Major vault protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Major vault protein

Gene product:

major vault protein, putative

Species:

Leishmania major

UniProt:

Q4Q1N7_LEIMA

TriTrypDb:

LmjF.36.1870 , LMJLV39_360025200 , LMJSD75_360025300

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4Q1N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1N7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.489
CLV_C14_Caspase3-7	192	196	PF00656	0.425
CLV_C14_Caspase3-7	357	361	PF00656	0.400
CLV_C14_Caspase3-7	408	412	PF00656	0.416
CLV_NRD_NRD_1	147	149	PF00675	0.240
CLV_NRD_NRD_1	260	262	PF00675	0.452
CLV_NRD_NRD_1	317	319	PF00675	0.353
CLV_NRD_NRD_1	402	404	PF00675	0.483
CLV_NRD_NRD_1	470	472	PF00675	0.621
CLV_NRD_NRD_1	633	635	PF00675	0.296
CLV_NRD_NRD_1	727	729	PF00675	0.441
CLV_PCSK_KEX2_1	147	149	PF00082	0.216
CLV_PCSK_KEX2_1	290	292	PF00082	0.426
CLV_PCSK_KEX2_1	317	319	PF00082	0.331
CLV_PCSK_KEX2_1	402	404	PF00082	0.483
CLV_PCSK_KEX2_1	633	635	PF00082	0.296
CLV_PCSK_KEX2_1	727	729	PF00082	0.514
CLV_PCSK_KEX2_1	789	791	PF00082	0.428
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.415
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.461
CLV_PCSK_SKI1_1	120	124	PF00082	0.282
CLV_PCSK_SKI1_1	153	157	PF00082	0.232
CLV_PCSK_SKI1_1	284	288	PF00082	0.376
CLV_PCSK_SKI1_1	318	322	PF00082	0.336
CLV_PCSK_SKI1_1	471	475	PF00082	0.639
CLV_PCSK_SKI1_1	489	493	PF00082	0.129
CLV_PCSK_SKI1_1	503	507	PF00082	0.204
CLV_PCSK_SKI1_1	510	514	PF00082	0.217
CLV_PCSK_SKI1_1	634	638	PF00082	0.296
CLV_PCSK_SKI1_1	680	684	PF00082	0.390
CLV_PCSK_SKI1_1	727	731	PF00082	0.402
CLV_PCSK_SKI1_1	771	775	PF00082	0.497
CLV_PCSK_SKI1_1	789	793	PF00082	0.342
DEG_SCF_FBW7_1	583	588	PF00400	0.447
DEG_SCF_FBW7_2	250	256	PF00400	0.434
DOC_CKS1_1	250	255	PF01111	0.426
DOC_CYCLIN_RxL_1	725	735	PF00134	0.401
DOC_CYCLIN_RxL_1	771	781	PF00134	0.579
DOC_CYCLIN_RxL_1	787	797	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	650	656	PF00134	0.447
DOC_MAPK_gen_1	680	688	PF00069	0.427
DOC_MAPK_gen_1	798	805	PF00069	0.522
DOC_MAPK_HePTP_8	563	575	PF00069	0.401
DOC_MAPK_MEF2A_6	120	127	PF00069	0.447
DOC_MAPK_MEF2A_6	566	575	PF00069	0.420
DOC_MAPK_MEF2A_6	680	688	PF00069	0.385
DOC_PP1_RVXF_1	501	507	PF00149	0.457
DOC_PP4_FxxP_1	156	159	PF00568	0.414
DOC_PP4_FxxP_1	217	220	PF00568	0.409
DOC_PP4_FxxP_1	326	329	PF00568	0.406
DOC_PP4_FxxP_1	551	554	PF00568	0.401
DOC_USP7_MATH_1	134	138	PF00917	0.515
DOC_USP7_MATH_1	220	224	PF00917	0.318
DOC_USP7_MATH_1	34	38	PF00917	0.454
DOC_USP7_MATH_1	354	358	PF00917	0.441
DOC_USP7_MATH_1	487	491	PF00917	0.401
