LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4Q1P9_LEIMA
TriTrypDb:
LmjF.36.1750 , LMJLV39_360024000 * , LMJSD75_360024100
Length:
544

Annotations

LeishMANIAdb annotations

A membrane-associated WD40 domain protein. Might be a receptor for some unidentified partner molecule.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 4
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

Q4Q1P9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 409 411 PF00675 0.527
CLV_NRD_NRD_1 512 514 PF00675 0.446
CLV_PCSK_KEX2_1 409 411 PF00082 0.540
CLV_PCSK_KEX2_1 512 514 PF00082 0.410
CLV_PCSK_SKI1_1 190 194 PF00082 0.614
CLV_PCSK_SKI1_1 239 243 PF00082 0.518
CLV_PCSK_SKI1_1 398 402 PF00082 0.615
DEG_APCC_DBOX_1 119 127 PF00400 0.349
DEG_Kelch_Keap1_1 286 291 PF01344 0.445
DEG_SPOP_SBC_1 2 6 PF00917 0.471
DOC_ANK_TNKS_1 248 255 PF00023 0.421
DOC_ANK_TNKS_1 81 88 PF00023 0.370
DOC_CYCLIN_yCln2_LP_2 136 142 PF00134 0.333
DOC_MAPK_DCC_7 329 337 PF00069 0.408
DOC_MAPK_DCC_7 66 75 PF00069 0.471
DOC_MAPK_gen_1 465 474 PF00069 0.477
DOC_MAPK_HePTP_8 63 75 PF00069 0.462
DOC_MAPK_MEF2A_6 329 337 PF00069 0.406
DOC_MAPK_MEF2A_6 66 75 PF00069 0.471
DOC_PP2B_LxvP_1 296 299 PF13499 0.378
DOC_PP2B_PxIxI_1 332 338 PF00149 0.391
DOC_PP4_FxxP_1 330 333 PF00568 0.338
DOC_SPAK_OSR1_1 329 333 PF12202 0.420
DOC_USP7_MATH_1 176 180 PF00917 0.568
DOC_USP7_MATH_1 219 223 PF00917 0.426
DOC_USP7_MATH_1 3 7 PF00917 0.657
DOC_USP7_MATH_1 94 98 PF00917 0.429
DOC_WW_Pin1_4 241 246 PF00397 0.306
DOC_WW_Pin1_4 297 302 PF00397 0.307
DOC_WW_Pin1_4 381 386 PF00397 0.459
DOC_WW_Pin1_4 413 418 PF00397 0.306
DOC_WW_Pin1_4 426 431 PF00397 0.206
DOC_WW_Pin1_4 528 533 PF00397 0.730
LIG_14-3-3_CanoR_1 409 415 PF00244 0.320
LIG_Actin_WH2_2 456 472 PF00022 0.393
LIG_Actin_WH2_2 49 67 PF00022 0.426
LIG_BRCT_BRCA1_1 221 225 PF00533 0.390
LIG_BRCT_BRCA1_1 257 261 PF00533 0.458
LIG_BRCT_BRCA1_1 521 525 PF00533 0.567
LIG_BRCT_BRCA1_1 79 83 PF00533 0.416
LIG_BRCT_BRCA1_1 98 102 PF00533 0.195
LIG_deltaCOP1_diTrp_1 48 53 PF00928 0.358
LIG_EH_1 132 136 PF12763 0.363
LIG_FHA_1 167 173 PF00498 0.459
LIG_FHA_1 279 285 PF00498 0.394
LIG_FHA_1 35 41 PF00498 0.386
LIG_FHA_2 111 117 PF00498 0.446
LIG_FHA_2 123 129 PF00498 0.319
LIG_FHA_2 336 342 PF00498 0.311
LIG_FHA_2 447 453 PF00498 0.344
LIG_GBD_Chelix_1 12 20 PF00786 0.604
LIG_GBD_Chelix_1 483 491 PF00786 0.413
LIG_HCF-1_HBM_1 137 140 PF13415 0.328
LIG_Integrin_isoDGR_2 407 409 PF01839 0.567
LIG_IRF3_LxIS_1 238 244 PF10401 0.343
LIG_LIR_Apic_2 327 333 PF02991 0.339
LIG_LIR_Apic_2 413 417 PF02991 0.306
LIG_LIR_Gen_1 121 130 PF02991 0.452
LIG_LIR_Gen_1 268 277 PF02991 0.374
LIG_LIR_Gen_1 331 341 PF02991 0.357
LIG_LIR_Gen_1 444 451 PF02991 0.363
LIG_LIR_Gen_1 52 60 PF02991 0.446
LIG_LIR_Gen_1 97 104 PF02991 0.381
LIG_LIR_Nem_3 121 127 PF02991 0.441
