Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1S8_LEIMA

TriTrypDb:

LmjF.36.1480 , LMJLV39_360020900 , LMJSD75_360020900

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	353	357	PF00656	0.471
CLV_C14_Caspase3-7	53	57	PF00656	0.554
CLV_NRD_NRD_1	231	233	PF00675	0.696
CLV_PCSK_SKI1_1	19	23	PF00082	0.454
CLV_PCSK_SKI1_1	195	199	PF00082	0.399
CLV_PCSK_SKI1_1	96	100	PF00082	0.526
DEG_Nend_UBRbox_2	1	3	PF02207	0.611
DEG_SPOP_SBC_1	252	256	PF00917	0.652
DEG_SPOP_SBC_1	404	408	PF00917	0.655
DOC_CKS1_1	282	287	PF01111	0.476
DOC_CYCLIN_RxL_1	121	131	PF00134	0.541
DOC_CYCLIN_RxL_1	199	210	PF00134	0.524
DOC_CYCLIN_RxL_1	307	317	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	279	285	PF00134	0.507
DOC_MAPK_gen_1	16	25	PF00069	0.469
DOC_MAPK_gen_1	299	308	PF00069	0.384
DOC_MAPK_gen_1	327	336	PF00069	0.585
DOC_MAPK_MEF2A_6	10	17	PF00069	0.615
DOC_MAPK_MEF2A_6	130	139	PF00069	0.396
DOC_USP7_MATH_1	114	118	PF00917	0.630
DOC_USP7_MATH_1	122	126	PF00917	0.553
DOC_USP7_MATH_1	252	256	PF00917	0.631
DOC_USP7_MATH_1	405	409	PF00917	0.664
DOC_USP7_MATH_1	52	56	PF00917	0.701
DOC_WW_Pin1_4	204	209	PF00397	0.398
DOC_WW_Pin1_4	281	286	PF00397	0.444
DOC_WW_Pin1_4	379	384	PF00397	0.449
DOC_WW_Pin1_4	56	61	PF00397	0.642
LIG_14-3-3_CanoR_1	275	280	PF00244	0.512
LIG_14-3-3_CanoR_1	323	327	PF00244	0.524
LIG_14-3-3_CanoR_1	91	95	PF00244	0.563
LIG_Actin_WH2_2	309	325	PF00022	0.503
LIG_Actin_WH2_2	80	98	PF00022	0.416
LIG_APCC_ABBA_1	15	20	PF00400	0.453
LIG_APCC_ABBA_1	306	311	PF00400	0.397
LIG_BRCT_BRCA1_1	124	128	PF00533	0.489
LIG_BRCT_BRCA1_1	393	397	PF00533	0.438
LIG_FHA_1	144	150	PF00498	0.624
LIG_FHA_1	199	205	PF00498	0.466
LIG_FHA_1	20	26	PF00498	0.451
LIG_FHA_1	329	335	PF00498	0.549
LIG_FHA_1	386	392	PF00498	0.351
LIG_FHA_1	97	103	PF00498	0.690
LIG_FHA_2	136	142	PF00498	0.362
LIG_FHA_2	205	211	PF00498	0.442
LIG_FHA_2	254	260	PF00498	0.627
LIG_FHA_2	282	288	PF00498	0.500
LIG_FHA_2	336	342	PF00498	0.395
LIG_FHA_2	57	63	PF00498	0.672
LIG_PTAP_UEV_1	248	253	PF05743	0.503
LIG_SH2_STAP1	293	297	PF00017	0.454
LIG_SH2_STAP1	358	362	PF00017	0.482
LIG_SH2_STAT3	293	296	PF00017	0.457
LIG_SH2_STAT5	178	181	PF00017	0.401
LIG_SH2_STAT5	304	307	PF00017	0.369
LIG_SH3_3	246	252	PF00018	0.458
LIG_SH3_3	279	285	PF00018	0.481
LIG_SH3_3	377	383	PF00018	0.379
LIG_SH3_3	398	404	PF00018	0.647
LIG_SUMO_SIM_par_1	196	201	PF11976	0.415
LIG_SUMO_SIM_par_1	20	27	PF11976	0.579
LIG_TRAF2_1	271	274	PF00917	0.465