DOC_USP7_MATH_1	615	619	PF00917	0.428
DOC_USP7_MATH_1	733	737	PF00917	0.464
DOC_USP7_MATH_1	739	743	PF00917	0.474
DOC_USP7_MATH_1	752	756	PF00917	0.500
DOC_USP7_UBL2_3	536	540	PF12436	0.417
DOC_WW_Pin1_4	141	146	PF00397	0.512
DOC_WW_Pin1_4	249	254	PF00397	0.483
DOC_WW_Pin1_4	361	366	PF00397	0.496
DOC_WW_Pin1_4	524	529	PF00397	0.453
DOC_WW_Pin1_4	581	586	PF00397	0.496
DOC_WW_Pin1_4	858	863	PF00397	0.467
LIG_14-3-3_CanoR_1	291	301	PF00244	0.398
LIG_14-3-3_CanoR_1	317	327	PF00244	0.379
LIG_14-3-3_CanoR_1	33	43	PF00244	0.480
LIG_14-3-3_CanoR_1	416	420	PF00244	0.475
LIG_14-3-3_CanoR_1	480	485	PF00244	0.260
LIG_14-3-3_CanoR_1	489	497	PF00244	0.385
LIG_14-3-3_CanoR_1	815	819	PF00244	0.622
LIG_APCC_ABBA_1	100	105	PF00400	0.414
LIG_APCC_ABBA_1	729	734	PF00400	0.374
LIG_APCC_ABBAyCdc20_2	728	734	PF00400	0.378
LIG_BIR_III_4	79	83	PF00653	0.496
LIG_BRCT_BRCA1_1	189	193	PF00533	0.461
LIG_BRCT_BRCA1_1	617	621	PF00533	0.401
LIG_CaM_IQ_9	782	798	PF13499	0.523
LIG_deltaCOP1_diTrp_1	578	581	PF00928	0.457
LIG_deltaCOP1_diTrp_1	90	100	PF00928	0.496
LIG_EVH1_2	44	48	PF00568	0.480
LIG_FHA_1	192	198	PF00498	0.489
LIG_FHA_1	21	27	PF00498	0.359
LIG_FHA_1	268	274	PF00498	0.408
LIG_FHA_1	362	368	PF00498	0.496
LIG_FHA_1	418	424	PF00498	0.443
LIG_FHA_1	44	50	PF00498	0.474
LIG_FHA_1	500	506	PF00498	0.450
LIG_FHA_1	540	546	PF00498	0.501
LIG_FHA_1	556	562	PF00498	0.417
LIG_FHA_1	68	74	PF00498	0.432
LIG_FHA_2	186	192	PF00498	0.394
LIG_FHA_2	244	250	PF00498	0.559
LIG_FHA_2	395	401	PF00498	0.494
LIG_FHA_2	433	439	PF00498	0.447
LIG_FHA_2	582	588	PF00498	0.496
LIG_FHA_2	63	69	PF00498	0.504
LIG_FHA_2	658	664	PF00498	0.441
LIG_FHA_2	779	785	PF00498	0.543
LIG_FHA_2	828	834	PF00498	0.442
LIG_LIR_Apic_2	244	250	PF02991	0.498
LIG_LIR_Apic_2	323	329	PF02991	0.370
LIG_LIR_Apic_2	438	444	PF02991	0.496
LIG_LIR_Apic_2	483	487	PF02991	0.420
LIG_LIR_Apic_2	92	98	PF02991	0.482
LIG_LIR_Gen_1	12	19	PF02991	0.383
LIG_LIR_Gen_1	206	215	PF02991	0.390
LIG_LIR_Gen_1	297	306	PF02991	0.338
LIG_LIR_Gen_1	46	56	PF02991	0.254
LIG_LIR_Gen_1	516	524	PF02991	0.401
LIG_LIR_Gen_1	618	629	PF02991	0.444
LIG_LIR_Nem_3	12	16	PF02991	0.370
LIG_LIR_Nem_3	161	166	PF02991	0.435
LIG_LIR_Nem_3	206	211	PF02991	0.374
LIG_LIR_Nem_3	297	302	PF02991	0.332
LIG_LIR_Nem_3	46	51	PF02991	0.344
LIG_LIR_Nem_3	516	522	PF02991	0.401
LIG_LIR_Nem_3	54	59	PF02991	0.414
LIG_LIR_Nem_3	578	583	PF02991	0.449
LIG_LIR_Nem_3	618	624	PF02991	0.430
LIG_LIR_Nem_3	79	84	PF02991	0.454
LIG_LYPXL_L_2	102	111	PF13949	0.496
LIG_LYPXL_yS_3	163	166	PF13949	0.457
LIG_Pex14_2	217	221	PF04695	0.427
LIG_REV1ctd_RIR_1	323	328	PF16727	0.369
LIG_SH2_CRK	131	135	PF00017	0.496