LIG_LIR_Nem_3 267 273 PF02991 0.344
LIG_LIR_Nem_3 331 337 PF02991 0.333
LIG_LIR_Nem_3 429 434 PF02991 0.383
LIG_LIR_Nem_3 444 448 PF02991 0.316
LIG_LIR_Nem_3 494 498 PF02991 0.436
LIG_LIR_Nem_3 52 56 PF02991 0.404
LIG_LIR_Nem_3 97 101 PF02991 0.387
LIG_NRBOX 446 452 PF00104 0.343
LIG_Pex14_1 229 233 PF04695 0.340
LIG_Pex14_2 185 189 PF04695 0.400
LIG_Pex14_2 225 229 PF04695 0.323
LIG_Pex14_2 367 371 PF04695 0.446
LIG_Pex14_2 431 435 PF04695 0.339
LIG_REV1ctd_RIR_1 432 439 PF16727 0.429
LIG_SH2_CRK 414 418 PF00017 0.332
LIG_SH2_CRK 498 502 PF00017 0.634
LIG_SH2_CRK 98 102 PF00017 0.325
LIG_SH2_GRB2like 393 396 PF00017 0.338
LIG_SH2_NCK_1 414 418 PF00017 0.348
LIG_SH2_NCK_1 98 102 PF00017 0.325
LIG_SH2_PTP2 334 337 PF00017 0.364
LIG_SH2_PTP2 471 474 PF00017 0.386
LIG_SH2_SRC 334 337 PF00017 0.364
LIG_SH2_SRC 393 396 PF00017 0.338
LIG_SH2_STAP1 140 144 PF00017 0.327
LIG_SH2_STAP1 393 397 PF00017 0.424
LIG_SH2_STAP1 98 102 PF00017 0.325
LIG_SH2_STAT5 122 125 PF00017 0.355
LIG_SH2_STAT5 152 155 PF00017 0.371
LIG_SH2_STAT5 164 167 PF00017 0.328
LIG_SH2_STAT5 271 274 PF00017 0.289
LIG_SH2_STAT5 311 314 PF00017 0.509
LIG_SH2_STAT5 334 337 PF00017 0.315
LIG_SH2_STAT5 41 44 PF00017 0.334
LIG_SH2_STAT5 422 425 PF00017 0.429
LIG_SH2_STAT5 471 474 PF00017 0.369
LIG_SH2_STAT5 516 519 PF00017 0.684
LIG_SH2_STAT5 59 62 PF00017 0.301
LIG_SH2_STAT5 90 93 PF00017 0.305
LIG_SH3_1 437 443 PF00018 0.383
LIG_SH3_3 209 215 PF00018 0.490
LIG_SH3_3 242 248 PF00018 0.313
LIG_SH3_3 281 287 PF00018 0.366
LIG_SH3_3 295 301 PF00018 0.268
LIG_SH3_3 437 443 PF00018 0.334
LIG_Sin3_3 13 20 PF02671 0.577
LIG_SUMO_SIM_anti_2 399 405 PF11976 0.384
LIG_SUMO_SIM_par_1 399 405 PF11976 0.332
LIG_SUMO_SIM_par_1 446 452 PF11976 0.288
LIG_SUMO_SIM_par_1 488 494 PF11976 0.475
LIG_TRAF2_1 113 116 PF00917 0.517
LIG_TRAF2_1 201 204 PF00917 0.538
LIG_TRAF2_1 207 210 PF00917 0.516
LIG_TRAF2_2 326 331 PF00917 0.301
LIG_TYR_ITIM 332 337 PF00017 0.369
LIG_TYR_ITIM 469 474 PF00017 0.434
LIG_TYR_ITIM 496 501 PF00017 0.542
LIG_WRC_WIRS_1 492 497 PF05994 0.461
LIG_WRC_WIRS_1 50 55 PF05994 0.378
MOD_CK1_1 227 233 PF00069 0.365
MOD_CK1_1 234 240 PF00069 0.331
MOD_CK1_1 278 284 PF00069 0.397
MOD_CK1_1 316 322 PF00069 0.431
MOD_CK1_1 413 419 PF00069 0.335
MOD_CK1_1 479 485 PF00069 0.444
MOD_CK1_1 5 11 PF00069 0.542
MOD_CK1_1 52 58 PF00069 0.397
MOD_CK1_1 527 533 PF00069 0.728
MOD_CK2_1 110 116 PF00069 0.449
MOD_CK2_1 122 128 PF00069 0.321
MOD_CK2_1 204 210 PF00069 0.558
MOD_CK2_1 335 341 PF00069 0.333
MOD_CK2_1 446 452 PF00069 0.333
MOD_Cter_Amidation 407 410 PF01082 0.550
MOD_GlcNHglycan 104 107 PF01048 0.543
MOD_GlcNHglycan 178 181 PF01048 0.720
MOD_GlcNHglycan 206 209 PF01048 0.701
MOD_GlcNHglycan 220 224 PF01048 0.494
MOD_GlcNHglycan 25 28 PF01048 0.715
MOD_GlcNHglycan 257 260 PF01048 0.665
MOD_GlcNHglycan 288 291 PF01048 0.651
