Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania major

UniProt:

Q4Q1P2_LEIMA

TriTrypDb:

LmjF.36.1820 , LMJLV39_360024700 , LMJSD75_360024800

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Show entries

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Previous1Next

Expansion

Sequence features

Q4Q1P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.672
CLV_C14_Caspase3-7	316	320	PF00656	0.591
CLV_C14_Caspase3-7	54	58	PF00656	0.470
CLV_C14_Caspase3-7	652	656	PF00656	0.590
CLV_NRD_NRD_1	105	107	PF00675	0.470
CLV_NRD_NRD_1	524	526	PF00675	0.702
CLV_NRD_NRD_1	543	545	PF00675	0.534
CLV_NRD_NRD_1	673	675	PF00675	0.758
CLV_NRD_NRD_1	696	698	PF00675	0.700
CLV_NRD_NRD_1	824	826	PF00675	0.675

Previous1 2 3 4 5…28Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQV2	Leishmania donovani	83%	100%
A4HP46	Leishmania braziliensis	47%	98%
A4IDF3	Leishmania infantum	84%	100%
E9ASV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%

Previous1Next