Conserved oligomeric Golgi complex subunit 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1Q1_LEIMA

TriTrypDb:

LmjF.36.1730 , LMJLV39_360023800 , LMJSD75_360023800

Length:

951

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0005801	cis-Golgi network	5	12
GO:0016020	membrane	2	12
GO:0017119	Golgi transport complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0099023	vesicle tethering complex	2	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q1Q1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1Q1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.370
CLV_C14_Caspase3-7	415	419	PF00656	0.614
CLV_C14_Caspase3-7	537	541	PF00656	0.448
CLV_C14_Caspase3-7	599	603	PF00656	0.539
CLV_C14_Caspase3-7	663	667	PF00656	0.526
CLV_C14_Caspase3-7	685	689	PF00656	0.547
CLV_NRD_NRD_1	170	172	PF00675	0.295
CLV_NRD_NRD_1	345	347	PF00675	0.416
CLV_NRD_NRD_1	706	708	PF00675	0.471
CLV_PCSK_FUR_1	704	708	PF00082	0.543
CLV_PCSK_KEX2_1	345	347	PF00082	0.379
CLV_PCSK_KEX2_1	706	708	PF00082	0.518
CLV_PCSK_SKI1_1	125	129	PF00082	0.606
CLV_PCSK_SKI1_1	171	175	PF00082	0.371
CLV_PCSK_SKI1_1	232	236	PF00082	0.320
CLV_PCSK_SKI1_1	558	562	PF00082	0.326
CLV_PCSK_SKI1_1	668	672	PF00082	0.425
CLV_PCSK_SKI1_1	814	818	PF00082	0.516
CLV_PCSK_SKI1_1	830	834	PF00082	0.591
CLV_Separin_Metazoa	176	180	PF03568	0.427
DEG_APCC_DBOX_1	507	515	PF00400	0.352
DOC_CYCLIN_RxL_1	703	714	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.581
DOC_MAPK_FxFP_2	31	34	PF00069	0.627
DOC_MAPK_gen_1	100	108	PF00069	0.591
DOC_MAPK_gen_1	171	177	PF00069	0.386
DOC_MAPK_gen_1	232	241	PF00069	0.411
DOC_MAPK_gen_1	30	37	PF00069	0.579
DOC_MAPK_gen_1	715	725	PF00069	0.590
DOC_MAPK_MEF2A_6	18	27	PF00069	0.569
DOC_MAPK_MEF2A_6	235	243	PF00069	0.393
DOC_MAPK_MEF2A_6	391	398	PF00069	0.446
DOC_MAPK_MEF2A_6	607	615	PF00069	0.450
DOC_PP1_RVXF_1	556	562	PF00149	0.330
DOC_PP1_RVXF_1	617	624	PF00149	0.516
DOC_PP1_RVXF_1	769	776	PF00149	0.522
DOC_PP2B_LxvP_1	23	26	PF13499	0.580
DOC_PP2B_LxvP_1	35	38	PF13499	0.641
DOC_PP4_FxxP_1	31	34	PF00568	0.579
DOC_PP4_FxxP_1	609	612	PF00568	0.503
DOC_PP4_FxxP_1	905	908	PF00568	0.594
DOC_USP7_MATH_1	472	476	PF00917	0.444
DOC_USP7_MATH_1	596	600	PF00917	0.657
DOC_USP7_MATH_1	69	73	PF00917	0.754
DOC_USP7_MATH_1	748	752	PF00917	0.473
DOC_USP7_MATH_1	799	803	PF00917	0.526