LIG_SH2_CRK	208	212	PF00017	0.357
LIG_SH2_CRK	282	286	PF00017	0.420
LIG_SH2_CRK	299	303	PF00017	0.235
LIG_SH2_CRK	484	488	PF00017	0.404
LIG_SH2_CRK	56	60	PF00017	0.447
LIG_SH2_CRK	81	85	PF00017	0.482
LIG_SH2_NCK_1	131	135	PF00017	0.385
LIG_SH2_PTP2	462	465	PF00017	0.541
LIG_SH2_SRC	247	250	PF00017	0.405
LIG_SH2_STAP1	282	286	PF00017	0.379
LIG_SH2_STAP1	299	303	PF00017	0.263
LIG_SH2_STAP1	577	581	PF00017	0.401
LIG_SH2_STAP1	807	811	PF00017	0.524
LIG_SH2_STAT3	497	500	PF00017	0.496
LIG_SH2_STAT5	154	157	PF00017	0.428
LIG_SH2_STAT5	177	180	PF00017	0.468
LIG_SH2_STAT5	210	213	PF00017	0.372
LIG_SH2_STAT5	342	345	PF00017	0.473
LIG_SH2_STAT5	405	408	PF00017	0.392
LIG_SH2_STAT5	414	417	PF00017	0.375
LIG_SH2_STAT5	432	435	PF00017	0.401
LIG_SH2_STAT5	462	465	PF00017	0.584
LIG_SH2_STAT5	544	547	PF00017	0.509
LIG_SH2_STAT5	56	59	PF00017	0.432
LIG_SH2_STAT5	580	583	PF00017	0.417
LIG_SH2_STAT5	607	610	PF00017	0.496
LIG_SH2_STAT5	854	857	PF00017	0.424
LIG_SH3_1	247	253	PF00018	0.486
LIG_SH3_2	250	255	PF14604	0.426
LIG_SH3_2	528	533	PF14604	0.462
LIG_SH3_3	247	253	PF00018	0.479
LIG_SH3_3	275	281	PF00018	0.328
LIG_SH3_3	374	380	PF00018	0.501
LIG_SH3_3	38	44	PF00018	0.404
LIG_SH3_3	398	404	PF00018	0.418
LIG_SH3_3	46	52	PF00018	0.257
LIG_SH3_3	502	508	PF00018	0.496
LIG_SH3_3	525	531	PF00018	0.419
LIG_SH3_3	95	101	PF00018	0.407
LIG_SUMO_SIM_anti_2	734	743	PF11976	0.406
LIG_SUMO_SIM_par_1	520	525	PF11976	0.432
LIG_TRAF2_1	234	237	PF00917	0.462
LIG_TRAF2_1	435	438	PF00917	0.417
LIG_TRAF2_1	620	623	PF00917	0.496
LIG_TRAF2_1	722	725	PF00917	0.523
LIG_TRAF2_1	794	797	PF00917	0.505
LIG_TRAF2_1	810	813	PF00917	0.586
LIG_TRAF2_1	88	91	PF00917	0.496
LIG_TRAF2_2	366	371	PF00917	0.416
LIG_TRFH_1	100	104	PF08558	0.414
LIG_TRFH_1	277	281	PF08558	0.348
LIG_TRFH_1	325	329	PF08558	0.403
LIG_TYR_ITIM	486	491	PF00017	0.496
LIG_TYR_ITSM	159	166	PF00017	0.457
LIG_TYR_ITSM	52	59	PF00017	0.416
LIG_WRC_WIRS_1	355	360	PF05994	0.400
MOD_CDC14_SPxK_1	144	147	PF00782	0.416
MOD_CDK_SPxK_1	141	147	PF00069	0.416
MOD_CDK_SPxK_1	249	255	PF00069	0.420
MOD_CDK_SPxxK_3	141	148	PF00069	0.447
MOD_CK1_1	141	147	PF00069	0.513
MOD_CK1_1	361	367	PF00069	0.447
MOD_CK1_1	37	43	PF00069	0.444
MOD_CK1_1	555	561	PF00069	0.451
MOD_CK1_1	661	667	PF00069	0.427
MOD_CK1_1	743	749	PF00069	0.546
MOD_CK1_1	754	760	PF00069	0.475
MOD_CK1_1	761	767	PF00069	0.491
MOD_CK2_1	185	191	PF00069	0.438
MOD_CK2_1	231	237	PF00069	0.437
MOD_CK2_1	394	400	PF00069	0.485
MOD_CK2_1	432	438	PF00069	0.447
MOD_CK2_1	754	760	PF00069	0.464
MOD_CK2_1	778	784	PF00069	0.512
MOD_CK2_1	827	833	PF00069	0.437
MOD_CK2_1	85	91	PF00069	0.496
