J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1Q4_LEIMA

TriTrypDb:

LmjF.36.1700 , LMJLV39_360023500 , LMJSD75_360023300

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1Q4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Q4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.782
CLV_C14_Caspase3-7	412	416	PF00656	0.712
CLV_NRD_NRD_1	164	166	PF00675	0.697
CLV_NRD_NRD_1	17	19	PF00675	0.774
CLV_NRD_NRD_1	299	301	PF00675	0.758
CLV_NRD_NRD_1	421	423	PF00675	0.754
CLV_NRD_NRD_1	436	438	PF00675	0.658
CLV_NRD_NRD_1	474	476	PF00675	0.582
CLV_NRD_NRD_1	501	503	PF00675	0.743
CLV_PCSK_KEX2_1	164	166	PF00082	0.697
CLV_PCSK_KEX2_1	17	19	PF00082	0.765
CLV_PCSK_KEX2_1	299	301	PF00082	0.758
CLV_PCSK_KEX2_1	436	438	PF00082	0.728
CLV_PCSK_KEX2_1	474	476	PF00082	0.582
CLV_PCSK_KEX2_1	501	503	PF00082	0.743
CLV_PCSK_SKI1_1	272	276	PF00082	0.703
CLV_PCSK_SKI1_1	475	479	PF00082	0.608
CLV_PCSK_SKI1_1	55	59	PF00082	0.670
CLV_PCSK_SKI1_1	89	93	PF00082	0.686
DEG_APCC_DBOX_1	474	482	PF00400	0.610
DEG_Nend_Nbox_1	1	3	PF02207	0.773
DEG_SCF_FBW7_1	243	250	PF00400	0.763
DEG_SPOP_SBC_1	110	114	PF00917	0.697
DEG_SPOP_SBC_1	255	259	PF00917	0.762
DOC_CKS1_1	130	135	PF01111	0.804
DOC_CKS1_1	244	249	PF01111	0.747
DOC_CKS1_1	319	324	PF01111	0.770
DOC_CYCLIN_yClb1_LxF_4	427	433	PF00134	0.716
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.683
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.719
DOC_MAPK_gen_1	472	480	PF00069	0.629
DOC_MAPK_MEF2A_6	303	312	PF00069	0.741
DOC_MAPK_MEF2A_6	472	480	PF00069	0.629
DOC_PP2B_LxvP_1	197	200	PF13499	0.704
DOC_PP2B_LxvP_1	369	372	PF13499	0.585
DOC_PP2B_LxvP_1	58	61	PF13499	0.688
DOC_PP2B_LxvP_1	74	77	PF13499	0.716
DOC_PP4_FxxP_1	130	133	PF00568	0.804
DOC_PP4_FxxP_1	9	12	PF00568	0.683
DOC_USP7_MATH_1	110	114	PF00917	0.715
DOC_USP7_MATH_1	172	176	PF00917	0.709
DOC_USP7_MATH_1	180	184	PF00917	0.692
DOC_USP7_MATH_1	191	195	PF00917	0.607
DOC_USP7_MATH_1	25	29	PF00917	0.642
DOC_USP7_MATH_1	255	259	PF00917	0.776
DOC_USP7_MATH_1	283	287	PF00917	0.816
DOC_USP7_MATH_1	331	335	PF00917	0.817
DOC_USP7_MATH_1	364	368	PF00917	0.721
DOC_USP7_MATH_1	441	445	PF00917	0.802
DOC_USP7_MATH_1	484	488	PF00917	0.647
DOC_WW_Pin1_4	129	134	PF00397	0.667
DOC_WW_Pin1_4	243	248	PF00397	0.763
DOC_WW_Pin1_4	274	279	PF00397	0.711
DOC_WW_Pin1_4	318	323	PF00397	0.782
DOC_WW_Pin1_4	345	350	PF00397	0.688
DOC_WW_Pin1_4	45	50	PF00397	0.697
LIG_14-3-3_CanoR_1	224	230	PF00244	0.668
LIG_BIR_III_4	507	511	PF00653	0.569
LIG_BRCT_BRCA1_1	113	117	PF00533	0.658
LIG_BRCT_BRCA1_1	402	406	PF00533	0.655
LIG_BRCT_BRCA1_1	449	453	PF00533	0.691
LIG_CtBP_PxDLS_1	356	360	PF00389	0.824
LIG_deltaCOP1_diTrp_1	40	45	PF00928	0.664
