Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania major

UniProt:

Q4Q1P6_LEIMA

TriTrypDb:

LmjF.36.1780 , LMJLV39_360024300 , LMJSD75_360024400

Length:

745

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1P6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.506
CLV_C14_Caspase3-7	394	398	PF00656	0.574
CLV_C14_Caspase3-7	497	501	PF00656	0.514
CLV_C14_Caspase3-7	548	552	PF00656	0.465
CLV_NRD_NRD_1	101	103	PF00675	0.528
CLV_NRD_NRD_1	345	347	PF00675	0.524
CLV_NRD_NRD_1	384	386	PF00675	0.650
CLV_NRD_NRD_1	445	447	PF00675	0.513
CLV_NRD_NRD_1	646	648	PF00675	0.705
CLV_NRD_NRD_1	655	657	PF00675	0.581
CLV_NRD_NRD_1	683	685	PF00675	0.737
CLV_NRD_NRD_1	712	714	PF00675	0.793
CLV_NRD_NRD_1	85	87	PF00675	0.384
CLV_PCSK_KEX2_1	101	103	PF00082	0.528
CLV_PCSK_KEX2_1	384	386	PF00082	0.660
CLV_PCSK_KEX2_1	445	447	PF00082	0.490
CLV_PCSK_KEX2_1	646	648	PF00082	0.705
CLV_PCSK_KEX2_1	654	656	PF00082	0.586
CLV_PCSK_KEX2_1	682	684	PF00082	0.805
CLV_PCSK_KEX2_1	712	714	PF00082	0.749
CLV_PCSK_KEX2_1	718	720	PF00082	0.634
CLV_PCSK_KEX2_1	85	87	PF00082	0.384
CLV_PCSK_PC1ET2_1	654	656	PF00082	0.679
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.696
CLV_PCSK_SKI1_1	342	346	PF00082	0.422
CLV_PCSK_SKI1_1	349	353	PF00082	0.396
CLV_PCSK_SKI1_1	406	410	PF00082	0.515
CLV_PCSK_SKI1_1	461	465	PF00082	0.418
CLV_PCSK_SKI1_1	608	612	PF00082	0.332
CLV_PCSK_SKI1_1	85	89	PF00082	0.450
DEG_APCC_DBOX_1	233	241	PF00400	0.465
DEG_APCC_DBOX_1	607	615	PF00400	0.476
DEG_APCC_DBOX_1	84	92	PF00400	0.386
DEG_SPOP_SBC_1	5	9	PF00917	0.602
DOC_CKS1_1	622	627	PF01111	0.354
DOC_CYCLIN_RxL_1	346	356	PF00134	0.418
DOC_CYCLIN_RxL_1	403	411	PF00134	0.521
DOC_CYCLIN_RxL_1	82	90	PF00134	0.381
DOC_MAPK_gen_1	28	37	PF00069	0.539
DOC_MAPK_gen_1	346	352	PF00069	0.536
DOC_MAPK_gen_1	445	451	PF00069	0.492
DOC_MAPK_gen_1	510	519	PF00069	0.521
DOC_MAPK_gen_1	82	91	PF00069	0.380
DOC_MAPK_MEF2A_6	512	520	PF00069	0.452
DOC_PP2B_LxvP_1	221	224	PF13499	0.671
DOC_USP7_MATH_1	176	180	PF00917	0.639
DOC_USP7_MATH_1	18	22	PF00917	0.476
DOC_USP7_MATH_1	383	387	PF00917	0.616
DOC_USP7_MATH_1	398	402	PF00917	0.447
DOC_USP7_MATH_1	420	424	PF00917	0.534
DOC_USP7_MATH_1	5	9	PF00917	0.613
DOC_USP7_MATH_1	641	645	PF00917	0.742
DOC_USP7_UBL2_3	26	30	PF12436	0.556
DOC_USP7_UBL2_3	457	461	PF12436	0.511