MOD_GlcNHglycan	117	120	PF01048	0.262
MOD_GlcNHglycan	136	139	PF01048	0.201
MOD_GlcNHglycan	182	185	PF01048	0.454
MOD_GlcNHglycan	233	236	PF01048	0.258
MOD_GlcNHglycan	294	297	PF01048	0.453
MOD_GlcNHglycan	339	342	PF01048	0.427
MOD_GlcNHglycan	445	448	PF01048	0.273
MOD_GlcNHglycan	524	527	PF01048	0.214
MOD_GlcNHglycan	627	630	PF01048	0.249
MOD_GlcNHglycan	734	738	PF01048	0.348
MOD_GlcNHglycan	742	745	PF01048	0.436
MOD_GlcNHglycan	754	757	PF01048	0.507
MOD_GlcNHglycan	869	872	PF01048	0.527
MOD_GlcNHglycan	87	90	PF01048	0.271
MOD_GSK3_1	134	141	PF00069	0.509
MOD_GSK3_1	14	21	PF00069	0.416
MOD_GSK3_1	185	192	PF00069	0.453
MOD_GSK3_1	285	292	PF00069	0.543
MOD_GSK3_1	350	357	PF00069	0.479
MOD_GSK3_1	379	386	PF00069	0.447
MOD_GSK3_1	428	435	PF00069	0.416
MOD_GSK3_1	520	527	PF00069	0.430
MOD_GSK3_1	539	546	PF00069	0.510
MOD_GSK3_1	581	588	PF00069	0.534
MOD_GSK3_1	603	610	PF00069	0.473
MOD_GSK3_1	657	664	PF00069	0.432
MOD_GSK3_1	739	746	PF00069	0.447
MOD_GSK3_1	754	761	PF00069	0.553
MOD_GSK3_1	854	861	PF00069	0.499
MOD_N-GLC_1	21	26	PF02516	0.364
MOD_N-GLC_1	310	315	PF02516	0.479
MOD_N-GLC_1	555	560	PF02516	0.232
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	185	190	PF00069	0.408
MOD_NEK2_1	193	198	PF00069	0.481
MOD_NEK2_1	285	290	PF00069	0.419
MOD_NEK2_1	358	363	PF00069	0.549
MOD_NEK2_1	657	662	PF00069	0.414
MOD_NEK2_1	678	683	PF00069	0.383
MOD_NEK2_1	778	783	PF00069	0.500
MOD_NEK2_1	845	850	PF00069	0.453
MOD_PIKK_1	294	300	PF00454	0.431
MOD_PIKK_1	489	495	PF00454	0.401
MOD_PIKK_1	496	502	PF00454	0.401
MOD_PIKK_1	51	57	PF00454	0.496
MOD_PIKK_1	661	667	PF00454	0.450
MOD_PKA_2	180	186	PF00069	0.448
MOD_PKA_2	415	421	PF00069	0.473
MOD_PKA_2	814	820	PF00069	0.621
MOD_Plk_1	310	316	PF00069	0.420
MOD_Plk_1	321	327	PF00069	0.268
MOD_Plk_1	761	767	PF00069	0.530
MOD_Plk_2-3	593	599	PF00069	0.510
MOD_Plk_4	1	7	PF00069	0.545
MOD_Plk_4	158	164	PF00069	0.414
MOD_Plk_4	321	327	PF00069	0.301
MOD_Plk_4	379	385	PF00069	0.465
MOD_Plk_4	428	434	PF00069	0.442
MOD_Plk_4	603	609	PF00069	0.414
MOD_Plk_4	814	820	PF00069	0.603
MOD_ProDKin_1	141	147	PF00069	0.512
MOD_ProDKin_1	249	255	PF00069	0.489
MOD_ProDKin_1	361	367	PF00069	0.496
MOD_ProDKin_1	524	530	PF00069	0.453
MOD_ProDKin_1	581	587	PF00069	0.496
MOD_ProDKin_1	858	864	PF00069	0.468
MOD_SUMO_for_1	109	112	PF00179	0.412
MOD_SUMO_rev_2	112	117	PF00179	0.482
MOD_SUMO_rev_2	464	474	PF00179	0.534
MOD_SUMO_rev_2	795	801	PF00179	0.524
TRG_DiLeu_BaEn_2	212	218	PF01217	0.447
TRG_DiLeu_BaLyEn_6	787	792	PF01217	0.425
TRG_ENDOCYTIC_2	13	16	PF00928	0.320
TRG_ENDOCYTIC_2	163	166	PF00928	0.457
TRG_ENDOCYTIC_2	208	211	PF00928	0.361
