CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania major

UniProt:

Q4Q1N6_LEIMA

TriTrypDb:

LmjF.36.1880 , LMJLV39_360025300 , LMJSD75_360025400

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4Q1N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1N6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006270	DNA replication initiation	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	320	324	PF00656	0.774
CLV_NRD_NRD_1	174	176	PF00675	0.447
CLV_NRD_NRD_1	231	233	PF00675	0.528
CLV_NRD_NRD_1	478	480	PF00675	0.328
CLV_NRD_NRD_1	620	622	PF00675	0.531
CLV_NRD_NRD_1	64	66	PF00675	0.597
CLV_NRD_NRD_1	91	93	PF00675	0.425
CLV_NRD_NRD_1	95	97	PF00675	0.451
CLV_PCSK_KEX2_1	176	178	PF00082	0.581
CLV_PCSK_KEX2_1	212	214	PF00082	0.614
CLV_PCSK_KEX2_1	231	233	PF00082	0.528
CLV_PCSK_KEX2_1	478	480	PF00082	0.323
CLV_PCSK_KEX2_1	622	624	PF00082	0.496
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.614
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.563
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.494
CLV_PCSK_PC7_1	172	178	PF00082	0.571
CLV_PCSK_SKI1_1	112	116	PF00082	0.491
CLV_PCSK_SKI1_1	212	216	PF00082	0.633
CLV_PCSK_SKI1_1	353	357	PF00082	0.344
CLV_PCSK_SKI1_1	501	505	PF00082	0.344
DEG_Nend_UBRbox_3	1	3	PF02207	0.608
DEG_SPOP_SBC_1	386	390	PF00917	0.449
DOC_CKS1_1	482	487	PF01111	0.376
DOC_MAPK_gen_1	240	250	PF00069	0.433
DOC_MAPK_MEF2A_6	184	192	PF00069	0.412
DOC_MAPK_MEF2A_6	247	255	PF00069	0.367
DOC_MAPK_MEF2A_6	280	289	PF00069	0.425
DOC_PP2B_LxvP_1	381	384	PF13499	0.328
DOC_PP2B_LxvP_1	486	489	PF13499	0.448
DOC_USP7_MATH_1	104	108	PF00917	0.419
DOC_USP7_MATH_1	357	361	PF00917	0.371
DOC_USP7_MATH_1	386	390	PF00917	0.449
DOC_USP7_MATH_1	539	543	PF00917	0.328
DOC_USP7_UBL2_3	208	212	PF12436	0.568
DOC_USP7_UBL2_3	215	219	PF12436	0.521
DOC_USP7_UBL2_3	298	302	PF12436	0.550
DOC_USP7_UBL2_3	567	571	PF12436	0.567
DOC_USP7_UBL2_3	93	97	PF12436	0.487
DOC_WW_Pin1_4	260	265	PF00397	0.560
DOC_WW_Pin1_4	481	486	PF00397	0.376
LIG_14-3-3_CanoR_1	112	121	PF00244	0.524
LIG_14-3-3_CanoR_1	175	180	PF00244	0.511
LIG_14-3-3_CanoR_1	472	480	PF00244	0.344
LIG_14-3-3_CanoR_1	51	57	PF00244	0.619
LIG_14-3-3_CanoR_1	96	100	PF00244	0.496
LIG_Actin_WH2_2	241	256	PF00022	0.443
LIG_Actin_WH2_2	543	561	PF00022	0.413
LIG_APCC_ABBA_1	197	202	PF00400	0.664
LIG_BRCT_BRCA1_1	423	427	PF00533	0.328
LIG_Clathr_ClatBox_1	284	288	PF01394	0.441
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.344
LIG_deltaCOP1_diTrp_1	446	449	PF00928	0.344
LIG_EH1_1	164	172	PF00400	0.479
LIG_eIF4E_1	368	374	PF01652	0.328