DOC_WW_Pin1_4	103	108	PF00397	0.625
DOC_WW_Pin1_4	124	129	PF00397	0.753
DOC_WW_Pin1_4	171	176	PF00397	0.724
DOC_WW_Pin1_4	215	220	PF00397	0.662
DOC_WW_Pin1_4	621	626	PF00397	0.370
DOC_WW_Pin1_4	646	651	PF00397	0.761
DOC_WW_Pin1_4	664	669	PF00397	0.726
LIG_14-3-3_CanoR_1	195	199	PF00244	0.811
LIG_14-3-3_CanoR_1	259	268	PF00244	0.440
LIG_14-3-3_CanoR_1	328	336	PF00244	0.509
LIG_14-3-3_CanoR_1	384	389	PF00244	0.659
LIG_14-3-3_CanoR_1	446	452	PF00244	0.468
LIG_14-3-3_CanoR_1	555	560	PF00244	0.556
LIG_14-3-3_CanoR_1	712	717	PF00244	0.682
LIG_14-3-3_CanoR_1	86	92	PF00244	0.476
LIG_Actin_WH2_2	244	261	PF00022	0.405
LIG_APCC_ABBA_1	47	52	PF00400	0.511
LIG_BIR_III_4	242	246	PF00653	0.502
LIG_BIR_III_4	397	401	PF00653	0.517
LIG_BRCT_BRCA1_1	436	440	PF00533	0.454
LIG_deltaCOP1_diTrp_1	561	568	PF00928	0.441
LIG_DLG_GKlike_1	555	562	PF00625	0.500
LIG_FHA_1	106	112	PF00498	0.689
LIG_FHA_1	17	23	PF00498	0.588
LIG_FHA_1	216	222	PF00498	0.683
LIG_FHA_1	260	266	PF00498	0.430
LIG_FHA_1	293	299	PF00498	0.513
LIG_FHA_1	329	335	PF00498	0.483
LIG_FHA_1	394	400	PF00498	0.465
LIG_FHA_1	416	422	PF00498	0.459
LIG_FHA_1	428	434	PF00498	0.284
LIG_FHA_1	480	486	PF00498	0.393
LIG_FHA_1	579	585	PF00498	0.423
LIG_FHA_1	622	628	PF00498	0.359
LIG_FHA_1	702	708	PF00498	0.798
LIG_FHA_2	104	110	PF00498	0.649
LIG_FHA_2	156	162	PF00498	0.737
LIG_FHA_2	227	233	PF00498	0.595
LIG_FHA_2	468	474	PF00498	0.554
LIG_FHA_2	525	531	PF00498	0.502
LIG_GBD_Chelix_1	404	412	PF00786	0.515
LIG_HP1_1	63	67	PF01393	0.479
LIG_Integrin_RGD_1	522	524	PF01839	0.428
LIG_LIR_Apic_2	12	18	PF02991	0.598
LIG_LIR_Gen_1	166	175	PF02991	0.744
LIG_LIR_Gen_1	318	329	PF02991	0.535
LIG_LIR_Gen_1	437	447	PF02991	0.431
LIG_LIR_Gen_1	524	532	PF02991	0.381
LIG_LIR_Gen_1	538	547	PF02991	0.414
LIG_LIR_Gen_1	69	77	PF02991	0.455
LIG_LIR_Nem_3	166	170	PF02991	0.752
LIG_LIR_Nem_3	318	324	PF02991	0.516
LIG_LIR_Nem_3	410	416	PF02991	0.394
LIG_LIR_Nem_3	437	443	PF02991	0.437
LIG_LIR_Nem_3	462	467	PF02991	0.390
LIG_LIR_Nem_3	524	529	PF02991	0.359
LIG_LIR_Nem_3	538	542	PF02991	0.402
LIG_LIR_Nem_3	69	74	PF02991	0.433
LIG_Pex14_2	440	444	PF04695	0.420
LIG_PTB_Apo_2	587	594	PF02174	0.441
LIG_Rb_LxCxE_1	524	546	PF01857	0.320
LIG_Rb_LxCxE_1	613	624	PF01857	0.480
LIG_SH2_GRB2like	436	439	PF00017	0.453
LIG_SH2_NCK_1	44	48	PF00017	0.516
