Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1Q6_LEIMA

TriTrypDb:

LmjF.36.1680 , LMJLV39_360023300 , LMJSD75_360023100

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1Q6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Q6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.624
CLV_C14_Caspase3-7	624	628	PF00656	0.487
CLV_NRD_NRD_1	126	128	PF00675	0.486
CLV_NRD_NRD_1	173	175	PF00675	0.696
CLV_NRD_NRD_1	178	180	PF00675	0.503
CLV_NRD_NRD_1	205	207	PF00675	0.581
CLV_NRD_NRD_1	347	349	PF00675	0.657
CLV_NRD_NRD_1	41	43	PF00675	0.558
CLV_NRD_NRD_1	489	491	PF00675	0.494
CLV_NRD_NRD_1	572	574	PF00675	0.752
CLV_NRD_NRD_1	604	606	PF00675	0.578
CLV_NRD_NRD_1	635	637	PF00675	0.595
CLV_NRD_NRD_1	663	665	PF00675	0.628
CLV_NRD_NRD_1	689	691	PF00675	0.701
CLV_NRD_NRD_1	70	72	PF00675	0.497
CLV_NRD_NRD_1	750	752	PF00675	0.547
CLV_PCSK_FUR_1	661	665	PF00082	0.682
CLV_PCSK_KEX2_1	126	128	PF00082	0.486
CLV_PCSK_KEX2_1	173	175	PF00082	0.696
CLV_PCSK_KEX2_1	178	180	PF00082	0.503
CLV_PCSK_KEX2_1	205	207	PF00082	0.573
CLV_PCSK_KEX2_1	347	349	PF00082	0.769
CLV_PCSK_KEX2_1	41	43	PF00082	0.531
CLV_PCSK_KEX2_1	489	491	PF00082	0.494
CLV_PCSK_KEX2_1	572	574	PF00082	0.752
CLV_PCSK_KEX2_1	604	606	PF00082	0.578
CLV_PCSK_KEX2_1	635	637	PF00082	0.530
CLV_PCSK_KEX2_1	663	665	PF00082	0.625
CLV_PCSK_KEX2_1	688	690	PF00082	0.708
CLV_PCSK_KEX2_1	70	72	PF00082	0.545
CLV_PCSK_KEX2_1	750	752	PF00082	0.547
CLV_PCSK_PC7_1	174	180	PF00082	0.518
CLV_PCSK_SKI1_1	126	130	PF00082	0.494
CLV_PCSK_SKI1_1	162	166	PF00082	0.618
CLV_PCSK_SKI1_1	174	178	PF00082	0.496
CLV_PCSK_SKI1_1	314	318	PF00082	0.523
CLV_PCSK_SKI1_1	323	327	PF00082	0.531
CLV_PCSK_SKI1_1	536	540	PF00082	0.652
CLV_PCSK_SKI1_1	595	599	PF00082	0.479
CLV_PCSK_SKI1_1	741	745	PF00082	0.594
CLV_PCSK_SKI1_1	751	755	PF00082	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.478
DEG_SPOP_SBC_1	255	259	PF00917	0.492
DEG_SPOP_SBC_1	722	726	PF00917	0.637
DOC_CYCLIN_RxL_1	738	748	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	539	542	PF00134	0.513
DOC_MAPK_DCC_7	7	16	PF00069	0.578
DOC_MAPK_gen_1	178	184	PF00069	0.500
DOC_MAPK_MEF2A_6	589	598	PF00069	0.591
DOC_MAPK_RevD_3	112	127	PF00069	0.482
DOC_PP1_RVXF_1	312	318	PF00149	0.511
DOC_PP2B_LxvP_1	364	367	PF13499	0.760
DOC_PP2B_LxvP_1	539	542	PF13499	0.625
DOC_PP4_FxxP_1	192	195	PF00568	0.601
DOC_PP4_FxxP_1	555	558	PF00568	0.573
DOC_USP7_MATH_1	106	110	PF00917	0.527
DOC_USP7_MATH_1	200	204	PF00917	0.545