LIG_FHA_1	161	167	PF00498	0.400
LIG_FHA_1	240	246	PF00498	0.490
LIG_FHA_1	266	272	PF00498	0.459
LIG_FHA_1	336	342	PF00498	0.449
LIG_FHA_1	446	452	PF00498	0.307
LIG_FHA_1	472	478	PF00498	0.330
LIG_FHA_1	542	548	PF00498	0.338
LIG_FHA_1	582	588	PF00498	0.475
LIG_FHA_1	6	12	PF00498	0.469
LIG_FHA_1	83	89	PF00498	0.516
LIG_FHA_2	23	29	PF00498	0.483
LIG_FHA_2	356	362	PF00498	0.363
LIG_LIR_Gen_1	288	297	PF02991	0.451
LIG_LIR_Gen_1	367	377	PF02991	0.328
LIG_LIR_Gen_1	82	91	PF02991	0.409
LIG_LIR_Nem_3	28	32	PF02991	0.459
LIG_LIR_Nem_3	288	293	PF02991	0.459
LIG_LIR_Nem_3	367	372	PF02991	0.328
LIG_LIR_Nem_3	82	87	PF02991	0.405
LIG_NRBOX	149	155	PF00104	0.384
LIG_NRBOX	184	190	PF00104	0.407
LIG_PCNA_PIPBox_1	12	21	PF02747	0.561
LIG_PCNA_yPIPBox_3	12	24	PF02747	0.568
LIG_PCNA_yPIPBox_3	141	154	PF02747	0.567
LIG_PCNA_yPIPBox_3	175	189	PF02747	0.464
LIG_PDZ_Class_3	629	634	PF00595	0.506
LIG_PTB_Apo_2	4	11	PF02174	0.493
LIG_PTB_Phospho_1	4	10	PF10480	0.504
LIG_SH2_CRK	290	294	PF00017	0.447
LIG_SH2_CRK	569	573	PF00017	0.516
LIG_SH2_NCK_1	593	597	PF00017	0.356
LIG_SH2_SRC	599	602	PF00017	0.488
LIG_SH2_STAP1	84	88	PF00017	0.385
LIG_SH2_STAT3	71	74	PF00017	0.486
LIG_SH2_STAT5	10	13	PF00017	0.434
LIG_SH2_STAT5	252	255	PF00017	0.372
LIG_SH2_STAT5	368	371	PF00017	0.344
LIG_SH2_STAT5	4	7	PF00017	0.524
LIG_SH2_STAT5	84	87	PF00017	0.487
LIG_SH3_3	139	145	PF00018	0.432
LIG_SH3_3	482	488	PF00018	0.344
LIG_SH3_3	605	611	PF00018	0.495
LIG_Sin3_3	124	131	PF02671	0.465
LIG_SUMO_SIM_anti_2	459	464	PF11976	0.330
LIG_SUMO_SIM_anti_2	546	551	PF11976	0.340
LIG_SUMO_SIM_par_1	343	349	PF11976	0.328
LIG_SUMO_SIM_par_1	459	464	PF11976	0.344
LIG_TYR_ITIM	250	255	PF00017	0.377
LIG_UBA3_1	170	176	PF00899	0.447
LIG_UBA3_1	293	302	PF00899	0.430
LIG_UBA3_1	460	466	PF00899	0.328
LIG_UBA3_1	90	97	PF00899	0.440
MOD_CK1_1	160	166	PF00069	0.417
MOD_CK1_1	336	342	PF00069	0.449
MOD_CK1_1	385	391	PF00069	0.449
MOD_CK1_1	412	418	PF00069	0.328
MOD_CK1_1	421	427	PF00069	0.328
MOD_CK1_1	541	547	PF00069	0.363
MOD_CK1_1	548	554	PF00069	0.363
MOD_CK1_1	95	101	PF00069	0.589
MOD_CK2_1	114	120	PF00069	0.558
MOD_CK2_1	355	361	PF00069	0.385
MOD_CK2_1	51	57	PF00069	0.542
MOD_CK2_1	95	101	PF00069	0.498
MOD_GlcNHglycan	116	119	PF01048	0.514
MOD_GlcNHglycan	384	387	PF01048	0.427
MOD_GlcNHglycan	390	393	PF01048	0.400
MOD_GlcNHglycan	417	420	PF01048	0.328
MOD_GlcNHglycan	535	538	PF01048	0.389
MOD_GSK3_1	256	263	PF00069	0.405
MOD_GSK3_1	313	320	PF00069	0.683
MOD_GSK3_1	332	339	PF00069	0.444
MOD_GSK3_1	353	360	PF00069	0.385
MOD_GSK3_1	382	389	PF00069	0.395
MOD_GSK3_1	409	416	PF00069	0.321