DOC_USP7_MATH_1	828	832	PF00917	0.703
DOC_USP7_MATH_1	853	857	PF00917	0.704
DOC_USP7_MATH_1	86	90	PF00917	0.463
DOC_USP7_MATH_1	863	867	PF00917	0.661
DOC_USP7_MATH_1	876	880	PF00917	0.720
DOC_USP7_MATH_1	881	885	PF00917	0.713
DOC_USP7_MATH_1	940	944	PF00917	0.791
DOC_WW_Pin1_4	267	272	PF00397	0.498
DOC_WW_Pin1_4	287	292	PF00397	0.427
DOC_WW_Pin1_4	295	300	PF00397	0.596
DOC_WW_Pin1_4	433	438	PF00397	0.552
DOC_WW_Pin1_4	572	577	PF00397	0.488
DOC_WW_Pin1_4	58	63	PF00397	0.667
DOC_WW_Pin1_4	904	909	PF00397	0.750
LIG_14-3-3_CanoR_1	100	109	PF00244	0.567
LIG_14-3-3_CanoR_1	125	134	PF00244	0.516
LIG_14-3-3_CanoR_1	139	145	PF00244	0.276
LIG_14-3-3_CanoR_1	210	215	PF00244	0.325
LIG_14-3-3_CanoR_1	257	261	PF00244	0.287
LIG_14-3-3_CanoR_1	294	299	PF00244	0.685
LIG_14-3-3_CanoR_1	400	406	PF00244	0.498
LIG_14-3-3_CanoR_1	529	533	PF00244	0.496
LIG_14-3-3_CanoR_1	562	566	PF00244	0.323
LIG_14-3-3_CanoR_1	568	572	PF00244	0.377
LIG_14-3-3_CanoR_1	830	839	PF00244	0.587
LIG_14-3-3_CanoR_1	912	916	PF00244	0.656
LIG_14-3-3_CanoR_1	941	950	PF00244	0.719
LIG_Actin_WH2_2	337	353	PF00022	0.433
LIG_Actin_WH2_2	651	667	PF00022	0.515
LIG_APCC_ABBA_1	633	638	PF00400	0.333
LIG_BIR_II_1	1	5	PF00653	0.697
LIG_BRCT_BRCA1_1	207	211	PF00533	0.411
LIG_BRCT_BRCA1_1	269	273	PF00533	0.515
LIG_BRCT_BRCA1_1	666	670	PF00533	0.400
LIG_Clathr_ClatBox_1	511	515	PF01394	0.378
LIG_deltaCOP1_diTrp_1	622	630	PF00928	0.405
LIG_EH_1	200	204	PF12763	0.411
LIG_EVH1_1	905	909	PF00568	0.618
LIG_FHA_1	149	155	PF00498	0.278
LIG_FHA_1	275	281	PF00498	0.489
LIG_FHA_1	575	581	PF00498	0.525
LIG_FHA_1	739	745	PF00498	0.547
LIG_FHA_1	813	819	PF00498	0.685
LIG_FHA_1	908	914	PF00498	0.647
LIG_FHA_2	188	194	PF00498	0.343
LIG_FHA_2	4	10	PF00498	0.698
LIG_FHA_2	40	46	PF00498	0.681
LIG_FHA_2	661	667	PF00498	0.450
LIG_FHA_2	690	696	PF00498	0.456
LIG_FHA_2	780	786	PF00498	0.528
LIG_GBD_Chelix_1	459	467	PF00786	0.353
LIG_GBD_Chelix_1	543	551	PF00786	0.494
LIG_LIR_Apic_2	606	612	PF02991	0.541
LIG_LIR_Apic_2	622	626	PF02991	0.522
LIG_LIR_Apic_2	72	77	PF02991	0.548
LIG_LIR_Apic_2	904	908	PF02991	0.565
LIG_LIR_Apic_2	932	936	PF02991	0.591
LIG_LIR_Gen_1	208	219	PF02991	0.325
LIG_LIR_Gen_1	322	330	PF02991	0.477
LIG_LIR_Gen_1	339	348	PF02991	0.554
LIG_LIR_Gen_1	545	552	PF02991	0.410
LIG_LIR_Gen_1	627	637	PF02991	0.393
LIG_LIR_Gen_1	734	744	PF02991	0.433
