ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2, putative

Species:

Leishmania major

UniProt:

Q4Q1S2_LEIMA

TriTrypDb:

LmjF.36.1540 , LMJLV39_360021500 , LMJSD75_360021500

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	458	462	PF00656	0.641
CLV_NRD_NRD_1	14	16	PF00675	0.465
CLV_NRD_NRD_1	197	199	PF00675	0.698
CLV_NRD_NRD_1	451	453	PF00675	0.665
CLV_NRD_NRD_1	675	677	PF00675	0.311
CLV_NRD_NRD_1	786	788	PF00675	0.249
CLV_NRD_NRD_1	911	913	PF00675	0.488
CLV_PCSK_KEX2_1	14	16	PF00082	0.463
CLV_PCSK_KEX2_1	197	199	PF00082	0.697
CLV_PCSK_KEX2_1	451	453	PF00082	0.665
CLV_PCSK_KEX2_1	632	634	PF00082	0.530
CLV_PCSK_KEX2_1	675	677	PF00082	0.311
CLV_PCSK_KEX2_1	786	788	PF00082	0.361
CLV_PCSK_KEX2_1	827	829	PF00082	0.306
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.530
CLV_PCSK_PC1ET2_1	827	829	PF00082	0.306
CLV_PCSK_SKI1_1	660	664	PF00082	0.420
CLV_PCSK_SKI1_1	675	679	PF00082	0.310
CLV_PCSK_SKI1_1	694	698	PF00082	0.328
DEG_APCC_DBOX_1	632	640	PF00400	0.601
DEG_APCC_DBOX_1	674	682	PF00400	0.310
DEG_SPOP_SBC_1	338	342	PF00917	0.606
DEG_SPOP_SBC_1	576	580	PF00917	0.592
DEG_SPOP_SBC_1	703	707	PF00917	0.336
DEG_SPOP_SBC_1	709	713	PF00917	0.288
DOC_CKS1_1	299	304	PF01111	0.648
DOC_CYCLIN_RxL_1	673	680	PF00134	0.383
DOC_CYCLIN_yClb1_LxF_4	791	797	PF00134	0.294
DOC_MAPK_DCC_7	789	799	PF00069	0.294
DOC_MAPK_gen_1	660	669	PF00069	0.383
DOC_MAPK_gen_1	675	681	PF00069	0.310
DOC_MAPK_gen_1	786	796	PF00069	0.457
DOC_MAPK_MEF2A_6	539	546	PF00069	0.437
DOC_MAPK_MEF2A_6	663	671	PF00069	0.383
DOC_PP1_RVXF_1	495	502	PF00149	0.509
DOC_PP2B_LxvP_1	178	181	PF13499	0.675
DOC_PP2B_LxvP_1	411	414	PF13499	0.554
DOC_PP2B_LxvP_1	887	890	PF13499	0.460
DOC_PP4_FxxP_1	171	174	PF00568	0.596
DOC_PP4_FxxP_1	227	230	PF00568	0.592
DOC_USP7_MATH_1	104	108	PF00917	0.651
DOC_USP7_MATH_1	118	122	PF00917	0.570
DOC_USP7_MATH_1	144	148	PF00917	0.654
DOC_USP7_MATH_1	22	26	PF00917	0.602
DOC_USP7_MATH_1	247	251	PF00917	0.682
DOC_USP7_MATH_1	255	259	PF00917	0.604
DOC_USP7_MATH_1	276	280	PF00917	0.646
DOC_USP7_MATH_1	313	317	PF00917	0.633
DOC_USP7_MATH_1	345	349	PF00917	0.738
DOC_USP7_MATH_1	444	448	PF00917	0.642
DOC_USP7_MATH_1	460	464	PF00917	0.633
DOC_USP7_MATH_1	52	56	PF00917	0.548
DOC_USP7_MATH_1	556	560	PF00917	0.498
DOC_USP7_MATH_1	576	580	PF00917	0.489
DOC_USP7_MATH_1	62	66	PF00917	0.537
DOC_USP7_MATH_1	661	665	PF00917	0.486
DOC_USP7_MATH_1	703	707	PF00917	0.308
DOC_USP7_MATH_1	709	713	PF00917	0.248
DOC_USP7_MATH_1	788	792	PF00917	0.247
DOC_USP7_MATH_1	845	849	PF00917	0.395
DOC_USP7_UBL2_3	835	839	PF12436	0.245
DOC_USP7_UBL2_3	909	913	PF12436	0.497
DOC_WW_Pin1_4	125	130	PF00397	0.687
DOC_WW_Pin1_4	146	151	PF00397	0.633
DOC_WW_Pin1_4	226	231	PF00397	0.716
