LeishMANIAdb
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Putative serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine protein kinase
Gene product:
NEK family Serine/threonine-protein kinase, putative
Species:
Leishmania major
UniProt:
Q4Q1S3_LEIMA
TriTrypDb:
LmjF.36.1530 , LMJLV39_360021400 , LMJSD75_360021400
Length:
501

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 56
NetGPI no yes: 0, no: 56
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1S3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 57
GO:0006793 phosphorus metabolic process 3 57
GO:0006796 phosphate-containing compound metabolic process 4 57
GO:0006807 nitrogen compound metabolic process 2 57
GO:0008152 metabolic process 1 57
GO:0009987 cellular process 1 57
GO:0016310 phosphorylation 5 57
GO:0019538 protein metabolic process 3 57
GO:0036211 protein modification process 4 57
GO:0043170 macromolecule metabolic process 3 57
GO:0043412 macromolecule modification 4 57
GO:0044237 cellular metabolic process 2 57
GO:0044238 primary metabolic process 2 57
GO:0071704 organic substance metabolic process 2 57
GO:1901564 organonitrogen compound metabolic process 3 57
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 57
GO:0003824 catalytic activity 1 57
GO:0004672 protein kinase activity 3 57
GO:0004674 protein serine/threonine kinase activity 4 41
GO:0005488 binding 1 57
GO:0005524 ATP binding 5 57
GO:0016301 kinase activity 4 57
GO:0016740 transferase activity 2 57
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 57
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 57
GO:0017076 purine nucleotide binding 4 57
GO:0030554 adenyl nucleotide binding 5 57
GO:0032553 ribonucleotide binding 3 57
GO:0032555 purine ribonucleotide binding 4 57
GO:0032559 adenyl ribonucleotide binding 5 57
GO:0035639 purine ribonucleoside triphosphate binding 4 57
GO:0036094 small molecule binding 2 57
GO:0043167 ion binding 2 57
GO:0043168 anion binding 3 57
GO:0097159 organic cyclic compound binding 2 57
GO:0097367 carbohydrate derivative binding 2 57
GO:0140096 catalytic activity, acting on a protein 2 57
GO:1901265 nucleoside phosphate binding 3 57
GO:1901363 heterocyclic compound binding 2 57

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 367 371 PF00656 0.510
CLV_C14_Caspase3-7 455 459 PF00656 0.452
CLV_NRD_NRD_1 226 228 PF00675 0.279
CLV_NRD_NRD_1 350 352 PF00675 0.559
CLV_NRD_NRD_1 395 397 PF00675 0.303
CLV_NRD_NRD_1 471 473 PF00675 0.312
CLV_NRD_NRD_1 59 61 PF00675 0.337
CLV_PCSK_KEX2_1 169 171 PF00082 0.355
CLV_PCSK_KEX2_1 225 227 PF00082 0.281
CLV_PCSK_KEX2_1 249 251 PF00082 0.294
CLV_PCSK_KEX2_1 294 296 PF00082 0.394
CLV_PCSK_KEX2_1 349 351 PF00082 0.519
CLV_PCSK_KEX2_1 394 396 PF00082 0.319
CLV_PCSK_KEX2_1 471 473 PF00082 0.305
CLV_PCSK_KEX2_1 59 61 PF00082 0.307
CLV_PCSK_PC1ET2_1 169 171 PF00082 0.166
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.273
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.368
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.322
CLV_PCSK_SKI1_1 174 178 PF00082 0.303
CLV_PCSK_SKI1_1 299 303 PF00082 0.327