LIG_LIR_Gen_1	888	899	PF02991	0.600
LIG_LIR_Nem_3	208	214	PF02991	0.325
LIG_LIR_Nem_3	322	326	PF02991	0.483
LIG_LIR_Nem_3	339	344	PF02991	0.564
LIG_LIR_Nem_3	404	409	PF02991	0.431
LIG_LIR_Nem_3	501	507	PF02991	0.345
LIG_LIR_Nem_3	622	628	PF02991	0.394
LIG_LIR_Nem_3	629	633	PF02991	0.358
LIG_LIR_Nem_3	734	740	PF02991	0.426
LIG_LIR_Nem_3	888	894	PF02991	0.602
LIG_LYPXL_S_1	624	628	PF13949	0.326
LIG_LYPXL_yS_3	625	628	PF13949	0.333
LIG_MYND_1	493	497	PF01753	0.397
LIG_NRBOX	19	25	PF00104	0.589
LIG_NRBOX	785	791	PF00104	0.536
LIG_PCNA_PIPBox_1	769	778	PF02747	0.527
LIG_PCNA_yPIPBox_3	783	793	PF02747	0.584
LIG_PDZ_Class_3	946	951	PF00595	0.739
LIG_Rb_LxCxE_1	722	741	PF01857	0.524
LIG_SH2_CRK	933	937	PF00017	0.599
LIG_SH2_NCK_1	74	78	PF00017	0.549
LIG_SH2_NCK_1	915	919	PF00017	0.600
LIG_SH2_NCK_1	933	937	PF00017	0.479
LIG_SH2_PTP2	610	613	PF00017	0.283
LIG_SH2_SRC	408	411	PF00017	0.505
LIG_SH2_SRC	610	613	PF00017	0.364
LIG_SH2_SRC	74	77	PF00017	0.567
LIG_SH2_SRC	776	779	PF00017	0.525
LIG_SH2_STAP1	237	241	PF00017	0.314
LIG_SH2_STAT3	566	569	PF00017	0.563
LIG_SH2_STAT5	387	390	PF00017	0.464
LIG_SH2_STAT5	408	411	PF00017	0.505
LIG_SH2_STAT5	566	569	PF00017	0.498
LIG_SH2_STAT5	584	587	PF00017	0.501
LIG_SH2_STAT5	610	613	PF00017	0.387
LIG_SH2_STAT5	776	779	PF00017	0.543
LIG_SH3_1	900	906	PF00018	0.586
LIG_SH3_2	809	814	PF14604	0.506
LIG_SH3_3	391	397	PF00018	0.362
LIG_SH3_3	56	62	PF00018	0.745
LIG_SH3_3	737	743	PF00018	0.433
LIG_SH3_3	806	812	PF00018	0.553
LIG_SH3_3	836	842	PF00018	0.803
LIG_SH3_3	896	902	PF00018	0.728
LIG_SH3_3	903	909	PF00018	0.727
LIG_SH3_5	929	933	PF00018	0.580
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.586
LIG_SUMO_SIM_anti_2	644	649	PF11976	0.465
LIG_TRAF2_1	322	325	PF00917	0.360
LIG_UBA3_1	214	220	PF00899	0.331
MOD_CDK_SPxK_1	572	578	PF00069	0.490
MOD_CDK_SPxxK_3	287	294	PF00069	0.483
MOD_CK1_1	259	265	PF00069	0.292
MOD_CK1_1	290	296	PF00069	0.621
MOD_CK1_1	300	306	PF00069	0.606
MOD_CK1_1	572	578	PF00069	0.536
MOD_CK1_1	631	637	PF00069	0.369
MOD_CK1_1	660	666	PF00069	0.545
MOD_CK1_1	714	720	PF00069	0.441
MOD_CK1_1	856	862	PF00069	0.749
MOD_CK1_1	907	913	PF00069	0.740
MOD_CK2_1	319	325	PF00069	0.361
MOD_CK2_1	355	361	PF00069	0.476
MOD_CK2_1	383	389	PF00069	0.461
MOD_CK2_1	39	45	PF00069	0.544
MOD_CK2_1	495	501	PF00069	0.455