MOD_CK1_1	113	119	PF00069	0.593
MOD_CK1_1	153	159	PF00069	0.659
MOD_CK1_1	255	261	PF00069	0.555
MOD_CK2_1	135	141	PF00069	0.408
MOD_CK2_1	253	259	PF00069	0.699
MOD_CK2_1	281	287	PF00069	0.450
MOD_CK2_1	322	328	PF00069	0.505
MOD_CK2_1	335	341	PF00069	0.563
MOD_CK2_1	56	62	PF00069	0.686
MOD_GlcNHglycan	103	106	PF01048	0.649
MOD_GlcNHglycan	112	115	PF01048	0.545
MOD_GlcNHglycan	217	220	PF01048	0.647
MOD_GlcNHglycan	249	252	PF01048	0.610
MOD_GlcNHglycan	29	32	PF01048	0.546
MOD_GlcNHglycan	317	321	PF01048	0.582
MOD_GlcNHglycan	358	361	PF01048	0.477
MOD_GSK3_1	110	117	PF00069	0.610
MOD_GSK3_1	135	142	PF00069	0.430
MOD_GSK3_1	200	207	PF00069	0.467
MOD_GSK3_1	247	254	PF00069	0.580
MOD_GSK3_1	328	335	PF00069	0.595
MOD_GSK3_1	35	42	PF00069	0.555
MOD_GSK3_1	356	363	PF00069	0.542
MOD_GSK3_1	391	398	PF00069	0.513
MOD_GSK3_1	399	406	PF00069	0.646
MOD_GSK3_1	52	59	PF00069	0.563
MOD_GSK3_1	64	71	PF00069	0.659
MOD_GSK3_1	96	103	PF00069	0.589
MOD_N-GLC_1	360	365	PF02516	0.546
MOD_NEK2_1	135	140	PF00069	0.403
MOD_NEK2_1	198	203	PF00069	0.538
MOD_NEK2_1	237	242	PF00069	0.561
MOD_NEK2_1	253	258	PF00069	0.503
MOD_NEK2_1	295	300	PF00069	0.404
MOD_NEK2_1	3	8	PF00069	0.431
MOD_NEK2_1	316	321	PF00069	0.443
MOD_NEK2_1	322	327	PF00069	0.507
MOD_NEK2_1	369	374	PF00069	0.556
MOD_NEK2_1	391	396	PF00069	0.542
MOD_NEK2_1	40	45	PF00069	0.502
MOD_PIKK_1	150	156	PF00454	0.612
MOD_PIKK_1	68	74	PF00454	0.795
MOD_PKA_2	100	106	PF00069	0.578
MOD_PKA_2	107	113	PF00069	0.634
MOD_PKA_2	237	243	PF00069	0.536
MOD_PKA_2	274	280	PF00069	0.510
MOD_PKA_2	322	328	PF00069	0.434
MOD_PKA_2	90	96	PF00069	0.527
MOD_Plk_1	122	128	PF00069	0.676
MOD_Plk_1	19	25	PF00069	0.451
MOD_Plk_1	332	338	PF00069	0.660
MOD_Plk_1	96	102	PF00069	0.608
MOD_Plk_4	135	141	PF00069	0.355
MOD_Plk_4	3	9	PF00069	0.494
MOD_Plk_4	35	41	PF00069	0.484
MOD_Plk_4	391	397	PF00069	0.520
MOD_Plk_4	90	96	PF00069	0.473
MOD_ProDKin_1	204	210	PF00069	0.401
MOD_ProDKin_1	281	287	PF00069	0.443
MOD_ProDKin_1	379	385	PF00069	0.447
MOD_ProDKin_1	56	62	PF00069	0.647
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK24	Leptomonas seymouri	55%	93%
A0A0S4JIK9	Bodo saltans	32%	96%
A0A1X0P835	Trypanosomatidae	36%	82%
A0A3R7KEY6	Trypanosoma rangeli	40%	88%
A0A3S7XAM2	Leishmania donovani	93%	100%
A4HP08	Leishmania braziliensis	76%	84%
A4HP27	Leishmania braziliensis	76%	84%
A4IDB7	Leishmania infantum	93%	100%
D0A2Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B4F6	Trypanosoma cruzi	39%	91%