CLV_PCSK_SKI1_1 336 340 PF00082 0.443
CLV_PCSK_SKI1_1 383 387 PF00082 0.394
CLV_PCSK_SKI1_1 471 475 PF00082 0.261
CLV_Separin_Metazoa 81 85 PF03568 0.174
DEG_APCC_DBOX_1 39 47 PF00400 0.248
DOC_ANK_TNKS_1 27 34 PF00023 0.389
DOC_CKS1_1 302 307 PF01111 0.402
DOC_CKS1_1 437 442 PF01111 0.329
DOC_CYCLIN_yCln2_LP_2 35 41 PF00134 0.304
DOC_MAPK_gen_1 174 183 PF00069 0.306
DOC_MAPK_gen_1 339 347 PF00069 0.507
DOC_MAPK_gen_1 394 400 PF00069 0.286
DOC_MAPK_MEF2A_6 349 356 PF00069 0.591
DOC_MAPK_MEF2A_6 361 368 PF00069 0.566
DOC_MAPK_RevD_3 155 170 PF00069 0.350
DOC_MAPK_RevD_3 236 250 PF00069 0.313
DOC_PP1_RVXF_1 372 378 PF00149 0.494
DOC_PP1_RVXF_1 469 476 PF00149 0.289
DOC_USP7_MATH_1 2 6 PF00917 0.494
DOC_USP7_MATH_1 202 206 PF00917 0.268
DOC_USP7_UBL2_3 138 142 PF12436 0.286
DOC_WW_Pin1_4 212 217 PF00397 0.307
DOC_WW_Pin1_4 26 31 PF00397 0.611
DOC_WW_Pin1_4 301 306 PF00397 0.345
DOC_WW_Pin1_4 368 373 PF00397 0.502
DOC_WW_Pin1_4 436 441 PF00397 0.320
DOC_WW_Pin1_4 75 80 PF00397 0.345
LIG_14-3-3_CanoR_1 351 357 PF00244 0.600
LIG_14-3-3_CanoR_1 361 365 PF00244 0.619
LIG_14-3-3_CanoR_1 488 494 PF00244 0.365
LIG_APCC_ABBA_1 398 403 PF00400 0.177
LIG_APCC_ABBAyCdc20_2 169 175 PF00400 0.317
LIG_BIR_II_1 1 5 PF00653 0.548
LIG_BIR_III_1 1 5 PF00653 0.352
LIG_BIR_III_3 1 5 PF00653 0.352
LIG_BRCT_BRCA1_1 35 39 PF00533 0.532
LIG_BRCT_BRCA1_1 437 441 PF00533 0.433
LIG_CaM_IQ_9 421 437 PF13499 0.402
LIG_Clathr_ClatBox_1 418 422 PF01394 0.177
LIG_deltaCOP1_diTrp_1 484 493 PF00928 0.400
LIG_FHA_1 17 23 PF00498 0.484
LIG_FHA_1 304 310 PF00498 0.435
LIG_FHA_1 361 367 PF00498 0.523
LIG_FHA_1 409 415 PF00498 0.364
LIG_FHA_2 201 207 PF00498 0.337
LIG_FHA_2 22 28 PF00498 0.515
LIG_FHA_2 339 345 PF00498 0.526
LIG_FHA_2 407 413 PF00498 0.321
LIG_FHA_2 453 459 PF00498 0.456
LIG_FHA_2 76 82 PF00498 0.368
LIG_Integrin_isoDGR_2 469 471 PF01839 0.177
LIG_IRF3_LxIS_1 305 312 PF10401 0.237
LIG_LIR_Apic_2 215 221 PF02991 0.302
LIG_LIR_Gen_1 438 449 PF02991 0.298
LIG_LIR_Gen_1 96 105 PF02991 0.308
LIG_LIR_Nem_3 36 42 PF02991 0.479
LIG_LIR_Nem_3 438 444 PF02991 0.298
LIG_LIR_Nem_3 445 451 PF02991 0.282
LIG_LIR_Nem_3 492 496 PF02991 0.268
LIG_LIR_Nem_3 94 100 PF02991 0.290
LIG_NRBOX 237 243 PF00104 0.276
LIG_PCNA_PIPBox_1 487 496 PF02747 0.177
LIG_PCNA_yPIPBox_3 278 288 PF02747 0.176
LIG_Pex14_1 393 397 PF04695 0.294
LIG_Pex14_2 16 20 PF04695 0.388
LIG_Pex14_2 463 467 PF04695 0.303
LIG_Rb_pABgroove_1 263 271 PF01858 0.144
LIG_SH2_CRK 269 273 PF00017 0.162
LIG_SH2_GRB2like 127 130 PF00017 0.336
LIG_SH2_NCK_1 127 131 PF00017 0.336
LIG_SH2_PTP2 218 221 PF00017 0.300
LIG_SH2_PTP2 310 313 PF00017 0.236
LIG_SH2_PTP2 397 400 PF00017 0.177
LIG_SH2_SRC 127 130 PF00017 0.338
LIG_SH2_STAP1 200 204 PF00017 0.304
LIG_SH2_STAP1 229 233 PF00017 0.315
LIG_SH2_STAP1 57 61 PF00017 0.192
LIG_SH2_STAT3 77 80 PF00017 0.174
LIG_SH2_STAT5 218 221 PF00017 0.302
LIG_SH2_STAT5 310 313 PF00017 0.369
LIG_SH2_STAT5 397 400 PF00017 0.304
LIG_SH2_STAT5 42 45 PF00017 0.349
LIG_SH2_STAT5 454 457 PF00017 0.293
LIG_SH2_STAT5 77 80 PF00017 0.377
LIG_SH2_STAT5 97 100 PF00017 0.272
LIG_SUMO_SIM_anti_2 420 425 PF11976 0.352
LIG_SUMO_SIM_par_1 416 422 PF11976 0.333
