B box-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted tripartite motif protein

Species:

Leishmania major

UniProt:

Q4Q1S1_LEIMA

TriTrypDb:

LmjF.36.1550 , LMJLV39_360021600 , LMJSD75_360021600

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S1

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.563
CLV_C14_Caspase3-7	783	787	PF00656	0.659
CLV_MEL_PAP_1	740	746	PF00089	0.616
CLV_NRD_NRD_1	273	275	PF00675	0.576
CLV_NRD_NRD_1	397	399	PF00675	0.530
CLV_NRD_NRD_1	421	423	PF00675	0.535
CLV_NRD_NRD_1	812	814	PF00675	0.695
CLV_NRD_NRD_1	839	841	PF00675	0.725
CLV_PCSK_FUR_1	419	423	PF00082	0.531
CLV_PCSK_KEX2_1	272	274	PF00082	0.576
CLV_PCSK_KEX2_1	3	5	PF00082	0.688
CLV_PCSK_KEX2_1	397	399	PF00082	0.530
CLV_PCSK_KEX2_1	421	423	PF00082	0.535
CLV_PCSK_KEX2_1	498	500	PF00082	0.601
CLV_PCSK_KEX2_1	839	841	PF00082	0.706
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.688
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.553
CLV_PCSK_SKI1_1	374	378	PF00082	0.514
CLV_PCSK_SKI1_1	40	44	PF00082	0.650
CLV_PCSK_SKI1_1	498	502	PF00082	0.687
CLV_PCSK_SKI1_1	658	662	PF00082	0.554
CLV_PCSK_SKI1_1	774	778	PF00082	0.701
DOC_CKS1_1	597	602	PF01111	0.668
DOC_CYCLIN_RxL_1	771	782	PF00134	0.695
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.520
DOC_MAPK_gen_1	3	11	PF00069	0.645
DOC_MAPK_gen_1	734	742	PF00069	0.697
DOC_MAPK_gen_1	839	846	PF00069	0.721
DOC_MAPK_MEF2A_6	839	848	PF00069	0.721
DOC_MAPK_RevD_3	383	398	PF00069	0.473
DOC_PP2B_LxvP_1	62	65	PF13499	0.628
DOC_PP2B_LxvP_1	827	830	PF13499	0.645
DOC_PP4_FxxP_1	70	73	PF00568	0.497
DOC_USP7_MATH_1	219	223	PF00917	0.748
DOC_USP7_MATH_1	22	26	PF00917	0.638
DOC_USP7_MATH_1	225	229	PF00917	0.524
DOC_USP7_MATH_1	393	397	PF00917	0.394
DOC_USP7_MATH_1	401	405	PF00917	0.392
DOC_USP7_MATH_1	408	412	PF00917	0.400
DOC_USP7_MATH_1	598	602	PF00917	0.803
DOC_USP7_MATH_1	73	77	PF00917	0.518
DOC_USP7_MATH_1	822	826	PF00917	0.671
DOC_WW_Pin1_4	145	150	PF00397	0.635
DOC_WW_Pin1_4	221	226	PF00397	0.660
DOC_WW_Pin1_4	425	430	PF00397	0.525
DOC_WW_Pin1_4	485	490	PF00397	0.643
DOC_WW_Pin1_4	596	601	PF00397	0.664
DOC_WW_Pin1_4	686	691	PF00397	0.571
DOC_WW_Pin1_4	92	97	PF00397	0.668
LIG_14-3-3_CanoR_1	194	198	PF00244	0.461
LIG_14-3-3_CanoR_1	252	260	PF00244	0.480
LIG_14-3-3_CanoR_1	278	285	PF00244	0.380
LIG_14-3-3_CanoR_1	397	406	PF00244	0.483
LIG_14-3-3_CanoR_1	40	47	PF00244	0.653
