Putative exoribonuclease 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-3' exoribonuclease D, putative

Species:

Leishmania major

UniProt:

Q4Q1P5_LEIMA

TriTrypDb:

LmjF.36.1790 , LMJLV39_360024400 , LMJSD75_360024500

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P5

Function

Biological processes
Term	Name	Level	Count
GO:0000956	nuclear-transcribed mRNA catabolic process	7	2
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006401	RNA catabolic process	5	2
GO:0006402	mRNA catabolic process	6	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009987	cellular process	1	12
GO:0010468	regulation of gene expression	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0010629	negative regulation of gene expression	6	2
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	12
GO:0046700	heterocycle catabolic process	4	2
GO:0048519	negative regulation of biological process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0004532	RNA exonuclease activity	5	2
GO:0004534	5'-3' RNA exonuclease activity	7	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	12
GO:0008409	5'-3' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.515
CLV_C14_Caspase3-7	24	28	PF00656	0.482
CLV_C14_Caspase3-7	407	411	PF00656	0.523
CLV_C14_Caspase3-7	441	445	PF00656	0.458
CLV_NRD_NRD_1	115	117	PF00675	0.245
CLV_NRD_NRD_1	419	421	PF00675	0.331
CLV_NRD_NRD_1	741	743	PF00675	0.741
CLV_NRD_NRD_1	758	760	PF00675	0.454
CLV_NRD_NRD_1	773	775	PF00675	0.667
CLV_NRD_NRD_1	791	793	PF00675	0.720
CLV_NRD_NRD_1	822	824	PF00675	0.707
CLV_NRD_NRD_1	862	864	PF00675	0.777
CLV_PCSK_FUR_1	113	117	PF00082	0.245
CLV_PCSK_FUR_1	771	775	PF00082	0.778
CLV_PCSK_KEX2_1	115	117	PF00082	0.245
CLV_PCSK_KEX2_1	730	732	PF00082	0.770
CLV_PCSK_KEX2_1	743	745	PF00082	0.501
CLV_PCSK_KEX2_1	758	760	PF00082	0.558
CLV_PCSK_KEX2_1	773	775	PF00082	0.601
CLV_PCSK_KEX2_1	790	792	PF00082	0.679
CLV_PCSK_KEX2_1	822	824	PF00082	0.731
CLV_PCSK_KEX2_1	836	838	PF00082	0.737
CLV_PCSK_KEX2_1	862	864	PF00082	0.761
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.791
CLV_PCSK_PC1ET2_1	743	745	PF00082	0.505
CLV_PCSK_PC1ET2_1	758	760	PF00082	0.597
CLV_PCSK_PC1ET2_1	836	838	PF00082	0.746
CLV_PCSK_SKI1_1	166	170	PF00082	0.331
CLV_PCSK_SKI1_1	186	190	PF00082	0.303
CLV_PCSK_SKI1_1	459	463	PF00082	0.291
CLV_PCSK_SKI1_1	553	557	PF00082	0.289
CLV_PCSK_SKI1_1	707	711	PF00082	0.473
