KU80 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

KU80 protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1S6_LEIMA

TriTrypDb:

LmjF.36.1500 , LMJLV39_360021100 , LMJSD75_360021100

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1S6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.492
CLV_C14_Caspase3-7	311	315	PF00656	0.667
CLV_C14_Caspase3-7	405	409	PF00656	0.554
CLV_C14_Caspase3-7	425	429	PF00656	0.317
CLV_C14_Caspase3-7	459	463	PF00656	0.427
CLV_C14_Caspase3-7	511	515	PF00656	0.546
CLV_C14_Caspase3-7	568	572	PF00656	0.437
CLV_C14_Caspase3-7	866	870	PF00656	0.689
CLV_NRD_NRD_1	296	298	PF00675	0.592
CLV_NRD_NRD_1	695	697	PF00675	0.433
CLV_NRD_NRD_1	752	754	PF00675	0.524
CLV_NRD_NRD_1	838	840	PF00675	0.613
CLV_PCSK_KEX2_1	295	297	PF00082	0.597
CLV_PCSK_KEX2_1	695	697	PF00082	0.433
CLV_PCSK_KEX2_1	752	754	PF00082	0.524
CLV_PCSK_KEX2_1	860	862	PF00082	0.689
CLV_PCSK_KEX2_1	887	889	PF00082	0.717
CLV_PCSK_KEX2_1	901	903	PF00082	0.538
CLV_PCSK_KEX2_1	905	907	PF00082	0.492
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.689
CLV_PCSK_PC1ET2_1	887	889	PF00082	0.747
CLV_PCSK_PC1ET2_1	901	903	PF00082	0.562
CLV_PCSK_PC1ET2_1	905	907	PF00082	0.510
CLV_PCSK_SKI1_1	237	241	PF00082	0.480
CLV_PCSK_SKI1_1	402	406	PF00082	0.509
CLV_PCSK_SKI1_1	433	437	PF00082	0.404
CLV_PCSK_SKI1_1	53	57	PF00082	0.441
CLV_PCSK_SKI1_1	553	557	PF00082	0.597
CLV_PCSK_SKI1_1	662	666	PF00082	0.501
CLV_PCSK_SKI1_1	696	700	PF00082	0.579
CLV_PCSK_SKI1_1	840	844	PF00082	0.578
CLV_PCSK_SKI1_1	85	89	PF00082	0.609
CLV_PCSK_SKI1_1	887	891	PF00082	0.651
CLV_PCSK_SKI1_1	942	946	PF00082	0.588
DEG_APCC_DBOX_1	84	92	PF00400	0.600
DEG_SPOP_SBC_1	587	591	PF00917	0.579
DEG_SPOP_SBC_1	786	790	PF00917	0.595
DOC_CKS1_1	435	440	PF01111	0.417
DOC_CYCLIN_RxL_1	430	439	PF00134	0.434
DOC_CYCLIN_RxL_1	548	560	PF00134	0.541
DOC_CYCLIN_yClb5_NLxxxL_5	673	682	PF00134	0.423
DOC_MAPK_FxFP_2	543	546	PF00069	0.485
DOC_MAPK_gen_1	612	621	PF00069	0.584
DOC_MAPK_gen_1	82	91	PF00069	0.602
DOC_MAPK_gen_1	843	853	PF00069	0.631
DOC_MAPK_RevD_3	680	696	PF00069	0.428
DOC_PP1_RVXF_1	206	213	PF00149	0.445
DOC_PP1_SILK_1	201	206	PF00149	0.430
DOC_PP2B_LxvP_1	600	603	PF13499	0.618
DOC_PP4_FxxP_1	543	546	PF00568	0.429
DOC_PP4_FxxP_1	55	58	PF00568	0.455
DOC_USP7_MATH_1	155	159	PF00917	0.510
DOC_USP7_MATH_1	22	26	PF00917	0.520
DOC_USP7_MATH_1	302	306	PF00917	0.628
DOC_USP7_MATH_1	313	317	PF00917	0.664
DOC_USP7_MATH_1	336	340	PF00917	0.649
DOC_USP7_MATH_1	558	562	PF00917	0.490
DOC_USP7_MATH_1	570	574	PF00917	0.574
DOC_USP7_MATH_1	587	591	PF00917	0.628
DOC_USP7_MATH_1	603	607	PF00917	0.587
DOC_USP7_MATH_1	614	618	PF00917	0.547
DOC_USP7_MATH_1	638	642	PF00917	0.673
DOC_USP7_MATH_1	655	659	PF00917	0.399
DOC_USP7_MATH_1	70	74	PF00917	0.500
