Universal minicircle sequence binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein

Species:

Leishmania major

UniProt:

Q4Q1R3_LEIMA

TriTrypDb:

LmjF.36.1620 , LMJLV39_360022500 , LMJSD75_360022300

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1R3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1R3

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034250	positive regulation of amide metabolic process	6	2
GO:0045727	positive regulation of translation	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000765	regulation of cytoplasmic translation	7	2
GO:2000767	positive regulation of cytoplasmic translation	8	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0045182	translation regulator activity	1	2
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.629
CLV_NRD_NRD_1	104	106	PF00675	0.594
CLV_NRD_NRD_1	152	154	PF00675	0.520
CLV_NRD_NRD_1	22	24	PF00675	0.681
CLV_PCSK_KEX2_1	22	24	PF00082	0.534
DOC_CYCLIN_RxL_1	40	50	PF00134	0.471
DOC_MAPK_MEF2A_6	54	61	PF00069	0.529
DOC_USP7_MATH_1	34	38	PF00917	0.597
DOC_USP7_MATH_1	84	88	PF00917	0.514
DOC_WW_Pin1_4	13	18	PF00397	0.451
DOC_WW_Pin1_4	7	12	PF00397	0.528
LIG_14-3-3_CanoR_1	25	34	PF00244	0.482
LIG_14-3-3_CanoR_1	43	48	PF00244	0.564
LIG_BRCT_BRCA1_1	9	13	PF00533	0.460
LIG_FHA_1	114	120	PF00498	0.402
LIG_FHA_1	140	146	PF00498	0.278
LIG_FHA_1	162	168	PF00498	0.395
LIG_FHA_2	26	32	PF00498	0.525
LIG_LIR_Nem_3	36	41	PF02991	0.504
LIG_SH3_2	17	22	PF14604	0.457
LIG_SH3_3	14	20	PF00018	0.510
LIG_SH3_CIN85_PxpxPR_1	17	22	PF14604	0.457
LIG_SUMO_SIM_par_1	42	48	PF11976	0.421
LIG_WW_3	19	23	PF00397	0.462
MOD_CK1_1	55	61	PF00069	0.558
MOD_CK1_1	62	68	PF00069	0.266
MOD_GlcNHglycan	61	64	PF01048	0.546
MOD_GSK3_1	113	120	PF00069	0.402
MOD_GSK3_1	139	146	PF00069	0.402
MOD_GSK3_1	161	168	PF00069	0.395
MOD_GSK3_1	21	28	PF00069	0.687
MOD_GSK3_1	39	46	PF00069	0.593
MOD_GSK3_1	55	62	PF00069	0.607
MOD_GSK3_1	91	98	PF00069	0.383
MOD_NEK2_1	45	50	PF00069	0.545
MOD_NEK2_1	52	57	PF00069	0.492
MOD_NEK2_1	6	11	PF00069	0.603
MOD_NEK2_1	75	80	PF00069	0.383
MOD_NEK2_2	84	89	PF00069	0.516
MOD_PKA_2	21	27	PF00069	0.475
MOD_PKA_2	55	61	PF00069	0.409
MOD_PKB_1	23	31	PF00069	0.473
MOD_Plk_4	55	61	PF00069	0.631
MOD_ProDKin_1	7	13	PF00069	0.530
MOD_SUMO_rev_2	120	129	PF00179	0.395
MOD_SUMO_rev_2	146	155	PF00179	0.395
MOD_SUMO_rev_2	98	107	PF00179	0.395
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.468
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.433
TRG_ER_diArg_1	21	23	PF00400	0.583
TRG_ER_diArg_1	54	57	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD50	Leptomonas seymouri	36%	100%
A0A1X0P815	Trypanosomatidae	49%	85%
A0A1X0P8V4	Trypanosomatidae	34%	90%
A0A3Q8IK17	Leishmania donovani	87%	100%
A0A3R7K9Q9	Trypanosoma rangeli	37%	91%
A0A3S5H821	Leishmania donovani	35%	100%
A0A422MWM4	Trypanosoma rangeli	42%	100%
A4HP24	Leishmania braziliensis	38%	100%
A4IDD4	Leishmania infantum	35%	100%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	82%
D0A311	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AST3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	96%
E9AST5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O42395	Gallus gallus	35%	100%
P36627	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	98%
P53849	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P53996	Mus musculus	33%	98%
P62633	Homo sapiens	33%	99%
P62634	Rattus norvegicus	33%	99%
Q3T0Q6	Bos taurus	35%	100%
Q4Q1R1	Leishmania major	40%	100%
Q5R5R5	Pongo abelii	33%	99%
Q8T8R1	Drosophila melanogaster	35%	100%
Q8WW36	Homo sapiens	30%	100%
V5BJZ6	Trypanosoma cruzi	35%	91%
V5BU64	Trypanosoma cruzi	50%	91%
V5BU71	Trypanosoma cruzi	45%	100%