DOC_WW_Pin1_4	234	239	PF00397	0.648
DOC_WW_Pin1_4	298	303	PF00397	0.605
DOC_WW_Pin1_4	309	314	PF00397	0.624
DOC_WW_Pin1_4	341	346	PF00397	0.748
DOC_WW_Pin1_4	466	471	PF00397	0.676
DOC_WW_Pin1_4	60	65	PF00397	0.621
DOC_WW_Pin1_4	699	704	PF00397	0.344
DOC_WW_Pin1_4	768	773	PF00397	0.398
LIG_14-3-3_CanoR_1	151	156	PF00244	0.662
LIG_14-3-3_CanoR_1	206	214	PF00244	0.599
LIG_14-3-3_CanoR_1	265	274	PF00244	0.654
LIG_14-3-3_CanoR_1	479	483	PF00244	0.735
LIG_14-3-3_CanoR_1	575	582	PF00244	0.559
LIG_14-3-3_CanoR_1	613	618	PF00244	0.651
LIG_14-3-3_CanoR_1	660	666	PF00244	0.358
LIG_14-3-3_CanoR_1	694	704	PF00244	0.453
LIG_14-3-3_CanoR_1	99	108	PF00244	0.550
LIG_Actin_WH2_2	899	914	PF00022	0.482
LIG_APCC_ABBA_1	864	869	PF00400	0.310
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_4	56	60	PF00653	0.553
LIG_BIR_III_4	809	813	PF00653	0.310
LIG_BRCT_BRCA1_1	345	349	PF00533	0.656
LIG_BRCT_BRCA1_1	66	70	PF00533	0.544
LIG_BRCT_BRCA1_1	697	701	PF00533	0.245
LIG_BRCT_BRCA1_1	718	722	PF00533	0.383
LIG_BRCT_BRCA1_1	94	98	PF00533	0.614
LIG_CaM_IQ_9	423	439	PF13499	0.570
LIG_EVH1_1	178	182	PF00568	0.619
LIG_EVH1_2	542	546	PF00568	0.382
LIG_FHA_1	143	149	PF00498	0.577
LIG_FHA_1	238	244	PF00498	0.642
LIG_FHA_1	267	273	PF00498	0.654
LIG_FHA_1	413	419	PF00498	0.600
LIG_FHA_1	421	427	PF00498	0.615
LIG_FHA_1	552	558	PF00498	0.486
LIG_FHA_1	684	690	PF00498	0.310
LIG_FHA_1	732	738	PF00498	0.342
LIG_FHA_1	802	808	PF00498	0.313
LIG_FHA_2	348	354	PF00498	0.670
LIG_FHA_2	365	371	PF00498	0.606
LIG_FHA_2	543	549	PF00498	0.408
LIG_FHA_2	695	701	PF00498	0.245
LIG_LIR_Apic_2	169	174	PF02991	0.594
LIG_LIR_Apic_2	224	230	PF02991	0.564
LIG_LIR_Gen_1	246	255	PF02991	0.679
LIG_LIR_Gen_1	548	557	PF02991	0.409
LIG_LIR_Gen_1	680	690	PF02991	0.310
LIG_LIR_Gen_1	793	803	PF02991	0.310
LIG_LIR_Nem_3	162	168	PF02991	0.665
LIG_LIR_Nem_3	246	251	PF02991	0.683
LIG_LIR_Nem_3	41	47	PF02991	0.600
LIG_LIR_Nem_3	465	471	PF02991	0.615
LIG_LIR_Nem_3	545	550	PF02991	0.389
LIG_LIR_Nem_3	680	685	PF02991	0.310
LIG_LIR_Nem_3	698	704	PF02991	0.310
LIG_LIR_Nem_3	747	752	PF02991	0.344
LIG_LIR_Nem_3	793	799	PF02991	0.310
LIG_LIR_Nem_3	898	902	PF02991	0.465
LIG_LYPXL_S_1	43	47	PF13949	0.635
LIG_LYPXL_yS_3	44	47	PF13949	0.671
LIG_MYND_1	190	194	PF01753	0.629
LIG_Pex14_2	867	871	PF04695	0.310
LIG_SH2_STAP1	547	551	PF00017	0.375
LIG_SH2_STAT3	17	20	PF00017	0.490
LIG_SH2_STAT5	165	168	PF00017	0.599
LIG_SH2_STAT5	550	553	PF00017	0.445
LIG_SH2_STAT5	744	747	PF00017	0.310
LIG_SH2_STAT5	860	863	PF00017	0.489
LIG_SH3_3	171	177	PF00018	0.594
LIG_SH3_3	228	234	PF00018	0.620
LIG_SH3_3	296	302	PF00018	0.606
LIG_SH3_3	316	322	PF00018	0.486
LIG_SH3_3	923	929	PF00018	0.441
LIG_Sin3_3	803	810	PF02671	0.299
