Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania major

UniProt:

Q4Q1S0_LEIMA

TriTrypDb:

LmjF.36.1560 , LMJLV39_360021700 , LMJSD75_360021700

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	8
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4Q1S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.525
CLV_C14_Caspase3-7	177	181	PF00656	0.362
CLV_C14_Caspase3-7	90	94	PF00656	0.550
CLV_NRD_NRD_1	432	434	PF00675	0.665
CLV_PCSK_KEX2_1	432	434	PF00082	0.665
CLV_PCSK_SKI1_1	263	267	PF00082	0.485
CLV_PCSK_SKI1_1	269	273	PF00082	0.407
CLV_PCSK_SKI1_1	390	394	PF00082	0.768
CLV_PCSK_SKI1_1	445	449	PF00082	0.760
CLV_PCSK_SKI1_1	482	486	PF00082	0.662
CLV_PCSK_SKI1_1	498	502	PF00082	0.490
DEG_SPOP_SBC_1	358	362	PF00917	0.755
DOC_CDC14_PxL_1	237	245	PF14671	0.479
DOC_CDC14_PxL_1	461	469	PF14671	0.623
DOC_CDC14_PxL_1	67	75	PF14671	0.477
DOC_CYCLIN_RxL_1	195	206	PF00134	0.407
DOC_MAPK_gen_1	107	117	PF00069	0.460
DOC_MAPK_gen_1	263	273	PF00069	0.517
DOC_MAPK_gen_1	432	439	PF00069	0.659
DOC_MAPK_MEF2A_6	110	119	PF00069	0.451
DOC_MAPK_MEF2A_6	238	245	PF00069	0.482
DOC_MAPK_MEF2A_6	432	441	PF00069	0.632
DOC_PP1_RVXF_1	267	274	PF00149	0.494
DOC_PP2B_LxvP_1	448	451	PF13499	0.660
DOC_PP4_FxxP_1	331	334	PF00568	0.544
DOC_USP7_MATH_1	26	30	PF00917	0.671
DOC_USP7_MATH_1	358	362	PF00917	0.707
DOC_USP7_MATH_1	366	370	PF00917	0.659
DOC_USP7_MATH_1	427	431	PF00917	0.550
DOC_WW_Pin1_4	21	26	PF00397	0.635
DOC_WW_Pin1_4	404	409	PF00397	0.678
LIG_14-3-3_CanoR_1	110	119	PF00244	0.529
LIG_14-3-3_CanoR_1	165	173	PF00244	0.351
LIG_14-3-3_CanoR_1	174	179	PF00244	0.471
LIG_14-3-3_CanoR_1	231	240	PF00244	0.558
LIG_14-3-3_CanoR_1	269	274	PF00244	0.464
LIG_14-3-3_CanoR_1	404	408	PF00244	0.663
LIG_Actin_WH2_2	28	43	PF00022	0.538
LIG_BRCT_BRCA1_1	112	116	PF00533	0.436
LIG_BRCT_BRCA1_1	208	212	PF00533	0.505
LIG_BRCT_BRCA1_1	361	365	PF00533	0.679
LIG_FHA_1	110	116	PF00498	0.405
LIG_FHA_1	183	189	PF00498	0.475
LIG_FHA_1	192	198	PF00498	0.383
LIG_FHA_1	387	393	PF00498	0.727
LIG_FHA_1	458	464	PF00498	0.697
LIG_FHA_2	136	142	PF00498	0.483
LIG_FHA_2	242	248	PF00498	0.421
LIG_FHA_2	302	308	PF00498	0.718
LIG_FHA_2	34	40	PF00498	0.513
LIG_FHA_2	473	479	PF00498	0.666
LIG_FHA_2	88	94	PF00498	0.536
LIG_IBAR_NPY_1	50	52	PF08397	0.593
LIG_Integrin_isoDGR_2	471	473	PF01839	0.689
LIG_Integrin_RGD_1	16	18	PF01839	0.670
LIG_LIR_Gen_1	113	124	PF02991	0.405
LIG_LIR_Gen_1	410	421	PF02991	0.634
LIG_LIR_Nem_3	113	119	PF02991	0.440
LIG_LIR_Nem_3	144	149	PF02991	0.289
LIG_LIR_Nem_3	393	398	PF02991	0.634
LIG_LIR_Nem_3	410	416	PF02991	0.628
LIG_LIR_Nem_3	419	425	PF02991	0.587
LIG_LIR_Nem_3	46	52	PF02991	0.556
LIG_Pex14_2	148	152	PF04695	0.434
LIG_SH2_CRK	214	218	PF00017	0.305
LIG_SH2_CRK	422	426	PF00017	0.477
LIG_SH2_NCK_1	214	218	PF00017	0.422
LIG_SH2_PTP2	413	416	PF00017	0.625
LIG_SH2_PTP2	76	79	PF00017	0.454
LIG_SH2_STAP1	306	310	PF00017	0.730