LIG_14-3-3_CanoR_1	448	454	PF00244	0.497
LIG_14-3-3_CanoR_1	477	482	PF00244	0.642
LIG_14-3-3_CanoR_1	627	632	PF00244	0.729
LIG_14-3-3_CanoR_1	658	663	PF00244	0.595
LIG_14-3-3_CanoR_1	743	747	PF00244	0.640
LIG_14-3-3_CanoR_1	762	771	PF00244	0.503
LIG_14-3-3_CanoR_1	789	796	PF00244	0.660
LIG_14-3-3_CanoR_1	797	807	PF00244	0.618
LIG_14-3-3_CanoR_1	839	846	PF00244	0.721
LIG_Actin_WH2_2	359	376	PF00022	0.503
LIG_Actin_WH2_2	388	405	PF00022	0.518
LIG_Actin_WH2_2	657	673	PF00022	0.548
LIG_APCC_ABBA_1	287	292	PF00400	0.405
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	66	70	PF00533	0.542
LIG_deltaCOP1_diTrp_1	118	127	PF00928	0.479
LIG_DLG_GKlike_1	477	484	PF00625	0.595
LIG_DLG_GKlike_1	627	635	PF00625	0.641
LIG_FHA_1	449	455	PF00498	0.524
LIG_FHA_1	585	591	PF00498	0.728
LIG_FHA_1	597	603	PF00498	0.614
LIG_FHA_1	659	665	PF00498	0.672
LIG_FHA_1	687	693	PF00498	0.712
LIG_FHA_1	731	737	PF00498	0.595
LIG_FHA_1	799	805	PF00498	0.688
LIG_FHA_1	839	845	PF00498	0.722
LIG_FHA_2	101	107	PF00498	0.569
LIG_FHA_2	18	24	PF00498	0.582
LIG_FHA_2	28	34	PF00498	0.574
LIG_FHA_2	436	442	PF00498	0.489
LIG_FHA_2	486	492	PF00498	0.694
LIG_FHA_2	50	56	PF00498	0.618
LIG_FHA_2	806	812	PF00498	0.708
LIG_Integrin_RGD_1	568	570	PF01839	0.553
LIG_LIR_Apic_2	67	73	PF02991	0.516
LIG_LIR_Gen_1	224	233	PF02991	0.464
LIG_LIR_Gen_1	480	489	PF02991	0.628
LIG_LIR_Nem_3	145	150	PF02991	0.585
LIG_LIR_Nem_3	224	229	PF02991	0.472
LIG_LIR_Nem_3	350	355	PF02991	0.464
LIG_LIR_Nem_3	480	484	PF02991	0.602
LIG_LIR_Nem_3	67	71	PF02991	0.530
LIG_LIR_Nem_3	697	702	PF02991	0.692
LIG_MYND_1	643	647	PF01753	0.562
LIG_MYND_1	69	73	PF01753	0.478
LIG_PCNA_PIPBox_1	406	415	PF02747	0.377
LIG_PDZ_Class_2	843	848	PF00595	0.719
LIG_PTAP_UEV_1	215	220	PF05743	0.666
LIG_SH2_CRK	497	501	PF00017	0.592
LIG_SH2_STAP1	355	359	PF00017	0.503
LIG_SH2_STAP1	662	666	PF00017	0.698
LIG_SH2_STAT5	197	200	PF00017	0.515
LIG_SH2_STAT5	806	809	PF00017	0.692
LIG_SH3_3	210	216	PF00018	0.798
LIG_SH3_3	510	516	PF00018	0.650
LIG_SH3_3	594	600	PF00018	0.715
LIG_SH3_3	637	643	PF00018	0.693
LIG_SH3_3	673	679	PF00018	0.585
LIG_SH3_3	741	747	PF00018	0.713
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.465
LIG_SUMO_SIM_par_1	82	88	PF11976	0.541
LIG_WRC_WIRS_1	409	414	PF05994	0.375
LIG_WRC_WIRS_1	478	483	PF05994	0.583
MOD_CDK_SPK_2	686	691	PF00069	0.571
MOD_CK1_1	143	149	PF00069	0.613
MOD_CK1_1	16	22	PF00069	0.649