LIG_SH2_NCK_1	526	530	PF00017	0.340
LIG_SH2_PTP2	71	74	PF00017	0.520
LIG_SH2_SRC	199	202	PF00017	0.558
LIG_SH2_SRC	634	637	PF00017	0.549
LIG_SH2_STAP1	436	440	PF00017	0.454
LIG_SH2_STAP1	505	509	PF00017	0.389
LIG_SH2_STAP1	539	543	PF00017	0.514
LIG_SH2_STAT5	303	306	PF00017	0.373
LIG_SH2_STAT5	339	342	PF00017	0.388
LIG_SH2_STAT5	407	410	PF00017	0.543
LIG_SH2_STAT5	526	529	PF00017	0.385
LIG_SH2_STAT5	634	637	PF00017	0.612
LIG_SH2_STAT5	71	74	PF00017	0.520
LIG_SH2_STAT5	99	102	PF00017	0.660
LIG_SH3_1	634	640	PF00018	0.559
LIG_SH3_1	647	653	PF00018	0.544
LIG_SH3_2	650	655	PF14604	0.658
LIG_SH3_3	216	222	PF00018	0.633
LIG_SH3_3	387	393	PF00018	0.711
LIG_SH3_3	619	625	PF00018	0.506
LIG_SH3_3	634	640	PF00018	0.521
LIG_SH3_3	647	653	PF00018	0.577
LIG_SUMO_SIM_anti_2	476	483	PF11976	0.426
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.502
LIG_SUMO_SIM_par_1	63	69	PF11976	0.482
LIG_TRAF2_1	354	357	PF00917	0.497
LIG_TYR_ITIM	42	47	PF00017	0.510
LIG_UBA3_1	88	93	PF00899	0.573
MOD_CDC14_SPxK_1	127	130	PF00782	0.660
MOD_CDK_SPxK_1	124	130	PF00069	0.653
MOD_CDK_SPxxK_3	621	628	PF00069	0.365
MOD_CK1_1	166	172	PF00069	0.826
MOD_CK1_1	186	192	PF00069	0.505
MOD_CK1_1	20	26	PF00069	0.418
MOD_CK1_1	206	212	PF00069	0.596
MOD_CK1_1	391	397	PF00069	0.733
MOD_CK1_1	434	440	PF00069	0.451
MOD_CK1_1	701	707	PF00069	0.760
MOD_CK1_1	8	14	PF00069	0.641
MOD_CK2_1	132	138	PF00069	0.656
MOD_CK2_1	420	426	PF00069	0.552
MOD_CK2_1	467	473	PF00069	0.501
MOD_CK2_1	524	530	PF00069	0.502
MOD_CK2_1	613	619	PF00069	0.477
MOD_CK2_1	658	664	PF00069	0.536
MOD_GlcNHglycan	11	14	PF01048	0.513
MOD_GlcNHglycan	112	117	PF01048	0.682
MOD_GlcNHglycan	134	137	PF01048	0.688
MOD_GlcNHglycan	188	191	PF01048	0.549
MOD_GlcNHglycan	208	211	PF01048	0.595
MOD_GlcNHglycan	381	384	PF01048	0.734
MOD_GlcNHglycan	719	722	PF01048	0.646
MOD_GlcNHglycan	78	81	PF01048	0.500
MOD_GSK3_1	124	131	PF00069	0.746
MOD_GSK3_1	16	23	PF00069	0.469
MOD_GSK3_1	166	173	PF00069	0.730
MOD_GSK3_1	199	206	PF00069	0.657
MOD_GSK3_1	363	370	PF00069	0.604
MOD_GSK3_1	379	386	PF00069	0.618
MOD_GSK3_1	388	395	PF00069	0.662
MOD_GSK3_1	4	11	PF00069	0.637
MOD_GSK3_1	427	434	PF00069	0.536
MOD_LATS_1	326	332	PF00433	0.351
MOD_N-GLC_1	103	108	PF02516	0.567
MOD_N-GLC_2	118	120	PF02516	0.562
MOD_NEK2_1	183	188	PF00069	0.564