MOD_CK2_1	689	695	PF00069	0.449
MOD_CK2_1	710	716	PF00069	0.460
MOD_CK2_1	748	754	PF00069	0.535
MOD_CK2_1	828	834	PF00069	0.773
MOD_GlcNHglycan	103	106	PF01048	0.481
MOD_GlcNHglycan	144	147	PF01048	0.378
MOD_GlcNHglycan	165	168	PF01048	0.285
MOD_GlcNHglycan	207	210	PF01048	0.325
MOD_GlcNHglycan	232	235	PF01048	0.360
MOD_GlcNHglycan	248	251	PF01048	0.360
MOD_GlcNHglycan	282	286	PF01048	0.621
MOD_GlcNHglycan	304	307	PF01048	0.740
MOD_GlcNHglycan	336	339	PF01048	0.557
MOD_GlcNHglycan	357	360	PF01048	0.574
MOD_GlcNHglycan	447	450	PF01048	0.688
MOD_GlcNHglycan	744	747	PF01048	0.458
MOD_GlcNHglycan	821	824	PF01048	0.775
MOD_GlcNHglycan	830	833	PF01048	0.746
MOD_GlcNHglycan	843	846	PF01048	0.673
MOD_GlcNHglycan	855	858	PF01048	0.702
MOD_GlcNHglycan	866	869	PF01048	0.603
MOD_GlcNHglycan	878	881	PF01048	0.723
MOD_GlcNHglycan	88	91	PF01048	0.748
MOD_GlcNHglycan	916	919	PF01048	0.703
MOD_GSK3_1	155	162	PF00069	0.292
MOD_GSK3_1	205	212	PF00069	0.281
MOD_GSK3_1	226	233	PF00069	0.300
MOD_GSK3_1	281	288	PF00069	0.571
MOD_GSK3_1	290	297	PF00069	0.575
MOD_GSK3_1	300	307	PF00069	0.673
MOD_GSK3_1	433	440	PF00069	0.596
MOD_GSK3_1	538	545	PF00069	0.490
MOD_GSK3_1	624	631	PF00069	0.378
MOD_GSK3_1	660	667	PF00069	0.537
MOD_GSK3_1	710	717	PF00069	0.462
MOD_GSK3_1	726	733	PF00069	0.383
MOD_GSK3_1	738	745	PF00069	0.354
MOD_GSK3_1	86	93	PF00069	0.666
MOD_GSK3_1	881	888	PF00069	0.659
MOD_GSK3_1	889	896	PF00069	0.686
MOD_GSK3_1	907	914	PF00069	0.680
MOD_GSK3_1	941	948	PF00069	0.805
MOD_N-GLC_1	163	168	PF02516	0.266
MOD_N-GLC_1	689	694	PF02516	0.443
MOD_NEK2_1	101	106	PF00069	0.672
MOD_NEK2_1	224	229	PF00069	0.348
MOD_NEK2_1	304	309	PF00069	0.546
MOD_NEK2_1	355	360	PF00069	0.607
MOD_NEK2_1	467	472	PF00069	0.440
MOD_NEK2_1	506	511	PF00069	0.392
MOD_NEK2_1	561	566	PF00069	0.330
MOD_NEK2_1	567	572	PF00069	0.365
MOD_NEK2_1	628	633	PF00069	0.379
MOD_NEK2_1	664	669	PF00069	0.466
MOD_NEK2_1	680	685	PF00069	0.430
MOD_NEK2_1	710	715	PF00069	0.597
MOD_NEK2_1	864	869	PF00069	0.532
MOD_NEK2_2	340	345	PF00069	0.357
MOD_PIKK_1	125	131	PF00454	0.575
MOD_PIKK_1	226	232	PF00454	0.381
MOD_PIKK_1	274	280	PF00454	0.449
MOD_PIKK_1	412	418	PF00454	0.568
MOD_PIKK_1	552	558	PF00454	0.325
MOD_PIKK_1	738	744	PF00454	0.519
MOD_PIKK_1	779	785	PF00454	0.596
MOD_PIKK_1	941	947	PF00454	0.733
MOD_PKA_2	140	146	PF00069	0.489