DOC_USP7_MATH_1	255	259	PF00917	0.536
DOC_USP7_MATH_1	279	283	PF00917	0.639
DOC_USP7_MATH_1	286	290	PF00917	0.647
DOC_USP7_MATH_1	379	383	PF00917	0.567
DOC_USP7_MATH_1	391	395	PF00917	0.545
DOC_USP7_MATH_1	502	506	PF00917	0.725
DOC_USP7_MATH_1	532	536	PF00917	0.613
DOC_USP7_MATH_1	703	707	PF00917	0.628
DOC_USP7_MATH_1	716	720	PF00917	0.593
DOC_USP7_MATH_1	771	775	PF00917	0.545
DOC_USP7_MATH_2	254	260	PF00917	0.489
DOC_USP7_UBL2_3	515	519	PF12436	0.543
DOC_WW_Pin1_4	248	253	PF00397	0.749
DOC_WW_Pin1_4	272	277	PF00397	0.514
DOC_WW_Pin1_4	315	320	PF00397	0.518
DOC_WW_Pin1_4	329	334	PF00397	0.572
DOC_WW_Pin1_4	636	641	PF00397	0.606
DOC_WW_Pin1_4	652	657	PF00397	0.639
DOC_WW_Pin1_4	714	719	PF00397	0.603
LIG_14-3-3_CanoR_1	115	123	PF00244	0.520
LIG_14-3-3_CanoR_1	144	148	PF00244	0.532
LIG_14-3-3_CanoR_1	228	234	PF00244	0.579
LIG_14-3-3_CanoR_1	410	414	PF00244	0.593
LIG_14-3-3_CanoR_1	420	425	PF00244	0.423
LIG_14-3-3_CanoR_1	523	531	PF00244	0.503
LIG_14-3-3_CanoR_1	604	613	PF00244	0.604
LIG_14-3-3_CanoR_1	650	654	PF00244	0.528
LIG_Actin_WH2_2	149	164	PF00022	0.541
LIG_Actin_WH2_2	2	17	PF00022	0.467
LIG_BIR_III_2	30	34	PF00653	0.603
LIG_BIR_III_4	352	356	PF00653	0.622
LIG_BRCT_BRCA1_1	256	260	PF00533	0.583
LIG_CaM_IQ_9	107	123	PF13499	0.481
LIG_CaM_IQ_9	62	78	PF13499	0.534
LIG_CaM_NSCaTE_8	617	624	PF13499	0.555
LIG_eIF4E_1	210	216	PF01652	0.546
LIG_EVH1_1	653	657	PF00568	0.520
LIG_FHA_1	133	139	PF00498	0.520
LIG_FHA_1	218	224	PF00498	0.573
LIG_FHA_1	22	28	PF00498	0.562
LIG_FHA_1	261	267	PF00498	0.659
LIG_FHA_1	545	551	PF00498	0.657
LIG_FHA_1	558	564	PF00498	0.539
LIG_FHA_1	6	12	PF00498	0.580
LIG_FHA_1	702	708	PF00498	0.564
LIG_FHA_1	73	79	PF00498	0.540
LIG_FHA_2	622	628	PF00498	0.575
LIG_FHA_2	637	643	PF00498	0.520
LIG_Integrin_RGD_1	245	247	PF01839	0.630
LIG_Integrin_RGD_1	456	458	PF01839	0.581
LIG_IRF3_LxIS_1	13	19	PF10401	0.484
LIG_LIR_Apic_2	553	558	PF02991	0.581
LIG_LIR_Apic_2	561	567	PF02991	0.589
LIG_LIR_Gen_1	734	744	PF02991	0.543
LIG_LIR_Nem_3	312	316	PF02991	0.688
LIG_LIR_Nem_3	320	325	PF02991	0.640
LIG_LIR_Nem_3	734	739	PF02991	0.521
LIG_LIR_Nem_3	94	98	PF02991	0.498
LIG_SH2_CRK	313	317	PF00017	0.595
LIG_SH2_CRK	451	455	PF00017	0.480
LIG_SH2_CRK	564	568	PF00017	0.591
LIG_SH2_GRB2like	747	750	PF00017	0.550
LIG_SH2_NCK_1	388	392	PF00017	0.514
LIG_SH2_STAP1	388	392	PF00017	0.514
LIG_SH2_STAT3	677	680	PF00017	0.590
LIG_SH2_STAT5	210	213	PF00017	0.503