CLV_PCSK_SKI1_1	862	866	PF00082	0.733
DEG_SPOP_SBC_1	801	805	PF00917	0.711
DEG_SPOP_SBC_1	855	859	PF00917	0.752
DOC_CDC14_PxL_1	497	505	PF14671	0.456
DOC_CDC14_PxL_1	530	538	PF14671	0.470
DOC_CKS1_1	156	161	PF01111	0.445
DOC_CYCLIN_RxL_1	88	101	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.579
DOC_MAPK_gen_1	315	323	PF00069	0.456
DOC_MAPK_gen_1	591	599	PF00069	0.550
DOC_MAPK_gen_1	88	98	PF00069	0.445
DOC_MAPK_MEF2A_6	78	87	PF00069	0.469
DOC_MAPK_MEF2A_6	91	100	PF00069	0.405
DOC_MAPK_NFAT4_5	93	101	PF00069	0.445
DOC_PP2B_LxvP_1	579	582	PF13499	0.456
DOC_PP2B_LxvP_1	637	640	PF13499	0.596
DOC_SPAK_OSR1_1	425	429	PF12202	0.383
DOC_USP7_MATH_1	310	314	PF00917	0.531
DOC_USP7_MATH_1	389	393	PF00917	0.548
DOC_USP7_MATH_1	400	404	PF00917	0.501
DOC_USP7_MATH_1	461	465	PF00917	0.517
DOC_USP7_MATH_1	626	630	PF00917	0.623
DOC_USP7_MATH_1	643	647	PF00917	0.452
DOC_USP7_MATH_1	723	727	PF00917	0.700
DOC_USP7_MATH_1	801	805	PF00917	0.716
DOC_USP7_MATH_1	821	825	PF00917	0.493
DOC_USP7_MATH_1	854	858	PF00917	0.678
DOC_USP7_MATH_1	864	868	PF00917	0.690
DOC_USP7_MATH_1	874	878	PF00917	0.587
DOC_USP7_UBL2_3	357	361	PF12436	0.503
DOC_USP7_UBL2_3	373	377	PF12436	0.376
DOC_USP7_UBL2_3	730	734	PF12436	0.788
DOC_USP7_UBL2_3	832	836	PF12436	0.765
DOC_WW_Pin1_4	155	160	PF00397	0.445
DOC_WW_Pin1_4	734	739	PF00397	0.757
LIG_14-3-3_CanoR_1	186	191	PF00244	0.506
LIG_14-3-3_CanoR_1	210	216	PF00244	0.496
LIG_14-3-3_CanoR_1	249	258	PF00244	0.536
LIG_14-3-3_CanoR_1	383	391	PF00244	0.505
LIG_14-3-3_CanoR_1	518	522	PF00244	0.504
LIG_14-3-3_CanoR_1	535	539	PF00244	0.354
LIG_BRCT_BRCA1_1	113	117	PF00533	0.445
LIG_BRCT_BRCA1_1	159	163	PF00533	0.445
LIG_Clathr_ClatBox_1	596	600	PF01394	0.554
LIG_deltaCOP1_diTrp_1	181	192	PF00928	0.456
LIG_deltaCOP1_diTrp_1	492	495	PF00928	0.456
LIG_EH1_1	523	531	PF00400	0.445
LIG_eIF4E_1	497	503	PF01652	0.506
LIG_FHA_1	220	226	PF00498	0.446
LIG_FHA_1	314	320	PF00498	0.445
LIG_FHA_1	422	428	PF00498	0.514
LIG_FHA_1	508	514	PF00498	0.463
LIG_FHA_1	61	67	PF00498	0.445
LIG_FHA_1	649	655	PF00498	0.550
LIG_FHA_1	868	874	PF00498	0.575
LIG_FHA_2	268	274	PF00498	0.445
LIG_FHA_2	383	389	PF00498	0.562
LIG_FHA_2	439	445	PF00498	0.510
LIG_FHA_2	700	706	PF00498	0.547
LIG_KLC1_Yacidic_2	46	51	PF13176	0.456
LIG_LIR_Apic_2	139	144	PF02991	0.533
LIG_LIR_Apic_2	490	496	PF02991	0.445
LIG_LIR_Gen_1	278	287	PF02991	0.405
LIG_LIR_Gen_1	292	301	PF02991	0.417
LIG_LIR_Gen_1	341	352	PF02991	0.475
LIG_LIR_Gen_1	44	52	PF02991	0.461
LIG_LIR_Gen_1	73	83	PF02991	0.456
LIG_LIR_Nem_3	182	188	PF02991	0.449
LIG_LIR_Nem_3	278	282	PF02991	0.395
LIG_LIR_Nem_3	292	297	PF02991	0.443
LIG_LIR_Nem_3	341	347	PF02991	0.445
LIG_LIR_Nem_3	363	369	PF02991	0.474
LIG_LIR_Nem_3	44	48	PF02991	0.474
LIG_LIR_Nem_3	490	494	PF02991	0.445
LIG_LIR_Nem_3	574	578	PF02991	0.449
LIG_LIR_Nem_3	705	709	PF02991	0.528
LIG_LIR_Nem_3	77	83	PF02991	0.458
LIG_LYPXL_S_1	559	563	PF13949	0.331
LIG_LYPXL_yS_3	560	563	PF13949	0.531
LIG_Pex14_1	479	483	PF04695	0.445
LIG_Pex14_1	491	495	PF04695	0.445
LIG_Pex14_2	296	300	PF04695	0.445
LIG_Pex14_2	350	354	PF04695	0.445
LIG_Pex14_2	603	607	PF04695	0.503
LIG_Pex14_2	76	80	PF04695	0.456
LIG_Rb_LxCxE_1	463	485	PF01857	0.486
LIG_Rb_LxCxE_1	605	624	PF01857	0.435
LIG_SH2_CRK	141	145	PF00017	0.550
LIG_SH2_CRK	367	371	PF00017	0.464
LIG_SH2_CRK	499	503	PF00017	0.445
LIG_SH2_CRK	575	579	PF00017	0.445
LIG_SH2_CRK	706	710	PF00017	0.488
LIG_SH2_GRB2like	265	268	PF00017	0.409
LIG_SH2_GRB2like	45	48	PF00017	0.506
LIG_SH2_STAP1	45	49	PF00017	0.506
LIG_SH2_STAP1	661	665	PF00017	0.495
LIG_SH2_STAT3	335	338	PF00017	0.523
LIG_SH2_STAT5	174	177	PF00017	0.531
LIG_SH2_STAT5	208	211	PF00017	0.445
LIG_SH2_STAT5	265	268	PF00017	0.324
LIG_SH2_STAT5	326	329	PF00017	0.445
LIG_SH2_STAT5	335	338	PF00017	0.445
LIG_SH2_STAT5	437	440	PF00017	0.463
LIG_SH2_STAT5	473	476	PF00017	0.451
LIG_SH2_STAT5	484	487	PF00017	0.433
LIG_SH2_STAT5	49	52	PF00017	0.456
LIG_SH2_STAT5	494	497	PF00017	0.445
LIG_SH2_STAT5	609	612	PF00017	0.446
LIG_SH3_3	153	159	PF00018	0.440
LIG_SH3_3	304	310	PF00018	0.445
LIG_SH3_3	519	525	PF00018	0.445
LIG_SH3_3	546	552	PF00018	0.445
LIG_SH3_3	637	643	PF00018	0.528
LIG_SH3_3	86	92	PF00018	0.470
LIG_SH3_3	870	876	PF00018	0.613
LIG_SH3_5	216	220	PF00018	0.550
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.506
LIG_SUMO_SIM_par_1	310	316	PF11976	0.435
LIG_SUMO_SIM_par_1	562	567	PF11976	0.527
LIG_SUMO_SIM_par_1	595	602	PF11976	0.578
LIG_TYR_ITIM	342	347	PF00017	0.470
LIG_UBA3_1	349	357	PF00899	0.550
LIG_UBA3_1	359	364	PF00899	0.432
LIG_UBA3_1	412	421	PF00899	0.463
LIG_WW_3	737	741	PF00397	0.661
MOD_CDC14_SPxK_1	737	740	PF00782	0.700
MOD_CDK_SPxK_1	734	740	PF00069	0.708
MOD_CK1_1	136	142	PF00069	0.431
MOD_CK1_1	313	319	PF00069	0.445
MOD_CK1_1	38	44	PF00069	0.480
MOD_CK1_1	647	653	PF00069	0.545
MOD_CK1_1	726	732	PF00069	0.757
MOD_CK1_1	802	808	PF00069	0.713
MOD_CK1_1	845	851	PF00069	0.736
MOD_CK1_1	857	863	PF00069	0.699
MOD_CK1_1	867	873	PF00069	0.796
MOD_CK2_1	236	242	PF00069	0.445
MOD_CK2_1	267	273	PF00069	0.446
MOD_CK2_1	382	388	PF00069	0.530
MOD_CK2_1	776	782	PF00069	0.757
MOD_CK2_1	845	851	PF00069	0.723
MOD_Cter_Amidation	833	836	PF01082	0.808
MOD_GlcNHglycan	40	43	PF01048	0.298
MOD_GlcNHglycan	417	420	PF01048	0.323
MOD_GlcNHglycan	519	522	PF01048	0.330
MOD_GlcNHglycan	628	631	PF01048	0.623
MOD_GlcNHglycan	814	817	PF01048	0.645
MOD_GSK3_1	123	130	PF00069	0.470
MOD_GSK3_1	186	193	PF00069	0.506
MOD_GSK3_1	643	650	PF00069	0.553
MOD_GSK3_1	786	793	PF00069	0.745
MOD_GSK3_1	795	802	PF00069	0.720
MOD_GSK3_1	808	815	PF00069	0.570
MOD_GSK3_1	836	843	PF00069	0.724
MOD_GSK3_1	854	861	PF00069	0.631
MOD_GSK3_1	879	886	PF00069	0.770
MOD_N-GLC_1	220	225	PF02516	0.307
MOD_N-GLC_1	266	271	PF02516	0.424
MOD_N-GLC_1	352	357	PF02516	0.336
MOD_N-GLC_1	571	576	PF02516	0.298
MOD_N-GLC_1	714	719	PF02516	0.713
MOD_N-GLC_2	131	133	PF02516	0.306
MOD_N-GLC_2	797	799	PF02516	0.542
MOD_NEK2_1	236	241	PF00069	0.455
MOD_NEK2_1	252	257	PF00069	0.414
MOD_NEK2_1	266	271	PF00069	0.301
MOD_NEK2_1	352	357	PF00069	0.498
MOD_NEK2_1	415	420	PF00069	0.444
MOD_NEK2_1	433	438	PF00069	0.387
MOD_NEK2_1	509	514	PF00069	0.543
MOD_NEK2_1	517	522	PF00069	0.514
MOD_NEK2_1	603	608	PF00069	0.431
MOD_NEK2_1	678	683	PF00069	0.515
MOD_NEK2_1	880	885	PF00069	0.801
MOD_NEK2_2	310	315	PF00069	0.445
MOD_NEK2_2	534	539	PF00069	0.531
MOD_PIKK_1	211	217	PF00454	0.506
MOD_PIKK_1	334	340	PF00454	0.523
MOD_PIKK_1	461	467	PF00454	0.426
MOD_PIKK_1	699	705	PF00454	0.522
MOD_PIKK_1	836	842	PF00454	0.771
MOD_PKA_1	760	766	PF00069	0.779
MOD_PKA_1	790	796	PF00069	0.771
MOD_PKA_1	822	828	PF00069	0.759
MOD_PKA_1	835	841	PF00069	0.750
MOD_PKA_2	382	388	PF00069	0.562
MOD_PKA_2	517	523	PF00069	0.504
MOD_PKA_2	534	540	PF00069	0.354
MOD_PKA_2	760	766	PF00069	0.773
MOD_PKA_2	790	796	PF00069	0.706
MOD_PKA_2	805	811	PF00069	0.658
MOD_PKA_2	821	827	PF00069	0.748
MOD_PKA_2	836	842	PF00069	0.567
MOD_PKA_2	845	851	PF00069	0.721
MOD_PKA_2	867	873	PF00069	0.720
MOD_PKA_2	874	880	PF00069	0.754
MOD_PKB_1	759	767	PF00069	0.795
MOD_PKB_1	774	782	PF00069	0.780
MOD_Plk_1	220	226	PF00069	0.506
MOD_Plk_1	266	272	PF00069	0.383