LIG_TRAF2_1 24 27 PF00917 0.577
LIG_TRAF2_1 328 331 PF00917 0.511
LIG_TRAF2_1 341 344 PF00917 0.300
LIG_TRAF2_1 78 81 PF00917 0.174
LIG_TYR_ITIM 241 246 PF00017 0.307
LIG_UBA3_1 241 249 PF00899 0.303
LIG_WRC_WIRS_1 490 495 PF05994 0.177
MOD_CDC14_SPxK_1 371 374 PF00782 0.527
MOD_CDK_SPxK_1 368 374 PF00069 0.560
MOD_CDK_SPxxK_3 301 308 PF00069 0.177
MOD_CK1_1 297 303 PF00069 0.181
MOD_CK1_1 320 326 PF00069 0.538
MOD_CK1_1 389 395 PF00069 0.353
MOD_CK1_1 428 434 PF00069 0.304
MOD_CK1_1 452 458 PF00069 0.280
MOD_CK1_1 489 495 PF00069 0.170
MOD_CK1_1 49 55 PF00069 0.301
MOD_CK2_1 200 206 PF00069 0.336
MOD_CK2_1 21 27 PF00069 0.489
MOD_CK2_1 338 344 PF00069 0.448
MOD_CK2_1 439 445 PF00069 0.317
MOD_CK2_1 75 81 PF00069 0.436
MOD_Cter_Amidation 469 472 PF01082 0.314
MOD_GlcNHglycan 177 180 PF01048 0.334
MOD_GlcNHglycan 284 287 PF01048 0.337
MOD_GlcNHglycan 319 322 PF01048 0.450
MOD_GlcNHglycan 326 329 PF01048 0.427
MOD_GlcNHglycan 48 51 PF01048 0.298
MOD_GlcNHglycan 85 88 PF01048 0.394
MOD_GSK3_1 136 143 PF00069 0.340
MOD_GSK3_1 208 215 PF00069 0.311
MOD_GSK3_1 297 304 PF00069 0.392
MOD_GSK3_1 320 327 PF00069 0.508
MOD_GSK3_1 360 367 PF00069 0.470
MOD_GSK3_1 385 392 PF00069 0.328
MOD_GSK3_1 413 420 PF00069 0.357
MOD_GSK3_1 42 49 PF00069 0.363
MOD_GSK3_1 435 442 PF00069 0.345
MOD_NEK2_1 182 187 PF00069 0.300
MOD_NEK2_1 194 199 PF00069 0.299
MOD_NEK2_1 261 266 PF00069 0.321
MOD_NEK2_1 309 314 PF00069 0.350
MOD_NEK2_1 360 365 PF00069 0.489
MOD_OFUCOSY 90 95 PF10250 0.174
MOD_PKA_1 294 300 PF00069 0.369
MOD_PKA_2 294 300 PF00069 0.318
MOD_PKA_2 33 39 PF00069 0.624
MOD_PKA_2 360 366 PF00069 0.541
MOD_PKA_2 428 434 PF00069 0.177
MOD_PKA_2 83 89 PF00069 0.174
MOD_PKB_1 225 233 PF00069 0.160
MOD_Plk_1 330 336 PF00069 0.539
MOD_Plk_1 389 395 PF00069 0.344
MOD_Plk_4 116 122 PF00069 0.402
MOD_Plk_4 279 285 PF00069 0.248
MOD_Plk_4 297 303 PF00069 0.405
MOD_Plk_4 42 48 PF00069 0.378
MOD_Plk_4 489 495 PF00069 0.421
MOD_Plk_4 51 57 PF00069 0.314
MOD_ProDKin_1 212 218 PF00069 0.307
MOD_ProDKin_1 26 32 PF00069 0.619
MOD_ProDKin_1 301 307 PF00069 0.345
MOD_ProDKin_1 368 374 PF00069 0.486
MOD_ProDKin_1 436 442 PF00069 0.320
MOD_ProDKin_1 75 81 PF00069 0.345
MOD_SUMO_rev_2 132 139 PF00179 0.300
TRG_DiLeu_BaEn_1 88 93 PF01217 0.313
TRG_ENDOCYTIC_2 243 246 PF00928 0.296
TRG_ENDOCYTIC_2 269 272 PF00928 0.239
TRG_ENDOCYTIC_2 310 313 PF00928 0.394
TRG_ENDOCYTIC_2 397 400 PF00928 0.344
TRG_ENDOCYTIC_2 401 404 PF00928 0.299
TRG_ENDOCYTIC_2 97 100 PF00928 0.335
TRG_ER_diArg_1 224 227 PF00400 0.284
TRG_ER_diArg_1 349 351 PF00400 0.596
TRG_ER_diArg_1 395 397 PF00400 0.314
TRG_ER_diArg_1 471 473 PF00400 0.323
TRG_ER_diArg_1 59 62 PF00400 0.364
TRG_NLS_MonoExtN_4 292 297 PF00514 0.177
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.436
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.509
TRG_Pf-PMV_PEXEL_1 472 476 PF00026 0.260

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 35% 100%
A0A0N0P953 Leptomonas seymouri 35% 100%
A0A0N1I9A0 Leptomonas seymouri 31% 77%
A0A0N1PD05 Leptomonas seymouri 32% 100%
A0A0N1PE80 Leptomonas seymouri 26% 89%