LIG_deltaCOP1_diTrp_1	537	544	PF00928	0.693
LIG_FHA_1	257	263	PF00498	0.821
LIG_FHA_1	319	325	PF00498	0.803
LIG_FHA_1	346	352	PF00498	0.745
LIG_FHA_1	6	12	PF00498	0.705
LIG_FHA_2	381	387	PF00498	0.595
LIG_LIR_Apic_2	128	133	PF02991	0.806
LIG_LIR_Apic_2	20	25	PF02991	0.557
LIG_LIR_Apic_2	6	12	PF02991	0.681
LIG_LIR_Gen_1	175	186	PF02991	0.639
LIG_LIR_Gen_1	28	36	PF02991	0.786
LIG_LIR_Gen_1	425	433	PF02991	0.693
LIG_LIR_Gen_1	448	457	PF02991	0.715
LIG_LIR_Gen_1	519	528	PF02991	0.635
LIG_LIR_Gen_1	538	545	PF02991	0.462
LIG_LIR_Gen_1	90	96	PF02991	0.787
LIG_LIR_Nem_3	175	181	PF02991	0.641
LIG_LIR_Nem_3	264	269	PF02991	0.723
LIG_LIR_Nem_3	28	33	PF02991	0.711
LIG_LIR_Nem_3	425	430	PF02991	0.694
LIG_LIR_Nem_3	448	452	PF02991	0.715
LIG_LIR_Nem_3	519	524	PF02991	0.626
LIG_LIR_Nem_3	538	544	PF02991	0.462
LIG_MLH1_MIPbox_1	449	453	PF16413	0.772
LIG_MYND_1	322	326	PF01753	0.727
LIG_MYND_1	56	60	PF01753	0.678
LIG_Pex14_1	41	45	PF04695	0.667
LIG_Pex14_2	221	225	PF04695	0.685
LIG_Pex14_2	91	95	PF04695	0.687
LIG_PTAP_UEV_1	67	72	PF05743	0.691
LIG_RPA_C_Fungi	431	443	PF08784	0.727
LIG_SH2_STAP1	449	453	PF00017	0.670
LIG_SH2_STAT5	521	524	PF00017	0.684
LIG_SH3_1	164	170	PF00018	0.715
LIG_SH3_1	236	242	PF00018	0.731
LIG_SH3_3	104	110	PF00018	0.570
LIG_SH3_3	164	170	PF00018	0.725
LIG_SH3_3	181	187	PF00018	0.546
LIG_SH3_3	236	242	PF00018	0.711
LIG_SH3_3	245	251	PF00018	0.746
LIG_SH3_3	265	271	PF00018	0.695
LIG_SH3_3	305	311	PF00018	0.712
LIG_SH3_3	316	322	PF00018	0.684
LIG_SH3_3	33	39	PF00018	0.673
LIG_SH3_3	348	354	PF00018	0.763
LIG_SH3_3	489	495	PF00018	0.813
LIG_SH3_3	57	63	PF00018	0.644
LIG_SH3_3	65	71	PF00018	0.738
LIG_SUMO_SIM_par_1	355	361	PF11976	0.720
LIG_SUMO_SIM_par_1	62	67	PF11976	0.756
LIG_TRAF2_1	326	329	PF00917	0.681
LIG_TRAF2_1	383	386	PF00917	0.588
LIG_UBA3_1	478	485	PF00899	0.664
LIG_WRC_WIRS_1	42	47	PF05994	0.672
LIG_WRC_WIRS_1	449	454	PF05994	0.674
LIG_WW_3	246	250	PF00397	0.767
MOD_CDC14_SPxK_1	277	280	PF00782	0.717
MOD_CDK_SPxK_1	243	249	PF00069	0.763
MOD_CDK_SPxK_1	274	280	PF00069	0.712
MOD_CDK_SPxxK_3	129	136	PF00069	0.702
MOD_CDK_SPxxK_3	318	325	PF00069	0.726
MOD_CK1_1	113	119	PF00069	0.696
MOD_CK1_1	209	215	PF00069	0.779
MOD_CK1_1	217	223	PF00069	0.674
MOD_CK1_1	258	264	PF00069	0.781
MOD_CK1_1	28	34	PF00069	0.766
MOD_CK1_1	334	340	PF00069	0.761
MOD_CK1_1	358	364	PF00069	0.706
MOD_CK1_1	380	386	PF00069	0.739
MOD_CK1_1	43	49	PF00069	0.570
MOD_CK1_1	487	493	PF00069	0.618
MOD_CK1_1	519	525	PF00069	0.687
MOD_CK1_1	527	533	PF00069	0.697
MOD_CK1_1	90	96	PF00069	0.759
MOD_CK1_1	99	105	PF00069	0.594
MOD_CK2_1	282	288	PF00069	0.743
MOD_CK2_1	380	386	PF00069	0.583
MOD_CK2_1	453	459	PF00069	0.685
MOD_GlcNHglycan	113	116	PF01048	0.746