MOD_CK1_1	204	210	PF00069	0.646
MOD_CK1_1	25	31	PF00069	0.631
MOD_CK1_1	396	402	PF00069	0.376
MOD_CK1_1	428	434	PF00069	0.555
MOD_CK1_1	447	453	PF00069	0.556
MOD_CK1_1	522	528	PF00069	0.713
MOD_CK1_1	632	638	PF00069	0.786
MOD_CK1_1	651	657	PF00069	0.558
MOD_CK1_1	790	796	PF00069	0.709
MOD_CK1_1	95	101	PF00069	0.686
MOD_CK2_1	100	106	PF00069	0.567
MOD_CK2_1	225	231	PF00069	0.620
MOD_CK2_1	412	418	PF00069	0.491
MOD_CK2_1	435	441	PF00069	0.488
MOD_CK2_1	49	55	PF00069	0.620
MOD_CK2_1	73	79	PF00069	0.506
MOD_CK2_1	760	766	PF00069	0.759
MOD_GlcNHglycan	121	124	PF01048	0.473
MOD_GlcNHglycan	14	18	PF01048	0.607
MOD_GlcNHglycan	142	145	PF01048	0.621
MOD_GlcNHglycan	150	153	PF01048	0.544
MOD_GlcNHglycan	177	180	PF01048	0.637
MOD_GlcNHglycan	210	213	PF01048	0.674
MOD_GlcNHglycan	216	219	PF01048	0.719
MOD_GlcNHglycan	221	224	PF01048	0.630
MOD_GlcNHglycan	390	394	PF01048	0.516
MOD_GlcNHglycan	399	402	PF01048	0.417
MOD_GlcNHglycan	403	406	PF01048	0.385
MOD_GlcNHglycan	471	474	PF01048	0.614
MOD_GlcNHglycan	508	512	PF01048	0.638
MOD_GlcNHglycan	521	524	PF01048	0.589
MOD_GlcNHglycan	536	541	PF01048	0.544
MOD_GlcNHglycan	62	65	PF01048	0.558
MOD_GlcNHglycan	631	634	PF01048	0.740
MOD_GlcNHglycan	686	689	PF01048	0.785
MOD_GlcNHglycan	75	78	PF01048	0.504
MOD_GSK3_1	13	20	PF00069	0.591
MOD_GSK3_1	131	138	PF00069	0.648
MOD_GSK3_1	139	146	PF00069	0.578
MOD_GSK3_1	166	173	PF00069	0.463
MOD_GSK3_1	193	200	PF00069	0.526
MOD_GSK3_1	204	211	PF00069	0.561
MOD_GSK3_1	22	29	PF00069	0.529
MOD_GSK3_1	221	228	PF00069	0.482
MOD_GSK3_1	325	332	PF00069	0.562
MOD_GSK3_1	389	396	PF00069	0.429
MOD_GSK3_1	397	404	PF00069	0.453
MOD_GSK3_1	408	415	PF00069	0.394
MOD_GSK3_1	444	451	PF00069	0.505
MOD_GSK3_1	60	67	PF00069	0.573
MOD_GSK3_1	623	630	PF00069	0.725
MOD_GSK3_1	631	638	PF00069	0.787
MOD_GSK3_1	648	655	PF00069	0.555
MOD_GSK3_1	682	689	PF00069	0.675
MOD_GSK3_1	690	697	PF00069	0.592
MOD_GSK3_1	787	794	PF00069	0.719
MOD_GSK3_1	834	841	PF00069	0.699
MOD_GSK3_1	90	97	PF00069	0.691
MOD_N-GLC_1	166	171	PF02516	0.448
MOD_N-GLC_1	17	22	PF02516	0.533
MOD_N-GLC_1	780	785	PF02516	0.673
MOD_N-GLC_2	474	476	PF02516	0.601
MOD_NEK2_1	135	140	PF00069	0.664
MOD_NEK2_1	150	155	PF00069	0.450
MOD_NEK2_1	175	180	PF00069	0.505
MOD_NEK2_1	188	193	PF00069	0.440
MOD_NEK2_1	246	251	PF00069	0.423
MOD_NEK2_1	290	295	PF00069	0.373
MOD_NEK2_1	412	417	PF00069	0.532
MOD_NEK2_1	631	636	PF00069	0.714
MOD_NEK2_1	742	747	PF00069	0.653