DOC_USP7_MATH_1	703	707	PF00917	0.638
DOC_USP7_MATH_1	760	764	PF00917	0.758
DOC_USP7_MATH_1	786	790	PF00917	0.715
DOC_USP7_UBL2_3	418	422	PF12436	0.469
DOC_USP7_UBL2_3	840	844	PF12436	0.609
DOC_USP7_UBL2_3	901	905	PF12436	0.575
DOC_USP7_UBL2_3	913	917	PF12436	0.548
DOC_WW_Pin1_4	11	16	PF00397	0.422
DOC_WW_Pin1_4	434	439	PF00397	0.396
DOC_WW_Pin1_4	502	507	PF00397	0.576
DOC_WW_Pin1_4	518	523	PF00397	0.522
DOC_WW_Pin1_4	666	671	PF00397	0.561
DOC_WW_Pin1_4	719	724	PF00397	0.711
DOC_WW_Pin1_4	736	741	PF00397	0.576
DOC_WW_Pin1_4	809	814	PF00397	0.663
DOC_WW_Pin1_4	924	929	PF00397	0.606
LIG_14-3-3_CanoR_1	516	525	PF00244	0.512
LIG_14-3-3_CanoR_1	541	546	PF00244	0.426
LIG_14-3-3_CanoR_1	612	621	PF00244	0.584
LIG_14-3-3_CanoR_1	695	701	PF00244	0.462
LIG_14-3-3_CanoR_1	846	853	PF00244	0.730
LIG_Actin_WH2_2	479	497	PF00022	0.397
LIG_BIR_III_2	468	472	PF00653	0.539
LIG_BIR_III_2	854	858	PF00653	0.595
LIG_CaM_IQ_9	832	848	PF13499	0.574
LIG_FHA_1	151	157	PF00498	0.439
LIG_FHA_1	376	382	PF00498	0.431
LIG_FHA_1	435	441	PF00498	0.559
LIG_FHA_1	44	50	PF00498	0.420
LIG_FHA_1	447	453	PF00498	0.324
LIG_FHA_1	503	509	PF00498	0.677
LIG_FHA_1	589	595	PF00498	0.684
LIG_FHA_1	614	620	PF00498	0.538
LIG_FHA_1	621	627	PF00498	0.415
LIG_FHA_1	685	691	PF00498	0.424
LIG_FHA_1	729	735	PF00498	0.678
LIG_FHA_1	736	742	PF00498	0.626
LIG_FHA_2	213	219	PF00498	0.454
LIG_FHA_2	364	370	PF00498	0.456
LIG_FHA_2	403	409	PF00498	0.461
LIG_FHA_2	509	515	PF00498	0.513
LIG_FHA_2	706	712	PF00498	0.450
LIG_GBD_Chelix_1	190	198	PF00786	0.424
LIG_HP1_1	127	131	PF01393	0.308
LIG_IBAR_NPY_1	126	128	PF08397	0.418
LIG_IRF3_LxIS_1	163	170	PF10401	0.393
LIG_LIR_Apic_2	542	546	PF02991	0.435
LIG_LIR_Gen_1	165	172	PF02991	0.324
LIG_LIR_Gen_1	34	43	PF02991	0.316
LIG_LIR_Gen_1	382	391	PF02991	0.328
LIG_LIR_Gen_1	5	11	PF02991	0.434
LIG_LIR_LC3C_4	849	853	PF02991	0.557
LIG_LIR_Nem_3	139	145	PF02991	0.340
LIG_LIR_Nem_3	165	169	PF02991	0.312
LIG_LIR_Nem_3	34	38	PF02991	0.316
LIG_LIR_Nem_3	411	416	PF02991	0.350
LIG_LIR_Nem_3	5	9	PF02991	0.404
LIG_PAM2_1	524	536	PF00658	0.431
LIG_PCNA_yPIPBox_3	612	625	PF02747	0.536
LIG_PTB_Apo_2	450	457	PF02174	0.404
LIG_PTB_Apo_2	485	492	PF02174	0.442
LIG_PTB_Phospho_1	485	491	PF10480	0.442
LIG_SH2_CRK	421	425	PF00017	0.520
LIG_SH2_CRK	491	495	PF00017	0.356
LIG_SH2_NCK_1	466	470	PF00017	0.546
LIG_SH2_NCK_1	644	648	PF00017	0.552
LIG_SH2_SRC	466	469	PF00017	0.539
LIG_SH2_SRC	745	748	PF00017	0.623
LIG_SH2_SRC	807	810	PF00017	0.522
LIG_SH2_STAP1	747	751	PF00017	0.509
LIG_SH2_STAT3	109	112	PF00017	0.373
LIG_SH2_STAT5	109	112	PF00017	0.285
LIG_SH2_STAT5	128	131	PF00017	0.422
LIG_SH2_STAT5	416	419	PF00017	0.355
LIG_SH2_STAT5	485	488	PF00017	0.336
LIG_SH2_STAT5	496	499	PF00017	0.350
LIG_SH2_STAT5	644	647	PF00017	0.553