LIG_SH2_STAT5	4	7	PF00017	0.595
LIG_SH2_STAT5	435	438	PF00017	0.459
LIG_SH2_STAT5	677	680	PF00017	0.590
LIG_SH2_STAT5	747	750	PF00017	0.592
LIG_SH3_1	7	13	PF00018	0.569
LIG_SH3_2	10	15	PF14604	0.471
LIG_SH3_2	656	661	PF14604	0.591
LIG_SH3_3	135	141	PF00018	0.464
LIG_SH3_3	246	252	PF00018	0.719
LIG_SH3_3	273	279	PF00018	0.538
LIG_SH3_3	332	338	PF00018	0.609
LIG_SH3_3	651	657	PF00018	0.644
LIG_SH3_3	7	13	PF00018	0.569
LIG_SUMO_SIM_anti_2	762	768	PF11976	0.546
LIG_SUMO_SIM_par_1	507	513	PF11976	0.642
LIG_TRAF2_1	318	321	PF00917	0.568
LIG_TRAF2_1	510	513	PF00917	0.572
LIG_UBA3_1	324	329	PF00899	0.565
LIG_WW_2	656	659	PF00397	0.560
LIG_WW_3	540	544	PF00397	0.594
MOD_CK1_1	19	25	PF00069	0.615
MOD_CK1_1	217	223	PF00069	0.619
MOD_CK1_1	230	236	PF00069	0.524
MOD_CK1_1	258	264	PF00069	0.685
MOD_CK1_1	382	388	PF00069	0.551
MOD_CK1_1	394	400	PF00069	0.620
MOD_CK1_1	462	468	PF00069	0.634
MOD_CK1_1	583	589	PF00069	0.648
MOD_CK1_1	652	658	PF00069	0.612
MOD_CK1_1	717	723	PF00069	0.658
MOD_CK2_1	19	25	PF00069	0.565
MOD_CK2_1	233	239	PF00069	0.502
MOD_CK2_1	272	278	PF00069	0.490
MOD_CK2_1	279	285	PF00069	0.483
MOD_CK2_1	315	321	PF00069	0.578
MOD_CK2_1	419	425	PF00069	0.558
MOD_CK2_1	606	612	PF00069	0.625
MOD_CK2_1	636	642	PF00069	0.550
MOD_CK2_1	771	777	PF00069	0.607
MOD_Cter_Amidation	345	348	PF01082	0.620
MOD_Cter_Amidation	633	636	PF01082	0.559
MOD_GlcNHglycan	18	21	PF01048	0.643
MOD_GlcNHglycan	216	219	PF01048	0.586
MOD_GlcNHglycan	235	238	PF01048	0.608
MOD_GlcNHglycan	341	344	PF01048	0.607
MOD_GlcNHglycan	381	384	PF01048	0.534
MOD_GlcNHglycan	393	396	PF01048	0.545
MOD_GlcNHglycan	467	470	PF01048	0.564
MOD_GlcNHglycan	498	501	PF01048	0.615
MOD_GlcNHglycan	516	519	PF01048	0.504
MOD_GlcNHglycan	591	594	PF01048	0.540
MOD_GlcNHglycan	608	611	PF01048	0.517
MOD_GlcNHglycan	773	776	PF01048	0.570
MOD_GSK3_1	106	113	PF00069	0.613
MOD_GSK3_1	16	23	PF00069	0.620
MOD_GSK3_1	224	231	PF00069	0.665
MOD_GSK3_1	254	261	PF00069	0.584
MOD_GSK3_1	334	341	PF00069	0.731
MOD_GSK3_1	405	412	PF00069	0.644
MOD_GSK3_1	459	466	PF00069	0.632
MOD_GSK3_1	581	588	PF00069	0.588
MOD_GSK3_1	714	721	PF00069	0.760
MOD_GSK3_1	767	774	PF00069	0.560
MOD_N-GLC_1	20	25	PF02516	0.625
MOD_NEK2_1	14	19	PF00069	0.645
MOD_NEK2_1	260	265	PF00069	0.574
MOD_NEK2_1	328	333	PF00069	0.542
MOD_NEK2_1	339	344	PF00069	0.599
MOD_NEK2_1	34	39	PF00069	0.498
MOD_NEK2_1	464	469	PF00069	0.506
MOD_NEK2_1	5	10	PF00069	0.744
MOD_NEK2_1	620	625	PF00069	0.560