LIG_SUMO_SIM_par_1	321	327	PF11976	0.649
LIG_SUMO_SIM_par_1	422	428	PF11976	0.573
LIG_TRAF2_1	215	218	PF00917	0.682
LIG_TRAF2_1	27	30	PF00917	0.536
LIG_TRAF2_1	334	337	PF00917	0.662
LIG_TRAF2_1	352	355	PF00917	0.495
LIG_TRAF2_1	462	465	PF00917	0.552
LIG_UBA3_1	681	688	PF00899	0.245
LIG_WRC_WIRS_1	289	294	PF05994	0.564
LIG_WRC_WIRS_1	505	510	PF05994	0.573
LIG_WW_3	536	540	PF00397	0.477
MOD_CDC14_SPxK_1	771	774	PF00782	0.245
MOD_CDK_SPK_2	146	151	PF00069	0.606
MOD_CDK_SPK_2	64	69	PF00069	0.616
MOD_CDK_SPxK_1	768	774	PF00069	0.245
MOD_CK1_1	107	113	PF00069	0.562
MOD_CK1_1	121	127	PF00069	0.609
MOD_CK1_1	209	215	PF00069	0.623
MOD_CK1_1	229	235	PF00069	0.675
MOD_CK1_1	237	243	PF00069	0.580
MOD_CK1_1	339	345	PF00069	0.619
MOD_CK1_1	347	353	PF00069	0.622
MOD_CK1_1	396	402	PF00069	0.657
MOD_CK1_1	416	422	PF00069	0.619
MOD_CK1_1	432	438	PF00069	0.609
MOD_CK1_1	447	453	PF00069	0.581
MOD_CK1_1	469	475	PF00069	0.635
MOD_CK1_1	612	618	PF00069	0.628
MOD_CK1_1	63	69	PF00069	0.593
MOD_CK1_1	699	705	PF00069	0.448
MOD_CK1_1	707	713	PF00069	0.344
MOD_CK1_1	830	836	PF00069	0.339
MOD_CK1_1	92	98	PF00069	0.641
MOD_CK2_1	212	218	PF00069	0.779
MOD_CK2_1	23	29	PF00069	0.594
MOD_CK2_1	272	278	PF00069	0.644
MOD_CK2_1	331	337	PF00069	0.623
MOD_CK2_1	347	353	PF00069	0.671
MOD_CK2_1	364	370	PF00069	0.615
MOD_CK2_1	542	548	PF00069	0.392
MOD_CK2_1	694	700	PF00069	0.245
MOD_Cter_Amidation	195	198	PF01082	0.682
MOD_Cter_Amidation	825	828	PF01082	0.345
MOD_DYRK1A_RPxSP_1	146	150	PF00069	0.571
MOD_GlcNHglycan	183	186	PF01048	0.617
MOD_GlcNHglycan	213	217	PF01048	0.777
MOD_GlcNHglycan	269	272	PF01048	0.655
MOD_GlcNHglycan	274	277	PF01048	0.650
MOD_GlcNHglycan	333	336	PF01048	0.738
MOD_GlcNHglycan	396	399	PF01048	0.653
MOD_GlcNHglycan	430	434	PF01048	0.756
MOD_GlcNHglycan	471	474	PF01048	0.630
MOD_GlcNHglycan	508	511	PF01048	0.654
MOD_GlcNHglycan	558	561	PF01048	0.524
MOD_GlcNHglycan	634	639	PF01048	0.676
MOD_GlcNHglycan	646	649	PF01048	0.482
MOD_GlcNHglycan	91	94	PF01048	0.640
MOD_GlcNHglycan	95	98	PF01048	0.586
MOD_GSK3_1	110	117	PF00069	0.635
MOD_GSK3_1	118	125	PF00069	0.562
MOD_GSK3_1	142	149	PF00069	0.663
MOD_GSK3_1	20	27	PF00069	0.465
MOD_GSK3_1	222	229	PF00069	0.658
MOD_GSK3_1	257	264	PF00069	0.772
MOD_GSK3_1	272	279	PF00069	0.724
MOD_GSK3_1	309	316	PF00069	0.696
MOD_GSK3_1	336	343	PF00069	0.644
MOD_GSK3_1	345	352	PF00069	0.672
MOD_GSK3_1	412	419	PF00069	0.625
MOD_GSK3_1	425	432	PF00069	0.657
MOD_GSK3_1	504	511	PF00069	0.707
MOD_GSK3_1	60	67	PF00069	0.630
MOD_GSK3_1	609	616	PF00069	0.559
MOD_GSK3_1	661	668	PF00069	0.290
MOD_GSK3_1	677	684	PF00069	0.445
MOD_GSK3_1	690	697	PF00069	0.375
MOD_GSK3_1	699	706	PF00069	0.333
MOD_GSK3_1	722	729	PF00069	0.320
MOD_GSK3_1	766	773	PF00069	0.346
