Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania major

UniProt:

Q4Q1P2_LEIMA

TriTrypDb:

LmjF.36.1820 , LMJLV39_360024700 , LMJSD75_360024800

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1P2

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0003924	GTPase activity	7	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0019003	GDP binding	4	2
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.672
CLV_C14_Caspase3-7	316	320	PF00656	0.591
CLV_C14_Caspase3-7	54	58	PF00656	0.470
CLV_C14_Caspase3-7	652	656	PF00656	0.590
CLV_NRD_NRD_1	105	107	PF00675	0.470
CLV_NRD_NRD_1	524	526	PF00675	0.702
CLV_NRD_NRD_1	543	545	PF00675	0.534
CLV_NRD_NRD_1	673	675	PF00675	0.758
CLV_NRD_NRD_1	696	698	PF00675	0.700
CLV_NRD_NRD_1	824	826	PF00675	0.675
CLV_NRD_NRD_1	844	846	PF00675	0.664
CLV_PCSK_FUR_1	522	526	PF00082	0.679
CLV_PCSK_KEX2_1	216	218	PF00082	0.766
CLV_PCSK_KEX2_1	524	526	PF00082	0.702
CLV_PCSK_KEX2_1	527	529	PF00082	0.666
CLV_PCSK_KEX2_1	824	826	PF00082	0.709
CLV_PCSK_KEX2_1	844	846	PF00082	0.598
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.642
CLV_PCSK_PC1ET2_1	527	529	PF00082	0.693
CLV_PCSK_SKI1_1	107	111	PF00082	0.470
CLV_PCSK_SKI1_1	123	127	PF00082	0.253
CLV_PCSK_SKI1_1	32	36	PF00082	0.375
CLV_PCSK_SKI1_1	454	458	PF00082	0.606
CLV_PCSK_SKI1_1	71	75	PF00082	0.470
CLV_PCSK_SKI1_1	830	834	PF00082	0.649
DEG_APCC_DBOX_1	105	113	PF00400	0.428
DEG_APCC_DBOX_1	308	316	PF00400	0.653
DEG_SPOP_SBC_1	807	811	PF00917	0.668
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.470
DOC_MAPK_gen_1	104	112	PF00069	0.470
DOC_MAPK_gen_1	672	679	PF00069	0.699
DOC_MAPK_gen_1	841	850	PF00069	0.582
DOC_MAPK_MEF2A_6	328	337	PF00069	0.552
DOC_MAPK_MEF2A_6	841	850	PF00069	0.572
DOC_MAPK_MEF2A_6	93	100	PF00069	0.470
DOC_MAPK_NFAT4_5	328	336	PF00069	0.548
DOC_PP1_RVXF_1	69	75	PF00149	0.470
DOC_PP2B_LxvP_1	300	303	PF13499	0.688
DOC_PP2B_PxIxI_1	17	23	PF00149	0.524
DOC_PP2B_PxIxI_1	845	851	PF00149	0.572
DOC_PP4_FxxP_1	424	427	PF00568	0.656
DOC_USP7_MATH_1	192	196	PF00917	0.590
DOC_USP7_MATH_1	304	308	PF00917	0.645
DOC_USP7_MATH_1	353	357	PF00917	0.740
DOC_USP7_MATH_1	358	362	PF00917	0.708
DOC_USP7_MATH_1	367	371	PF00917	0.610
DOC_USP7_MATH_1	373	377	PF00917	0.520
DOC_USP7_MATH_1	387	391	PF00917	0.533
DOC_USP7_MATH_1	45	49	PF00917	0.470
DOC_USP7_MATH_1	463	467	PF00917	0.646
DOC_USP7_MATH_1	552	556	PF00917	0.630
DOC_USP7_MATH_1	649	653	PF00917	0.612
DOC_USP7_MATH_1	730	734	PF00917	0.783
DOC_USP7_MATH_1	807	811	PF00917	0.765
DOC_USP7_MATH_1	816	820	PF00917	0.770
DOC_USP7_MATH_1	826	830	PF00917	0.645
DOC_USP7_UBL2_3	545	549	PF12436	0.711