TRG_ENDOCYTIC_2	282	285	PF00928	0.339
TRG_ENDOCYTIC_2	299	302	PF00928	0.248
TRG_ENDOCYTIC_2	462	465	PF00928	0.609
TRG_ENDOCYTIC_2	488	491	PF00928	0.454
TRG_ENDOCYTIC_2	56	59	PF00928	0.414
TRG_ENDOCYTIC_2	580	583	PF00928	0.427
TRG_ENDOCYTIC_2	779	782	PF00928	0.509
TRG_ENDOCYTIC_2	81	84	PF00928	0.496
TRG_ER_diArg_1	146	148	PF00400	0.526
TRG_ER_diArg_1	317	319	PF00400	0.353
TRG_ER_diArg_1	401	403	PF00400	0.430
TRG_ER_diArg_1	632	634	PF00400	0.496
TRG_ER_diArg_1	714	717	PF00400	0.570
TRG_ER_diArg_1	727	729	PF00400	0.505
TRG_NES_CRM1_1	222	237	PF08389	0.252
TRG_NES_CRM1_1	840	852	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.296
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	790	795	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	809	813	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z8	Leptomonas seymouri	72%	97%
A0A0N1I3S9	Leptomonas seymouri	36%	100%
A0A0S4ISQ0	Bodo saltans	45%	100%
A0A0S4JL46	Bodo saltans	37%	100%
A0A1X0NXD4	Trypanosomatidae	36%	100%
A0A1X0P2V2	Trypanosomatidae	37%	100%
A0A1X0P8P2	Trypanosomatidae	48%	100%
A0A3Q8IKW2	Leishmania donovani	31%	91%
A0A3S7WNY9	Leishmania donovani	36%	100%
A0A3S7XAQ4	Leishmania donovani	96%	100%
A0A422NIL8	Trypanosoma rangeli	37%	100%
A0A422NLE5	Trypanosoma rangeli	48%	100%
A0A422NYK3	Trypanosoma rangeli	37%	100%
A4H452	Leishmania braziliensis	36%	100%
A4HP51	Leishmania braziliensis	89%	100%
A4HSC9	Leishmania infantum	36%	100%
A4HZA7	Leishmania infantum	32%	91%
A4IDF8	Leishmania infantum	96%	100%
C9ZPY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A1L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A336	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AIP9	Leishmania braziliensis	33%	100%
E9AKB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ASV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AUY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	91%
P34118	Dictyostelium discoideum	37%	100%
P54659	Dictyostelium discoideum	35%	100%
Q14764	Homo sapiens	38%	98%
Q3SYU9	Bos taurus	38%	98%
Q4CUM2	Trypanosoma cruzi (strain CL Brener)	36%	100%
Q4QCJ5	Leishmania major	31%	91%
Q4QJJ7	Leishmania major	36%	100%
Q57Z03	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	36%	100%
Q5EAJ7	Strongylocentrotus purpuratus	37%	100%
Q5R9N2	Pongo abelii	38%	98%
Q5ZMI4	Gallus gallus	38%	100%
Q62667	Rattus norvegicus	38%	100%
Q6P3L0	Danio rerio	37%	100%
Q6PF69	Xenopus laevis	37%	100%
Q90405	Diplobatis ommata	37%	100%
Q9DGM7	Ictalurus punctatus	37%	100%
Q9EQK5	Mus musculus	38%	100%
V5AUX6	Trypanosoma cruzi	36%	100%
V5B0K2	Trypanosoma cruzi	36%	100%