MOD_PKA_2	148	154	PF00069	0.256
MOD_PKA_2	178	184	PF00069	0.274
MOD_PKA_2	209	215	PF00069	0.346
MOD_PKA_2	256	262	PF00069	0.287
MOD_PKA_2	293	299	PF00069	0.696
MOD_PKA_2	528	534	PF00069	0.496
MOD_PKA_2	561	567	PF00069	0.328
MOD_PKA_2	664	670	PF00069	0.473
MOD_PKA_2	714	720	PF00069	0.451
MOD_PKA_2	911	917	PF00069	0.656
MOD_PKA_2	940	946	PF00069	0.616
MOD_Plk_1	11	17	PF00069	0.542
MOD_Plk_1	163	169	PF00069	0.281
MOD_Plk_1	281	287	PF00069	0.627
MOD_Plk_1	628	634	PF00069	0.368
MOD_Plk_1	689	695	PF00069	0.467
MOD_Plk_1	799	805	PF00069	0.578
MOD_Plk_4	12	18	PF00069	0.582
MOD_Plk_4	210	216	PF00069	0.277
MOD_Plk_4	297	303	PF00069	0.623
MOD_Plk_4	401	407	PF00069	0.517
MOD_Plk_4	528	534	PF00069	0.467
MOD_Plk_4	561	567	PF00069	0.366
MOD_Plk_4	579	585	PF00069	0.470
MOD_ProDKin_1	267	273	PF00069	0.495
MOD_ProDKin_1	287	293	PF00069	0.427
MOD_ProDKin_1	295	301	PF00069	0.596
MOD_ProDKin_1	433	439	PF00069	0.552
MOD_ProDKin_1	572	578	PF00069	0.490
MOD_ProDKin_1	58	64	PF00069	0.672
MOD_ProDKin_1	904	910	PF00069	0.751
MOD_SUMO_for_1	173	176	PF00179	0.360
MOD_SUMO_for_1	816	819	PF00179	0.535
MOD_SUMO_rev_2	415	422	PF00179	0.543
MOD_SUMO_rev_2	660	670	PF00179	0.516
TRG_DiLeu_BaEn_1	12	17	PF01217	0.637
TRG_DiLeu_BaEn_1	754	759	PF01217	0.574
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.329
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.252
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.393
TRG_ENDOCYTIC_2	134	137	PF00928	0.556
TRG_ENDOCYTIC_2	504	507	PF00928	0.327
TRG_ENDOCYTIC_2	610	613	PF00928	0.446
TRG_ENDOCYTIC_2	625	628	PF00928	0.362
TRG_ER_diArg_1	344	346	PF00400	0.369
TRG_ER_diArg_1	507	510	PF00400	0.389
TRG_ER_diArg_1	703	706	PF00400	0.512
TRG_NES_CRM1_1	325	339	PF08389	0.346
TRG_NLS_MonoExtC_3	170	176	PF00514	0.266
TRG_Pf-PMV_PEXEL_1	510	515	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	550	554	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	706	711	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I905	Leptomonas seymouri	66%	99%
A0A0S4J053	Bodo saltans	29%	100%
A0A1X0P8U2	Trypanosomatidae	35%	100%
A0A3R7KGY7	Trypanosoma rangeli	35%	100%
A0A3S7XAQ6	Leishmania donovani	94%	100%
A4HP37	Leishmania braziliensis	76%	97%
A4IDE4	Leishmania infantum	94%	100%
D0A320	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
V5DKX4	Trypanosoma cruzi	35%	100%