DOC_WW_Pin1_4	215	220	PF00397	0.777
DOC_WW_Pin1_4	273	278	PF00397	0.632
DOC_WW_Pin1_4	349	354	PF00397	0.760
DOC_WW_Pin1_4	568	573	PF00397	0.589
DOC_WW_Pin1_4	597	602	PF00397	0.624
DOC_WW_Pin1_4	742	747	PF00397	0.611
DOC_WW_Pin1_4	760	765	PF00397	0.706
DOC_WW_Pin1_4	770	775	PF00397	0.663
LIG_14-3-3_CanoR_1	104	110	PF00244	0.470
LIG_14-3-3_CanoR_1	130	138	PF00244	0.448
LIG_14-3-3_CanoR_1	217	223	PF00244	0.568
LIG_14-3-3_CanoR_1	328	334	PF00244	0.549
LIG_14-3-3_CanoR_1	419	425	PF00244	0.649
LIG_14-3-3_CanoR_1	525	534	PF00244	0.724
LIG_14-3-3_CanoR_1	697	701	PF00244	0.709
LIG_14-3-3_CanoR_1	71	81	PF00244	0.438
LIG_14-3-3_CanoR_1	736	743	PF00244	0.701
LIG_14-3-3_CanoR_1	772	782	PF00244	0.730
LIG_14-3-3_CanoR_1	808	816	PF00244	0.793
LIG_APCC_ABBAyCdc20_2	37	43	PF00400	0.470
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_FHA_1	274	280	PF00498	0.824
LIG_FHA_1	297	303	PF00498	0.705
LIG_FHA_1	31	37	PF00498	0.470
LIG_FHA_1	330	336	PF00498	0.454
LIG_FHA_1	668	674	PF00498	0.756
LIG_FHA_2	132	138	PF00498	0.413
LIG_FHA_2	160	166	PF00498	0.627
LIG_FHA_2	219	225	PF00498	0.542
LIG_FHA_2	246	252	PF00498	0.742
LIG_FHA_2	47	53	PF00498	0.446
LIG_FHA_2	58	64	PF00498	0.345
LIG_Integrin_RGD_1	653	655	PF01839	0.625
LIG_Integrin_RGD_1	691	693	PF01839	0.617
LIG_LIR_Apic_2	423	427	PF02991	0.656
LIG_LIR_Gen_1	221	230	PF02991	0.493
LIG_LIR_Gen_1	332	341	PF02991	0.391
LIG_LIR_Gen_1	57	67	PF02991	0.470
LIG_LIR_Nem_3	135	141	PF02991	0.438
LIG_LIR_Nem_3	221	225	PF02991	0.503
LIG_LIR_Nem_3	332	337	PF02991	0.369
LIG_LIR_Nem_3	512	517	PF02991	0.583
LIG_LIR_Nem_3	57	62	PF02991	0.470
LIG_LIR_Nem_3	716	721	PF02991	0.695
LIG_SH2_CRK	70	74	PF00017	0.470
LIG_SH2_GRB2like	415	418	PF00017	0.542
LIG_SH2_NCK_1	59	63	PF00017	0.470
LIG_SH2_SRC	39	42	PF00017	0.470
LIG_SH2_STAP1	536	540	PF00017	0.691
LIG_SH2_STAT3	458	461	PF00017	0.664
LIG_SH2_STAT5	180	183	PF00017	0.621
LIG_SH2_STAT5	334	337	PF00017	0.372
LIG_SH2_STAT5	39	42	PF00017	0.470
LIG_SH2_STAT5	415	418	PF00017	0.638
LIG_SH2_STAT5	458	461	PF00017	0.664
LIG_SH2_STAT5	557	560	PF00017	0.579
LIG_SH2_STAT5	59	62	PF00017	0.199
LIG_SH2_STAT5	64	67	PF00017	0.402
LIG_SH2_STAT5	90	93	PF00017	0.470
LIG_SH3_2	823	828	PF14604	0.744
LIG_SH3_3	566	572	PF00018	0.590
LIG_SH3_3	630	636	PF00018	0.683
LIG_SH3_3	800	806	PF00018	0.745
LIG_SH3_3	820	826	PF00018	0.668
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.406
LIG_SUMO_SIM_par_1	21	27	PF11976	0.470
LIG_SUMO_SIM_par_1	393	399	PF11976	0.556
LIG_SUMO_SIM_par_1	799	804	PF11976	0.632
LIG_SUMO_SIM_par_1	95	102	PF11976	0.467
LIG_SxIP_EBH_1	419	431	PF03271	0.664
LIG_TRAF2_1	794	797	PF00917	0.693