MOD_NEK2_1	823	828	PF00069	0.669
MOD_NEK2_2	369	374	PF00069	0.504
MOD_OFUCOSY	163	170	PF10250	0.436
MOD_OFUCOSY	291	297	PF10250	0.405
MOD_PIKK_1	197	203	PF00454	0.570
MOD_PIKK_1	277	283	PF00454	0.380
MOD_PIKK_1	325	331	PF00454	0.508
MOD_PIKK_1	34	40	PF00454	0.670
MOD_PIKK_1	635	641	PF00454	0.705
MOD_PIKK_1	649	655	PF00454	0.566
MOD_PIKK_1	834	840	PF00454	0.729
MOD_PKA_1	397	403	PF00069	0.520
MOD_PKA_1	813	819	PF00069	0.700
MOD_PKA_1	839	845	PF00069	0.722
MOD_PKA_2	193	199	PF00069	0.528
MOD_PKA_2	214	220	PF00069	0.530
MOD_PKA_2	251	257	PF00069	0.461
MOD_PKA_2	277	283	PF00069	0.380
MOD_PKA_2	396	402	PF00069	0.521
MOD_PKA_2	447	453	PF00069	0.486
MOD_PKA_2	590	596	PF00069	0.738
MOD_PKA_2	690	696	PF00069	0.561
MOD_PKA_2	736	742	PF00069	0.706
MOD_PKA_2	788	794	PF00069	0.624
MOD_PKA_2	838	844	PF00069	0.723
MOD_PKB_1	621	629	PF00069	0.682
MOD_PKB_1	656	664	PF00069	0.552
MOD_Plk_1	17	23	PF00069	0.564
MOD_Plk_1	170	176	PF00069	0.482
MOD_Plk_1	188	194	PF00069	0.428
MOD_Plk_1	341	347	PF00069	0.380
MOD_Plk_1	389	395	PF00069	0.465
MOD_Plk_1	584	590	PF00069	0.664
MOD_Plk_1	612	618	PF00069	0.660
MOD_Plk_1	760	766	PF00069	0.668
MOD_Plk_1	780	786	PF00069	0.543
MOD_Plk_1	823	829	PF00069	0.650
MOD_Plk_2-3	760	766	PF00069	0.668
MOD_Plk_4	156	162	PF00069	0.471
MOD_Plk_4	170	176	PF00069	0.398
MOD_Plk_4	188	194	PF00069	0.428
MOD_Plk_4	347	353	PF00069	0.471
MOD_Plk_4	408	414	PF00069	0.448
MOD_Plk_4	428	434	PF00069	0.422
MOD_Plk_4	477	483	PF00069	0.698
MOD_Plk_4	584	590	PF00069	0.706
MOD_ProDKin_1	145	151	PF00069	0.631
MOD_ProDKin_1	221	227	PF00069	0.640
MOD_ProDKin_1	425	431	PF00069	0.520
MOD_ProDKin_1	485	491	PF00069	0.639
MOD_ProDKin_1	596	602	PF00069	0.668
MOD_ProDKin_1	686	692	PF00069	0.568
MOD_ProDKin_1	92	98	PF00069	0.665
MOD_SUMO_rev_2	228	236	PF00179	0.570
MOD_SUMO_rev_2	350	359	PF00179	0.462
TRG_DiLeu_BaEn_1	585	590	PF01217	0.666
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.645
TRG_ENDOCYTIC_2	497	500	PF00928	0.595
TRG_ER_diArg_1	272	274	PF00400	0.576
TRG_ER_diArg_1	419	422	PF00400	0.553
TRG_ER_diArg_1	618	621	PF00400	0.665
TRG_ER_diArg_1	656	659	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	658	663	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAN9	Leishmania donovani	88%	100%
A4HP15	Leishmania braziliensis	64%	100%
A4IDC4	Leishmania infantum	88%	100%
E9ASS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%