNHglycan	527	530	PF01048	0.677
MOD_GlcNHglycan	534	537	PF01048	0.593
MOD_GlcNHglycan	54	57	PF01048	0.518
MOD_GlcNHglycan	543	546	PF01048	0.573
MOD_GlcNHglycan	577	580	PF01048	0.669
MOD_GlcNHglycan	585	588	PF01048	0.586
MOD_GlcNHglycan	614	617	PF01048	0.611
MOD_GlcNHglycan	82	85	PF01048	0.738
MOD_GSK3_1	157	164	PF00069	0.798
MOD_GSK3_1	173	180	PF00069	0.603
MOD_GSK3_1	206	213	PF00069	0.736
MOD_GSK3_1	250	257	PF00069	0.766
MOD_GSK3_1	263	270	PF00069	0.620
MOD_GSK3_1	274	281	PF00069	0.624
MOD_GSK3_1	334	341	PF00069	0.685
MOD_GSK3_1	382	389	PF00069	0.727
MOD_GSK3_1	39	46	PF00069	0.727
MOD_GSK3_1	391	398	PF00069	0.627
MOD_GSK3_1	401	408	PF00069	0.586
MOD_GSK3_1	411	418	PF00069	0.667
MOD_GSK3_1	429	436	PF00069	0.730
MOD_GSK3_1	471	478	PF00069	0.618
MOD_GSK3_1	499	506	PF00069	0.629
MOD_GSK3_1	513	520	PF00069	0.595
MOD_GSK3_1	521	528	PF00069	0.660
MOD_GSK3_1	537	544	PF00069	0.666
MOD_GSK3_1	562	569	PF00069	0.685
MOD_GSK3_1	570	577	PF00069	0.653
MOD_GSK3_1	579	586	PF00069	0.516
MOD_GSK3_1	587	594	PF00069	0.461
MOD_GSK3_1	605	612	PF00069	0.569
MOD_GSK3_1	629	636	PF00069	0.493
MOD_N-GLC_1	13	18	PF02516	0.608
MOD_N-GLC_1	198	203	PF02516	0.589
MOD_N-GLC_1	320	325	PF02516	0.628
MOD_N-GLC_2	75	77	PF02516	0.567
MOD_NEK2_1	143	148	PF00069	0.614
MOD_NEK2_1	161	166	PF00069	0.751
MOD_NEK2_1	384	389	PF00069	0.604
MOD_NEK2_1	433	438	PF00069	0.672
MOD_NEK2_1	531	536	PF00069	0.671
MOD_NEK2_1	583	588	PF00069	0.647
MOD_NEK2_1	592	597	PF00069	0.438
MOD_NEK2_1	629	634	PF00069	0.401
MOD_PIKK_1	244	250	PF00454	0.649
MOD_PIKK_1	281	287	PF00454	0.589
MOD_PIKK_1	320	326	PF00454	0.662
MOD_PIKK_1	43	49	PF00454	0.701
MOD_PIKK_1	499	505	PF00454	0.646
MOD_PK_1	538	544	PF00069	0.549
MOD_PKA_1	513	519	PF00069	0.654
MOD_PKA_1	52	58	PF00069	0.703
MOD_PKA_2	278	284	PF00069	0.559
MOD_PKA_2	33	39	PF00069	0.658
MOD_PKA_2	350	356	PF00069	0.708
MOD_PKA_2	372	378	PF00069	0.664
MOD_PKA_2	385	391	PF00069	0.570
MOD_PKA_2	433	439	PF00069	0.765
MOD_PKA_2	513	519	PF00069	0.650
MOD_PKA_2	52	58	PF00069	0.651
MOD_PKA_2	537	543	PF00069	0.678
MOD_PKA_2	566	572	PF00069	0.672
MOD_PKA_2	575	581	PF00069	0.632
MOD_PKA_2	617	623	PF00069	0.578
MOD_PKA_2	629	635	PF00069	0.473
MOD_Plk_1	198	204	PF00069	0.622
MOD_Plk_1	310	316	PF00069	0.640
MOD_Plk_1	475	481	PF00069	0.678
MOD_Plk_1	507	513	PF00069	0.643
MOD_Plk_1	538	544	PF00069	0.707
MOD_Plk_1	605	611	PF00069	0.590
MOD_Plk_1	7	13	PF00069	0.661
MOD_Plk_2-3	617	623	PF00069	0.612
MOD_Plk_4	254	260	PF00069	0.661
MOD_Plk_4	334	340	PF00069	0.778
MOD_Plk_4	395	401	PF00069	0.689
MOD_Plk_4	475	481	PF00069	0.554
MOD_Plk_4	579	585	PF00069	0.735
MOD_ProDKin_1	162	168	PF00069	0.717
MOD_ProDKin_1	18	24	PF00069	0.632
MOD_ProDKin_1	216	222	PF00069	0.664
MOD_ProDKin_1	263	269	PF00069	0.663
MOD_ProDKin_1	338	344	PF00069	0.709
MOD_ProDKin_1	351	357	PF00069	0.595
MOD_ProDKin_1	361	367	PF00069	0.605
MOD_ProDKin_1	387	393	PF00069	0.721
MOD_ProDKin_1	458	464	PF00069	0.787
MOD_ProDKin_1	466	472	PF00069	0.719
MOD_ProDKin_1	493	499	PF00069	0.651
MOD_ProDKin_1	568	574	PF00069	0.602
MOD_SUMO_for_1	634	637	PF00179	0.559
MOD_SUMO_rev_2	469	478	PF00179	0.634
MOD_SUMO_rev_2	599	609	PF00179	0.522
TRG_DiLeu_BaEn_1	401	406	PF01217	0.527
TRG_DiLeu_BaLyEn_6	454	459	PF01217	0.640
TRG_ENDOCYTIC_2	317	320	PF00928	0.803
TRG_ENDOCYTIC_2	601	604	PF00928	0.664
TRG_ER_diArg_1	301	304	PF00400	0.624
TRG_ER_diArg_1	327	329	PF00400	0.748
TRG_ER_diArg_1	425	427	PF00400	0.690
TRG_ER_diArg_1	51	53	PF00400	0.663
TRG_ER_diArg_1	512	514	PF00400	0.642
TRG_ER_diArg_1	556	559	PF00400	0.629
TRG_ER_diArg_1	640	643	PF00400	0.571
TRG_ER_diArg_1	646	648	PF00400	0.584
TRG_ER_diArg_1	98	101	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK06	Leishmania donovani	83%	100%
A4HP06	Leishmania braziliensis	50%	100%
A4HP26	Leishmania braziliensis	48%	100%
A4IDB5	Leishmania infantum	82%	100%
E9ASR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%