LIG_WRC_WIRS_1	421	426	PF05994	0.630
LIG_WW_3	805	809	PF00397	0.634
MOD_CDK_SPK_2	215	220	PF00069	0.713
MOD_CK1_1	218	224	PF00069	0.550
MOD_CK1_1	271	277	PF00069	0.663
MOD_CK1_1	284	290	PF00069	0.594
MOD_CK1_1	356	362	PF00069	0.734
MOD_CK1_1	376	382	PF00069	0.516
MOD_CK1_1	420	426	PF00069	0.637
MOD_CK1_1	444	450	PF00069	0.697
MOD_CK1_1	46	52	PF00069	0.432
MOD_CK1_1	483	489	PF00069	0.583
MOD_CK1_1	496	502	PF00069	0.590
MOD_CK1_1	535	541	PF00069	0.748
MOD_CK1_1	580	586	PF00069	0.703
MOD_CK1_1	600	606	PF00069	0.747
MOD_CK1_1	628	634	PF00069	0.723
MOD_CK1_1	647	653	PF00069	0.568
MOD_CK1_1	773	779	PF00069	0.792
MOD_CK1_1	79	85	PF00069	0.468
MOD_CK1_1	791	797	PF00069	0.666
MOD_CK1_1	8	14	PF00069	0.619
MOD_CK2_1	245	251	PF00069	0.685
MOD_CK2_1	358	364	PF00069	0.702
MOD_CK2_1	46	52	PF00069	0.403
MOD_CK2_1	475	481	PF00069	0.717
MOD_CK2_1	567	573	PF00069	0.719
MOD_CK2_1	7	13	PF00069	0.656
MOD_CK2_1	79	85	PF00069	0.470
MOD_CK2_1	791	797	PF00069	0.749
MOD_CK2_1	816	822	PF00069	0.734
MOD_Cter_Amidation	525	528	PF01082	0.728
MOD_Cter_Amidation	546	549	PF01082	0.682
MOD_GlcNHglycan	12	16	PF01048	0.535
MOD_GlcNHglycan	176	179	PF01048	0.517
MOD_GlcNHglycan	196	199	PF01048	0.441
MOD_GlcNHglycan	261	264	PF01048	0.604
MOD_GlcNHglycan	347	350	PF01048	0.677
MOD_GlcNHglycan	369	372	PF01048	0.680
MOD_GlcNHglycan	378	381	PF01048	0.704
MOD_GlcNHglycan	398	401	PF01048	0.570
MOD_GlcNHglycan	436	439	PF01048	0.762
MOD_GlcNHglycan	465	468	PF01048	0.678
MOD_GlcNHglycan	554	557	PF01048	0.609
MOD_GlcNHglycan	579	582	PF01048	0.759
MOD_GlcNHglycan	617	620	PF01048	0.651
MOD_GlcNHglycan	630	633	PF01048	0.766
MOD_GlcNHglycan	728	731	PF01048	0.716
MOD_GlcNHglycan	732	735	PF01048	0.665
MOD_GlcNHglycan	738	741	PF01048	0.680
MOD_GlcNHglycan	78	81	PF01048	0.406
MOD_GlcNHglycan	793	796	PF01048	0.734
MOD_GlcNHglycan	810	813	PF01048	0.556
MOD_GSK3_1	152	159	PF00069	0.624
MOD_GSK3_1	246	253	PF00069	0.773
MOD_GSK3_1	268	275	PF00069	0.754
MOD_GSK3_1	284	291	PF00069	0.620
MOD_GSK3_1	341	348	PF00069	0.726
MOD_GSK3_1	349	356	PF00069	0.678
MOD_GSK3_1	459	466	PF00069	0.683
MOD_GSK3_1	46	53	PF00069	0.446
MOD_GSK3_1	492	499	PF00069	0.695
MOD_GSK3_1	505	512	PF00069	0.680
MOD_GSK3_1	535	542	PF00069	0.767
MOD_GSK3_1	558	565	PF00069	0.686
MOD_GSK3_1	596	603	PF00069	0.759
MOD_GSK3_1	640	647	PF00069	0.720
MOD_GSK3_1	663	670	PF00069	0.766
MOD_GSK3_1	696	703	PF00069	0.697
MOD_GSK3_1	7	14	PF00069	0.615
MOD_GSK3_1	72	79	PF00069	0.470
MOD_GSK3_1	726	733	PF00069	0.623
MOD_GSK3_1	742	749	PF00069	0.595
MOD_GSK3_1	768	775	PF00069	0.816
MOD_GSK3_1	777	784	PF00069	0.671
MOD_GSK3_1	859	866	PF00069	0.604