LIG_SH2_STAT5	681	684	PF00017	0.465
LIG_SH2_STAT5	745	748	PF00017	0.623
LIG_SH3_3	392	398	PF00018	0.495
LIG_SH3_3	468	474	PF00018	0.563
LIG_SH3_3	709	715	PF00018	0.641
LIG_SH3_3	810	816	PF00018	0.523
LIG_SH3_3	817	823	PF00018	0.532
LIG_SH3_3	934	940	PF00018	0.608
LIG_SUMO_SIM_par_1	519	527	PF11976	0.483
LIG_SxIP_EBH_1	771	781	PF03271	0.581
LIG_TRAF2_1	267	270	PF00917	0.733
LIG_TRAF2_1	474	477	PF00917	0.488
LIG_WRC_WIRS_1	163	168	PF05994	0.379
LIG_WRC_WIRS_1	746	751	PF05994	0.571
MOD_CDK_SPK_2	809	814	PF00069	0.642
MOD_CDK_SPK_2	924	929	PF00069	0.606
MOD_CDK_SPxxK_3	502	509	PF00069	0.539
MOD_CK1_1	13	19	PF00069	0.558
MOD_CK1_1	170	176	PF00069	0.352
MOD_CK1_1	189	195	PF00069	0.372
MOD_CK1_1	439	445	PF00069	0.537
MOD_CK1_1	481	487	PF00069	0.410
MOD_CK1_1	539	545	PF00069	0.473
MOD_CK1_1	561	567	PF00069	0.482
MOD_CK1_1	588	594	PF00069	0.707
MOD_CK1_1	617	623	PF00069	0.528
MOD_CK1_1	669	675	PF00069	0.562
MOD_CK1_1	722	728	PF00069	0.693
MOD_CK1_1	767	773	PF00069	0.674
MOD_CK1_1	784	790	PF00069	0.715
MOD_CK1_1	870	876	PF00069	0.581
MOD_CK2_1	23	29	PF00069	0.554
MOD_CK2_1	264	270	PF00069	0.740
MOD_CK2_1	363	369	PF00069	0.550
MOD_CK2_1	653	659	PF00069	0.593
MOD_CK2_1	705	711	PF00069	0.470
MOD_CK2_1	785	791	PF00069	0.619
MOD_Cter_Amidation	857	860	PF01082	0.676
MOD_Cter_Amidation	903	906	PF01082	0.585
MOD_GlcNHglycan	122	125	PF01048	0.513
MOD_GlcNHglycan	131	134	PF01048	0.349
MOD_GlcNHglycan	15	18	PF01048	0.552
MOD_GlcNHglycan	157	160	PF01048	0.484
MOD_GlcNHglycan	338	341	PF01048	0.595
MOD_GlcNHglycan	361	364	PF01048	0.575
MOD_GlcNHglycan	408	411	PF01048	0.412
MOD_GlcNHglycan	424	427	PF01048	0.453
MOD_GlcNHglycan	480	483	PF01048	0.467
MOD_GlcNHglycan	528	531	PF01048	0.464
MOD_GlcNHglycan	538	541	PF01048	0.418
MOD_GlcNHglycan	560	563	PF01048	0.481
MOD_GlcNHglycan	629	632	PF01048	0.517
MOD_GlcNHglycan	636	639	PF01048	0.567
MOD_GlcNHglycan	64	67	PF01048	0.421
MOD_GlcNHglycan	640	643	PF01048	0.508
MOD_GlcNHglycan	650	653	PF01048	0.724
MOD_GlcNHglycan	724	727	PF01048	0.596
MOD_GlcNHglycan	741	744	PF01048	0.586
MOD_GlcNHglycan	76	80	PF01048	0.589
MOD_GlcNHglycan	772	775	PF01048	0.774
MOD_GlcNHglycan	791	795	PF01048	0.427
MOD_GlcNHglycan	848	851	PF01048	0.559
MOD_GlcNHglycan	861	864	PF01048	0.558
MOD_GlcNHglycan	869	872	PF01048	0.636
MOD_GSK3_1	252	259	PF00069	0.620
MOD_GSK3_1	271	278	PF00069	0.605
MOD_GSK3_1	279	286	PF00069	0.538
MOD_GSK3_1	326	333	PF00069	0.760
MOD_GSK3_1	359	366	PF00069	0.626
MOD_GSK3_1	371	378	PF00069	0.410
MOD_GSK3_1	402	409	PF00069	0.671
MOD_GSK3_1	442	449	PF00069	0.454
MOD_GSK3_1	477	484	PF00069	0.490
MOD_GSK3_1	504	511	PF00069	0.597
MOD_GSK3_1	512	519	PF00069	0.498
MOD_GSK3_1	557	564	PF00069	0.443
MOD_GSK3_1	585	592	PF00069	0.645
MOD_GSK3_1	613	620	PF00069	0.545