MOD_GlcNHglycan	12	15	PF01048	0.706
MOD_GlcNHglycan	120	123	PF01048	0.760
MOD_GlcNHglycan	159	162	PF01048	0.761
MOD_GlcNHglycan	193	196	PF01048	0.693
MOD_GlcNHglycan	336	339	PF01048	0.725
MOD_GlcNHglycan	365	369	PF01048	0.653
MOD_GlcNHglycan	406	409	PF01048	0.776
MOD_GlcNHglycan	45	48	PF01048	0.612
MOD_GlcNHglycan	482	485	PF01048	0.646
MOD_GlcNHglycan	523	527	PF01048	0.659
MOD_GlcNHglycan	67	71	PF01048	0.674
MOD_GSK3_1	109	116	PF00069	0.593
MOD_GSK3_1	187	194	PF00069	0.791
MOD_GSK3_1	220	227	PF00069	0.661
MOD_GSK3_1	243	250	PF00069	0.841
MOD_GSK3_1	254	261	PF00069	0.649
MOD_GSK3_1	279	286	PF00069	0.595
MOD_GSK3_1	341	348	PF00069	0.665
MOD_GSK3_1	400	407	PF00069	0.658
MOD_GSK3_1	41	48	PF00069	0.614
MOD_GSK3_1	448	455	PF00069	0.675
MOD_GSK3_1	480	487	PF00069	0.741
MOD_GSK3_1	490	497	PF00069	0.641
MOD_GSK3_1	512	519	PF00069	0.647
MOD_GSK3_1	97	104	PF00069	0.668
MOD_N-GLC_1	345	350	PF02516	0.741
MOD_N-GLC_1	453	458	PF02516	0.684
MOD_NEK2_1	225	230	PF00069	0.664
MOD_NEK2_1	279	284	PF00069	0.768
MOD_NEK2_1	332	337	PF00069	0.742
MOD_NEK2_1	375	380	PF00069	0.646
MOD_NEK2_1	401	406	PF00069	0.653
MOD_NEK2_1	414	419	PF00069	0.732
MOD_NEK2_1	452	457	PF00069	0.689
MOD_NEK2_1	524	529	PF00069	0.705
MOD_PIKK_1	441	447	PF00454	0.685
MOD_PIKK_1	490	496	PF00454	0.674
MOD_PKA_2	209	215	PF00069	0.750
MOD_PKA_2	225	231	PF00069	0.602
MOD_PKA_2	279	285	PF00069	0.617
MOD_PKA_2	380	386	PF00069	0.718
MOD_PKA_2	96	102	PF00069	0.676
MOD_Plk_1	155	161	PF00069	0.716
MOD_Plk_1	217	223	PF00069	0.696
MOD_Plk_1	447	453	PF00069	0.774
MOD_Plk_1	5	11	PF00069	0.660
MOD_Plk_2-3	463	469	PF00069	0.640
MOD_Plk_4	103	109	PF00069	0.570
MOD_Plk_4	25	31	PF00069	0.551
MOD_Plk_4	401	407	PF00069	0.657
MOD_Plk_4	448	454	PF00069	0.774
MOD_Plk_4	87	93	PF00069	0.756
MOD_ProDKin_1	129	135	PF00069	0.668
MOD_ProDKin_1	243	249	PF00069	0.765
MOD_ProDKin_1	274	280	PF00069	0.712
MOD_ProDKin_1	318	324	PF00069	0.784
MOD_ProDKin_1	345	351	PF00069	0.689
MOD_ProDKin_1	45	51	PF00069	0.699
MOD_SUMO_rev_2	205	215	PF00179	0.702
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.810
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.727
TRG_ENDOCYTIC_2	449	452	PF00928	0.609
TRG_ENDOCYTIC_2	521	524	PF00928	0.684
TRG_ER_diArg_1	16	18	PF00400	0.762
TRG_ER_diArg_1	163	165	PF00400	0.695
TRG_ER_diArg_1	473	475	PF00400	0.587
TRG_NES_CRM1_1	468	482	PF08389	0.606
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.800

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH7	Leptomonas seymouri	50%	100%
A0A3S7XAN3	Leishmania donovani	92%	100%
A4HP34	Leishmania braziliensis	65%	98%
A4IDE1	Leishmania infantum	92%	100%
E9ASU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%