MOD_N-GLC_1	288	293	PF02516	0.598
MOD_N-GLC_1	492	497	PF02516	0.715
MOD_N-GLC_1	726	731	PF02516	0.722
MOD_N-GLC_1	791	796	PF02516	0.733
MOD_N-GLC_1	834	839	PF02516	0.606
MOD_N-GLC_2	267	269	PF02516	0.704
MOD_NEK2_1	156	161	PF00069	0.497
MOD_NEK2_1	272	277	PF00069	0.603
MOD_NEK2_1	313	318	PF00069	0.575
MOD_NEK2_1	398	403	PF00069	0.554
MOD_NEK2_1	411	416	PF00069	0.508
MOD_NEK2_1	434	439	PF00069	0.607
MOD_NEK2_1	450	455	PF00069	0.595
MOD_NEK2_1	5	10	PF00069	0.642
MOD_NEK2_1	55	60	PF00069	0.470
MOD_NEK2_1	558	563	PF00069	0.686
MOD_NEK2_1	574	579	PF00069	0.759
MOD_NEK2_1	834	839	PF00069	0.631
MOD_NEK2_1	99	104	PF00069	0.470
MOD_NEK2_2	296	301	PF00069	0.630
MOD_NEK2_2	329	334	PF00069	0.543
MOD_NEK2_2	846	851	PF00069	0.571
MOD_PIKK_1	444	450	PF00454	0.569
MOD_PIKK_1	516	522	PF00454	0.712
MOD_PIKK_1	663	669	PF00454	0.715
MOD_PIKK_1	816	822	PF00454	0.761
MOD_PIKK_1	860	866	PF00454	0.708
MOD_PKA_1	245	251	PF00069	0.685
MOD_PKA_2	105	111	PF00069	0.470
MOD_PKA_2	327	333	PF00069	0.449
MOD_PKA_2	450	456	PF00069	0.698
MOD_PKA_2	46	52	PF00069	0.375
MOD_PKA_2	696	702	PF00069	0.753
MOD_PKA_2	721	727	PF00069	0.707
MOD_PKA_2	807	813	PF00069	0.789
MOD_Plk_1	11	17	PF00069	0.540
MOD_Plk_1	250	256	PF00069	0.590
MOD_Plk_1	417	423	PF00069	0.631
MOD_Plk_1	496	502	PF00069	0.750
MOD_Plk_1	509	515	PF00069	0.590
MOD_Plk_1	51	57	PF00069	0.406
MOD_Plk_1	625	631	PF00069	0.659
MOD_Plk_2-3	152	158	PF00069	0.477
MOD_Plk_2-3	186	192	PF00069	0.580
MOD_Plk_4	105	111	PF00069	0.470
MOD_Plk_4	329	335	PF00069	0.367
MOD_Plk_4	393	399	PF00069	0.598
MOD_Plk_4	411	417	PF00069	0.613
MOD_Plk_4	420	426	PF00069	0.647
MOD_Plk_4	51	57	PF00069	0.375
MOD_ProDKin_1	215	221	PF00069	0.762
MOD_ProDKin_1	273	279	PF00069	0.634
MOD_ProDKin_1	349	355	PF00069	0.762
MOD_ProDKin_1	568	574	PF00069	0.590
MOD_ProDKin_1	597	603	PF00069	0.627
MOD_ProDKin_1	742	748	PF00069	0.614
MOD_ProDKin_1	760	766	PF00069	0.706
MOD_ProDKin_1	770	776	PF00069	0.665
MOD_SUMO_rev_2	316	323	PF00179	0.585
TRG_DiLeu_BaEn_2	139	145	PF01217	0.470
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.470
TRG_ENDOCYTIC_2	334	337	PF00928	0.372
TRG_ENDOCYTIC_2	59	62	PF00928	0.470
TRG_ENDOCYTIC_2	64	67	PF00928	0.402
TRG_ENDOCYTIC_2	70	73	PF00928	0.321
TRG_ER_diArg_1	103	106	PF00400	0.375
TRG_ER_diArg_1	522	525	PF00400	0.600
TRG_ER_diArg_1	671	674	PF00400	0.755
TRG_ER_diArg_1	823	825	PF00400	0.625
TRG_ER_diArg_1	843	845	PF00400	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQV2	Leishmania donovani	83%	100%
A4HP46	Leishmania braziliensis	47%	98%
A4IDF3	Leishmania infantum	84%	100%
E9ASV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%