MOD_GlcNHglycan 320 323 PF01048 0.666
MOD_GlcNHglycan 389 392 PF01048 0.507
MOD_GlcNHglycan 394 398 PF01048 0.550
MOD_GlcNHglycan 423 426 PF01048 0.608
MOD_GlcNHglycan 518 524 PF01048 0.509
MOD_GlcNHglycan 526 529 PF01048 0.506
MOD_GlcNHglycan 92 95 PF01048 0.511
MOD_GSK3_1 1 8 PF00069 0.671
MOD_GSK3_1 151 158 PF00069 0.339
MOD_GSK3_1 162 169 PF00069 0.368
MOD_GSK3_1 204 211 PF00069 0.533
MOD_GSK3_1 224 231 PF00069 0.344
MOD_GSK3_1 261 268 PF00069 0.437
MOD_GSK3_1 30 37 PF00069 0.454
MOD_GSK3_1 312 319 PF00069 0.472
MOD_GSK3_1 413 420 PF00069 0.325
MOD_GSK3_1 524 531 PF00069 0.705
MOD_GSK3_1 90 97 PF00069 0.383
MOD_N-GLC_1 110 115 PF02516 0.619
MOD_N-GLC_1 116 121 PF02516 0.578
MOD_N-GLC_1 264 269 PF02516 0.622
MOD_NEK2_1 102 107 PF00069 0.301
MOD_NEK2_1 151 156 PF00069 0.364
MOD_NEK2_1 21 26 PF00069 0.678
MOD_NEK2_1 224 229 PF00069 0.312
MOD_NEK2_1 318 323 PF00069 0.398
MOD_NEK2_1 524 529 PF00069 0.732
MOD_NEK2_1 89 94 PF00069 0.322
MOD_NEK2_2 140 145 PF00069 0.364
MOD_PIKK_1 178 184 PF00454 0.551
MOD_PIKK_1 324 330 PF00454 0.387
MOD_PKA_2 162 168 PF00069 0.431
MOD_PKA_2 348 354 PF00069 0.438
MOD_PKA_2 94 100 PF00069 0.392
MOD_Plk_1 140 146 PF00069 0.371
MOD_Plk_1 202 208 PF00069 0.534
MOD_Plk_1 264 270 PF00069 0.418
MOD_Plk_1 313 319 PF00069 0.444
MOD_Plk_1 519 525 PF00069 0.723
MOD_Plk_2-3 49 55 PF00069 0.258
MOD_Plk_4 208 214 PF00069 0.526
MOD_Plk_4 265 271 PF00069 0.388
MOD_Plk_4 36 42 PF00069 0.431
MOD_Plk_4 446 452 PF00069 0.376
MOD_Plk_4 476 482 PF00069 0.382
MOD_Plk_4 491 497 PF00069 0.302
MOD_Plk_4 5 11 PF00069 0.465
MOD_ProDKin_1 241 247 PF00069 0.306
MOD_ProDKin_1 297 303 PF00069 0.306
MOD_ProDKin_1 381 387 PF00069 0.456
MOD_ProDKin_1 413 419 PF00069 0.314
MOD_ProDKin_1 426 432 PF00069 0.208
MOD_ProDKin_1 528 534 PF00069 0.732
MOD_SUMO_rev_2 128 134 PF00179 0.294
MOD_SUMO_rev_2 462 469 PF00179 0.488
TRG_DiLeu_BaLyEn_6 242 247 PF01217 0.354
TRG_DiLeu_BaLyEn_6 529 534 PF01217 0.733
TRG_ENDOCYTIC_2 270 273 PF00928 0.309
TRG_ENDOCYTIC_2 334 337 PF00928 0.324
TRG_ENDOCYTIC_2 471 474 PF00928 0.377
TRG_ENDOCYTIC_2 498 501 PF00928 0.633
TRG_ENDOCYTIC_2 98 101 PF00928 0.327
TRG_ER_diArg_1 409 411 PF00400 0.340
TRG_ER_diArg_1 512 515 PF00400 0.643
TRG_Pf-PMV_PEXEL_1 249 253 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 515 519 PF00026 0.499

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7G1 Leptomonas seymouri 67% 100%
A0A0S4ISR8 Bodo saltans 41% 100%
A0A1X0P7T5 Trypanosomatidae 54% 100%
A0A3Q8IKI2 Leishmania donovani 94% 100%
A0A3R7NQT8 Trypanosoma rangeli 48% 100%
A4HP39 Leishmania braziliensis 81% 100%
A4IDE6 Leishmania infantum 93% 99%
D0A322 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9ASU7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BJV5 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS