Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1P4_LEIMA

TriTrypDb:

LmjF.36.1800 , LMJLV39_360024500 , LMJSD75_360024600

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005882	intermediate filament	6	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q1P4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.361
CLV_NRD_NRD_1	243	245	PF00675	0.518
CLV_NRD_NRD_1	86	88	PF00675	0.516
CLV_PCSK_KEX2_1	10	12	PF00082	0.359
CLV_PCSK_KEX2_1	243	245	PF00082	0.518
CLV_PCSK_KEX2_1	291	293	PF00082	0.596
CLV_PCSK_KEX2_1	58	60	PF00082	0.464
CLV_PCSK_KEX2_1	88	90	PF00082	0.471
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.505
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.447
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.464
CLV_PCSK_PC7_1	54	60	PF00082	0.445
CLV_PCSK_PC7_1	84	90	PF00082	0.347
CLV_PCSK_SKI1_1	183	187	PF00082	0.564
CLV_PCSK_SKI1_1	243	247	PF00082	0.459
CLV_PCSK_SKI1_1	72	76	PF00082	0.548
DEG_APCC_DBOX_1	222	230	PF00400	0.518
DOC_MAPK_gen_1	87	96	PF00069	0.531
DOC_USP7_MATH_1	132	136	PF00917	0.554
DOC_USP7_MATH_1	25	29	PF00917	0.347
LIG_14-3-3_CanoR_1	275	281	PF00244	0.492
LIG_14-3-3_CanoR_1	72	82	PF00244	0.430
LIG_APCC_ABBA_1	94	99	PF00400	0.407
LIG_APCC_ABBAyCdc20_2	93	99	PF00400	0.410
LIG_BIR_II_1	1	5	PF00653	0.366
LIG_FHA_1	90	96	PF00498	0.413
LIG_FHA_2	280	286	PF00498	0.624
LIG_PCNA_PIPBox_1	16	25	PF02747	0.421
LIG_SH2_GRB2like	22	25	PF00017	0.421
LIG_SH2_NCK_1	258	262	PF00017	0.541
LIG_SH2_SRC	22	25	PF00017	0.421
LIG_SH2_STAP1	113	117	PF00017	0.366
LIG_SH2_STAP1	97	101	PF00017	0.404
LIG_SH2_STAT3	154	157	PF00017	0.430
LIG_SH2_STAT5	154	157	PF00017	0.396
LIG_SH2_STAT5	22	25	PF00017	0.420
LIG_TRAF2_1	123	126	PF00917	0.557
LIG_TRAF2_1	239	242	PF00917	0.489
LIG_UBA3_1	52	58	PF00899	0.358
MOD_CK1_1	139	145	PF00069	0.536
MOD_CK2_1	168	174	PF00069	0.511
MOD_CK2_1	279	285	PF00069	0.559
MOD_GlcNHglycan	101	104	PF01048	0.420
MOD_GlcNHglycan	27	30	PF01048	0.361
MOD_GlcNHglycan	32	35	PF01048	0.355
MOD_GSK3_1	132	139	PF00069	0.667
MOD_N-GLC_1	183	188	PF02516	0.522
MOD_N-GLC_1	99	104	PF02516	0.471
MOD_NEK2_1	136	141	PF00069	0.485
MOD_NEK2_1	279	284	PF00069	0.549
MOD_PIKK_1	177	183	PF00454	0.531
MOD_PIKK_1	274	280	PF00454	0.488
MOD_PKA_2	139	145	PF00069	0.404
MOD_PKA_2	274	280	PF00069	0.462
MOD_PKB_1	87	95	PF00069	0.349
MOD_Plk_1	183	189	PF00069	0.466
MOD_Plk_1	99	105	PF00069	0.467
MOD_Plk_2-3	260	266	PF00069	0.402
MOD_SUMO_for_1	198	201	PF00179	0.415
TRG_DiLeu_BaEn_1	77	82	PF01217	0.435
TRG_DiLeu_BaEn_3	241	247	PF01217	0.446
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.450
TRG_DiLeu_LyEn_5	77	82	PF01217	0.435
TRG_ER_diArg_1	10	12	PF00400	0.405
TRG_ER_diArg_1	243	245	PF00400	0.504
TRG_ER_diArg_1	86	89	PF00400	0.489
TRG_NLS_MonoExtC_3	86	91	PF00514	0.467
TRG_NLS_MonoExtN_4	84	91	PF00514	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW3	Leptomonas seymouri	43%	72%
A0A1X0P838	Trypanosomatidae	25%	74%
A0A3S5H822	Leishmania donovani	90%	76%
A0A422NLC8	Trypanosoma rangeli	26%	83%
A4HP44	Leishmania braziliensis	67%	79%
A4IDF1	Leishmania infantum	90%	100%
E9ASV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	77%
V5B4D1	Trypanosoma cruzi	24%	83%