Queuosine salvage protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2419), putative

Species:

Leishmania major

UniProt:

Q4Q1Q7_LEIMA

TriTrypDb:

LmjF.36.1670 , LMJLV39_360023200 , LMJSD75_360023000

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q1Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Q7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0101030	tRNA-guanine transglycosylation	7	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.427
CLV_NRD_NRD_1	204	206	PF00675	0.379
CLV_NRD_NRD_1	310	312	PF00675	0.319
CLV_PCSK_KEX2_1	204	206	PF00082	0.379
CLV_PCSK_KEX2_1	310	312	PF00082	0.319
CLV_PCSK_KEX2_1	511	513	PF00082	0.337
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.337
CLV_PCSK_SKI1_1	124	128	PF00082	0.399
CLV_PCSK_SKI1_1	451	455	PF00082	0.487
CLV_PCSK_SKI1_1	466	470	PF00082	0.241
CLV_PCSK_SKI1_1	528	532	PF00082	0.499
DOC_ANK_TNKS_1	316	323	PF00023	0.499
DOC_CKS1_1	480	485	PF01111	0.391
DOC_CYCLIN_RxL_1	472	482	PF00134	0.391
DOC_MAPK_gen_1	255	264	PF00069	0.383
DOC_MAPK_gen_1	277	287	PF00069	0.270
DOC_MAPK_gen_1	431	440	PF00069	0.376
DOC_MAPK_gen_1	511	519	PF00069	0.391
DOC_MAPK_MEF2A_6	25	32	PF00069	0.450
DOC_MAPK_MEF2A_6	255	264	PF00069	0.351
DOC_MAPK_NFAT4_5	25	33	PF00069	0.326
DOC_MAPK_NFAT4_5	257	265	PF00069	0.367
DOC_PP1_RVXF_1	233	239	PF00149	0.396
DOC_PP1_RVXF_1	473	480	PF00149	0.394
DOC_PP2B_LxvP_1	249	252	PF13499	0.528
DOC_PP2B_LxvP_1	286	289	PF13499	0.484
DOC_PP2B_LxvP_1	454	457	PF13499	0.394
DOC_PP4_FxxP_1	168	171	PF00568	0.576
DOC_USP7_MATH_1	126	130	PF00917	0.410
DOC_USP7_MATH_1	229	233	PF00917	0.446
DOC_USP7_MATH_1	365	369	PF00917	0.577
DOC_USP7_MATH_1	407	411	PF00917	0.579
DOC_USP7_MATH_1	65	69	PF00917	0.524
DOC_WW_Pin1_4	244	249	PF00397	0.523
DOC_WW_Pin1_4	479	484	PF00397	0.449
LIG_14-3-3_CanoR_1	271	276	PF00244	0.439
LIG_14-3-3_CanoR_1	466	471	PF00244	0.394
LIG_14-3-3_CanoR_1	486	491	PF00244	0.162
LIG_14-3-3_CanoR_1	77	85	PF00244	0.625
LIG_APCC_ABBA_1	438	443	PF00400	0.391
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BRCT_BRCA1_1	411	415	PF00533	0.387
LIG_BRCT_BRCA1_1	91	95	PF00533	0.470
LIG_CSL_BTD_1	249	252	PF09270	0.435
LIG_DLG_GKlike_1	271	278	PF00625	0.410
LIG_FHA_1	125	131	PF00498	0.590
LIG_FHA_1	229	235	PF00498	0.366
LIG_Integrin_RGD_1	224	226	PF01839	0.587
LIG_LIR_Apic_2	166	171	PF02991	0.578
LIG_LIR_Apic_2	426	430	PF02991	0.300
LIG_LIR_Gen_1	314	323	PF02991	0.510
LIG_LIR_Gen_1	53	64	PF02991	0.422
LIG_LIR_Nem_3	135	140	PF02991	0.456
LIG_LIR_Nem_3	273	279	PF02991	0.329
LIG_LIR_Nem_3	314	318	PF02991	0.454
LIG_LIR_Nem_3	53	59	PF02991	0.412
LIG_OCRL_FandH_1	55	67	PF00620	0.322
LIG_PAM2_1	378	390	PF00658	0.563
LIG_Pex14_2	215	219	PF04695	0.472
LIG_PTAP_UEV_1	379	384	PF05743	0.614
LIG_RPA_C_Fungi	266	278	PF08784	0.412
LIG_RPA_C_Fungi	305	317	PF08784	0.281
LIG_SH2_CRK	276	280	PF00017	0.393
LIG_SH2_CRK	427	431	PF00017	0.300
LIG_SH2_CRK	529	533	PF00017	0.394
LIG_SH2_NCK_1	141	145	PF00017	0.480
LIG_SH2_SRC	427	430	PF00017	0.335
LIG_SH2_SRC	441	444	PF00017	0.335
LIG_SH2_STAP1	312	316	PF00017	0.407
LIG_SH2_STAP1	441	445	PF00017	0.394
LIG_SH2_STAP1	521	525	PF00017	0.395
LIG_SH2_STAT5	103	106	PF00017	0.294
LIG_SH2_STAT5	201	204	PF00017	0.432