MOD_NEK2_1	244	249	PF00069	0.505
MOD_NEK2_1	6	11	PF00069	0.628
MOD_NEK2_2	194	199	PF00069	0.549
MOD_NEK2_2	456	461	PF00069	0.322
MOD_NEK2_2	505	510	PF00069	0.515
MOD_NEK2_2	87	92	PF00069	0.568
MOD_PIKK_1	199	205	PF00454	0.560
MOD_PIKK_1	641	647	PF00454	0.716
MOD_PK_1	431	437	PF00069	0.445
MOD_PKA_1	384	390	PF00069	0.631
MOD_PKA_1	712	718	PF00069	0.674
MOD_PKA_2	132	138	PF00069	0.694
MOD_PKA_2	148	154	PF00069	0.818
MOD_PKA_2	194	200	PF00069	0.678
MOD_PKA_2	258	264	PF00069	0.468
MOD_PKA_2	383	389	PF00069	0.662
MOD_PKA_2	467	473	PF00069	0.550
MOD_PKA_2	685	691	PF00069	0.760
MOD_PKA_2	712	718	PF00069	0.684
MOD_PKA_2	735	741	PF00069	0.745
MOD_PKB_1	553	561	PF00069	0.511
MOD_Plk_1	128	134	PF00069	0.707
MOD_Plk_1	176	182	PF00069	0.689
MOD_Plk_1	425	431	PF00069	0.560
MOD_Plk_1	51	57	PF00069	0.530
MOD_Plk_1	688	694	PF00069	0.705
MOD_Plk_2-3	685	691	PF00069	0.642
MOD_Plk_4	244	250	PF00069	0.403
MOD_Plk_4	431	437	PF00069	0.464
MOD_Plk_4	480	486	PF00069	0.375
MOD_Plk_4	500	506	PF00069	0.527
MOD_Plk_4	51	57	PF00069	0.412
MOD_Plk_4	728	734	PF00069	0.581
MOD_ProDKin_1	103	109	PF00069	0.632
MOD_ProDKin_1	124	130	PF00069	0.756
MOD_ProDKin_1	171	177	PF00069	0.721
MOD_ProDKin_1	215	221	PF00069	0.658
MOD_ProDKin_1	621	627	PF00069	0.362
MOD_ProDKin_1	646	652	PF00069	0.759
MOD_ProDKin_1	664	670	PF00069	0.721
MOD_SUMO_rev_2	276	282	PF00179	0.534
MOD_SUMO_rev_2	353	360	PF00179	0.486
MOD_SUMO_rev_2	469	477	PF00179	0.608
TRG_DiLeu_BaEn_1	312	317	PF01217	0.570
TRG_DiLeu_BaEn_2	68	74	PF01217	0.505
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.528
TRG_ENDOCYTIC_2	44	47	PF00928	0.509
TRG_ENDOCYTIC_2	526	529	PF00928	0.385
TRG_ENDOCYTIC_2	539	542	PF00928	0.392
TRG_ENDOCYTIC_2	71	74	PF00928	0.520
TRG_ER_diArg_1	233	236	PF00400	0.488
TRG_ER_diArg_1	444	446	PF00400	0.491
TRG_ER_diArg_1	553	556	PF00400	0.482
TRG_ER_diArg_1	655	657	PF00400	0.557
TRG_ER_diArg_1	682	684	PF00400	0.765
TRG_ER_diArg_1	84	86	PF00400	0.382
TRG_NLS_MonoExtN_4	653	658	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KED7	Trypanosoma rangeli	31%	100%
A0A3S7XAR1	Leishmania donovani	90%	100%
A4HP42	Leishmania braziliensis	70%	99%
A4IDE9	Leishmania infantum	90%	100%
D0A326	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ASV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%