LIG_SH2_STAT3	97	100	PF00017	0.561
LIG_SH2_STAT5	413	416	PF00017	0.632
LIG_SH2_STAT5	457	460	PF00017	0.611
LIG_SH2_STAT5	57	60	PF00017	0.540
LIG_SH2_STAT5	76	79	PF00017	0.218
LIG_SH3_3	17	23	PF00018	0.649
LIG_SH3_3	8	14	PF00018	0.656
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.608
LIG_SUMO_SIM_par_1	198	203	PF11976	0.401
LIG_TRAF2_1	36	39	PF00917	0.526
LIG_TRAF2_1	451	454	PF00917	0.643
LIG_TRAF2_1	492	495	PF00917	0.744
MOD_CK1_1	203	209	PF00069	0.405
MOD_CK1_1	321	327	PF00069	0.708
MOD_CK1_1	369	375	PF00069	0.715
MOD_CK1_1	397	403	PF00069	0.627
MOD_CK2_1	310	316	PF00069	0.698
MOD_CK2_1	33	39	PF00069	0.513
MOD_CK2_1	472	478	PF00069	0.722
MOD_DYRK1A_RPxSP_1	404	408	PF00069	0.668
MOD_GlcNHglycan	233	236	PF01048	0.556
MOD_GlcNHglycan	252	256	PF01048	0.288
MOD_GlcNHglycan	28	31	PF01048	0.555
MOD_GlcNHglycan	323	326	PF01048	0.686
MOD_GlcNHglycan	345	348	PF01048	0.744
MOD_GlcNHglycan	366	369	PF01048	0.771
MOD_GlcNHglycan	399	403	PF01048	0.637
MOD_GlcNHglycan	429	432	PF01048	0.538
MOD_GSK3_1	297	304	PF00069	0.678
MOD_GSK3_1	334	341	PF00069	0.697
MOD_GSK3_1	360	367	PF00069	0.651
MOD_GSK3_1	386	393	PF00069	0.755
MOD_GSK3_1	394	401	PF00069	0.666
MOD_GSK3_1	403	410	PF00069	0.559
MOD_GSK3_1	57	64	PF00069	0.455
MOD_LATS_1	108	114	PF00433	0.470
MOD_LATS_1	229	235	PF00433	0.447
MOD_N-GLC_1	203	208	PF02516	0.245
MOD_N-GLC_2	6	8	PF02516	0.637
MOD_NEK2_1	150	155	PF00069	0.497
MOD_NEK2_1	191	196	PF00069	0.395
MOD_NEK2_1	200	205	PF00069	0.260
MOD_NEK2_1	212	217	PF00069	0.352
MOD_NEK2_1	398	403	PF00069	0.752
MOD_NEK2_1	40	45	PF00069	0.562
MOD_NEK2_1	55	60	PF00069	0.421
MOD_PKA_2	109	115	PF00069	0.532
MOD_PKA_2	335	341	PF00069	0.637
MOD_PKA_2	403	409	PF00069	0.654
MOD_PKA_2	472	478	PF00069	0.665
MOD_PKB_1	172	180	PF00069	0.401
MOD_Plk_1	203	209	PF00069	0.384
MOD_Plk_1	33	39	PF00069	0.592
MOD_Plk_4	241	247	PF00069	0.482
MOD_Plk_4	360	366	PF00069	0.665
MOD_Plk_4	459	465	PF00069	0.611
MOD_ProDKin_1	21	27	PF00069	0.633
MOD_ProDKin_1	404	410	PF00069	0.677
MOD_SUMO_for_1	492	495	PF00179	0.499
MOD_SUMO_rev_2	34	43	PF00179	0.506
TRG_DiLeu_BaEn_2	143	149	PF01217	0.447
TRG_DiLeu_BaEn_2	419	425	PF01217	0.587
TRG_ENDOCYTIC_2	413	416	PF00928	0.657
TRG_ENDOCYTIC_2	422	425	PF00928	0.592
TRG_ENDOCYTIC_2	52	55	PF00928	0.557
TRG_ENDOCYTIC_2	76	79	PF00928	0.407
TRG_ER_diArg_1	156	159	PF00400	0.362
TRG_ER_diArg_1	290	293	PF00400	0.566
TRG_NES_CRM1_1	239	252	PF08389	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P712	Leptomonas seymouri	49%	100%
A0A1X0P7V7	Trypanosomatidae	28%	100%
A0A3Q8IIX2	Leishmania donovani	90%	100%
A1A4H9	Bos taurus	23%	97%
A4IDC5	Leishmania infantum	90%	100%
D4A6D8	Rattus norvegicus	24%	96%
E9AIX7	Leishmania braziliensis	67%	100%
E9ASS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q5R6B1	Pongo abelii	23%	96%
Q5RFE9	Pongo abelii	24%	84%
Q86UE6	Homo sapiens	24%	96%