MOD_NEK2_1	767	772	PF00069	0.649
MOD_NEK2_2	143	148	PF00069	0.546
MOD_NEK2_2	149	154	PF00069	0.566
MOD_NEK2_2	200	205	PF00069	0.522
MOD_NEK2_2	459	464	PF00069	0.517
MOD_NEK2_2	469	474	PF00069	0.456
MOD_PIKK_1	523	529	PF00454	0.613
MOD_PK_1	81	87	PF00069	0.558
MOD_PKA_2	14	20	PF00069	0.486
MOD_PKA_2	143	149	PF00069	0.495
MOD_PKA_2	227	233	PF00069	0.580
MOD_PKA_2	409	415	PF00069	0.648
MOD_PKA_2	419	425	PF00069	0.411
MOD_PKA_2	649	655	PF00069	0.530
MOD_PKA_2	760	766	PF00069	0.498
MOD_PKA_2	767	773	PF00069	0.515
MOD_PKB_1	688	696	PF00069	0.602
MOD_Plk_1	238	244	PF00069	0.500
MOD_Plk_1	255	261	PF00069	0.492
MOD_Plk_1	459	465	PF00069	0.539
MOD_Plk_1	775	781	PF00069	0.529
MOD_Plk_4	134	140	PF00069	0.519
MOD_Plk_4	279	285	PF00069	0.689
MOD_Plk_4	394	400	PF00069	0.587
MOD_Plk_4	502	508	PF00069	0.625
MOD_Plk_4	673	679	PF00069	0.634
MOD_Plk_4	682	688	PF00069	0.542
MOD_Plk_4	703	709	PF00069	0.523
MOD_ProDKin_1	248	254	PF00069	0.743
MOD_ProDKin_1	272	278	PF00069	0.513
MOD_ProDKin_1	315	321	PF00069	0.516
MOD_ProDKin_1	329	335	PF00069	0.574
MOD_ProDKin_1	636	642	PF00069	0.609
MOD_ProDKin_1	652	658	PF00069	0.640
MOD_ProDKin_1	714	720	PF00069	0.605
MOD_SUMO_rev_2	512	517	PF00179	0.548
TRG_DiLeu_BaEn_1	172	177	PF01217	0.563
TRG_DiLeu_BaEn_1	320	325	PF01217	0.579
TRG_DiLeu_BaEn_4	320	326	PF01217	0.582
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.520
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.539
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.702
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.627
TRG_DiLeu_BaLyEn_6	738	743	PF01217	0.519
TRG_DiLeu_LyEn_5	320	325	PF01217	0.537
TRG_ENDOCYTIC_2	313	316	PF00928	0.537
TRG_ENDOCYTIC_2	451	454	PF00928	0.470
TRG_ER_diArg_1	126	128	PF00400	0.458
TRG_ER_diArg_1	177	179	PF00400	0.523
TRG_ER_diArg_1	204	206	PF00400	0.568
TRG_ER_diArg_1	40	42	PF00400	0.530
TRG_ER_diArg_1	488	490	PF00400	0.512
TRG_ER_diArg_1	604	606	PF00400	0.609
TRG_ER_diArg_1	661	664	PF00400	0.622
TRG_ER_diArg_1	687	690	PF00400	0.705
TRG_ER_diArg_1	69	71	PF00400	0.560
TRG_ER_diArg_1	89	92	PF00400	0.461
TRG_NLS_MonoExtN_4	323	330	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	741	746	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF83	Leptomonas seymouri	32%	87%
A0A3S7XAQ0	Leishmania donovani	87%	100%
A4HP32	Leishmania braziliensis	62%	99%
A4IDD9	Leishmania infantum	87%	100%
E9ASU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%