Putative universal minicircle sequence binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

universal minicircle sequence binding protein, putative

Species:

Leishmania major

UniProt:

Q4Q1R0_LEIMA

TriTrypDb:

LmjF.36.1640 , LMJLV39_360022900 , LMJSD75_360022700

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1R0

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0010628	positive regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0034248	regulation of amide metabolic process	5	2
GO:0034250	positive regulation of amide metabolic process	6	2
GO:0045727	positive regulation of translation	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051246	regulation of protein metabolic process	5	2
GO:0051247	positive regulation of protein metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	2
GO:2000765	regulation of cytoplasmic translation	7	2
GO:2000767	positive regulation of cytoplasmic translation	8	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0045182	translation regulator activity	1	2
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.462
CLV_PCSK_KEX2_1	126	128	PF00082	0.690
CLV_PCSK_KEX2_1	8	10	PF00082	0.689
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.690
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.685
DOC_USP7_MATH_1	240	244	PF00917	0.651
DOC_USP7_MATH_2	59	65	PF00917	0.625
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_FHA_1	2	8	PF00498	0.701
LIG_SH3_3	4	10	PF00018	0.696
MOD_CK1_1	14	20	PF00069	0.473
MOD_CK1_1	213	219	PF00069	0.541
MOD_GlcNHglycan	129	132	PF01048	0.572
MOD_GlcNHglycan	136	139	PF01048	0.446
MOD_GlcNHglycan	162	165	PF01048	0.597
MOD_GlcNHglycan	190	193	PF01048	0.573
MOD_GlcNHglycan	203	206	PF01048	0.443
MOD_GlcNHglycan	212	215	PF01048	0.430
MOD_GlcNHglycan	63	66	PF01048	0.608
MOD_GlcNHglycan	87	90	PF01048	0.617
MOD_GSK3_1	112	119	PF00069	0.651
MOD_GSK3_1	134	141	PF00069	0.597
MOD_GSK3_1	201	208	PF00069	0.459
MOD_GSK3_1	210	217	PF00069	0.575
MOD_GSK3_1	240	247	PF00069	0.655
MOD_GSK3_1	9	16	PF00069	0.644
MOD_NEK2_2	138	143	PF00069	0.402
MOD_NEK2_2	166	171	PF00069	0.410
MOD_NEK2_2	251	256	PF00069	0.405
MOD_NEK2_2	68	73	PF00069	0.578
MOD_PIKK_1	112	118	PF00454	0.619
MOD_PKA_2	40	46	PF00069	0.622
MOD_PKB_1	9	17	PF00069	0.637
MOD_Plk_1	138	144	PF00069	0.402
MOD_Plk_1	166	172	PF00069	0.466
MOD_Plk_1	251	257	PF00069	0.413
MOD_SUMO_rev_2	2	10	PF00179	0.697
TRG_NLS_MonoCore_2	7	12	PF00514	0.678
TRG_NLS_MonoExtC_3	7	13	PF00514	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P715	Leptomonas seymouri	68%	96%
A0A0S4JI86	Bodo saltans	30%	98%
A0A1X0P815	Trypanosomatidae	47%	100%
A0A1X0P8V4	Trypanosomatidae	35%	100%
A0A3Q8IQS7	Leishmania donovani	97%	100%
A0A3R7K9Q9	Trypanosoma rangeli	36%	100%
A4HP28	Leishmania braziliensis	89%	98%
A4IDD5	Leishmania infantum	97%	100%
D0A309	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AST3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AST6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	91%
O65639	Arabidopsis thaliana	42%	91%
Q04832	Leishmania major	100%	100%
Q12476	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	79%
Q94C69	Arabidopsis thaliana	36%	90%
V5BJZ6	Trypanosoma cruzi	36%	100%
V5BU64	Trypanosoma cruzi	49%	100%