MOD_Plk_1	421	427	PF00069	0.527
MOD_Plk_1	438	444	PF00069	0.430
MOD_Plk_1	571	577	PF00069	0.498
MOD_Plk_1	611	617	PF00069	0.396
MOD_Plk_4	133	139	PF00069	0.383
MOD_Plk_4	186	192	PF00069	0.550
MOD_Plk_4	394	400	PF00069	0.533
MOD_Plk_4	551	557	PF00069	0.445
MOD_Plk_4	603	609	PF00069	0.381
MOD_ProDKin_1	155	161	PF00069	0.445
MOD_ProDKin_1	734	740	PF00069	0.757
MOD_SUMO_rev_2	200	206	PF00179	0.439
MOD_SUMO_rev_2	547	555	PF00179	0.506
MOD_SUMO_rev_2	845	850	PF00179	0.617
MOD_SUMO_rev_2	867	873	PF00179	0.556
TRG_DiLeu_BaEn_2	421	427	PF01217	0.437
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.445
TRG_ENDOCYTIC_2	265	268	PF00928	0.324
TRG_ENDOCYTIC_2	344	347	PF00928	0.465
TRG_ENDOCYTIC_2	366	369	PF00928	0.461
TRG_ENDOCYTIC_2	45	48	PF00928	0.464
TRG_ENDOCYTIC_2	49	52	PF00928	0.448
TRG_ENDOCYTIC_2	499	502	PF00928	0.453
TRG_ENDOCYTIC_2	560	563	PF00928	0.495
TRG_ENDOCYTIC_2	575	578	PF00928	0.366
TRG_ENDOCYTIC_2	706	709	PF00928	0.490
TRG_ER_diArg_1	113	116	PF00400	0.445
TRG_ER_diArg_1	144	147	PF00400	0.484
TRG_ER_diArg_1	423	426	PF00400	0.470
TRG_ER_diArg_1	739	742	PF00400	0.786
TRG_ER_diArg_1	790	792	PF00400	0.704
TRG_ER_diArg_1	827	830	PF00400	0.601
TRG_NES_CRM1_1	504	516	PF08389	0.503
TRG_NLS_Bipartite_1	730	746	PF00514	0.803
TRG_NLS_Bipartite_1	822	839	PF00514	0.765
TRG_NLS_MonoCore_2	757	762	PF00514	0.703
TRG_NLS_MonoExtC_3	741	746	PF00514	0.745
TRG_NLS_MonoExtN_4	739	746	PF00514	0.751
TRG_NLS_MonoExtN_4	758	763	PF00514	0.713
TRG_NLS_MonoExtN_4	832	839	PF00514	0.719
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.286
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.245
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA8	Leptomonas seymouri	87%	98%
A0A0S4IWC0	Bodo saltans	55%	100%
A0A1X0P7T7	Trypanosomatidae	58%	100%
A0A3Q8IH53	Leishmania donovani	93%	100%
A0A3R7LZH3	Trypanosoma rangeli	63%	100%
A4HP43	Leishmania braziliensis	88%	100%
A4IDF0	Leishmania infantum	93%	100%
D0A327	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ASV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q5R4L5	Pongo abelii	32%	94%
Q60SG7	Caenorhabditis briggsae	31%	92%
Q9FQ02	Arabidopsis thaliana	33%	88%
Q9FQ03	Arabidopsis thaliana	32%	88%
Q9FQ04	Arabidopsis thaliana	35%	95%
Q9H0D6	Homo sapiens	32%	94%
Q9U299	Caenorhabditis elegans	31%	92%
Q9VM71	Drosophila melanogaster	34%	99%
V5DKX1	Trypanosoma cruzi	61%	100%