A0A0S4IMB7 Bodo saltans 37% 100%
A0A0S4IQ75 Bodo saltans 32% 99%
A0A0S4IRZ7 Bodo saltans 33% 100%
A0A0S4IVW1 Bodo saltans 24% 80%
A0A0S4IX86 Bodo saltans 33% 100%
A0A0S4J7K4 Bodo saltans 25% 100%
A0A0S4J804 Bodo saltans 38% 96%
A0A0S4JIJ6 Bodo saltans 29% 89%
A0A0S4JPZ1 Bodo saltans 32% 100%
A0A1X0NIA0 Trypanosomatidae 33% 100%
A0A1X0NIX2 Trypanosomatidae 30% 100%
A0A1X0NJV4 Trypanosomatidae 28% 98%
A0A1X0NUB2 Trypanosomatidae 31% 86%
A0A1X0P1A2 Trypanosomatidae 28% 100%
A0A1X0P527 Trypanosomatidae 33% 100%
A0A1X0P549 Trypanosomatidae 36% 100%
A0A1X0P863 Trypanosomatidae 57% 100%
A0A1X0P994 Trypanosomatidae 57% 100%
A0A3Q8IAQ1 Leishmania donovani 39% 100%
A0A3Q8IFK8 Leishmania donovani 30% 100%
A0A3Q8IFW0 Leishmania donovani 33% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IJM9 Leishmania donovani 37% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3R7KCZ4 Trypanosoma rangeli 33% 100%
A0A3R7MKG5 Trypanosoma rangeli 31% 100%
A0A3S7X5M4 Leishmania donovani 30% 76%
A0A3S7X7Y2 Leishmania donovani 29% 100%
A0A3S7X9S2 Leishmania donovani 27% 100%
A0A3S7XAL3 Leishmania donovani 83% 100%
A0A3S7XAT9 Leishmania donovani 97% 100%
A0A422NCP0 Trypanosoma rangeli 57% 100%
A0A422NH41 Trypanosoma rangeli 29% 87%
A0A422NT89 Trypanosoma rangeli 24% 76%
A4HCE6 Leishmania braziliensis 38% 100%
A4HED7 Leishmania braziliensis 30% 100%
A4HJT5 Leishmania braziliensis 31% 100%
A4HJW2 Leishmania braziliensis 33% 100%
A4HKG9 Leishmania braziliensis 29% 76%
A4HLR0 Leishmania braziliensis 31% 100%
A4HN71 Leishmania braziliensis 27% 100%
A4HNI1 Leishmania braziliensis 36% 100%
A4HP12 Leishmania braziliensis 58% 98%
A4HP13 Leishmania braziliensis 90% 100%
A4HZW8 Leishmania infantum 39% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I435 Leishmania infantum 30% 100%
A4I7A1 Leishmania infantum 30% 100%
A4I7C4 Leishmania infantum 33% 100%
A4I7Z6 Leishmania infantum 30% 76%
A4I9Y5 Leishmania infantum 29% 100%
A4IBT4 Leishmania infantum 28% 100%
A4IBT9 Leishmania infantum 28% 100%
A4IC37 Leishmania infantum 38% 100%
A4IDC1 Leishmania infantum 58% 98%
A4IDC2 Leishmania infantum 97% 100%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
E9AFM1 Leishmania major 27% 100%
E9AFZ2 Leishmania major 37% 95%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 98%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 76%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
P11837 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 72%
Q03428 Trypanosoma brucei brucei 33% 100%
Q08942 Trypanosoma brucei brucei 35% 100%
Q0VD22 Bos taurus 27% 100%
Q2QMI0 Oryza sativa subsp. japonica 30% 100%
Q4Q1S4 Leishmania major 58% 98%
Q4Q2Z2 Leishmania major 29% 100%
Q4Q598 Leishmania major 31% 76%
Q4Q5T9 Leishmania major 33% 100%
Q4Q5W2 Leishmania major 36% 100%
Q4Q7W2 Leishmania major 30% 100%
Q4QBQ2 Leishmania major 39% 100%
Q5KQF5 Oryza sativa subsp. japonica 28% 100%
Q9C098 Homo sapiens 31% 77%
V5BHW8 Trypanosoma cruzi 24% 79%
V5BPJ0 Trypanosoma cruzi 58% 100%
V5D579 Trypanosoma cruzi 34% 100%
V5DFW9 Trypanosoma cruzi 30% 86%
V5DKY9 Trypanosoma cruzi 35% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS