Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1R9_LEIMA

TriTrypDb:

LmjF.36.1570 , LMJLV39_360021800 , LMJSD75_360021800

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1R9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008017	microtubule binding	5	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.526
CLV_NRD_NRD_1	196	198	PF00675	0.722
CLV_NRD_NRD_1	229	231	PF00675	0.668
CLV_NRD_NRD_1	256	258	PF00675	0.776
CLV_NRD_NRD_1	339	341	PF00675	0.818
CLV_NRD_NRD_1	457	459	PF00675	0.573
CLV_NRD_NRD_1	80	82	PF00675	0.589
CLV_NRD_NRD_1	91	93	PF00675	0.519
CLV_PCSK_KEX2_1	116	118	PF00082	0.607
CLV_PCSK_KEX2_1	195	197	PF00082	0.706
CLV_PCSK_KEX2_1	229	231	PF00082	0.690
CLV_PCSK_KEX2_1	339	341	PF00082	0.818
CLV_PCSK_KEX2_1	457	459	PF00082	0.573
CLV_PCSK_KEX2_1	82	84	PF00082	0.542
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.542
CLV_PCSK_SKI1_1	155	159	PF00082	0.511
CLV_PCSK_SKI1_1	249	253	PF00082	0.760
CLV_PCSK_SKI1_1	389	393	PF00082	0.635
CLV_PCSK_SKI1_1	411	415	PF00082	0.546
CLV_PCSK_SKI1_1	457	461	PF00082	0.526
CLV_PCSK_SKI1_1	466	470	PF00082	0.421
CLV_Separin_Metazoa	89	93	PF03568	0.564
DEG_APCC_DBOX_1	115	123	PF00400	0.470
DEG_APCC_DBOX_1	364	372	PF00400	0.617
DOC_CYCLIN_RxL_1	454	464	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.565
DOC_MAPK_gen_1	133	141	PF00069	0.612
DOC_MAPK_gen_1	406	412	PF00069	0.467
DOC_MAPK_gen_1	454	462	PF00069	0.575
DOC_MAPK_gen_1	81	90	PF00069	0.578
DOC_MAPK_MEF2A_6	155	162	PF00069	0.581
DOC_MAPK_MEF2A_6	17	24	PF00069	0.665
DOC_MAPK_MEF2A_6	174	183	PF00069	0.304
DOC_USP7_MATH_1	228	232	PF00917	0.791
DOC_USP7_MATH_1	270	274	PF00917	0.554
DOC_USP7_MATH_1	290	294	PF00917	0.699
DOC_USP7_MATH_1	3	7	PF00917	0.769
DOC_USP7_MATH_1	314	318	PF00917	0.772
DOC_USP7_MATH_1	327	331	PF00917	0.808
DOC_USP7_MATH_1	347	351	PF00917	0.705
DOC_USP7_MATH_1	36	40	PF00917	0.590
DOC_USP7_MATH_1	428	432	PF00917	0.678
DOC_USP7_UBL2_3	407	411	PF12436	0.577
DOC_WW_Pin1_4	235	240	PF00397	0.671
DOC_WW_Pin1_4	257	262	PF00397	0.714
DOC_WW_Pin1_4	333	338	PF00397	0.753
DOC_WW_Pin1_4	442	447	PF00397	0.739
LIG_14-3-3_CanoR_1	206	213	PF00244	0.587
LIG_14-3-3_CanoR_1	229	239	PF00244	0.737
LIG_14-3-3_CanoR_1	353	360	PF00244	0.661
LIG_14-3-3_CanoR_1	381	388	PF00244	0.635
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_CaM_IQ_9	34	50	PF13499	0.452
LIG_Clathr_ClatBox_1	159	163	PF01394	0.578
LIG_EH1_1	396	404	PF00400	0.556
LIG_FHA_1	25	31	PF00498	0.552
LIG_FHA_1	352	358	PF00498	0.596
LIG_FHA_1	398	404	PF00498	0.413
LIG_FHA_2	186	192	PF00498	0.613
LIG_FHA_2	21	27	PF00498	0.631
LIG_FHA_2	353	359	PF00498	0.594
LIG_GBD_Chelix_1	461	469	PF00786	0.528
LIG_Integrin_RGD_1	442	444	PF01839	0.542
LIG_LIR_Apic_2	238	244	PF02991	0.777
LIG_LIR_Gen_1	188	198	PF02991	0.688
LIG_LIR_Nem_3	188	193	PF02991	0.649
LIG_MAD2	280	288	PF02301	0.763
LIG_NRBOX	464	470	PF00104	0.533
LIG_NRBOX	86	92	PF00104	0.533
LIG_SH2_CRK	241	245	PF00017	0.660
LIG_SH2_NCK_1	267	271	PF00017	0.665
LIG_SH2_SRC	241	244	PF00017	0.694
LIG_SH2_SRC	267	270	PF00017	0.724
LIG_SH2_STAP1	375	379	PF00017	0.600
LIG_SH2_STAP1	55	59	PF00017	0.485
LIG_SH3_2	250	255	PF14604	0.606
LIG_SH3_3	247	253	PF00018	0.604
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.572
LIG_SUMO_SIM_par_1	158	163	PF11976	0.578
LIG_TRAF2_1	301	304	PF00917	0.728
LIG_TRAF2_1	383	386	PF00917	0.581
LIG_TRAF2_1	94	97	PF00917	0.489
LIG_UBA3_1	87	93	PF00899	0.546
LIG_WW_3	242	246	PF00397	0.695
MOD_CDC14_SPxK_1	336	339	PF00782	0.740
MOD_CDK_SPxK_1	333	339	PF00069	0.741
MOD_CDK_SPxxK_3	333	340	PF00069	0.741
MOD_CK1_1	10	16	PF00069	0.613
MOD_CK1_1	135	141	PF00069	0.416
MOD_CK1_1	18	24	PF00069	0.551
MOD_CK1_1	231	237	PF00069	0.677
MOD_CK1_1	293	299	PF00069	0.757
MOD_CK1_1	429	435	PF00069	0.666
MOD_CK1_1	445	451	PF00069	0.635
MOD_CK2_1	122	128	PF00069	0.505
MOD_CK2_1	185	191	PF00069	0.594
MOD_CK2_1	298	304	PF00069	0.724
MOD_CK2_1	3	9	PF00069	0.730
MOD_CK2_1	380	386	PF00069	0.598
MOD_GlcNHglycan	1	4	PF01048	0.778
MOD_GlcNHglycan	105	108	PF01048	0.543
MOD_GlcNHglycan	17	20	PF01048	0.535
MOD_GlcNHglycan	209	212	PF01048	0.685
MOD_GlcNHglycan	292	295	PF01048	0.809
MOD_GlcNHglycan	316	319	PF01048	0.765
MOD_GlcNHglycan	331	334	PF01048	0.835
MOD_GlcNHglycan	349	352	PF01048	0.695
MOD_GlcNHglycan	426	429	PF01048	0.704
MOD_GlcNHglycan	9	12	PF01048	0.628
MOD_GSK3_1	11	18	PF00069	0.544
MOD_GSK3_1	128	135	PF00069	0.612
MOD_GSK3_1	20	27	PF00069	0.501
MOD_GSK3_1	231	238	PF00069	0.656
MOD_GSK3_1	290	297	PF00069	0.718
MOD_GSK3_1	3	10	PF00069	0.674
MOD_GSK3_1	306	313	PF00069	0.642
MOD_GSK3_1	323	330	PF00069	0.769
MOD_GSK3_1	347	354	PF00069	0.617
MOD_GSK3_1	36	43	PF00069	0.464
MOD_GSK3_1	422	429	PF00069	0.567
MOD_N-GLC_1	294	299	PF02516	0.737
MOD_N-GLC_1	434	439	PF02516	0.783
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	15	20	PF00069	0.584
MOD_NEK2_1	298	303	PF00069	0.745
MOD_NEK2_1	426	431	PF00069	0.718
MOD_NEK2_2	294	299	PF00069	0.719
MOD_PIKK_1	128	134	PF00454	0.586
MOD_PIKK_1	298	304	PF00454	0.805
MOD_PIKK_1	320	326	PF00454	0.697
MOD_PKA_2	132	138	PF00069	0.580
MOD_PKA_2	205	211	PF00069	0.650
MOD_PKA_2	228	234	PF00069	0.707
MOD_PKA_2	352	358	PF00069	0.606
MOD_PKA_2	380	386	PF00069	0.601
MOD_PKA_2	397	403	PF00069	0.467
MOD_PKA_2	429	435	PF00069	0.677
MOD_Plk_1	294	300	PF00069	0.719
MOD_Plk_1	375	381	PF00069	0.613
MOD_Plk_1	434	440	PF00069	0.786
MOD_Plk_4	26	32	PF00069	0.475
MOD_Plk_4	271	277	PF00069	0.713
MOD_ProDKin_1	235	241	PF00069	0.673
MOD_ProDKin_1	257	263	PF00069	0.715
MOD_ProDKin_1	333	339	PF00069	0.755
MOD_ProDKin_1	442	448	PF00069	0.734
MOD_SUMO_for_1	148	151	PF00179	0.578
MOD_SUMO_for_1	165	168	PF00179	0.435
MOD_SUMO_rev_2	128	138	PF00179	0.574
MOD_SUMO_rev_2	21	30	PF00179	0.526
TRG_DiLeu_BaEn_1	408	413	PF01217	0.466
TRG_DiLeu_BaEn_1	464	469	PF01217	0.533
TRG_DiLeu_BaEn_4	421	427	PF01217	0.481
TRG_DiLeu_BaEn_4	96	102	PF01217	0.579
TRG_ENDOCYTIC_2	190	193	PF00928	0.656
TRG_ER_diArg_1	195	197	PF00400	0.713
TRG_ER_diArg_1	228	230	PF00400	0.688
TRG_ER_diArg_1	339	341	PF00400	0.820
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F5	Leptomonas seymouri	57%	98%
A0A0S4ISW4	Bodo saltans	33%	100%
A0A1X0P856	Trypanosomatidae	39%	100%
A0A3Q8INJ9	Leishmania donovani	94%	100%
A0A3R7RIJ2	Trypanosoma rangeli	37%	100%
A4HP16	Leishmania braziliensis	78%	100%
A4IDC6	Leishmania infantum	93%	100%
E9ASS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BU44	Trypanosoma cruzi	40%	100%