MOD_GSK3_1	421	428	PF00069	0.328
MOD_GSK3_1	441	448	PF00069	0.328
MOD_GSK3_1	46	53	PF00069	0.524
MOD_GSK3_1	541	548	PF00069	0.375
MOD_GSK3_1	550	557	PF00069	0.335
MOD_N-GLC_1	22	27	PF02516	0.484
MOD_N-GLC_1	441	446	PF02516	0.344
MOD_N-GLC_1	6	11	PF02516	0.471
MOD_NEK2_1	113	118	PF00069	0.541
MOD_NEK2_1	134	139	PF00069	0.533
MOD_NEK2_1	225	230	PF00069	0.509
MOD_NEK2_1	461	466	PF00069	0.344
MOD_NEK2_1	5	10	PF00069	0.495
MOD_NEK2_1	550	555	PF00069	0.344
MOD_PIKK_1	409	415	PF00454	0.328
MOD_PIKK_1	421	427	PF00454	0.328
MOD_PIKK_1	431	437	PF00454	0.328
MOD_PIKK_1	461	467	PF00454	0.340
MOD_PIKK_1	79	85	PF00454	0.515
MOD_PKA_1	175	181	PF00069	0.500
MOD_PKA_1	92	98	PF00069	0.556
MOD_PKA_2	471	477	PF00069	0.344
MOD_PKA_2	50	56	PF00069	0.600
MOD_PKA_2	95	101	PF00069	0.487
MOD_Plk_1	22	28	PF00069	0.481
MOD_Plk_1	364	370	PF00069	0.334
MOD_Plk_1	38	44	PF00069	0.399
MOD_Plk_1	445	451	PF00069	0.328
MOD_Plk_1	539	545	PF00069	0.328
MOD_Plk_1	6	12	PF00069	0.469
MOD_Plk_2-3	317	323	PF00069	0.725
MOD_Plk_4	14	20	PF00069	0.440
MOD_Plk_4	364	370	PF00069	0.344
MOD_Plk_4	38	44	PF00069	0.435
MOD_Plk_4	434	440	PF00069	0.450
MOD_Plk_4	491	497	PF00069	0.353
MOD_Plk_4	545	551	PF00069	0.381
MOD_Plk_4	6	12	PF00069	0.469
MOD_ProDKin_1	260	266	PF00069	0.559
MOD_ProDKin_1	481	487	PF00069	0.376
MOD_SUMO_for_1	214	217	PF00179	0.540
MOD_SUMO_for_1	616	619	PF00179	0.609
MOD_SUMO_rev_2	151	160	PF00179	0.572
MOD_SUMO_rev_2	202	209	PF00179	0.598
MOD_SUMO_rev_2	211	221	PF00179	0.567
TRG_DiLeu_BaEn_4	38	44	PF01217	0.507
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.428
TRG_ENDOCYTIC_2	252	255	PF00928	0.379
TRG_ENDOCYTIC_2	29	32	PF00928	0.455
TRG_ENDOCYTIC_2	290	293	PF00928	0.452
TRG_ENDOCYTIC_2	569	572	PF00928	0.512
TRG_ENDOCYTIC_2	593	596	PF00928	0.431
TRG_ENDOCYTIC_2	84	87	PF00928	0.392
TRG_ER_diArg_1	174	177	PF00400	0.540
TRG_ER_diArg_1	308	311	PF00400	0.747
TRG_ER_diArg_1	477	479	PF00400	0.328
TRG_ER_diArg_1	620	623	PF00400	0.606
TRG_NES_CRM1_1	371	387	PF08389	0.413
TRG_NLS_MonoExtC_3	211	216	PF00514	0.549
TRG_NLS_MonoExtC_3	620	625	PF00514	0.539
TRG_NLS_MonoExtN_4	172	179	PF00514	0.571
TRG_NLS_MonoExtN_4	210	216	PF00514	0.553
TRG_Pf-PMV_PEXEL_1	375	379	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K8	Leptomonas seymouri	87%	100%
A0A0S4J058	Bodo saltans	61%	100%
A0A1X0P7S6	Trypanosomatidae	71%	100%
A0A3R7JWC9	Trypanosoma rangeli	69%	100%
A0A3S7XAS0	Leishmania donovani	96%	100%
A4HP52	Leishmania braziliensis	92%	100%
A4IDF9	Leishmania infantum	97%	100%
D0A338	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DKS9	Trypanosoma cruzi	70%	100%