MOD_GSK3_1	634	641	PF00069	0.630
MOD_GSK3_1	715	722	PF00069	0.609
MOD_GSK3_1	735	742	PF00069	0.643
MOD_GSK3_1	760	767	PF00069	0.659
MOD_GSK3_1	781	788	PF00069	0.669
MOD_GSK3_1	803	810	PF00069	0.569
MOD_N-GLC_1	422	427	PF02516	0.460
MOD_N-GLC_1	617	622	PF02516	0.515
MOD_N-GLC_1	626	631	PF02516	0.437
MOD_N-GLC_1	893	898	PF02516	0.790
MOD_NEK2_1	212	217	PF00069	0.404
MOD_NEK2_1	303	308	PF00069	0.587
MOD_NEK2_1	370	375	PF00069	0.411
MOD_NEK2_1	376	381	PF00069	0.305
MOD_NEK2_1	456	461	PF00069	0.350
MOD_NEK2_1	508	513	PF00069	0.599
MOD_NEK2_1	62	67	PF00069	0.316
MOD_NEK2_2	48	53	PF00069	0.384
MOD_PIKK_1	70	76	PF00454	0.459
MOD_PIKK_1	760	766	PF00454	0.592
MOD_PKA_1	859	865	PF00069	0.667
MOD_PKA_2	446	452	PF00069	0.396
MOD_PKA_2	614	620	PF00069	0.599
MOD_PKA_2	633	639	PF00069	0.422
MOD_PKA_2	883	889	PF00069	0.761
MOD_PKB_1	75	83	PF00069	0.490
MOD_Plk_1	271	277	PF00069	0.672
MOD_Plk_1	617	623	PF00069	0.514
MOD_Plk_1	715	721	PF00069	0.673
MOD_Plk_2-3	264	270	PF00069	0.555
MOD_Plk_4	162	168	PF00069	0.383
MOD_Plk_4	199	205	PF00069	0.453
MOD_Plk_4	371	377	PF00069	0.478
MOD_Plk_4	396	402	PF00069	0.507
MOD_Plk_4	446	452	PF00069	0.376
MOD_Plk_4	456	462	PF00069	0.318
MOD_Plk_4	508	514	PF00069	0.537
MOD_Plk_4	620	626	PF00069	0.468
MOD_Plk_4	681	687	PF00069	0.478
MOD_Plk_4	764	770	PF00069	0.605
MOD_ProDKin_1	11	17	PF00069	0.416
MOD_ProDKin_1	434	440	PF00069	0.411
MOD_ProDKin_1	502	508	PF00069	0.579
MOD_ProDKin_1	518	524	PF00069	0.523
MOD_ProDKin_1	666	672	PF00069	0.555
MOD_ProDKin_1	719	725	PF00069	0.711
MOD_ProDKin_1	736	742	PF00069	0.573
MOD_ProDKin_1	809	815	PF00069	0.659
MOD_ProDKin_1	924	930	PF00069	0.608
MOD_SUMO_for_1	551	554	PF00179	0.550
MOD_SUMO_for_1	842	845	PF00179	0.574
MOD_SUMO_rev_2	139	145	PF00179	0.344
MOD_SUMO_rev_2	319	329	PF00179	0.823
MOD_SUMO_rev_2	476	481	PF00179	0.474
MOD_SUMO_rev_2	862	870	PF00179	0.677
TRG_DiLeu_BaEn_1	367	372	PF01217	0.474
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.549
TRG_ENDOCYTIC_2	128	131	PF00928	0.426
TRG_ENDOCYTIC_2	142	145	PF00928	0.319
TRG_ENDOCYTIC_2	421	424	PF00928	0.439
TRG_ENDOCYTIC_2	491	494	PF00928	0.351
TRG_ER_diArg_1	294	297	PF00400	0.658
TRG_ER_diArg_1	694	696	PF00400	0.434
TRG_ER_diArg_1	751	753	PF00400	0.537
TRG_ER_FFAT_2	763	773	PF00635	0.505
TRG_NLS_Bipartite_1	843	863	PF00514	0.572
TRG_NLS_Bipartite_1	887	904	PF00514	0.665
TRG_NLS_MonoExtN_4	857	863	PF00514	0.623
TRG_NLS_MonoExtN_4	898	904	PF00514	0.631
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W5	Leptomonas seymouri	61%	97%
A0A0S4JFW1	Bodo saltans	33%	100%
A0A1X0P867	Trypanosomatidae	38%	100%
A0A3S5H820	Leishmania donovani	89%	100%
A4HP10	Leishmania braziliensis	71%	100%
A4IDB9	Leishmania infantum	89%	100%
D0A2Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%