LIG_SH2_STAT5	525	528	PF00017	0.358
LIG_SH2_STAT5	9	12	PF00017	0.588
LIG_SH3_1	377	383	PF00018	0.542
LIG_SH3_3	141	147	PF00018	0.502
LIG_SH3_3	317	323	PF00018	0.502
LIG_SH3_3	377	383	PF00018	0.668
LIG_SH3_3	499	505	PF00018	0.403
LIG_SUMO_SIM_anti_2	256	263	PF11976	0.439
LIG_SUMO_SIM_par_1	106	111	PF11976	0.327
LIG_SUMO_SIM_par_1	259	266	PF11976	0.393
LIG_TRAF2_1	459	462	PF00917	0.394
LIG_WW_1	6	9	PF00397	0.416
MOD_CDK_SPxxK_3	479	486	PF00069	0.377
MOD_CK1_1	13	19	PF00069	0.463
MOD_CK1_1	148	154	PF00069	0.626
MOD_CK1_1	346	352	PF00069	0.421
MOD_CK1_1	367	373	PF00069	0.569
MOD_CK1_1	409	415	PF00069	0.317
MOD_CK1_1	79	85	PF00069	0.502
MOD_CK2_1	126	132	PF00069	0.500
MOD_CK2_1	395	401	PF00069	0.509
MOD_CK2_1	456	462	PF00069	0.391
MOD_CK2_1	85	91	PF00069	0.418
MOD_GlcNHglycan	147	150	PF01048	0.541
MOD_GlcNHglycan	160	163	PF01048	0.505
MOD_GlcNHglycan	172	175	PF01048	0.698
MOD_GlcNHglycan	195	198	PF01048	0.391
MOD_GlcNHglycan	231	234	PF01048	0.456
MOD_GlcNHglycan	3	6	PF01048	0.490
MOD_GlcNHglycan	380	383	PF01048	0.565
MOD_GlcNHglycan	397	400	PF01048	0.499
MOD_GlcNHglycan	411	414	PF01048	0.363
MOD_GlcNHglycan	417	420	PF01048	0.333
MOD_GlcNHglycan	458	461	PF01048	0.337
MOD_GlcNHglycan	514	517	PF01048	0.460
MOD_GlcNHglycan	67	70	PF01048	0.609
MOD_GlcNHglycan	78	81	PF01048	0.495
MOD_GSK3_1	1	8	PF00069	0.644
MOD_GSK3_1	10	17	PF00069	0.437
MOD_GSK3_1	122	129	PF00069	0.551
MOD_GSK3_1	224	231	PF00069	0.458
MOD_GSK3_1	323	330	PF00069	0.654
MOD_GSK3_1	364	371	PF00069	0.468
MOD_GSK3_1	395	402	PF00069	0.661
MOD_GSK3_1	409	416	PF00069	0.259
MOD_GSK3_1	75	82	PF00069	0.500
MOD_GSK3_1	85	92	PF00069	0.305
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	193	198	PF00069	0.396
MOD_NEK2_1	260	265	PF00069	0.363
MOD_NEK2_1	33	38	PF00069	0.519
MOD_NEK2_1	343	348	PF00069	0.400
MOD_NEK2_1	415	420	PF00069	0.323
MOD_NEK2_1	494	499	PF00069	0.417
MOD_NEK2_1	539	544	PF00069	0.302
MOD_PIKK_1	343	349	PF00454	0.411
MOD_PKA_2	14	20	PF00069	0.404
MOD_PKA_2	193	199	PF00069	0.373
MOD_PKA_2	270	276	PF00069	0.440
MOD_PKA_2	485	491	PF00069	0.382
MOD_PKA_2	76	82	PF00069	0.665
MOD_PKB_1	222	230	PF00069	0.409
MOD_Plk_1	407	413	PF00069	0.649
MOD_Plk_1	461	467	PF00069	0.337
MOD_Plk_4	188	194	PF00069	0.527
MOD_Plk_4	271	277	PF00069	0.352
MOD_Plk_4	28	34	PF00069	0.536
MOD_Plk_4	301	307	PF00069	0.403
MOD_Plk_4	40	46	PF00069	0.426
MOD_Plk_4	466	472	PF00069	0.410
MOD_Plk_4	89	95	PF00069	0.414
MOD_ProDKin_1	244	250	PF00069	0.520
MOD_ProDKin_1	479	485	PF00069	0.449
TRG_DiLeu_BaEn_1	256	261	PF01217	0.441
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.394
TRG_ENDOCYTIC_2	103	106	PF00928	0.327
TRG_ENDOCYTIC_2	141	144	PF00928	0.382
TRG_ENDOCYTIC_2	275	278	PF00928	0.403
TRG_ENDOCYTIC_2	312	315	PF00928	0.346
TRG_ER_diArg_1	203	205	PF00400	0.380
TRG_ER_diArg_1	310	312	PF00400	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P722	Leptomonas seymouri	51%	100%
A0A1X0P849	Trypanosomatidae	33%	100%
A0A3Q8INL6	Leishmania donovani	91%	100%
A4HP31	Leishmania braziliensis	74%	100%
A4IDD8	Leishmania infantum	92%	100%
D0A314	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AST9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%