MOD_GSK3_1	88	95	PF00069	0.634
MOD_GSK3_1	98	105	PF00069	0.583
MOD_N-GLC_1	151	156	PF02516	0.597
MOD_N-GLC_1	381	386	PF02516	0.534
MOD_N-GLC_1	394	399	PF02516	0.575
MOD_N-GLC_1	444	449	PF02516	0.628
MOD_N-GLC_1	694	699	PF02516	0.356
MOD_N-GLC_1	801	806	PF02516	0.294
MOD_NEK2_1	282	287	PF00069	0.651
MOD_NEK2_1	506	511	PF00069	0.584
MOD_NEK2_1	551	556	PF00069	0.426
MOD_NEK2_1	669	674	PF00069	0.358
MOD_NEK2_1	677	682	PF00069	0.310
MOD_NEK2_1	722	727	PF00069	0.345
MOD_NEK2_1	801	806	PF00069	0.331
MOD_NEK2_1	98	103	PF00069	0.664
MOD_NEK2_2	104	109	PF00069	0.642
MOD_PIKK_1	661	667	PF00454	0.369
MOD_PIKK_1	704	710	PF00454	0.290
MOD_PIKK_1	74	80	PF00454	0.649
MOD_PK_1	716	722	PF00069	0.383
MOD_PKA_1	827	833	PF00069	0.270
MOD_PKA_2	23	29	PF00069	0.598
MOD_PKA_2	264	270	PF00069	0.699
MOD_PKA_2	478	484	PF00069	0.732
MOD_PKA_2	570	576	PF00069	0.419
MOD_PKA_2	612	618	PF00069	0.576
MOD_PKA_2	731	737	PF00069	0.320
MOD_PKA_2	788	794	PF00069	0.337
MOD_PKA_2	827	833	PF00069	0.278
MOD_PKA_2	892	898	PF00069	0.419
MOD_PKA_2	98	104	PF00069	0.543
MOD_Plk_1	151	157	PF00069	0.608
MOD_Plk_1	38	44	PF00069	0.626
MOD_Plk_1	429	435	PF00069	0.740
MOD_Plk_1	74	80	PF00069	0.611
MOD_Plk_1	801	807	PF00069	0.305
MOD_Plk_2-3	30	36	PF00069	0.628
MOD_Plk_4	406	412	PF00069	0.737
MOD_Plk_4	413	419	PF00069	0.600
MOD_Plk_4	577	583	PF00069	0.571
MOD_Plk_4	677	683	PF00069	0.383
MOD_Plk_4	845	851	PF00069	0.245
MOD_ProDKin_1	125	131	PF00069	0.681
MOD_ProDKin_1	146	152	PF00069	0.633
MOD_ProDKin_1	226	232	PF00069	0.716
MOD_ProDKin_1	234	240	PF00069	0.649
MOD_ProDKin_1	298	304	PF00069	0.608
MOD_ProDKin_1	309	315	PF00069	0.623
MOD_ProDKin_1	341	347	PF00069	0.748
MOD_ProDKin_1	466	472	PF00069	0.675
MOD_ProDKin_1	60	66	PF00069	0.621
MOD_ProDKin_1	699	705	PF00069	0.344
MOD_ProDKin_1	768	774	PF00069	0.398
MOD_SUMO_for_1	715	718	PF00179	0.383
MOD_SUMO_rev_2	356	366	PF00179	0.634
MOD_SUMO_rev_2	386	396	PF00179	0.556
MOD_SUMO_rev_2	895	904	PF00179	0.401
TRG_ENDOCYTIC_2	165	168	PF00928	0.625
TRG_ENDOCYTIC_2	44	47	PF00928	0.671
TRG_ENDOCYTIC_2	482	485	PF00928	0.626
TRG_ENDOCYTIC_2	550	553	PF00928	0.427
TRG_ENDOCYTIC_2	749	752	PF00928	0.310
TRG_ENDOCYTIC_2	850	853	PF00928	0.383
TRG_ER_diArg_1	13	15	PF00400	0.472
TRG_ER_diArg_1	451	453	PF00400	0.679
TRG_ER_diArg_1	675	677	PF00400	0.344
TRG_ER_diArg_1	786	789	PF00400	0.345
TRG_ER_diArg_1	871	874	PF00400	0.324
TRG_NLS_MonoExtC_3	10	15	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	660	665	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB6	Leptomonas seymouri	35%	98%
A0A3S7XAP8	Leishmania donovani	86%	100%
A4HP14	Leishmania braziliensis	58%	100%
A4IDC3	Leishmania infantum	86%	100%
E9ASS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%